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| 1 | National differences in lipid response to postmenopausal hormone replacement therapy显示文摘 | Ranta V Oksanen H Arrenbrecht S | 2002 | Maturitas2002，42，4： | 1 |
| 2 | The calcinm-dependent nitric oxide production of human vascular endothelial ceils in preeclmpsia显示文摘 | Orpana AK Avela K Ranta V | 1996 | Am J Obstet Gynecol1996，174，： | 1 |
| 3 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 4 | Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency显示文摘 | Er?ranta A Kurra V Tahvanainen AM | | 0，，08： | 1 |
| 5 | Synchronous dynamics and rates of extinction in spatially structured populations显示文摘 | Heino M Kaitala V Ranta E | | 0，，： | 1 |
| 6 | EEG montage ar, alysis in the blind source separation framework 显示文摘 | RUIZ R A S RANTA R LOUIS-DORR V | 2011 | Biomedical Signal Pro- cessing and Control2011，6，1： | 1 |
| 7 | Synchrony in Population Dynamics显示文摘 | Ranta E Kaitala V Lindstrom J | | 0，，1364： | 1 |
| 8 | Synchrony in population dynamics显示文摘 | RANTA E KAITALA V LINDSTR o M J | 1995 | Proc R Soc Lond1995，262，： | 1 |
| 9 | Population dynamics and the colour of environmental noise显示文摘 | KAITALA V YLIKARJULA J RANTA E | 1997 | Proc R Soc Lond B1997，264，： | 1 |
| 10 | The calcium-dependent nitric oxide production of human vascular endothetial cells in preece-lampsia显示文摘 | Orpana AK Aveta K Ranta V | 1996 | Am J Obstet Gynecol1996，174，： | 1 |
| 11 | Synchrony dynamics and rates of extinction in spatially structured populations显示文摘 | HEINO M KAITALA V RANTA E | 1997 | Proc R Soc Lond B1997，264，： | 1 |
| 12 | Population dynamics consequences of delayed life-history effects 显示文摘 | Beckerman A Benton T G Ranta E Kaitala V Lundberg P | 2002 | TREE2002，17，： | 1 |
| 13 | Iterative wavelet-based denoising methods and robust outlier detection显示文摘 | Ranta R Louis-Dorr V Heinrich C | 2005 | IEEE Signal Processing Letters2005，12，8： | 1 |
| 14 | Sex in space: population dynamic consequences 显示文摘 | Ranta E Kaitala V Lindstrom J | 1999 | Proc R Soc Lond1999，266，1424： | 1 |
| 15 | Automatic segmentation and classification of bowel sounds显示文摘 | RANTA R LOUIS D V HEINRICH C H | 2002 | IEEE Signal Processing Letters2002，10，8： | 1 |
| 16 | Interpretation and improvement of an iterative wavelet-based denolsing method显示文摘 | RANTA R HEINRICH C H LOUIS D V | 2003 | IEEE Signal Processing Letters2003，10，8： | 1 |
| 17 | EEG montage analysis in the blind source separation framework显示文摘 | SALIDO RUIZ R A RANTA R LOUIS-DORR V | 2011 | Biomedical Signal Processing and Control2011，6，1： | 1 |
| 18 | Automatic segmentation and classification of bowel sounds 显示文摘 | Ranta R Louis D V Heinrich C H | 2002 | IEEE Signal Processing Letters2002，10，8： | 1 |
| 19 | The spatial dimension in population fluctuations显示文摘 | Ranta E Kaitala V Lundberg P | 1997 | Science1997，278，5343： | 1 |
| 20 | The clockwork of Finnish telraonid population dynamics 显示文摘 | Lindstrom J Ranta E Kaitala V | 1995 | Oikos1995，74，： | 1 |
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