|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder显示文摘AIM:To facilitate translational research on cholelithiasis,we have developed a rat model of human gallstones by exploiting the unique biliopancreatic features of this species.METHODS:Under anesthesia,16 adult rats of equal genders underwent two times of abdominal surgery.First,their common bile duct(CBD)was ligated to cause cholestasis by total biliary obstruction(TBO).On day 0,1,3,7,14,21 and 28 after TBO,magnetic resonance imaging(MRI)was conducted to monitor the dilatation of the CBD,and blood was sampled to analyze total serum bilirubin(TSB).Secondly,on day 30,the abdomen was re-opened and gallstone(s)collected from human patients were implanted in the dilated CBD asa virtual gallbladder(VGB),which was closed by suture ligation.This rat cholelithiasis model was examined by MRI,clinical observation,microcholangiography and histology.RESULTS:All rats survived two laparotomies.After ligation,the CBD was dilated to a stable size of 4 to30 mm in diameter on day 21-28,which became a VGB.The rats initially showed signs of jaundice that diminished over time,which paralleled with the evolving TSB levels from 0.6±0.3 mg/d L before ligation,through a peak of 10.9±1.9 mg/dL on day 14,until a nearly normalized value after day 28.The dilated CBD with thickened wall allowed an incision for implantation of human gallstones of 1-10 mm in diameter.The rat cholelithiasis was proven by in vivo MRI and postmortem microcholangiography and histomorphology.CONCLUSION:A rat model cholelithiasis with human gallstones has been established,which proves feasible,safe,reliable,nontoxic and cost-effective.Given the gallstones of human origin,applications of this model may be of help in translational research such as optical detection and lysis of gallstones by systemic drug administration. | Marlein Miranda Cona Yewei Liu Ting Yin Yuanbo Feng Feng Chen Stefaan Mulier Yue Li Jian Zhang Raymond Oyen Yicheng Ni | 2016 | World Journal of Methodology2016，6，2： | 7 |
| 2 | Updated developments on molecular imaging and therapeutic strategies directed against necrosis显示文摘Cell death plays important roles in living organisms and is a hallmark of numerous disorders such as cardiovascular diseases, sepsis and acute pancreatitis. Moreover, cell death also plays a pivotal role in the treatment of certain diseases, for example, cancer. Noninvasive visualization of cell death contributes to gained insight into diseases, development of individualized treatment plans, evaluation of treatment responses, and prediction of patient prognosis. On the other hand, cell death can also be targeted for the treatment of diseases. Although there are many ways for a cell to die, only apoptosis and necrosis have been extensively studied in terms of cell death related theranostics. This review mainly focuses on molecular imaging and therapeutic strategies directed against necrosis. Necrosis shares common morphological characteristics including the rupture of cell membrane integrity and release of cellular contents, which provide potential biomarkers for visualization of necrosis and necrosis targeted therapy. In the present review, we summarize the updated joint efforts to develop molecular imaging probes and therapeutic strategies targeting the biomarkers exposed by necrotic cells. Moreover, we also discuss the challenges in developing necrosis imaging probes and propose several biomarkers of necrosis that deserve to be explored in future imaging and therapy research. | Dongjian Zhang Meng Gao Qiaomei Jin Yicheng Ni Jian Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 3 | Pancreatic imaging:Current status of clinical practices and small animal studies显示文摘Different causative factors acting on the pancreas can result in diseases such as pancreatitis, diabetes and pancreatic tumors. The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice. In this minireview article different pancreatic imaging techniques are discussed, from the standard clinical imaging modalities and state of the art clinical magnetic resonance imaging techniques to current situations in pre-clinical pancreatic imaging studies. In particular, the challenges of pre-clinical rodent pancreatic imaging are addressed, with both the image acquisition techniques and the post-processing methods for rodent pancreatic imaging elaborated. | Ting Yin Yewei Liu Ronald Peeters Yuanbo Feng Yicheng Ni | 2017 | World Journal of Methodology2017，7，3： | 2 |
| 4 | An overview of translational(radio)pharmaceutical research related to certain oncological and non-oncological applications显示文摘Translational medicine pursues the conversion of scientific discovery into human health improvement.It aims to establish strategies for diagnosis and treatment of diseases.Cancer treatment is difficult.Radiopharmaceutical research has played an importantrole in multiple disciplines,particularly in translational oncology.Based on the natural phenomenon of necrosis avidity,Onco Ci Dia has emerged as a novel generic approach for treating solid malignancies.Under this systemic dual targeting strategy,a vascular disrupting agent first selectively causes massive tumor necrosis that is followed by iodine-131 labeled-hypericin(123IHyp),a necrosis-avid compound that kills the residual cancer cells by crossfire effect of beta radiation.In this review,by emphasizing the potential clinical applicability of Onco Ci Dia,we summarize our research activities including optimization of radioiodinated hypericin Hyp preparations and recent studies on the biodistribution,dosimetry,pharmacokinetic and,chemical and radiochemical toxicities of the preparations.Myocardial infarction is a global health problem.Although cardiac scintigraphy using radioactive perfusion tracers is used in the assessment of myocardial viability,searching for diagnostic imaging agents with authentic necrosis avidity is pursued.Therefore,a comparative study on the biological profiles of the necrosis avid 123I-Hyp and the commercially available 99mTc-Sestamibi was conducted and the results are demonstrated.Cholelithiasis or gallstone disease may cause gallbladder inflammation,infection and other severe complications.While studying the mechanisms underlying the necrosis avidity of Hyp and derivatives,their naturally occurring fluorophore property was exploited for targeting cholesterol as a main component of gallstones.The usefulness of Hyp as an optical imaging agent for cholelithiasis was studied and the results are presented.Multiple uses of automatic contrast injectors may reduce costs and save resources.However,cross-contaminations with bloodborne pathogens of infectious diseases may occur.We developed a radioactive method for safety evaluation of a new replaceable patient-delivery system.By mimicking pathogens with a radiotracer,we assessed the feasibility of using the system repeatedly without septic risks.This overview is deemed to be interesting to those involvedin the related fields for translational research. | Marlein Miranda Cona Peter de Witte Alfons Verbruggen Yicheng Ni | 2013 | World Journal of Methodology2013，3，4： | 2 |
| 5 | Local Recurrence After Hepatic Radiofrequency Coagulation: Multivariate Meta-Analysis and Review of Contributing Factors显示文摘 | Stefaan Mulier Yicheng Ni Jacques Jamart Theo Ruers Guy Marchal Luc Michel | 2005 | Annals of Surgery2005，，2： | 2 |
| 6 | A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research显示文摘 | Yuanbo Feng Yi Xie Huaijun Wang Feng Chen Yuxiang Ye Lixin Jin Guy Marchal Yicheng Ni | 2009 | The International Journal of Cardiovascular Imaging2009，，3： | 1 |
| 7 | Small-Animal PET of Tumor Damage Induced by Photothermal Ablation with ^sup 64^Cu-Bis-DOTA-Hypericin显示文摘 | Song Shaoli Xiong Chiyi Zhou Min Lu Wei Huang Qian Ku Geng Zhao Jun Flores Leo G Ni Yicheng Li Chun | 2011 | The Journal of Nuclear Medicine2011，，5： | 1 |
| 8 | Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease显示文摘AIM To develop a MRI-based method for accurate determination of liver volume(LV) and to explore the effect of long-term everolimus(EVR) treatment on LV in PCK rats with hepatomegaly. METHODS Thirty-one female PCK rats(model for polycystic-liverdisease: PCLD) were randomized into 3 groups and treatment was started at 16 wk, at the moment of extensive hepatomegaly(comparable to what is done in the human disease). Animals received: controls(n = 14), lanreotide(LAN: 3 mg/kg per 2 wk)(n = 10) or everolimus(EVR: 1 mg/kg per day)(n = 7). LV was measured at week 16, 24, 28. At week 28, all rats were sacrificed and liver tissue was harvested. Fibrosis was evaluated using quantitative image analysis. In addition, gene(quantitative RT-PCR) and protein expression(by Western blot) of the PI3K/Ak T/m TOR signaling pathway was investigated. RESULTS LV determination by MRI correlated excellent with the ex vivo measurements(r = 0.99, P < 0.001). The relative changes in LV at the end of treatment were:(controls) +31.8%;(LAN) +5.1% and(EVR) +8.8%, indicating a significantly halt of LV progression compared with controls(respectively, P = 0.01 and P = 0.04). Furthermore, EVR significantly reduced the amount of liver fibrosis(P = 0.004) thus might also prevent the development of portal hypertension. There was no difference in phosphorylation of Akt(Threonine 308) between LAN-treated PCK rats control PCK rats, whereas S6 was significantly more phosphorylated in the LAN group. Phosphorylation of Akt was not different between controls and EVR treated rats, however, for S6 there was significantly less phosphorylation in the EVR treated rats. Thus, both drugs interact with the PI3K/Ak T/m TOR signaling cascade but acting at different molecular levels.CONCLUSION Everolimus halts cyst growth comparable to lanreotide and reduces the development of fibrosis. m TORinhibition should be further explored in PCLD patients especially those that need immunosuppression. | Frederik Temmerman Feng Chen Louis Libbrecht Ingrid Vander Elst Petra Windmolders Yuanbo Feng Yicheng Ni Humbert De Smedt Frederik Nevens Jos van Pelt | 2017 | World Journal of Gastroenterology2017，23，30： | 1 |
| 9 | The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma显示文摘 | Baoying Hu Yicheng Xiong Runzhou Ni Lixian Wei Dawei Jiang Gang Wang Di Wu Tianxin Xu Fengbo Zhao Mingyan Zhu Chunhua Wan | 2014 | 2014 (1-2)2014，，1： | 1 |
| 10 | Tumor models and specific contrast agents for small animal imaging in oncology 显示文摘 | Yicheng Ni Huaijun Wang Feng Chen | 2009 | Methods2009，4，2： | 1 |
| 11 | Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats显示文摘 | Qingqing Wang Cuihua Jiang Shengzuo Fang Junhu Wang Yun Ji Xulan Shang Yicheng Ni Zhiqi Yin Jian Zhang | 2013 | Journal of Ethnopharmacology2013，，3： | 1 |
| 12 | The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma显示文摘 | Hu Baoying Xiong Yicheng Ni Runzhou | 2014 | Mol Cell Biochem2014，396，12： | 1 |
| 13 | Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours显示文摘 | Huaijun Wang Junjie Li Feng Chen Frederik Keyzer Jie Yu Yuanbo Feng Johan Nuyts Guy Marchal Yicheng Ni | 2010 | European Radiology2010，，8： | 1 |
| 14 | Murine liver implantation of radiation-induced fibrosarcoma: characterization with MR imaging, microangiography and histopathology显示文摘 | Huaijun Wang Marie Putte Feng Chen Frederik Keyzer Lixin Jin Jie Yu Guy Marchal Peter Witte Yicheng Ni | 2008 | European Radiology2008，，7： | 1 |
| 15 | Experimental and Clinical Radiofrequency Ablation: Proposal for Standardized Description of Coagulation Size and Geometry显示文摘 | Stefaan Mulier MD Yicheng Ni MD PhD Lars Frich MD Fernando Burdio MD Alban L. Denys MD Jean-Fran?ois Wispelaere MD Beno?t Dupas MD PhD Nagy Habib MD FRCS Michael Hoey PhD Maarten C. Jansen MD Marc Lacrosse MD Raymond Leveillee MD Yi Miao MD PhD Peter | 2007 | Annals of Surgical Oncology2007，，4： | 1 |
| 16 | Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model显示文摘 | Jiyang Jin Gaojun Teng Yi Feng Yanping Wu Qindi Jin Yu Wang Zhen Wang Qin Lu Yibo Jiang Shengqi Wang Feng Chen Guy Marchal Yicheng Ni | 2007 | CardioVascular and Interventional Radiology2007，，2： | 1 |
| 17 | Experimental and Clinical Radiofrequency Ablation: Proposal for Standardized Description of Coagulation Size and Geometry显示文摘 | Stefaan Mulier MD Yicheng Ni MD PhD Lars Frich MD Fernando Burdio MD Alban L. Denys MD Jean-Fran?ois Wispelaere MD Beno?t Dupas MD PhD Nagy Habib MD FRCS Michael Hoey PhD Maarten C. Jansen MD Marc Lacrosse MD Raymond Leveillee MD Yi Miao MD PhD Peter | 2007 | Annals of Surgical Oncology2007，，4： | 1 |
| 18 | Electrodes and multiple electrode systems for radiofrequency ablation: a proposal for updated terminology显示文摘 | Stefaan Mulier Yi Miao Peter Mulier Benoit Dupas Philippe Pereira Thierry Baere Riccardo Lencioni Raymond Leveillee Guy Marchal Luc Michel Yicheng Ni | 2005 | European Radiology2005，，4： | 1 |
| 19 | First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent显示文摘 | Yicheng Ni Dieter Huyghe Kristin Verbeke Peter A. Witte Johan Nuyts Luc Mortelmans Feng Chen Guy Marchal Alfons M. Verbruggen Guy M. Bormans | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，5： | 1 |
| 20 | Electrodes and multiple electrode systems for radiofrequency ablation: a proposal for updated terminology显示文摘 | Stefaan Mulier Yi Miao Peter Mulier Benoit Dupas Philippe Pereira Thierry Baere Riccardo Lencioni Raymond Leveillee Guy Marchal Luc Michel Yicheng Ni | 2005 | European Radiology2005，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员