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| 1 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 2 | Convergent Agency:Encouraging Transdisciplinary Approaches for Effective Climate Change Adaptation and Disaster Risk Reduction显示文摘Three recent global agreements have been established to facilitate the implementation of global-level responsibilities to deal with disaster risk reduction(DRR),human development,and climate change adaptation(CCA)respectively.While these agreements have a common goal of reducing social,economic,and environmental vulnerability,they have been developed by largely independent communities of practice.This has limited cross-fertilization despite the inherent multidimensional nature of global challenges and the considerable thematic overlap.We argue that developing a transdisciplinary strategy that effectively integrates disciplines,approaches,and knowledge systems will lead to greater and more sustainable impacts,together with a more efficient use of financial resources.Hybrid approaches should be encouraged during planning of future development efforts so that risk reduction is conducted simultaneously with CCA.Transdisciplinary processes are central to generating contextsensitive knowledge to support decisions on CCA and DRR options that minimize trade-offs and maximize synergies and complementarities required to guide sustainable development trajectories.Finally,building codes together with climate and risk-smart research,education,and awareness raising,are identified as priority entry points to materialize the blending of DRR and CCA approaches and effectively reduce risk while mitigating and adapting to climate change. | América Bendito Edmundo Barrios | 2016 | International Journal of Disaster Risk Science2016，7，4： | 2 |
| 3 | Effects of methotrexate on inflammatory alterations induced by obesity: An in vivo and in vitro study显示文摘 | Caroline Candida DeOliveira Simone Coghetto Acedo érica Martins Ferreira Gotardo Patricia de Oliveira Carvalho Thalita Rocha José Pedrazzoli Alessandra Gambero | 2012 | 2012 (1-2)2012，，1： | 1 |
| 4 | Additions of landscape metrics improve predictions of occurrence of species distribution models显示文摘Species distribution models are used to aid our understanding of the processes driving the spatial patterns of species' habitats.This approach has received criticism,however,largely because it neglects landscape metrics.We examined the relative impacts of landscape predictors on the accuracy of habitat models by constructing distribution models at regional scales incorporating environmental variables(climate,topography,vegetation,and soil types)and secondary species occurrence data,and using them to predict the occurrence of 36 species in 15 forest fragments where we conducted rapid surveys.We then selected six landscape predictors at the landscape scale and ran general linear models of species presence/absence with either a single scale predictor(the probabilities of occurrence of the distribution models or landscape variables) or multiple scale predictors(distribution models + one landscape variable).Our results indicated that distribution models alone had poor predictive abilities but were improved when landscape predictors were added;the species responses were not,however,similar to the multiple scale predictors.Our study thus highlights the importance of considering landscape metrics to generate more accurate habitat suitability models. | rica Hasui Vinícius X.Silva Rogrio G.T.Cunha Flavio N.Ramos Milton C.Ribeiro Mario Sacramento Marco T.P.Coelho Diego G.S.Pereira Bruno R.Ribeiro | 2017 | Journal of Forestry Research2017，28，5： | 1 |
| 5 | Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis显示文摘 | Marta Gassó Mireia Rubio Gregorio Varela María Cabré Joan Caballería Elena Alonso Ramón Deulofem Jordi Camps América Giménez María Pajares Albert Parés José M. Mato Joan Rodés | 1996 | Journal of Hepatology1996，，2： | 1 |
| 6 | Epige-netic regulation of PRAME in acute myeloid leukemia is differ-ent compared to CD34+ cells from healthy donors : effect of 5-AZA treatment显示文摘 | Gutierrez-CosIo S de la Rica L Ballestar E S | 2012 | Leuk Res2012，36，7： | 1 |
| 7 | Salivary Gland Tumor: A Review of 599 Cases in a Brazilian Population显示文摘 | Flávia Aparecida Oliveira Eliza Carla Barroso Duarte Cláudia Teixeira Taveira Aline Abreu Máximo érica Carvalho Aquino Rita de Cássia Alencar Eneida Franco Vencio | 2009 | Head and Neck Pathology2009，，4： | 1 |
| 8 | Evaluation of different sample pre-treatment and extraction procedures for mercury speciation in fish samples 显示文摘 | ORTIZ A I C ALBARRaN M Y RICA C C | 2002 | J Anal At Spectrom2002，17，： | 1 |
| 9 | SNPper: retrieval and analysis of human SNPs 显示文摘 | Rica A Kohanene S | 2002 | Bioinformatics2002，18，12： | 1 |
| 10 | Gravity inversion of a discontinuous relief stabilized by weighted smoothness constraints on depth显示文摘 | Val rica C F | 1999 | Geophysics1999，64，5： | 1 |
| 11 | The effects of flap ischemia on normal and diabetic progenitor cell function 显示文摘 | Rica Tanaka Mika Wada | 2008 | Plast Reconstr Surg2008，121，6： | 1 |
| 12 | Longitudinal study of prepregnancy cardiomelabolic risk factors and subsequen- trisk of gestational diabetes mellitus显示文摘 | Rica P Gunderson Charles P Quesenberry Jr | 2010 | Am J Epidemiology2010，172，10： | 1 |
| 13 | Activation of Cds nanoparticles by metallic ions and their selective interactions with PAMAM dendrimers显示文摘 | David D Geonel R G | 2004 | Colloid Polym Sci2004，282，： | 1 |
| 14 | Dynamical arching in a two dimensional granular flow显示文摘 | Francisco Vivanco Sergio Rica Francisco Melo | 2012 | GranularMatter2012，，14： | 1 |
| 15 | Density fingering in acidity fronts : effect of viscosity 显示文摘 | Tamas Rica Dezso Horvath Agota Toth | 2005 | Chemical Physics Letters2005，408，46： | 1 |
| 16 | Seasonal Variation, Chemical Composition and Antioxidant Activity of Brazilian Propolis Samples显示文摘 | érica Weinstein Teixeira Dejair Message Giuseppina Negri Antonio Salatino Paulo César Stringheta | 2007 | Evidence-Based Complementary and Alternative Medicine2007，，3： | 1 |
| 17 | Procalci- tonin - guided therapy may reduce length of antibiotic treatment in intensive care unit patients with secondary peritonitis : A multi- center retrospective study显示文摘 | Maseda E Suarez - de - la - Rica A Anillo V | 2015 | J Crit Care2015，30，3： | 1 |
| 18 | c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases显示文摘Our ability to learn and remember depends on the active formation,remodeling,and elimination of synapses.Thus,the development and growth of synapses as well as their weakening and elimination are essential for neuronal rewiring.The structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic plasticity.It has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative diseases.Much is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and memory.The non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the nucleus.This review focuses on c-Abl and its synaptic and neuronal functions.Here,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative diseases.Nevertheless,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative diseases.Thus,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against damage.Therefo re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic plasticity.By summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how its inhibition co uld be a potentially fruitful treatment to improve degenerative outcomes and delay memory loss. | Daniela A.Gutiérrez América Chandía-Cristi María JoséYáñez Silvana Zanlungo Alejandra R.Alvarez | 2023 | Neural Regeneration Research2023，18，2： | 1 |
| 19 | Plasmonic nanosensors with inverse sensitivity by means of enzyme-guided crystal growth显示文摘 | Rodriguez-Lorenzo L De La Rica R Alvarez-Puebla R A | 2012 | Nature Materials2012，11，7： | 1 |
| 20 | Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis显示文摘 | Thayane Rodrigues Leite Clemente Aline Noronha dos Santos José Narciso Sturaro érica Martins Ferreira Gotardo Caroline Candida de Oliveira Simone Coghetto Acedo Cintia Rabelo e Paiva Caria José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2012 | Scandinavian Journal of Gastroenterology (-)2012，，8： | 1 |
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