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| 1 | Chronic functional constipation is strongly linked to vitamin D deficiency显示文摘BACKGROUND Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.AIM To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.METHODS We performed a prospective case-control study, from May-June to November2017. Glucose/lactulose breath tests, radiopaque markers(multiple capsule techniques) and wireless motility capsule analysis were used to assess colonicand oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life(IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14(HADS-14 A and HADS-14 D).RESULTS We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels(P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests(IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group(P < 0.001), which significantly correlated with low vitamin D levels(r =-0.57, P < 0.001; r = 0.21, P = 0.01; r =-0.48, P < 0.001; r =-0.57, P < 0.001; r =-0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder(odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001).CONCLUSION Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients. | Alba Panarese Francesco Pesce Piero Porcelli Giuseppe Riezzo Palma Aurelia Iacovazzi Carla Maria Leone Massimo De Carne Caterina Mammone Rinaldi Endrit Shahini | 2019 | World Journal of Gastroenterology2019，25，14： | 8 |
| 2 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 3 | The effect of prebiotics in the management of neonatal hyperbilirubinaemia 显示文摘 | Bisceglia M Indrio F Riezzo G | 2009 | Acta Paediatr2009，98，10： | 1 |
| 4 | The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in pre- term newborns 显示文摘 | Indrio F Riezzo G Raimondi F | 2008 | J pediatr2008，152，6： | 1 |
| 5 | Gastrointes- tinal function development and microbiota 显示文摘 | DI MAURO A NEU J RIEZZO G | 2013 | Italian Journal of Pediatrics2013，39，： | 1 |
| 6 | Complement C3a expression and tryptase degranulation as promising his- topathological tests for diagnosing fatal amniotic fluid em- bolism 显示文摘 | Finesehi V Riezzo L Cantatore S | 2009 | Virchows Arch2009，454，3： | 1 |
| 7 | Lactobacillus reuteri Strain Combination In Helicobacter pylori Infection: A Randomized, Double-Blind, Placebo-Controlled Study显示文摘 | Ruggiero Francavilla Lorenzo Polimeno Antonella Demichina Giovanni Maurogiovanni Beatrice Principi Giuseppe Scaccianoce Enzo Ierardi Francesco Russo Giuseppe Riezzo Alfredo Di Leo Luciano Cavallo Antonio Francavilla James Versalovic | 2014 | Journal of Clinical Gastroenterology2014，，5： | 1 |
| 8 | Confocal laser scanning microscopy. Using new technology to answer old questions in forensic investigations显示文摘 | Emanuela Turillazzi Steven B. Karch Margherita Neri Cristoforo Pomara Irene Riezzo Vittorio Fineschi | 2008 | International Journal of Legal Medicine2008，，2： | 1 |
| 9 | Electrogastrography in healthy chil- dren : evaluation of normal values, influence of age, gender, and obe- sity显示文摘 | Riezzo G Chiloiro M Guerra V | 1998 | Dig Dis Sci1998，43，8： | 1 |
| 10 | Gastrointestinal func- tion development and microbiota显示文摘 | Di Mauro A Neu J Riezzo G | 2013 | Ital J Pediatr2013，39，： | 1 |
| 11 | Complement C3a expression and tryptase degranulation as promising histopathologieal tests for diagnosing fatal amniotie fluid embolism 显示文摘 | Fineschi V Riezzo I Cantatore S | 2009 | Virchows Arch2009，454，3： | 1 |
| 12 | The determination of firing distance applying a microscopic quantitative method and confocal laser scanning microscopy for detection of gunshot residue particles显示文摘 | Neri M Turillazzi E Riezzo I | 2007 | Int J Legal Med2007，121，： | 1 |
| 13 | The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in pre- term newborns显示文摘 | Indrio F Riezzo G Raimondi F | 2008 | J Pediatr2008，152，6： | 1 |
| 14 | Inulin-enriched pasta affects lipid profile and Lp(a)concentrations in Italian young healthy male volunteers显示文摘 | Francesco Russo Guglielmina Chimienti Giuseppe Riezzo | 2008 | Eur J Nutr2008，47，： | 1 |
| 15 | Maturation of gastric electrical ac- tivity, gastric emptying and intestinal permeability in preterm newborns during the first month of life 显示文摘 | Riezzo G Indrio F Raimondi F | 2009 | Ital J Pediatr2009，35，1： | 1 |
| 16 | Gastric Electrical Activity and Gastric Emptying in Preterm Newborns Fed Standard and Hydrolysate Formulas显示文摘 | Riezzo G Indrio F | 2001 | J Pediatr Gastroenterol Nutr2001，33，3： | 1 |
| 17 | Gastric electrical activity in normal neonates during the first year of life:effect of feeding with breast milk and formula显示文摘 | Riezzo G Castellana RM De Bellis T | 2003 | JGastroenterol2003，38，9： | 1 |
| 18 | The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm infants newboms显示文摘 | Tndrio F Riezzo G Raomondi F | 2008 | Pediatr2008，152，6： | 1 |
| 19 | Ceftriaxone intradermal test- related fatal anaphylactic shock: a medico-legal nightmare 显示文摘 | Riezzo I Bello S Neri M | 2010 | Allergy2010，65，1： | 1 |
| 20 | Complement C3a expression and tryptase degranulation as promising histopathological tests for diagnosing fatal amniotic fluid embolism显示文摘 | Vittorio Fineschi Irene Riezzo Santina Cantatore Cristoforo Pomara Emanuela Turillazzi Margherita Neri | 2009 | Virchows Archiv2009，，3： | 1 |
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