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| 1 | Anti-diabetic effects of Caulerpa lentillifera:stimulation of insulin secretion in pancreatic β-cells and enhancement of glucose uptake in adipocytes显示文摘Objective:To evaluate anti-diabetic effect of Caulrpa kntillifera(C.lentillifera).Methods:The inhibitory effect of C.lentillifera extract on dipeptidyl peptidase-IV and a-glucosidase enzyme was measured in a cell free system.Then,interleukin-1βand interferon-γinduced cell death and insulin secretion were measured in rat insulinoma(RIN)cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and ELISA kit,respectively.Glucose uptake and glucose transporter expression were measured by fluorometry and western blotting,using 3T3-Ll adipocytes.Results:C.lentillifera extract significantly decreased dipeptidyl peptidase-IV and a-glucosidase enzyme activities,and effectively inhibited cell death and iNOS expression in interleukin-1βand interfcron-γinduced RIK cells.Furthermore,C.lntillifera extract significantly enhanced insulin secretion in RTN cells and glucose transporter expression and glucose uptake in 3T3-L1adipocytes.Conclusions:Thus,our results suggest that C.lentillifera could be used as a potential antidiabetic agenl. | Bhesh Raj Sharma Dong Young Rhyu | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 12 |
| 2 | An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats显示文摘Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects. | Ji Yeong Kim Woo Joo Jeon Dong Hwee Kim Im Joo Rhyu Young Hwan Kim Inchan Youn Jong Woong Park | 2014 | Neural Regeneration Research2014，9，14： | 6 |
| 3 | Nelumbo Nucifera leaf extract attenuated pancreatic β-cells toxicity induced by interleukin-1β and interferon-γ, and increased insulin secrection of pancreatic β-cells in streptozotocin-induced diabetic rats显示文摘OBJECTIVE: To evaluate the effect of Nelumbo Nucifera leaf water extract(NNLE) on insulinoma(RIN)cells induced by interleukin-1β(IL-1β) and interferon-g(IFN-γ), and injured pancreatic β-cells induced by Streptozotocin(STZ) in rats.METHODS: The anti-oxidative effects of NNLE were assessedusing 1,1-diphenyl-2-picrylhydrazyl(DPPH)and nitric oxide(NO) scavenging assays. The inhibitory effect of NNLE on α-glucosidase and DPP(dipeptidyl peptidase)-IV was measured in vitro. Pancreatic β-cell protective and insulin secretory effects were assessed, using IL-1β and IFN-γ-induced rat RIN cells. STZ-induced diabetic rats were treated with 50, 100, and 400 mg/kg NNLE for 4 weeks. The effects of NNLE on blood glucose(BG), body weight(BW), and lipid profiles were measured.RESULTS: NNLE inhibited DPPH, NO, α-glucosidase,and DPP-Ⅳ which were directly linked to the function of β-cells. Furthermore, NNLE protected RIN cells from toxicity induced by IL-1β and IFN-γ, decreased NO production, and increased insulin secretion. NNLE caused a significant reduction in blood glucose, triglyceride(TG), total cholesterol(TC),blood urea nitrogen(BUN), and creatinine in STZ-induced diabetic rats. Furthermore, it significantly decreased BW loss in STZ-induced diabetic rats.CONCLUSION: Our results suggest that NNLE reduced the toxicity in insulinoma cells and increased insulin secretion in pancreatic β-cells in STZ-induced diabetic rats. | Bhesh Raj Sharma Min Suk Kim Dong Young Rhyu | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 3 |
| 4 | Recompression of vertebral body after balloon kyphoplasty for osteoporotic vertebral compression fracture显示文摘 | Young-Yul Kim Kee-Won Rhyu | 2010 | European Spine Journal2010，，11： | 2 |
| 5 | Newly discovered endocrine functions of the liver显示文摘The liver,the largest solid visceral organ of the body,has numerous endocrine functions,such as direct hormone and hepatokine production,hormone metabolism,synthesis of binding proteins,and processing and redistribution of metabolic fuels.In the last 10 years,many new endocrine functions of the liver have been discovered.Advances in the classical endocrine functions include delineation of mechanisms of liver production of endocrine hormones[including 25-hydroxyvitamin D,insulin-like growth factor 1(IGF-1),and angiotensinogen],hepatic metabolism of hormones(including thyroid hormones,glucagon-like peptide-1,and steroid hormones),and actions of specific binding proteins to glucocorticoids,sex steroids,and thyroid hormones.These studies have furthered insight into cirrhosis-associated endocrinopathies,such as hypogonadism,osteoporosis,IGF-1 deficiency,vitamin D deficiency,alterations in glucose and lipid homeostasis,and controversially relative adrenal insufficiency.Several novel endocrine functions of the liver have also been unraveled,elucidating the liver’s key negative feedback regulatory role in the pancreaticαcell-liver axis,which regulates pancreaticαcell mass,glucagon secretion,and circulating amino acid levels.Betatrophin and other hepatokines,such as fetuin-A and fibroblast growth factor 21,have also been discovered to play important endocrine roles in modulating insulin sensitivity,lipid metabolism,and body weight.It is expected that more endocrine functions of the liver will be revealed in the near future. | Jane Rhyu Run Yu | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 6 | Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells显示文摘 | RHYU D Y YANG Y HA H | 2005 | J Am Soc Nephrol2005，16，3： | 1 |
| 7 | Nitric oxide-mediated endothelium-dependent relaxation of rat thoracic aorta induced by aqueous extract of red rice fermented with Monascus rubber 显示文摘 | Rhyu M Kim D Kim H | 2000 | Journal of Ethnopharmacology2000，70，： | 1 |
| 8 | Overexpression of VEGF and angiopoietin 2:a key to high vascularity of hepatocellular carcinoma显示文摘 | Moon W S Rhyu K H Kang M J | 2003 | Mod Pathol2003，16，6： | 1 |
| 9 | Role of reactive oxygen species in transforming growth factor:betal-induced extracellular matrix accu- mulation in renal tubular epithelial cells显示文摘 | Rhyu DY Park J Sharma BR | 2012 | Transplant Proc2012，44，3： | 1 |
| 10 | Regional differences of four major rice cultivars in Korea by capillary electrophoresis显示文摘 | Rhyu M R Kim E Y Kim S S Chang Y S | 2001 | Food Science and Biotechnology2001，10，3： | 1 |
| 11 | Role of reactive oxygen species in TGF - β1 - induced mitogen - activated protein kinase activa- tion and epithelial mesenchymal transition in renal tubular epi- thelial cells 显示文摘 | Rhyu DY Yang Y Ha H | 2005 | J Am Soc Nephrol2005，16，3： | 1 |
| 12 | Telomeres,Telomerase,and immortality显示文摘 | Rhyu MS | | 0，，： | 1 |
| 13 | Telomere and immortality显示文摘 | Rhyu MS | 1995 | JNCI1995，87，12： | 1 |
| 14 | Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrykhydrazyl radical 显示文摘 | Cho EJ Yokozawa T Rhyu DY | 2003 | Phytomedicine2003，10，67： | 1 |
| 15 | Effects of aerobic ex- ercise training on cognitive function and cortical vascularity in monkeys 显示文摘 | Rhyu I J Bytheway JA Kohler S J | 2010 | Neuroscience2010，167，4： | 1 |
| 16 | The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures显示文摘 | Kim YH Rhyu IJ Park KW | 2001 | Neuroreport2001，15，： | 1 |
| 17 | Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells显示文摘 | RHYU DY YANG Y HA H | 2005 | J Am Soc Nephrol2005，16，3： | 1 |
| 18 | Asymmetric distribution of numb proteinduring division of the sensory organ precursor cell confers distinctfates to daughter cells显示文摘 | Rhyu MS Jan LY Jan YN | 1994 | Cell1994，76，3： | 1 |
| 19 | Maternal and cord bloodvitamin D status and childhood infection and allergic dis-ease:a systematic review显示文摘 | Fried DA Rhyu J Odato K | 2016 | Nutr Rev2016，74，6： | 1 |
| 20 | Role of reactive oxygen species in TGF-betal-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells显示文摘 | Rhyu DY Yang Y Ha H | 2005 | J Am Soc Nephrol2005，16，3： | 1 |
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