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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Crustal deformation on the Chinese mainland during 1998—2004 based on GPS data显示文摘This study focuses on resolving moderate amounts of crustal motion at the continental scale based on a large volume of global positioning system(GPS) data during 1998e2014. A state-of-the-art GPS processing strategy was used to resolve position time series and velocities from carrier beat phases for all available data. Position time series were closely analyzed to estimate linear constant, coseismic displacements, postseismic motions, and other parameters. We present coseismic offsets inferred from the GPS data for the 2010 Yushu and 2014 Yutian earthquakes, and also illustrate transient postseismic motions following the 2001 Kokoxili, 2008 Wenchuan, and 2011 Tohoku-Oki earthquakes. Since not all GPS position time series dominated by postseismic motions can be modeled and corrected reasonably, we present contemporary horizontal velocities from 2009 to 2014 for campaign stations and from 1998 to 2014 for continuous stations, irrespective of postseismic deformations. Our study concludes that we need to accumulate observations over a greater duration and apply accurate postseismic modeling to correct for transient displacement in order to resolve reasonable interseismic velocity. | Zhao Bin Huang Yong Zhang Caihong Wang Wei Tan Kai Du Rinlin | 2015 | Geodesy and Geodynamics2015，6，1： | 50 |
| 3 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 4 | Intelligent and connected vehicles: Current status and future perspectives显示文摘Intelligent connected vehicles(ICVs) are believed to change people's life in the near future by making the transportation safer,cleaner and more comfortable. Although many prototypes of ICVs have been developed to prove the concept of autonomous driving and the feasibility of improving traffic efficiency, there still exists a significant gap before achieving mass production of high-level ICVs. The objective of this study is to present an overview of both the state of the art and future perspectives of key technologies that are needed for future ICVs. It is a challenging task to review all related works and predict their future perspectives, especially for such a complex and interdisciplinary area of research. This article is organized to overview the ICV key technologies by answering three questions: what are the milestones in the history of ICVs; what are the electronic components needed for building an ICV platform; and what are the essential algorithms to enable intelligent driving? To answer the first question, the article has reviewed the history and the development milestones of ICVs. For the second question, the recent technology advances in electrical/electronic architecture, sensors, and actuators are presented. For the third question, the article focuses on the algorithms in decision making, as the perception and control algorithm are covered in the development of sensors and actuators. To achieve correct decision-making, there exist two different approaches: the principle-based approach and data-driven approach. The advantages and limitations of both approaches are explained and analyzed. Currently automotive engineers are concerned more with the vehicle platform technology, whereas the academic researchers prefer to focus on theoretical algorithms. However, only by incorporating elements from both worlds can we accelerate the production of high-level ICVs. | YANG DianGe JIANG Kun ZHAO Ding YU ChunLei CAO Zhong XIE ShiChao XIAO ZhongYang JIAO XinYu WANG SiJia ZHANG Kai | 2018 | Science China(Technological Sciences)2018，61，10： | 31 |
| 5 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 6 | Effects of Duhuojisheng Tang and combined therapies on prolapse of lumbar intervertebral disc:a systematic review of randomized control trails显示文摘OBJECTIVE:A systematic review of the literature was conducted to evaluate the curative effect and safety of Duhuojisheng Tang on prolapse of the lumbar intervertebral disc.METHODS:The databases of PubMed,China National Knowledge Infrastructure(CNKI),Chinese Scientific Journals Database(VIP),Chinese Biomedical Literature Database(CBM) and Chinese Medical Citation Index(CMCI) were searched up to January 30,2012.Randomized controlled trials were selected to compare Duhuojisheng Tang with one or more of the following treatments:traction,acupuncture,massage,cupping and Western medical treatment.The quality-evaluating standard and the software RevMan 5.1 in Cochrane coordinative net were used to analyze the data.The effective indexes of the results were clinical curative rate,effectiveness of alleviating clinical symptoms and adverse reaction.RESULTS:Thirty-one randomized controlled trials of low quality,involving 3915 patients were systematically evaluated.Statistical analyses showed that good curative effect was achieved in both the group using Duhuojisheng Tang alone and with combined therapies.CONCLUSION:Using Duhuojisheng Tang alone or combined with other therapies can effectively improve pain,leg-raising height and other clinical symptoms of patients with prolapse of lumbar intervertebral disc.Due to low methodological quality of the articles,no exact recommendations can be made. | Yanxu Ma Minghua Huang Jingyan Cui Kai Meng Yuhao Zhao | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 27 |
| 7 | Toward Wisdom-Evolutionary and Primitive-Concise 6G:A New Paradigm of Semantic Communication Networks显示文摘The sixth generation(6G)mobile networks will reshape the world by offering instant,efficient,and intelligent hyper-connectivity,as envisioned by the previously proposed Ubiquitous-X 6G networks.Such hyper-massive and global connectivity will introduce tremendous challenges into the operation and management of 6G networks,calling for revolutionary theories and technological innovations.To this end,we propose a new route to boost network capabilities toward a wisdom-evolutionary and primitive-concise network(WePCN)vision for the Ubiquitous-X 6G network.In particular,we aim to concretize the evolution path toward the WePCN by first conceiving a new semantic representation framework,namely semantic base,and then establishing an intelligent and efficient semantic communication(IE-SC)network architecture.In the IE-SC architecture,a semantic intelligence plane is employed to interconnect the semantic-empowered physical-bearing layer,network protocol layer,and application-intent layer via semantic information flows.The proposed architecture integrates artificial intelligence and network technologies to enable intelligent interactions among various communication objects in 6G.It features a lower bandwidth requirement,less redundancy,and more accurate intent identification.We also present a brief review of recent advances in semantic communications and highlight potential use cases,complemented by a range of open challenges for 6G. | Ping Zhang Wenjun Xu Hui Gao Kai Niu Xiaodong Xu Xiaoqi Qin Caixia Yuan Zhijin Qin Haitao Zhao Jibo Wei Fangwei Zhang | 2022 | Engineering2022，8，1： | 28 |
| 8 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 9 | Screening and breeding of high taxol producing fungi by genome shuffling显示文摘To apply the fundamental principles of genome shuffling in breeding of taxol-producing fungi, Nodulisporium sylviform was used as starting strain in this work. The procedures of protoplast fusion and genome shuffling were studied. Three hereditarily stable strains with high taxol production were obtained by four cycles of genome shuffling. The qualitative and quantitative analysis of taxol produced was confirmed using thin-layer chromatography (TLC), high performance liquid chromatography (HPLC) and LC-MS. A high taxol producing fungus, Nodulisporium sylviform F4-26, was obtained, which produced 516.37 μg/L taxol. This value is 64.41% higher than that of the starting strain NCEU-1 and 31.52%―44.72% higher than that of the parent strains. | ZHAO Kai, PING WenXiang, ZHANG LiNa, LIU Jun, LIN Yan, JIN Tao & ZHOU DongPo Laboratory of Microbiology, College of Life Science, Heilongjiang University, Harbin 150080, China | 2008 | Science China(Life Sciences)2008，51，3： | 25 |
| 10 | Composite of sulfur impregnated in porous hollow carbon spheres as the cathode of Li-S batteries with high performance显示文摘 | Kai Zhang Qing Zhao Zhanliang Tao Jun Chen | 2013 | Nano Research2013，6，1： | 25 |
| 11 | Sexual and reproductive health service needs of university/ college students: updates from a survey in Shanghai, China显示文摘瞄准:由在上海探索大学学生的态度和感觉支持为年轻人的繁殖健康服务的预备,中国,向繁殖健康。方法:从 2004 年 7 月到 2006 年 5 月,在上海的 14 所大学的 5 243 个学生参加了我们的调查。话题在性健康上并且性用性,到色情材料的暴露,和知识盖住繁殖保健服务,对的态度和经验的要求播送感染(STI )/AIDS。结果:提供了有效答案表的 5 067 个学生, 50.05% 是女性, 49.95% 是男性的, 14.86% 是医学院的学生,并且 85.14% 有非医学的背景。38.4% 回答者的一个总数以前收到了繁殖卫生教育。学生的多数支持了基于学校的繁殖卫生教育,并且也从书,同学,和因特网主要关于性获得了信息。婚前的性行为被 17.7% 调查参加者反对,并且 37.5% 能识别在问询表列出的 STI 的所有三种类型。尽管 83.7% 知道了 HIV 怎么被播送,仅仅, 55.7% 知道了什么时候使用避孕套, 57.8% 知道避孕套的使用能减少 HIV 感染的风险。结论:繁殖健康服务正在落后于大学学生的当前的态度和要求。尽管学生对性事的态度是开明的,他们繁殖健康和 STIs/AIDS 的知识仍然是有限的。提供有效、机密的繁殖健康服务给年轻人因此是必要的。 | Bin Chen Yong-Ning Lu Hong-Xiang Wang Qing-Liang Ma Xiao-Ming Zhao Jian-Hua Guo Kai Hu Yi-Xin Wang Yi-Ran Huang Pei Chen | 2008 | Asian Journal of Andrology2008，10，4： | 20 |
| 12 | Urban Three-dimensional Expansion and Its Driving Forces——A Case Study of Shanghai,China显示文摘Urban expansion is a phenomenon of urban space increase,and an important measuring index of the process of urbanization.Taking Shanghai as an example,the changes of urban average height and built-up area were studied to represent city's vertical and horizontal increases respectively,and statistical methods were used to analyze the driving forces of urban expansion.The research drew following conclusions:1) The urban expansion process of Shanghai from 1985 to 2006 had a clear periodic feature,and could be divided into three stages:vertical expansion in dominance,coordinated vertical and horizontal expansion,and horizontal expansion in dominance.2) The average height and quantity of buildings in core city were significantly bigger than those in suburbs,but the changing speed of the latter was faster.And 3) urbanization process was the major driving force for the city's horizontal expansion,while industrial structure improvement was the key driving factor for the vertical expansion.Those two driving forces were simultaneously affected by city's political factors. | SHI Longyu SHAO Guofan CUI Shenghui LI Xuanqi LIN Tao YIN Kai ZHAO Jingzhu | 2009 | Chinese Geographical Science2009，19，4： | 20 |
| 13 | Long-Term Outcome of Dynesys Dynamic Stabilization for Lumbar Spinal Stenosis显示文摘背景: 在过去的十年的许多临床的研究为为腰部的退化疾病与 Dynesys 动态稳定对待的病人显示了积极结果。然而,为腰部的针的狭窄的 Dynesys 的长期的结果很少被报导。学习是与腰部的针的狭窄为病人分析长期的临床、放射线学的结果的这的目的与 Dynesys 对待 stabilization.Methods : 有腰部的针的狭窄的 38 个病人从 2008 年 7 月与 Dynesys 稳定被对待到 2010 年 3 月。后续的最小的持续时间是 72 个月。病人根据退化 spondylolisthesis 被划分成狭窄和 spondylolisthesis 组。临床的结果用 Oswestry 残疾索引(ODI ) 和视觉模拟规模(管) 被评估。包括的 X 光线照相术的评估运动(ROM ) 和稳定的片断和上面的邻近的片断的圆盘高度变化。我们也评估了 X 光线照相术、征兆的邻近的片断退化(ASD ) 的出现 .Results : 在 spondylolisthesis 在狭窄组和 15 个病人有 23 个病人组。ODI 分数显著地在最后的后续评估被改进,作为与基线价值相比(16. | Yang Zhang Zhi-Cheng Zhang Fang Li Tian-Sheng Sun Jian-Lin Shan Kai Guan Guang-Min Zhao Li-Zhi Zhang | 2018 | Chinese Medical Journal2018，，21： | 20 |
| 14 | Bionic Mechanism and Kinematics Analysis of Hopping Robot Inspired by Locust Jumping显示文摘 | Diansheng Chen Junmao Yin Kai Zhao Wanjun Zheng Tianmiao Wang | 2011 | Journal of Bionic Engineering2011，8，4： | 19 |
| 15 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 16 | Effect of Glutamine Enriched Nutrition Support on Surgical Patients with Gastrointestinal Tumor: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Kai Kang Xiao-Liang Shu Yong-Sheng Zhang Xian-Li Liu Jian Zhao | 2015 | Chinese Medical Journal2015，，2： | 19 |
| 17 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 18 | Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma显示文摘AIM: To clarify the location and distribution of Kupffer cells in hepatocellular carcinoma (HCC), and to investigate their role in hepatocarcinogenesis.METHODS: Kupffer cells were immunohistochemically stained by streptavadin-peroxidase conjugated method (S-P). The numbers of Kupffer cells in cancerous, para-cancerous and adjacent normal liver tissues of 48 HCCs were comparatively examined.RESULTS: The mean number of Kupffer cells in cancerous,para-cancerous and adjacent normal liver tissues was 12.7±6.8, 18.1±8.2 and 18.9±7.9 respectively. The number of Kuppfer cells in cancerous tissues was significantly lower than that in para-cancerous tissues (t=2.423, P<0.05) and adjacent normal liver tissues (t=2.52t, P<0.05). As tumor size increased, the number of Kupffer cells in cancerous tissues significantly decreased (F=4.61, P<0.05). Moreover,there was also a significant difference in the number of Kupffer cells among well-differentiated, moderately-differentiated and poorly-differentiated cases(F=4.49, P<0.05).CONCLUSION: This study suggests that decrease of Kupffer cells in HCCs may play an important role in the carcinogenesis of HCC, the number of Kupffer cells in HCC is closely related to the size and differentiation grade of the tumor. | Kai Liu Xu He Xue-Zhong Lei Lian-San Zhao Hong Tang Li Liu Bing-Jun Lei Division of Molecular Biology of Infectious Disease Key Laboratory of Biotherapy of Human Disease,Ministry of Education,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China | 2003 | World Journal of Gastroenterology2003，9，9： | 19 |
| 19 | Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage- derived foam cells显示文摘 | Si-guo CHEN Ji XIAO Xie-hong LIU Mei-mei LIU Zhong-cheng MO Kai YIN Guo-jun ZHAO Jin JIANG Li-bao CUI Chun-zhi TAN Wei-dong YIN Chao-ke TANG | 2010 | Acta Pharmacologica Sinica2010，31，10： | 18 |
| 20 | Hydrogen Peroxide-Mediated Growth of the Root System Occurs via Auxin Signaling Modification and Variations in the Expression of Cell-Cycle Genes in Rice Seedlings Exposed to Cadmium Stress显示文摘The link between root growth,H2O2,auxin signaling,and the cell cycle in cadmium (Cd)-stressed rice (Oryza sativa L.cv.Zhonghua No.11) was analyzed in this study.Exposure to Cd induced a significant accumulation of Cd,but caused a decrease in zinc (Zn) content which resulted from the decreased expression of OsHMA9 and OsZIP.Analysis using a Cd-specific probe showed that Cd was mainly localized in the meristematic zone and vascular tissues.Formation and elongation of the root system were significantly promoted by 3-amino-1,2,4-triazole (AT),but were markedly inhibited by N,N'dimethylthiourea (DMTU) under Cd stress.The effect of H2O2 on Cd-stressed root growth was further confirmed by examining a gain-of-function rice mutant (carrying catalase1 and glutathione-S-transferase) in the presence or absence of diphenylene iodonium.DR5-GUS staining revealed close associations between H2O2 and the concentration and distribution of auxin.H2O2 affected the expression of key genes,including OsYUCCA,OsPIN,OsARF,and OsIAA,in the auxin signaling pathway in Cd-treated plants.These results suggest that H2O2 functions upstream of the auxin signaling pathway.Furthermore,H2O2 modified the expression of cell-cycle genes in Cd-treated roots.The effects of H2O2 on root system growth are therefore linked to auxin signal modification and to variations in the expression of cell-cycle genes in Cd-stressed rice.A working model for the effects of H2O2 on Cd-stressed root system growth is thus proposed and discussed in this paper. | Feng-Yun Zhao Ming-Ming Han Shi-Yong Zhang Kai Wang Cheng-Ren Zhang Tao Liu Wen Liu | 2012 | Journal of Integrative Plant Biology2012，54，12： | 18 |
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