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| 1 | Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus显示文摘The caterpillar fungus Ophiocordyceps sinensis (best known as Cordyceps sinensis) mummifies ghost moth larvae exclusively in Tibetan Plateau alpine ecosystems. Touted as 'Himalayan Viagra', the fungus is highly prized due to its medical benefits and dwindling supplies. Attempts to culture the sexual fruiting-body have failed and the huge market demand has led to severe devastation of local ecosystems and to the fungus heading towards extinction. By genome sequencing, we establish that unlike related insect pathogens O. sinensis contains two compatible mating-type genes in its genome and is self-fertile, i.e. homothallic. However, sexual processes are only initiated under native environmental conditions. O. sinensis resembles biotrophic plant pathogens in having a genome shaped by retrotransposon-driven expansions. The resulting changes in gene content suggest that O. sinensis has a biphasic pathogenic mechanism beginning with stealth pathogenesis in early host instars. O. sinensis is the first psychrophilic fungus sequenced and is adapted to extreme cold with putative antifreeze proteins and mechanisms for increasing lipid accumulation and fatty acid unsaturation. We hypothesize that for the inbreeding O. sinensis the massive proliferation of retrotransposons provides a tradeoff between the advantages of increased genetic variation independent of sexual recombination and deletion of genes dispensable for its specialized pathogenic lifestyle. | HU Xiao ZHANG YongJie XIAO GuoHua ZHENG Peng XIA YongLiang ZHANG XingYu ST LEGER Raymond J LIU XingZhong WANG ChengShu | 2013 | Chinese Science Bulletin2013，58，23： | 26 |
| 2 | Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder显示文摘AIM:To facilitate translational research on cholelithiasis,we have developed a rat model of human gallstones by exploiting the unique biliopancreatic features of this species.METHODS:Under anesthesia,16 adult rats of equal genders underwent two times of abdominal surgery.First,their common bile duct(CBD)was ligated to cause cholestasis by total biliary obstruction(TBO).On day 0,1,3,7,14,21 and 28 after TBO,magnetic resonance imaging(MRI)was conducted to monitor the dilatation of the CBD,and blood was sampled to analyze total serum bilirubin(TSB).Secondly,on day 30,the abdomen was re-opened and gallstone(s)collected from human patients were implanted in the dilated CBD asa virtual gallbladder(VGB),which was closed by suture ligation.This rat cholelithiasis model was examined by MRI,clinical observation,microcholangiography and histology.RESULTS:All rats survived two laparotomies.After ligation,the CBD was dilated to a stable size of 4 to30 mm in diameter on day 21-28,which became a VGB.The rats initially showed signs of jaundice that diminished over time,which paralleled with the evolving TSB levels from 0.6±0.3 mg/d L before ligation,through a peak of 10.9±1.9 mg/dL on day 14,until a nearly normalized value after day 28.The dilated CBD with thickened wall allowed an incision for implantation of human gallstones of 1-10 mm in diameter.The rat cholelithiasis was proven by in vivo MRI and postmortem microcholangiography and histomorphology.CONCLUSION:A rat model cholelithiasis with human gallstones has been established,which proves feasible,safe,reliable,nontoxic and cost-effective.Given the gallstones of human origin,applications of this model may be of help in translational research such as optical detection and lysis of gallstones by systemic drug administration. | Marlein Miranda Cona Yewei Liu Ting Yin Yuanbo Feng Feng Chen Stefaan Mulier Yue Li Jian Zhang Raymond Oyen Yicheng Ni | 2016 | World Journal of Methodology2016，6，2： | 7 |
| 3 | Long-term survival after intraluminal brachytherapy for inoperable hilar cholangiocarcinoma: A case report显示文摘Surgical resection with a tumor-free margin is the onlycurative treatment for hilar cholangiocarcinoma (Klatskin tumor). However, over half of the patients present late with unresectable tumors. Radiotherapy using external beamirradiation or intraluminal brachytherapy (ILBT) has been used to treat unresectable hilar cholangiocarcinoma with satisfactory outcome. We reported a patient with unresectable hilar cholangiocarcinoma surviving more than 6 years after combined external beam irradiation and ILBT. | Siu-Yin Chan Ronnie T. Poon Kelvin K. Ng Chi-Leung Liu Raymond T. Chan Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 4 | Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin显示文摘 | Yan-li LIU Hai-ming LIN Rong ZOU Jun-chao WU Rong HAN Laurence N RAYMOND Paul F REID Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，2： | 6 |
| 5 | An efficient method for privacy preserving location queries显示文摘最近,保存地点询问的隐私的问题吸引了许多研究。然而,有很少工作,集中于在地点隐私保藏和地点质问信息收集之间的折衷。处理这种折衷,我们建议坚持的隐私地点质问(PLQ ) ,保存地点质问处理的有效隐私框架。没有揭示用户地点信息,这个框架能启用基于地点的质问。框架能也便于基于地点的服务供应商关于基于的地点收集一些信息查询,它在实践是有用的。也就是, PLQ 由三个关键部件组成在顾客方面,在服务器方面的隐私询问处理器,和连接顾客和服务器的另外的信任第三方的地点 anonymizer。地点 anonymizer 基于一个地图层次模糊用户地点进一个 cloaked 区域。地图层次包含根据真实地形被划分的精确区域。隐私质问处理器处理请求近邻居(NN ) 地点基于质问。多角形(CHP ) 的新凸的壳算法用一个多角形 cloaked 区域为近邻居的询问被建议。我们高效地,进程地点基于的算法罐头查询的试验性的结果表演。 | Yubao LIU Xiuwei CHEN Zhan LI Zhijie LI Raymond Chi-Wing WONG | 2012 | Frontiers of Computer Science2012，6，4： | 5 |
| 6 | 原产地效应对“中国制造”品牌感知传递机制影响研究显示文摘以美国马萨诸塞州为主要调研环境,从原产地效应视角上深入探讨'中国制造'品牌感知的传递机制,通过编制量表和发放问卷,对国外消费者市场进行深入调查分析,研究国外消费者对'中国制造'品牌形象及国家形象的影响因素和作用机理,建立品牌感知传递机制模型,根据数据分析结果,得出影响消费者对'中国制造'感知的主要因素及其影响程度,提出促使国外消费者正面感知'中国制造'的建议和措施。 | 沈滔 Raymond Liu | 2017 | 科技创业月刊2017，30，8： | 4 |
| 7 | Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia显示文摘Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive.We implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V24689 I mutation in TTN, p.S2506 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size. | Jinsong Tang Yu Fan Hong Li Qun Xiang Deng-Feng Zhang Zongchang Li Ying He Yanhui Liao Ya Wang Fan He Fengyu Zhang Yin Yao Shugart Chunyu Liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang Yao Xiaogang Chen | 2017 | Journal of Genetics and Genomics2017，44，6： | 4 |
| 8 | Diversity of microbial plankton across the Three Gorges Dam of the Yangtze River,China显示文摘长江的三个峡水坝(TGD ) ,中国,在世界上是最大的灌溉和水力发电的工程工程之一。效果巨大人造象动物志和 macrophyte 上的 TGD 一样的工程是明显的,主要通过水动力学和流动模式的变化;然而,微生物怎么对如此的变化作出回应,是不太清楚的。这研究被瞄准在不同季节和地点在微生物引起的差异检验差别(在前面并且在 TGD 后面) 。另外,依附粒子、免费生活的社区之间的差别也被检验。在水列在后面并且在 TGD 前面的全部、潜在地活跃的微生物的社区结构与基于 DNA 、基于 RNA 的 16S rRNA 基因被分析在三个不同季节的种系发生的途径。16S rRNA 基因的克隆图书馆从提取 DNA 在扩大以后被准备并且为一些样品,在从提取 rRNA 准备 cDNA 以后。差别在不同季节并且在免费生活、依附粒子的社区之间在地点之间被观察。细菌并且 archaeal 社区比在冬季在夏天是更多样的,由于在夏天的更高滋养的层次和更温暖的温度比在冬季。依附粒子的微生物比免费生活的社区更多样,可能因为在粒子的更高滋养的层次和异构的 geochemical 微型环境。在细菌的社区结构的空间变化被观察,即,在 TGD 后面的水水库(在上游) 比在水坝前面招待了更多样的细菌的人口(下游) ,因为沉积和水从的多样的来源对水库在上游。这些结果在水坝建设影响的河生态系统为我们对环境变化的微生物引起的社区的回答的理解有重要含意。 | Shang Wang Raymond M. Dong Christina Z. Dong Liuqin Huang Hongchen Jiang Yuli Wei Liang Feng Deng Liu Guifang Yang Chuanlun Zhang Hailiang Dong | 2012 | Geoscience Frontiers2012，3，3： | 4 |
| 9 | 来源国效应研究述评显示文摘来源国效应(country-of-origin effect)相关理论在国际市场营销和国际化战略领域占据重要地位。国外相关研究由来已久,研究内容也已形成理论族群,但该领域的研究仍然存在相关概念的模糊和理论框架的缺失。针对来源国效应的检验由于样本差异、控制变量差异等因素的存在,相关结论尚无法形成体系化理论支撑。尤其是针对发展中国家逆向拓展发达国家市场时的来源国效应研究相对匮乏,一些调节变量的影响机理仍有待揭示。国内学者最近几年才开始关注来源国效应,主要聚焦于不同属性产品的来源国效应检验。文章回顾了来源国效应的相关概念演变,梳理了来源国效应的三种理论基础,总结了发展中国家企业进入发达国家的品牌战略,整合了研究内容的理论框架,概括了该领域常用的研究方法,并在此基础上指明了未来研究方向。文章作为一篇理论综述,希望通过文献梳理和分析,厘清研究主干和研究分支,为后续研究提供基础和参考。 | 刘建丽 Raymond Liu | 2018 | 商业经济与管理2018，，6： | 3 |
| 10 | 美国消费者“中国制造”品牌感知及其实证研究——来自美国马萨诸塞州的调查显示文摘国家形象对消费者购买行为选择和决策过程有很大的影响,但产品来源国形象(COO)是否具有相同的影响在文献研究中相对匮乏。该研究经过系统的文献整理,以美国马萨诸塞州为主要范围展开实证调查,通过深度访谈,多维尺度分析(MDS),回归模型拟合优度评估等统计手段,证实了国家形象和产品来源国形象(COO)之间的正相关关系,并验证了产品来源国形象对消费者品牌感知的影响效果。 | 沈滔 Raymond Liu | 2017 | 科技创业月刊2017，30，1： | 3 |
| 11 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 12 | An analysis of money laundering and terrorism financing typologies 显示文摘 | ANGELA IRWIN KIM-KWANG RAYMOND CHOO LIN LIU | 2011 | Jour- lal of Money Laundering Control2011，15，： | 1 |
| 13 | Transpacific transport and evolution of the optical properties of Asian dust显示文摘 | Zhaoyan Liu T. Duncan Fairlie Itsushi Uno Jingfeng Huang Dong Wu Ali Omar Jayanta Kar Mark Vaughan Raymond Rogers David Winker Charles Trepte Yongxiang Hu Wenbo Sun Bing Lin Anning Cheng | 2013 | Journal of Quantitative Spectroscopy and Radiative Transfer2013，，： | 1 |
| 14 | 查看详情显示文摘 | J Liu J P Raymond S Carsten | | 0，，24： | 1 |
| 15 | Carbon dioxide reforming of methane to synthesis gas over Ni-MCM-41 catalysts 显示文摘 | Liu Dapeng Raymond Lau Armando Borgna | 2009 | Applied Catalysis A : General2009，358，2： | 1 |
| 16 | Nano-structured manganese oxide as a cathodic catalyst for enhanced oxygen reduction in a microbial fuel cell fed with a synthetic wastewater显示文摘 | Xian-Wei Liu Xue-Fei Sun Yu-Xi Huang Guo-Ping Sheng Kang Zhou Raymond J. Zeng Fang Dong Shu-Guang Wang An-Wu Xu Zhong-Hua Tong Han-Qing Yu | 2010 | Water Research2010，，18： | 1 |
| 17 | Collecting the Intemet AS-level Topology显示文摘 | Beichuan Zhang Raymond Liu Daniel Massey Lixia Zhang | 2005 | ACM2005，35，1： | 1 |
| 18 | A passive wavelength demodulation system for guided-wav Bragg grating sensors 显示文摘 | Liu Kexing Measures Raymond M | 1992 | IEEE Photo Tech Lett1992，4，5： | 1 |
| 19 | Microbial communities involved in electricity generation from sulfide oxidation in a microbial fuel cell显示文摘 | Min Sun Zhong-Hua Tong Guo-Ping Sheng Yong-Zhen Chen Feng Zhang Zhe-Xuan Mu Hua-Lin Wang Raymond J. Zeng Xian-Wei Liu Han-Qing Yu Li Wei Fang Ma | 2010 | Biosensors and Bioelectronics2010，，2： | 1 |
| 20 | Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure显示文摘 | Andrew T. Yan Raymond T. Yan Francis G. Spinale Rizwan Afzal Himali R. Gunasinghe Malcolm Arnold Catherine Demers Robert S. Mckelvie Peter P. Liu | 2006 | Journal of Cardiac Failure2006，，7： | 1 |
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