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| 1 | 罗格列酮和全反式维甲酸对多发性骨髓瘤裸鼠移植瘤生长及血管形成的影响显示文摘目的研究罗格列酮(RGZ)和全反式维甲酸(ATRA)对多发性骨髓瘤裸鼠移植瘤生长和血管形成的影响。方法分别以不同浓度的RGZ和ATRA或RGZ+ATRA处理U266细胞24h,采用半定量RT—PCR法检测各组U266细胞中血管内皮细胞生长因子(VEGF)的表达。将U266细胞接种于4周龄Balb/c裸鼠一侧肩胛部皮下,接种1周后分别以RGZ和RGZ+ATRA腹腔注射干预,连续给药21d。第21天处死裸鼠,剥离皮下肿瘤并称重,将肿瘤组织分别进行HE和CD34、VEGF免疫组化染色。结果未经处理的对照组U266细胞中VEGFmRNA高表达;经RGZ处理后,VEGFmRNA的表达水平下调;经RGZ+ATRA处理后,VEGFmRNA的表达水平较RGZ组更低。U266细胞接种后,在裸鼠皮下均可形成肿瘤。腹腔用药后,RGZ组裸鼠移植瘤的体积和重量分别为(785±262)mm3和(1748±365)mg,均明显低于对照组(均P〈0.01);RGZ+ATRA组移植瘤的体积和再量分别为(154±89)mm3和(626±102)mg3均明显低于RGZ组(均P〈0.05)。各组裸鼠移植瘤中均有VEGF蛋白的表达,其中对照组VEGF蛋白的平均染色强度(IS)为2.20±0.40,明显高于RGZ组(1.48±0.37,P〈0.01);RGZ+ATRA组的Is为0.58±0.26,明显低于RGZ组(P〈0.01)。各组裸鼠移植瘤中均有CD34的表达,其中对照组CD34表达最强,微血管密度(MVD)为(56.4±15.2)个/高倍视野,明显高于RGZ组[(44.6±11.2)个/高倍视野,P〈0.05];RGZ+ATRA组CD34表达最弱,MVD为(21.5±8.6)个/高倍视野,明显低于RGZ组(P〈0.01)。结论RGZ和ATRA存体内环境中也能发挥抑制骨髓瘤细胞增殖和生长的作用。通过抑制骨髓瘤细胞中VEGF的表达从而阻断血管形成,可能也足RGZ和ATRA抗肿瘤作用的重要机制之一。 | 黄海雯 陈萍 李炳宗 傅晋翔 李军 张晓慧 刘睿 范银银 张宏 Howard C.H. Chow Anska Y. H. Leung Raymond Liang | 2012 | 中华肿瘤杂志2012，34，9： | 5 |
| 2 | Stakeholder orientation and business perform- ance:The case of service companies in China显示文摘 | Luk C Yau Oliver H M Chow Raymond P M | 2005 | Journal of International Marketing2005，13，13： | 1 |
| 3 | 罗格列酮与全反式维甲酸对骨髓瘤细胞分化的影响及其可能机制显示文摘目的探讨过氧化物酶体增殖物活化受体γ(PPARγ)的配体罗格列酮(RGZ)与全反式维甲酸(ATRA)对骨髓瘤细胞分化的影响及其可能机制。方法以RGZ和ATRA处理人骨髓瘤细胞U266和RPMI-8226,用^3H-掺入法检测细胞增殖变化;碘化丙啶(PI)染色后,以流式细胞仪检测细胞周期变化;瑞氏-姬母萨染色观察细胞形态学变化;流式细胞仪分析细胞表面CD49e的表达变化;Western blot方法检测p27^Kip1和p21^Waf1的表达变化。结果RGZ能显著抑制U266和RPMI-8226细胞的增殖,并且这种抑制作用呈剂量依赖性。经5μmol/LRGZ处理后,U266和RPMI-8226细胞G0/G1期细胞的比例分别为(45.2±6.7)%和(40.3±7.3)%,较对照组明显增加(均P〈0.05);G2/M期和S期细胞的比例分别为(52.2±7.4)%和(57.4±9.5)%,较对照组明显减少(均P〈0.05);CIM9e的表达率分别为(8.7±1.5)%和(7.9±1.6)%,较对照组明显上调(均P〈0.05)。以10μmol/LRGZ处理后,U266和RPMI-8226细胞的G0/G1期、G2/M期和S期细胞比例、CD49e的表达率均较5μmol/LRGZ组的变化更加显著。同时,经RGZ处理后,U266和RPMI-8226细胞的形态学变化也符合骨髓瘤细胞分化成熟的规律,p27^Kip1和p21^Waf1蛋白的表达量也较对照组明显增加。RGZ和ATRA联合对U266和RPMI-8226细胞影响较RGZ单独作用更加明显。结论RGZ可能通过上调p27^Kip1和p21^Waf1蛋白的表达,介导骨髓瘤细胞的周期阻滞,并诱导骨髓瘤细胞分化,抑制骨髓瘤细胞增殖。ATRA能增强RGZ对骨髓瘤细胞的上述作用,两者联合具有协同效应。 | 黄海雯 陈广华 常惠荣 Howard C.H. Chow Anska Y.H. Leung Raymond Liang 吴德沛 | 2009 | 中华肿瘤杂志2009，31，12： | 1 |
| 4 | Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer 显示文摘 | Michael A.S. Jewett Kamal Mattar Joan Basiuk Christopher G. Morash Stephen E. Pautler D. Robert Siemens Simon Tanguay Ricardo A. Rendon Martin E. Gleave Darrel E. Drachenberg Raymond Chow Hannah Chung Joseph L. Chin Neil E. Fleshner Andrew J. Evans Brenda | 2011 | European Urology2011，，： | 1 |
| 5 | Stakeholder orientation and busi- ness performance: the case of service companies in China显示文摘 | Luk Chung Leung Oliver Hm Yau Raymond Chow | 2005 | Journal of International Marketing2005，，13： | 1 |
| 6 | Is relationship marketing for everyone?显示文摘 | Oliver H.M. Yau Peter R. McFetridge Raymond P.M. Chow Jenny S.Y. Lee Leo Y.M. Sin Alan C.B. Tse | 2000 | European Journal of Marketing2000，，9： | 1 |
| 7 | Is Relationship Marketing for Everyone?显示文摘 | Oliver H M Yau Peter R McFetridge Raymond P M Chow | 2000 | European Journal of Marketing2000，34，9： | 1 |
| 8 | Age-related differences in the management and outcome of patients with acute coronary syndromes显示文摘 | Raymond T. Yan Andrew T. Yan Mary Tan Chi-Ming Chow David H. Fitchett Frank L. Ervin James Y.M. Cha Anatoly Langer Shaun G. Goodman | 2006 | American Heart Journal2006，，2： | 1 |
| 9 | Surgery for Cushing’s Syndrome: An Historical Review and Recent Ten-year Experience显示文摘 | John R. Porterfield Geoffrey B. Thompson William F. Young John T. Chow Raymond S. Fryrear Jon A. Heerden David R. Farley John L. D. Atkinson Fredric B. Meyer Charles F. Abboud Todd B. Nippoldt Neena Natt Dana Erickson Adrian Vella Paul C. Carpenter Melani | 2008 | World Journal of Surgery2008，，5： | 1 |
| 10 | Stakeholder Orientation and Business Performance: The Case of Service Companies in China 显示文摘 | Luk Chung Leung Oliver Hm Yau Raymond Chow | 2005 | Journal of Interna- tional Marketing2005，，13： | 1 |
| 11 | Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer <ce:link locator='eulogo1'/>显示文摘 | Michael A.S. Jewett Kamal Mattar Joan Basiuk Christopher G. Morash Stephen E. Pautler D. Robert Siemens Simon Tanguay Ricardo A. Rendon Martin E. Gleave Darrel E. Drachenberg Raymond Chow Hannah Chung Joseph L. Chin Neil E. Fleshner Andrew J. Evans Brenda | 2011 | European Urology2011，，1： | 1 |
| 12 | Market orientation and businesscom- petitiveness : A comparative study of firms in mainland China and Hong Kong 显示文摘 | Leo Y M Sin Alan C B Tse Oliver H M Yau Raymond Chow Jenny S Y Lee | 2003 | European Journal of Marketing2003，5，： | 1 |
| 13 | Stakeholder Orientation and Business Performance: The Case of Service Companies in China 显示文摘 | LUK CHUNG LEUNG OLIVER H M YAU RAYMOND P M CHOW | 2005 | Journal of International Marketing2005，，13： | 1 |
| 14 | Is relationship marketing for everyone?显示文摘 | Oliver H.M. Yau Peter R. McFetridge Raymond P.M. Chow Jenny S.Y. Lee Leo Y.M. Sin Alan C.B. Tse | 2000 | European Journal of Marketing2000，，9： | 1 |
| 15 | 弧里弧途显示文摘面积:约112平方米间隔:四室二厅听说,人的长相在一定程度上透露了他的贤愚善恶。大眼睛的人重感情,小眼睛的人重理智;唇厚的人多情,唇薄的人寡幸。又听说。 | Alex Chow Raymond Poon 黄浩然 梁慧敏 | 1998 | 城市住宅1998，，3： | 0 |
| 16 | 苦心经营显示文摘面积:47平方米(实用面积)间隔:三室一厅看这居室,一点也不能想像设计师所言的'成本有限'。单单一眼所见的装饰已很丰富了,而这也是很多人对室内设计的'期望';如果再深入留意一下,原来整所居室的间隔也经过改动,那么,你就可以知道这个设计其实是一个无价宝,因为设计师确实花了不少心思,而经营的苦心,更是难以用金钱计算的。 | Raymond Chow Eddie Cheung Dick Liu 李慧欣 | 1999 | 城市住宅1999，，12： | 0 |
| 17 | The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions显示文摘Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly common.International studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with age.Patients with PCL are at risk of developing pancreatic cancer,a disease with a poor prognosis.This publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local specialists.Methods:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March 2022.The expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and endocrinologists.Results:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these lesions.They should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the patient.Where indicated,patients should undergo pancreatectomy to excise PCL.Following pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and malnutrition.Therefore,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic function.Patients are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if indicated.Conclusions:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape. | Tan-To Cheung Yuk Tong Lee Raymond Shing-Yan Tang Wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok Wing Sun Chow Tak Wing Lai Wai-Kay Seto Thomas Yau | 2023 | Hepatobiliary Surgery and Nutrition2023，12，5： | 0 |
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