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| 1 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 2 | Optimization of butanol production from corn straw hydrolysate by Clostridium acetobutylicum using response surface method显示文摘Butanol is a new kind of very potential biofuels.Enzymatic hydrolysis of corn stalk was utilized in this study to produce butanol by Clostridium acetobutylicum CICC 8008.Plackett-Burman (P-B) design and Central Composite Design (CCD) were adopted to screen crucial factors during fermentation as well as the optimization of experimental conditions.The result demonstrated that among the seven factors,namely,Yeast extract,(NH 4) 2 SO 4,KH 2 PO 4,MgSO 4,FeSO 4,CuSO 4 and CaCO 3,only CaCO 3 was selected as the most critical factor.The optimization experiment results for CaCO 3 usage,temperature and reaction time by CCD were determined to be 5.04 g/L,35°C and 70 h,respectively.A corresponding mathematical model was established to predict the fermentation experiment and maximum butanol yield of 6.57 g/L was acquired.The result of verification experiment under the optimum conditions showed that 6.20 g/L was the maximum butanol yield.This demonstrated that statistical method was a powerful tool for the optimization of butanol production from enzymatic hydrolysis of corn stalk. | LIN YouSheng WANG Jing WANG XuMing SUN XiaoHong | 2011 | Chinese Science Bulletin2011，56，14： | 15 |
| 3 | Adjuvant chemotherapy with paclitaxel and cisplatin in lymph node-positive thoracic esophageal squamous cell carcinoma显示文摘Objective:No standard postoperative adjuvant chemotherapy has ever been established in node-positive esophageal squamous cell carcinoma(ESCC).This is a study to explore the effect of postoperative paclitaxel(PTX)and cisplatin(DDP)in lymph node-positive,completely resected thoracic ESCC patients.Methods:We conducted a prospective phase II trial.Patients had pathologically node-positive thoracic ESCC with negative margins.Outcomes of disease-free survival(DFS)and overall survival(OS)were compared with a matched historical control cohort.The postoperative chemotherapy regimen consisted of 4 to 6 cycles of PTX 150mg/m2 administered intravenously on d 1 followed by DDP 50 mg/m2 on d 2 every 14 d.Results:Forty-three patients were accrued from December 2007 to May 2012 at Cancer Hospital of Chinese Academy of Medical Sciences for adjuvant chemotherapy.The historical control group consisted of 80 patients who received complete resection but no adjuvant chemotherapy during the same period of time.Of the 43 patients with adjuvant chemotherapy,37(86.0%)patients completed 4 to 6 cycles of chemotherapy.The 3-year DFS rates were56.3%in the adjuvant group and 34.6%in the control group(P=0.006).The 3-year OS rates were 55.0%in the adjuvant group and 37.5%in the control group(P=0.013).Multivariate analysis revealed that postoperative chemotherapy was the significant predictor for improved OS(P=0.005).Conclusions:Biweekly adjuvant PTX and DDP might improve 3-year DFS and OS in lymph node-positive,curatively resected thoracic ESCC patients.These conclusions warrant further study in randomized phase III clinical trials. | Liangze Zhang Weiwei Li Xiao Lyu Yan Song Yousheng Mao Shaoming Wang Jing Huang | 2017 | Chinese Journal of Cancer Research2017，29，2： | 15 |
| 4 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 5 | THREE-DIMENSIONAL HYDROELASTIC ANALYSIS IN TIME DOMAIN WITH APPLICATION TO AN ELASTIC SHIP MODEL显示文摘According to the Price-Wu condition at the interface between flexible marine structure and the surrounding fluid flow, a solution to the three-dimensional potential flow in time domain around a flexible structure traveling in waves is expressed with a boundary integral equation in the present paper, where the Green function, satisfying the linearized free surface condition for the time-dependent problem, is employed. A hydroe-lastic analysis directly in time domain to predict loads, motions, and structural responses of ships at steady forward speed in a seaway is formulated. As a example of application, the comparisons are made among the numerical results given by present method, the experimental measurements and the prediction provided by the three-dimensional hydroelas-ticity theory in frequency domain. | Wang, Dayun Wu, Yousheng | 1998 | Journal of Hydrodynamics1998，10，4： | 8 |
| 6 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 7 | Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication显示文摘Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming process.Here,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid components.The hybrid perovskite inks endow fibres with super-smooth QD films.This,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into monofilaments.The bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving information.The successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables. | Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu Boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo Zeng | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 8 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 9 | Serum levels of perfluorinated compounds in the general population in Shenzhen, China显示文摘Perfluorinated compounds (PFCs) have been detected in many environmental matrices, biota, and nonoccupationally exposed populations in China recently. However, little is known about the distribution and levels of various PFCs in the general population living in areas where there is PFC exposure. In the present study, the levels and prevalence of ten target PFCs were determined in 227 serum samples from a population of nonoccupationally exposed individuals in Shenzhen, China. Results indicated that human exposure to PFCs was prevalent in Shenzhen. Perfluorooctanoate (PFOA) was the dominant PFC contaminant in the serum samples, with a median concentration of 6.72 ng/mL, followed by perfluorooctane sulfonate (PFOS) with a median concentration of 2.07 ng/mL. Other PFCs were detected at much lower concentrations, with median concentrations ranging from 0.02 to 0.87 ng/mL. Statistically, no significant (P>0.05) gender differences were observed for any of the PFCs. Significant (P<0.01) positive correlations were found between age and serum concentrations of the target PFCs, except for perfluorobutane sulfonate (R = 0.16, P = 0.01), perfluorohexanoic acid (R = 0.08, P = 0.22), and perfluoroheptanoic acid (R = 0.11, P = 0.10). Based on the one-compartment pharmacokinetic model, the total daily intakes of PFOA and PFOS for the general population in Shenzhen were calculated as 0.63 and 0.20 ng/kg body weight/day, respectively. | LI Xiao ZHANG JianQing LIU Wei LI XiaoNa ZHANG Xin JIANG YouSheng ZHOU Jian JIN YiHe | 2011 | Chinese Science Bulletin2011，56，28： | 5 |
| 10 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 11 | Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from Lung Cancer Patients显示文摘T cells and T cell receptors(TCRs)play pivotal roles in adaptive immune responses against tumors.The development of next-generation sequencing technologies has enabled the analysis of the TCRb repertoire usage.Given the scarce investigations on the TCR repertoire in lung cancer tissues,in this study,we analyzed TCRb repertoires in lung cancer tissues and the matched distant non-tumor lung tissues(normal lung tissues)from 15 lung cancer patients.Based on our results,the general distribution of T cell clones was similar between cancer tissues and normal lung tissues;however,the proportion of highly expanded clones was significantly higher in normal lung tissues than in cancer tissues(0.021%±0.002%vs.0.016%±0.001%,P=0.0054,Wilcoxon signed rank test).In addition,a significantly higher TCR diversity was observed in cancer tissues than in normal lung tissues(431.37±305.96 vs.166.20±101.58,P=0.0075,Mann-Whitney U test).Moreover,younger patients had a significantly higher TCR diversity than older patients(640.7±295.3 vs.291.8±233.6,P=0.036,Mann-Whitney U test),and the higher TCR diversity in tumors was significantly associated with worse cancer outcomes.Thus,we provided a comprehensive comparison of the TCR repertoires between cancer tissues and matched normal lung tissues and demonstrated the presence of distinct T cell immune microenvironments in lung cancer patients. | Xiang Wang Botao Zhang Yikun Yang Jiawei Zhu Shujun Cheng Yousheng Mao Lin Feng Ting Xiao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 5 |
| 12 | Fluid-structure interaction simulation of three-dimensional flexible hydrofoil in water tunnel显示文摘The closely coupled approach combined with the finite volume method(FVM) solver and the finite element method(FEM) solver is used to investigate the fluid-structure interaction(FSI) of a three-dimensional cantilevered hydrofoil in the water tunnel. The FVM solver and the coupled approach are verified and validated by comparing the numerical predictions with the experimental measurements, and good agreement is obtained concerning both the lift on the foil and the tip displacement. In the noncavitating flow, the result indicates that the growth of the initial incidence angle and the Reynolds number improves the deformation of the foil, and the lift on the foil is increased by the twist deformation. The normalized twist angle and displacement along the span of the hydrofoil for different incidence angles and Reynolds numbers are almost uniform. For the cavitation flow, it is shown that the small amplitude vibration of the foil has limited influence on the developing process of the partial cavity, and the quasi two-dimensional cavity shedding does not change the deformation mode of the hydrofoil. However, the frequency spectrum of the lift on the foil contains the frequency which is associated with the first bend frequency of the hydrofoil. | Shiliang HU Chuanjing LU Yousheng HE | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，1： | 5 |
| 13 | The electrical conductivity of H_2O at 0.21-4.18 GPa and 20 -350℃显示文摘The electrical conductivity of H2O in solid and liquid phases has been measured at 0.21-4.18 GPa and 20-350℃. The results indicate: ( i ) different phases of H2O in solid have different relations between electrical conductivity and temperature and pressure. The conductivity changes continuously with temperature, but discontinuously with the pressure between 2.11 and 2.58 GPa, which corresponds to the transforming pressure between ice (Ⅵ) and ice ( Ⅶ ) ; ( ii ) the con-ductivity of H2O in liquid all increases with temperature and pressure, but there are discontinuities at pressures between 0.57 and 0.9 GPa, and between 2.11 and 2.58 GPa, which are also consistent with the polymorph of ice (ice ( Ⅴ), ice (Ⅵ) and ice ( Ⅶ ) ) . This reflects that H2O in liquid at different pressures has quite different properties of electron chemistry. It is prob-ably the important reason that causes the layers with high electrical conductivity and low velocity in the earth’s crust and upper mantle. | ZHENG Haifei, XIE Hongsen, XU Yousheng, SONG Maoshuang, GUO Jie and ZHANG YuemingInstitute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China Department of Geology, Peking University, Beijing 100871, China | 1997 | Chinese Science Bulletin1997，42，12： | 5 |
| 14 | Interaction of Restin with transcription factors显示文摘Restin, a member of melanoma-associated antigen superfamily gene, was first cloned from differentiated leukemia cell induced by all trans-retinoic acid, and was able to inhibit cell proliferation, but the molecular mechanism was not clear. Since Restin was localized in cell nucleus, and its homolog member, Necdin (neuronal growth suppressor factor), could interact with transcription factors p53 and E2F1, we proposed that Restin might also function as Necdin through interacting with some transcription factors. In this study, transcription factors p53, AP1, ATFs and E2Fs were cloned and used in the mammalian two-hybrid system to identify their in- teraction with Restin. The results showed that only ATF3 had a strong interaction with Restin. It is interesting to know that ATF3 was an important transcription factor for G1 cell cycle initiation in physiological stress response. It was possible that the inhibition of cell proliferation by Restin might be related with the inhibition of ATF3 activity. | WU Yousheng LU Fan QI Yinxin WANG Ruihua ZHANG Jian LU Zifan ZHAO Zhongliang | 2005 | Science China(Life Sciences)2005，48，3： | 5 |
| 15 | Cell vibron polariton resonantly self-confined in the myelin sheath of nerve显示文摘Polaritons are arousing tremendous interests in physics and material sciences for their unique and amazing properties,especially including the condensation,lasing without inversion and even room-temperature superfluidity.Herein,we propose a cell vibron polariton(cell-VP):a collectively coherent mode of a photon and all phospholipid molecules in a myelin sheath formed by glial cells.Cell-VP can be resonantly self-confined in the myelin sheath under physiological conditions.The observations benefit from the specifically compact,ordered and polar thin-film structure of the sheath,and the relatively strong coupling of the mid-infrared photon with the vibrons of phospholipid tails in the myelin.The underlying physics is revealed to be the collectively coherent superposition of the photon and vibrons,the polariton induced significant enhancement of myelin permittivity,and the resonance of the polariton with the sheath.The captured cell-VPs in myelin sheaths may provide a promising way for super-efficient consumption of extra-weak bioenergy and even directly serve for quantum information.These findings further the understanding of nervous system operations at cellular level from the view of quantum mechanics. | Bo Song Yousheng Shu | 2020 | Nano Research2020，13，1： | 4 |
| 16 | Immunodiagnostic efficacy of detection of Schistosoma japonicum human infections in China:a meta analysis显示文摘Objective:To assess the diagnostic efficacy of the currently most widely used indirect hemagglutination assay(IHA) and enzyme-linked immunosorbent assay(ELISA) for detection of Schistosoma japonicum human infections.Methods:A comprehensive search was undertaken from China National Knowledge Infrastructure,Wanfang Database.VIP Database,PubMed. Cochrane Library,Science Citation Index Expanded.Proquest,and the inclusion and exclusion criteria were strictly settled.The funnel plot was used to assess the publication bias.Cochran’s Q test was employed to measure the homogeneity between studies,a summary receiver operating characteristic(SROC) curve was used to compare the diagnostic accuracy between the IHA and ELISA qualitatively by means of the Weighted Least Square method,the Ordinary Least Square method and the Robust regression method,and the diagnostic odds ratio(DOR) was drawn to compare the accuracy quantitatively.Results:Out of 785 publications,19 papers were eventually selected for analysis.Literature finality assessment indicated that minor publication bias existed in studies pertaining IHA test,but no bias was found in literatures regarding ELISA test.The heterogeneity test showed a heterogeneity between studies was present(χ~2 =466.07 and 34.67. both P values<0.0001).The areas under the SROC curves of IHA were all higher than that of ELISA test using the three methods(Weighted Least Square method:0.766 vs.0.695.Ordinary Least Square method:0.826 vs.0.741.Robust regression:0.815 vs.0.715).The TPR* values for IHA and EUSA were 0.710.0.759.0.749.and 0.650.0.686 and 0.666.respectively,and OR values were 5.997.9.937.8.893.and 3.432.4.784 and 3.959.respectively.The DOR of IHA was 9.41(95% CI:4.88-18.18).and 4.78(95%CI:3.21-7.13) for ELISA.Conclusions:All above results revealed that the diagnostic performance of IHA is better than that of ELISA.However,taking into account their unsatisfactory diagnostic value in areas with low infection intensity,a search for a better diagnostic test that can be applied in field situations in China should be given high priority. | Wei Wang Youzi Li Hongjun Li Yuntian Xing Guoli Qu Jianrong Dai Yousheng Liang | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 4 |
| 17 | Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus显示文摘Trans-neuronal viral tracing is becoming one of the most important methods for mapping neuronal circuit connections,but an anterograde trans-synaptic tracer compatible with functional assays is still lacking.Adeno-associated virus(AAV)is replication-defective,and its production of offspring needs the help of adenovirus(AV)[1]or herpesvirus co-infection[2].The replication deficiency,non-pathogenicity,easy manipulability。 | Fei Zhao Hai-Fei Jiang Wen-Bo Zeng Yousheng Shu Min-Hua Luo Shumin Duan | 2017 | Neuroscience Bulletin2017，33，3： | 4 |
| 18 | Structure and antibacterial activity of Ce3+ exchanged montmorillonites显示文摘Four kinds of Ce3+ exchanged montmorillonites(Ce/MMTs) were prepared by an ion-exchange reaction, and characterized with energy dispersive X-ray analysis (EDX), X-ray difference (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron micros-copy (SEM). The surface properties and antibacterial activity of Ce/MMTs were also investigated. The chemical compositions of Ce/MMTs were determined, and the cerium of Ce/MMTs was confirmed to be present as trivalent cerium state. The d001 basal spacings of Ce/MMTs were enlarged with the enhancement of the cerium contents, and the particles were formed with irregular shape. On increasing the Ce con-tents of Ce/MMTs, the special surface areas were decreased, but the total pore volumes and the average pore sizes were increased. The anti-bacterial activity of Ce/MMTs is increased with increasing the cerium contents, and 1.5g/L of Ce/MMT-3 containing 11.46wt.% of curium could remove all the Staphylococcus aureus and more than 99.9% of the Escherichia coli within 24.0 h of contact. Moreover, Ce/MMTs dis-played bactericidal activity. | OUYANG Yousheng XIE Yushan TAN Shaozao SHI Qingshan CHEN Yiben | 2009 | Journal of Rare Earths2009，27，5： | 4 |
| 19 | MULTIPOINT BLANK HOLDER FORCE CONTROL IN HYDROFORMING OF FUEL TANK显示文摘力量(BHF ) 控制的多点的空白的持有者的学习外面被得到 forhydroforming 一辆复杂形状摩托车燃料坦克。由有限元素方法(女性) 模拟,多点的空白的持有者柱体的配置和本地 BHF 的设置被优化,并且多点的 BHF 在上的影响流体力学的深绘画和 conventionalhydroforming 进程被学习。需要的液体压力和整个 BHF 为流体力学的深绘画过程被预言。最后,模拟结果被形成实验证明,并且他们在同意很好。 | WU Yousheng WANG Xinyun XIA Juchen HU Guoan SUN Yousong YANG Lin | 2006 | Chinese Journal of Mechanical Engineering2006，19，2： | 4 |
| 20 | Demonstration of biophoton-driven DNA replication via gold nanoparticle-distance modulated yield oscillation显示文摘Biologically,there exist two kinds of syntheses:photosynthesis and ATP-driven biosynthesis.The light harvesting of photosynthesis is known to achieve an efficiency of〜95%by the quantum energy transfer of photons.However,how the ATP-driven biosynthesis reaches its high efficiency still remains unknown.Deoxynucleotide triphosphates(dNTPs)in polymerase chain reaction(PCR)adopt the identical way of ATP to release their energy,and thus can be employed to explore the ATP energy process.Here,using a gold nanoparticle(AuNP)enhanced PCR(AuNP-PCR),we demonstrate that the energy released by phosphoanhydride-bond(PB)hydrolysis of dNTPs is in form of photons(PB-photons)to drive DNA replication,by modulating their resonance with the average inter-AuNP distance(D).The experimental results show that both the efficiency and yield of PCR periodically oscillate with D increasing,indicating a quantized process,but not simply a thermal one.The PB-photon wavelength is further determined to 8.4 pm.All these results support that the release,transfer and utilization of bioenergy are in the form of photons.Our findings of ATP-energy quantum conversion will open a new avenue to the studies of high-efficiency bioenergy utilization,biochemistry,biological quantum physics,and even brain sciences. | Na Li Daoling Peng Xianjing Zhang Yousheng Shu Feng Zhang Lei Jiang Bo Song | 2021 | Nano Research2021，14，1： | 4 |
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