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| 1 | Muscle-eye-brain disease and Fukuyama type congenital muscular dystrophy are not allelic显示文摘 | Ranta S Pihko H Santavuori P Tahvanainen E de la Chapelle A | 1995 | Neuromuscul Disord1995，5，3： | 1 |
| 2 | Polymerase chain reactionbased detection of rhinovirus,respiratory syncytial virus,and coronavirus in otitis media with effusion显示文摘 | Pitk(a)ranta A Jero J Arruda E | 1998 | J Pediatr1998，133，3： | 1 |
| 3 | The neuronal ceroid lipofuscinosis CLN8 membrane protein is a resident of the endoplasmic reticulum显示文摘 | Lonka L Kyttala A Ranta S | 2000 | Hum Mol Genet2000，9，11： | 1 |
| 4 | Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR显示文摘 | Pitk(a)ranta A Arruda E Malmberg H | 1997 | J Clin Microbiol1997，35，7： | 1 |
| 5 | Hypercalciuria in children with haemophilia suggests primary skeletal pathology显示文摘 | Ranta S Viljakainen H M?kipernaa A | 2011 | Br J Haematol2011，153，3： | 1 |
| 6 | The neuronal ceroid lipofuscinosis CLN8 membrane protein is a resident of the endoplasmic reticulum显示文摘 | Lonka L Kyttala A Ranta S | 2000 | Hum Mol Genet2000，9，11： | 1 |
| 7 | Skeletal stability of Le Fort Ⅰ osteotomy in patients with unilateral cleft lip and palate 显示文摘 | Heliovaara A Ranta R Hukki J | 2001 | Scand J Plast Reconstr Surg Hand Surg2001，35，1： | 1 |
| 8 | Hyponatremia due to an additive effect of carbamazepine and thiazide diuretics 显示文摘 | Ranta A Wooten GF | 2004 | Epilepsia2004，45，7： | 1 |
| 9 | Impaired interferon production by leukocytes from patients with Bell palsy and lack of findings suggestive for a systemic viral involvement显示文摘 | Pitk?ranta A Hovi T Peltomaa M | 1997 | The American Journal of Otology1997，18，2： | 1 |
| 10 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 11 | Hypercalciuria in children with haemophilia suggests primary skeletal pathology 显示文摘 | RANTA S VILJAKAINEN H MEKIPERNAA A | 2011 | Br J Haemato12011，153，3： | 1 |
| 12 | Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency显示文摘 | Er?ranta A Kurra V Tahvanainen AM | | 0，，08： | 1 |
| 13 | Management of stress and burnout of police personnel显示文摘 | Ranta RS Sud A | | JIAAP0，，： | 1 |
| 14 | Skeletal stability of Le Fort Ⅰ osteotomy in patients with isolated cleft palate and bilateral cleft lip and palate显示文摘 | Heli(o)vaara A Ranta R Hukki J | 2002 | Int J Oral Maxillofac Surg2002，31，4： | 1 |
| 15 | Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats显示文摘 | Erranta A Riutta A Fan M | 2012 | Am J Nephrol2012，35，5： | 1 |
| 16 | Culture model of human corneal epithelium for prediction of ocular drug absorption 显示文摘 | Toropainen E Ranta VP Talvitie A | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
| 17 | EEG montage ar, alysis in the blind source separation framework 显示文摘 | RUIZ R A S RANTA R LOUIS-DORR V | 2011 | Biomedical Signal Pro- cessing and Control2011，6，1： | 1 |
| 18 | Transscleral drug delivery to the posterior eye:prospects of pharmacokinetic modeling显示文摘 | Urtti A | 2006 | Adv Drug Deliv Rev2006，58，1： | 1 |
| 19 | Hypercalciuria in chil- dren with haemophilia suggests primary skeletal pathology显示文摘 | Ranta S Viljakainen H Makipernaa A | 2011 | Br J Haematol2011，153，3： | 1 |
| 20 | Secondary fermentationwith immobilized yeast-industrial scale显示文摘 | Gronqvist A Pajunen E Ranta B | 1989 | Proceedings of European Brewers Convention Congress1989，，： | 1 |
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