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| 1 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 2 | 亚洲地区饲料原料和配合饲料中霉菌毒素水平的调查显示文摘 | Hsin Yi Chen Rebekah Rawlings 奥特奇 | 2008 | 饲料研究2008，31，9： | 8 |
| 3 | 亚洲地区饲料和养猪业霉菌毒素危害的真实情况显示文摘霉菌毒素是动物饲料中的有害成分,通常导致动物的生产性能下降,免疫机能抑制,使动物患病,进而通过动物的肉、奶、内脏进入食品链中,危害人的健康。对这些易受环境和气候影响的天然毒素进行常规检查和实时监控是非常有必要的。这将有助于饲料生产企业做好控制动物体内霉菌毒素潜在问题的准备。饲料生产企业或选择在饲料中使用有效的霉菌毒素吸附剂,或避免购买和使用霉变的饲料原料。 | Hsin-Yi Chen Rebekah Rawlings 罗兰 | 2008 | 养猪2008，，3： | 7 |
| 4 | CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。 | Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF | 2011 | Acta Pharmacologica Sinica2011，32，7： | 6 |
| 5 | 亚洲地区饲料和畜禽养殖业霉菌毒素危害实况显示文摘业已证明,霉菌毒素是动物饲料中具有危害性的成分.它们可导致畜禽多种难以判断的综合病症。霉菌毒素通常导致动物的生产性能下降、免疫机能抑制、导致动物患病,进而通过动物的肉、奶、内脏进入人类的食品链中,危害人类的健康。对这些易受环境和气候影响的天然毒素进行常规检查和实时监控是非常有必要的,将有助于饲料生产企业做好控制动物体内霉菌毒素潜在问题的准备,饲料生产企业或通过选择使用正确有效的霉菌毒素吸附剂, | 陈心仪 Rebekah Rawlings | 2008 | 饲料广角2008，，10： | 6 |
| 6 | Use of Continuous Insulin Infusion Pumps in Young Children With Type 1 Diabetes: A Systematic Review显示文摘 | Jeanne N. Churchill Rebekah L. Ruppe Arlene Smaldone | 2009 | Journal of Pediatric Health Care2009，，3： | 2 |
| 7 | 亚洲地区饲料和畜禽养殖业霉菌毒素危害实况显示文摘霉菌毒素是动物饲料中具有危害性的成分,它们可导致畜禽多种难以判断的综合病症。霉菌毒素通常导致动物的生产性能下降、免疫机能抑制。 | 陈心仪 Rebekah Rawlings | 2008 | 中国畜牧兽医文摘2008，，4： | 2 |
| 8 | Defining the Learning Curve for Team-Based Laparoscopic Pancreaticoduodenectomy显示文摘 | Paul J. Speicher Daniel P. Nussbaum Rebekah R. White Sabino Zani Paul J. Mosca Dan G. Blazer Bryan M. Clary Theodore N. Pappas Douglas S. Tyler Alexander Perez | 2014 | Annals of Surgical Oncology2014，，12： | 2 |
| 9 | Cadmium isotope fractionation reveals genetic variation in Cd uptake and translocation by Theobroma cacao and role of natural resistanceassociated macrophage protein 5 and heavy metal ATPase-family transporters显示文摘In response to new European Union regulations,studies are underway to mitigate accumulation of toxic cadmium(Cd)in cacao(Theobroma cacao,Tc).This study advances such research with Cd isotope analyses of 19 genetically diverse cacao clones and yeast transformed to express cacao natural resistance-associated macrophage protein(NRAMP5)and heavy metal ATPases(HMAs).The plants were enriched in light Cd isotopes relative to the hydroponic solution withΔ^(114/110)Cd_(tot-sol)=−0.22±0.08‰.Leaves show a systematic enrichment of isotopically heavy Cd relative to total plants,in accord with closed-system isotope fractionation ofΔ^(114/110)C_(dseq-mob)=−0.13‰,by sequestering isotopically light Cd in roots/stems and mobilisation of remaining Cd to leaves.The findings demonstrate that(i)transfer of Cd between roots and leaves is primarily unidirectional;(ii)different clones utilise similar pathways for Cd sequestration,which differ from those of other studied plants;(iii)clones differ in their efficiency of Cd sequestration.Transgenic yeast that expresses TcNRAMP5(T.cacao natural resistance-associated macrophage gene)had isotopically lighter Cd than did cacao.This suggests that NRAMP5 transporters constitute an important pathway for uptake of Cd by cacao.Cd isotope signatures of transgenic yeast expressing HMA-family proteins suggest that they may contribute to Cd sequestration.The data are the first to record isotope fractionation induced by transporter proteins in vivo. | Rebekah E.T.Moore Ihsan Ullah Vinicius Hde Oliveira Samantha J.Hammond Stanislav Strekopytov Mark Tibbett Jim M.Dunwell Mark Rehkämper | 2020 | Horticulture Research2020，7，1： | 2 |
| 10 | Current Utility of Staging Laparoscopy for Pancreatic and Peripancreatic Neoplasms显示文摘 | Rebekah White Corrine Winston Mithat Gonen Michael D'Angelica William Jarnagin Yuman Fong Kevin Conlon Murray Brennan Peter Allen | 2008 | Journal of the American College of Surgeons2008，，3： | 1 |
| 11 | The cell surface marker CD36 selectively identifies matured, mitochondria-rich hPSC-cardiomyocytes显示文摘Dear Editor,Human pluripotent stem cell(hPSC)-derived cardiomyocytes(CMs)are of significant translational value to in vitro studies of human cardiac development,drug and cardiotoxicity testing and cardiac disease modelling.Differentiation of hPSCs to CMs,however,yields mixed cultures of atrial-,ventricular-,and pacemaker-like cells as well as non-CMs in variable proportions.1 Strategies to enrich CMs from non-CMs and to generate ventricular versus atrial cells have been successful;however,enriched hPSC-CMs are developmentally immature and fail to recapitulate key functional traits that are fundamental to the(patho)physiology of adult CMs.1,2 Moreover,these strategies do not adequately address experimental variabilities caused by differences in the genomes and differentiation capabilities of diverse hPSC lines.One validated approach that overcomes issues of cell heterogeneity and experimental variability is immunophenotyping;however,accessible markers suitable for defining mature,live CMs are lacking.Although cell surface markers such as SIRPA(CD172a)and VCAM1(CD106)3,4 have been used to sort for hPSC-CMs,they do not distinguish between maturation states.Here,we report the identification of CD36 as a cell surface marker of maturation,which can be used to reduce experimental variability and improve drug screens. | Ellen Ngar-Yun Poon Xiao-ling Luo Sarah EWebb Bin Yan Rui Zhao Stanley Chun Ming Wu Yong Yang Peng Zhang Huajun Bai Jiaofang Shao Ching Man Chan Godfrey Chi-Fung Chan Suk Ying Tsang Rebekah LGundry Huang-Tian Yang Kenneth RBoheler | 2020 | Cell Research2020，30，7： | 1 |
| 12 | Service convenience and social servicescape: retail vs hedonic setting显示文摘 | Doan T. Nguyen Tom DeWitt Rebekah Russell-Bennett | 2012 | Journal of Services Marketing2012，，4： | 1 |
| 13 | Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase显示文摘 | William FM Rebekah J Dathan C | 2000 | Brain Research2000，878，： | 1 |
| 14 | TheBrand Loyalty Life Cycle: Implications for Marketers 显示文摘 | Bennett Rebekah Sharyn Rundle- Thiele | 2005 | Journal of Brand Management2005，12，4： | 1 |
| 15 | Which platform do our users prefer: website or mobile app 显示文摘 | Shun Han Rebekah Wong | 2012 | Reference Services Re- view2012，，40： | 1 |
| 16 | The Effects of Distinctiveness Require Reinstatement of Organization: The Importance of Intentional Memory Instructions显示文摘 | Rebekah E Smith R.Reed Hunt | 2000 | Journal of Memory and Language2000，，3： | 1 |
| 17 | Kinetics of High Pressure Char Oxidation显示文摘 | Rebekah J S Jared W A William C H | 1999 | ACS Div of Fuel Chem Preprints1999，44，： | 1 |
| 18 | Linking perceived value of mobile marketing with the experiential consumption of mobile phones显示文摘 | Lynda Andrews Judy Drennan Rebekah Russell-Bennett | 2012 | European Journal of Marketing2012，，3： | 1 |
| 19 | Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits 显示文摘 | REBEKAH L C WINSTON S C STEVEN C E | 2007 | Molecular Genetics & Metabolism2007，90，3： | 1 |
| 20 | Liver from bone marrow in humans显示文摘 | Theise ND Manjunath N Rebekah G | 2000 | Hepatology2000，32，6： | 1 |
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