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| 1 | An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites显示文摘mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成,金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时, nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半,基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一, cyclodextrin (, CD ) 更暗淡的桥牌。在 vitro,研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了,为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成, MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点,显著地从而改进治疗学的功效。 | Guofeng Luo Weihai Chen Huizhen Jia Yunxia Sun Han Cheng Renxi Zhuo Xianzheng Zhang | 2015 | Nano Research2015，8，6： | 6 |
| 2 | Photoreductive degradation of sulfur hexafluoride in the presence of styrene显示文摘硫 hexafluoride (SF6 ) 在空气作为最强大的温室气体之一被知道。由苯乙烯的 SF6 的减少的相片降级被学习了以达到为硫 hexafluoride 污染开发新奇补习。破坏和 SF6 的移动效率(DRE ) 上的反应条件的效果在这研究被检验。两起始的 styrene-to-SF6 比率和起始的氧集中对 DRE 施加重要影响。SF6 移动效率在 0.2 的起始的 styrene-to-SF6 比率到达最大的价值。DRE 与增加氧集中在 0 ~ 0.09 mol/m3 然后减少的范围上与氧集中增加,这被发现。当水蒸汽被喂进煤气的混合时, DRE 稍微在整个学习时间规模上被提高。X光检查光电子光谱学( XPS )分析,和煤气的层析团,光谱测定( GCMS )和 Fourier 转变红外线的光谱学(英尺红外)分析,证明那是将近居住在煤气的阶段的起始的氟的符号在 SiF4 形式的所有,而,起始的硫在元素的硫形式被扔,在相片降级以后。从有毒的副产品免费,相片降级可以为 SF6 消退面对苯乙烯用作一种有希望的技术。 | HUANG Li GU Dinghong Yang Longyu Xia Lanyan ZHANG Renxi HOU Huiqi | 2008 | Journal of Environmental Sciences2008，20，2： | 5 |
| 3 | Template-module assembly to prepare low-molecular-weight gene transport system with enhanced transmembrane capability显示文摘Based on specific host-guest interactions between amine-modified ?-cyclodextrin(CD-TAEA) and functional adamantane(AD) derivatives, a module-template strategy has been proposed for the construction of low-molecular-weight cationic assemblies for gene transport. This strategy offers great flexibility in terms of the introduction of mono- or multi-functionality by the inclusion of one or more adamantane-based modules with the desired functionalities. As proof of concept, phenylboronic acid(PB) containing adamantane(PB-AD) was used as a model module in the hope of offering enhanced cytosolic delivery in consideration of the special affinity of PB groups with cell membranes. The physicochemical properties of the complexes formed with plasmid DNA, such as particle size, zeta potential and morphology were investigated. Confocal laser scanning microscopy and flow cytometry experiments demonstrated the important contribution of the functional PB-AD module to the considerably enhanced intracellular internalization and uptake by cellular nuclei. Compared to the parent CD-TAEA, PB-AD/CDTAEA assemblies mediated higher transfection rates, which were even comparable to that of PEI25K. In addition, PB-AD/CDTAEA displayed much lower cytotoxicity than PEI25K in both 293T and HeLa cell lines. The encouraging results suggest that CD-TAEA can be developed as a powerful template capable of readily accommodating various AD-based modules giving versatile functionalities for improved transfection. | YANG Bin LV Yin WANG QingRong LIU Yun AN Hong FENG Jun ZHANG XianZheng ZHUO RenXi | 2014 | Science China Chemistry2014，57，4： | 4 |
| 4 | Research progress of magnetic resonance imaging contrast agents显示文摘Magnetic resonance imaging (MRI) is a clinical diagnostic modality, which has become popular in hospitals around the world. Approximately 30% of MRI exams include the use of contrast agents. The research progress of the paramagnetic resonance imaging contrast agents was described briefly. Three important approaches in the soluble paramagnetic resonance imaging contrast agents design including nonionic, tissue-specific and macromolecular contrast agents were investigated. In addition, the problems in the research and development in future were discussed. | Guoping Yan Renxi Zhuo | 2001 | Chinese Science Bulletin2001，46，15： | 4 |
| 5 | Rates of oxygen consumption and tolerance of hypoxia and desiccation in Chinese black sleeper(Bostrichthys sinensis)and mudskipper(Boleophthalmus pectinirostris)embryos显示文摘The rates of oxygen consumption, tolerance of hypoxia and desiccation of the Chinese black sleeper (Bostrichthys sinensis) and mudskipper (Boleophthalmus pectinirostris) embryos were investigated. The pattern of oxygen consumption of the Chinese black sleeper embryos was similar to that of the mudskipper ones. The lowest rates of oxygen consumption[(1.65±0.66)nmol/ (ind.·h)] of the Chinese black sleeper embryos 16 h after fertilization and the lowest rates of oxygen consumption [(0.79± 0.08)nmol/(ind.·h)] of the mudskipper embryos 6 h after fertilization were recorded, respectively. Then the rates of oxygen consumption of these two species embryos increased gradually until hatching [(8.26±1.70)nmol/(ind.·h)in the Chinese black sleeper, (2.69±0.23)nmol/(ind.·h) in mudskipper]. After exposure to hypoxia water (0.16 mg/dm3), bradycardia of the embryos occurred in both the Chinese black sleeper and the mudskipper. However, the Chinese black sleeper embryos survived approximately 45 min longer than the mudskipper ones. After exposure to desiccation at a relative humidity of 58%, bradycardia of the embryos was observed in both the Chinese black sleeper and the mudskipper, and the Chinese black sleeper embryos lived approximately 9 min longer than the mudskipper ones. | CHEN Shixi HONG Wanshu ZHANG Qiyong WU Renxie WANG Qiong | 2006 | Acta Oceanologica Sinica2006，25，4： | 3 |
| 6 | Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells显示文摘Regulatory B cells(Bregs)are a functionally defined B cell subset,and IL-10 is crucial for the suppressive functions of Bregs.However,little is known regarding how IL-10 production is regulated in B cells.To explore the mechanisms by which IL-10 is regulated in B cells,we used mRNA microarrays to screen for molecules that are upregulated in IL-10-producing B cells and identified RNA-binding motif protein 47(Rbm47)as a post-transcriptional regulator.Rbm47 was found to promote IL-10 production in B cells.We found that Rbm47 promotes the stability of IL-10 mRNA by binding to AU-rich elements in the 3′untranslated region of Il10 mRNA.In addition,we demonstrated that the overexpression of Rbm47 enabled B cells to facilitate Foxp3+regulator T-cell induction and reduce the severity of DSS-induced ulcerative colitis.Taken together,these results suggest that Rbm47 plays an important role in regulating IL-10 at the post-transcriptional level,thus promoting the regulatory functions of B cells.The findings presented in this study not only increase our understanding of the post-translational regulation of IL-10 in B cells but also identify a novel strategy for the potential application of Bregs. | Yinxiang Wei Fanghui Zhang Yu Zhang Xiaoqian Wang Chen Xing Jing Guo Hui Zhang Zhimin Suo Yan Li Jianli Wang Renxi Wang Zhijian Cai | 2019 | Cellular & Molecular Immunology2019，16，6： | 2 |
| 7 | The Effect of CD3-Specific Monoclonal Antibody on Treating Experimental Autoimmune Myasthenia Gravis显示文摘CD3-specific monoclonal antibody was the first one used for clinical practice in field of transplantation. Recently,renewed interests have elicited in its capacity to prevent autoimmune diabetes by inducing immune tolerance. In this study, we tested whether this antibody can also be used to treat another kind of autoimmune disease myasthenia gravis (MG) and explored the possible mechanisms. MG is caused by an autoimmune damage mediated by antibody- and complement-mediated destruction of AChR at the neuromuscular junction. We found that administration of CD3-specific antibody (Fab)2 to an animal model with experimental autoimmune myasthenia gravis (EAMG) (B6 mice received 3 times of AChR/CFA immunization) could not significantly improve the clinical signs and clinical score. When the possible mechanisms were tested, we found that CD3 antibody treatment slightly down-regulated the T-cell response to AChR, modestly up-regulation the muscle strength. And no significant difference in the titers of IgG2b was found between CD3 antibody treated and control groups. These data indicated that CD3-specific antibody was not suitable for treating MG, an antibody- and complementmediated autoimmune disease, after this disease has been established. The role of CD3-specific antibody in treating this kind of disease remains to be determined. | Ruonan Xu~1 Jianan Wang~1 Guojiang Chen~1 Gencheng Han~1 Renxi Wang~1 Beifen Shen~1 Yan Li~(1,2) ~1Institute of Basic Medical Science,Academy of military Medical Science,Beijing 100850,China ~2Department of Molecular Immunology,Institute of Basic Medical Science,27 Taiping Road,Beijing 100850,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 2 |
| 8 | DEM Compression Based on Integer Wavelet Transform显示文摘DEM data is an important component of spatial database in GIS. The data volume is so huge that compression is necessary. Wavelet transform has many advantages and has become a trend in data compression. Considering the simplicity and high efficiency of the compression system, integer wavelet transform is applied to DEM and a simple coding algorithm with high efficiency is introduced. Experiments on a variety of DEM are carried out and some useful rules are presented at the end of this paper. | CHEN Renxi LI Xinhui | 2007 | Geo-Spatial Information Science2007，10，2： | 2 |
| 9 | Isolation and characterization of 49 polymorphic microsatellite loci for Decapterus maruadsi using SLAF-seq, and cross-amplifi cation to related species显示文摘Decapterus maruadsi is a commercially important species in China, but has been heavily exploited in some areas. There is a growing need to develop microsatellites promoting its genetic research for the adequate management of this ?shery resources. The recently developed speci?c-locus ampli?ed fragment sequencing(SLAF-seq) is an effcient and high-resolution method for genome-wide microsatellite markers discovery. In this study, 28 905 microsatellites(mono-to hexa-nucleotide repeats) were identi?ed using SLAF-seq technology, of which di-nucleotide was the most frequent(13 590, 47.02%), followed by mono-nucleotide(8 138, 28.15%), tri-nucleotide(5 727, 19.81%), tetra-nucleotide(1 104, 3.82%), pentanucleotide(234, 0.81%), and hexa-nucleotide(112, 0.39%). One hundred and thirty-two microsatellite loci(di-and tri-nucleotide) were randomly selected for ampli?cation and polymorphism, of which 49 were highly polymorphic and well-resolved. The average number of alleles per locus was 13.63, ranging from 4 to 25, and allele sizes varied between 110 bp and 309 bp. The observed heterozygosity( Ho) and expected heterozygosity( He) ranged from 0.233 to 1.000 and from 0.374 to 0.959, with mean values of 0.738 and0.836, respectively. The polymorphism information content(PIC) ranged from 0.341 to 0.941(mean=0.806).However, 12 loci deviated from Hardy-Weinberg equilibrium. Furthermore, transferability tests were also successful in validating the utility of the developed markers in ?ve phylogenetically related species of family Carangidae. A total of 48 microsatellite markers were successfully cross-ampli?ed in Decapterus macarellus, Decapterus macrosoma, Decapterus kurroides, Trachurus japonicus, and Selaroides leptolepis.The present microsatellites provided the ?rst known set of microsatellite DNA markers for D. maruadsi,D. macarellus, D. kurroides, and D. macrosoma, and would be useful for further population genetic and molecular phylogeny studies as well as help with the ?sheries management formulation and implementation of the understudied species. | NIU Sufang ZHAI Yun WU Renxie ZHANG Haoran TIAN Letian DENG Jiaxin XIAO Yao | 2019 | Journal of Oceanology and Limnology2019，37，1： | 2 |
| 10 | 显示文摘 | Zhang Jiantao Cheng Sixue Zhuo Renxi | 2003 | Colloid Polym Sei2003，281，： | 1 |
| 11 | Macroporous poly(N-isopropylacrylamide) hydrogels with fast response rates and improved protein release properties显示文摘 | Cheng Sixue Zhang Jiaotao Zhuo Renxi | 2003 | Journal of Biomedical Materials Research A2003，67，1： | 1 |
| 12 | Synthesis and properties of thermosensitive, crown ether incorpo- rated poly(N-isopropylacrylamide) hydrogel显示文摘 | Zhang Xianzheng Zhang Jiantao Zhuo Renxi | 2002 | Polymer2002，43，17： | 1 |
| 13 | Effects of Reaction Temperature and Reaction Time on Positive Thermosen-sitivity of Microspheres with Poly(acrylamide)/Poly(acrylic acid) IPN Shells显示文摘 | Xincai Xiao Renxi Zhuo Jian Xu | 2006 | European Polymer Journal2006，，42： | 1 |
| 14 | Current progress of polymeric gene vectors显示文摘After over 40 years of progress,gene therapy provides great opportunities for treating diseases from various genetic disorders,infections and cancers.The success of gene therapy largely depends on the availability of suitable gene vectors. As an attractive alternative to virus-based gene therapy, | ZENG Xuan SUN YunXia ZHUO RenXi ZHANG XianZheng | 2011 | Science China(Life Sciences)2011，54，11： | 1 |
| 15 | Synthesis and Properties of Degradable Hydrogels of Konjac Glucomannan Grafted Acrylic Acid for Colon-specific Drug Delivery显示文摘 | Chen Ligui Liu Zhilan Zhuo Renxi | 2005 | Polymer2005，，46： | 1 |
| 16 | Slow release behavior of starch-g-poly(vinyl alcohol) matrix for 2,4,5- trichlorophenoxyacetic acid herbicide显示文摘 | Zhu Zhifeng Zhuo Renxi | 2001 | European Polymer Journal2001，，37： | 1 |
| 17 | Synthesis and properties of thermosensitive poly(N-isopropytacrylanfide-co-methyhne-thaerylate)hydrogel with rapid response显示文摘 | Zhang Xianzheng Zhuo Renxi | 2002 | Materials Letters2002，52，： | 1 |
| 18 | Novel syxtthesis of tenlperature-sensitive poly(N-isopropylacrylamide)hydrogel with fast deswelling rate显示文摘 | Zhang Xianzheng Zhuo Renxi | 2000 | European Polymer Journal2000，36，： | 1 |
| 19 | Construction of functional aliphatic polycarbonates for biomedical applications显示文摘 | FENG Jun ZHUO Renxi ZHANG Xianzheng | 2012 | Progress in Polymer Science2012，37，： | 1 |
| 20 | Construction of functional aliphatic polycarbonates for biomedical applications显示文摘 | Feng Jun Zhou Renxi Zhang Xianzheng | 2012 | Progress in Polymer Science2012，37，2： | 1 |
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