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4篇 您的检索式:作者名="Rikhy"
    题名 作者 年代 出处 被引量
1Genetics on early onset inflammatory bowel disease:An update显示文摘Inflammatory bowel disease(IBD)is more common in adults than in children.Onset of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD(VEO-IBD)for children who are diagnosed before 6 years of age,infantile IBD who had the disease before 2 years of age and neonatal onset IBD for children less than 28 days of life.Children presenting with early onset disease may have a monogenic basis.Knowledge and awareness of the clinical manifestations facilitates early evaluation and diagnosis.Next generation sequencing is helpful in making the genetic diagnosis.Treatment of childhood IBD is difficult;targeted therapies and hematopoietic stem cell transplantation form the mainstay.In this review we aim to summarize the genetic defects associated with IBD phenotype.We describe genetic location and functions of various genetic defect associated with VEO-IBD with their key clinical manifestations.We also provide clinical clues to suspect these conditions and approaches to the diagnosis of these disorders and suitable treatment options.Johnson Nameirakpam Rashmi Rikhi Sanjay Singh Rawat Jyoti Sharma Deepti Suri 2020Genes & Diseases2020,7,1:3
2Plasma membrane polarity and compartmentalization are established before cellulatization in the fly embryo显示文摘Mavrakis M Rikhy R Lippincott-Schwartz J 0,,01:1
3Dynamics of the Dorsal morphogen gradient显示文摘Kanodia J S Rikhy R Kim Y Lurid V K DeLotto R LippincottSchwartz J 0,,:1
4Drosophila embryo syncytial blastoderm cellular architecture and morphogen gradient dynamics: Is there a correlation?显示文摘在在许多后生动物的动物的胚胎开发期间,到形式的首先区分的细胞类型是一个上皮的细胞。这上皮的层被身体轴形成的发展暗示修改产生各种各样的纸巾。产生的房间在自然是间充质的并且是另外的织物类型的来源。这对间充质的转变上皮被用于组织类型形成并且也在象癌症那样的疾病看。这里,我们在果蝇胚胎在细胞的建筑学形成上讨论最近的调查结果并且它怎么影响身体轴的发展节目形成。特别地这些研究在普通合胞体在每个原子核附近建议分隔空间的存在。尽管有血浆膜边界的缺席,每个原子核不仅它的自己的 endoplasmic 蜂窝胃和 Golgi 建筑群而且它的自己在它上面划分了血浆膜领域。这体系结构为在 syncytial 果蝇胚胎的 morphogen 坡度限制是潜在地必要的。我们讨论各种各样的性质 dorso 腹并且在果蝇合胞体的 antero 以后的 morphogen 坡度,它是可能的取决于胚胎的 syncytial 建筑学。Aparna SHERLEKAR Richa RIKHY 2012Frontiers in Biology2012,7,1:0
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