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	题名	作者	年代	出处	被引量
1	Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis显示文摘AIM To investigate the effect of adipose-derived mesenchymal stem cells(ADMSCs)and their conditioned media(CM) on hepatocellular carcinoma(HCC) cell tumorigenesis.METHODS The proliferation rate of HepG2 and PLC-PRF-5 HCC cancer cells was measured using the trypan blue exclusion method and confirmed using the cell-counting kit8(commonly known as CCK-8) assay. Apoptosis was detected by flow cytometry using annexin V-FITC. Protein and mRNA expression was quantified by ELISA and real time PCR, respectively. Migration and invasion rates were performed by Transwell migration and invasion assays. Wound healing was examined to confirm the data obtained from the migration assays.RESULTS Our data demonstrated that when co-culturing HCC cell lines with ADMSCs or treating them with ADMSC CM, the HCC cell proliferation rate was significantly inhibited and the apoptosis rate increased. The decreased proliferation rate was accompanied by an upregulation of P53 and Retinoblastoma mRNA and a downregulation of c-Myc and hTERT mRNA levels. More notably, ADMSCs and their CM suppressed the expression of the two important markers of HCC carcinogenicity, alpha-fetoprotein and Des-gamma-carboxyprothrombin. In addition, the migration and invasion levels of HepG2 and PLC-PRF-5 cells significantly decreased, potentially through increased expression of the tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3.CONCLUSION These findings shed new light on a protective and therapeutic role for ADMSCs and their CM in controlling HCC invasiveness and carcinogenesis.	Rim Serhal Nagib Saliba George Hilal Mayssam Moussa Ghada S Hassan Oula El Atat Nada Alaaeddine	2019	World Journal of Gastroenterology2019，25，5：	6
2	Experimental analysis of rotating arc behaviors in a rotary arc gap switch for a 500kJ capacitor bank显示文摘	Cho C H Rim G H Lee H S	2001	IEEE Transactions on Magnetics2001，37，1：	1
3	Anti-synchronization of Chaotic Oscillator显示文摘	Kim C M Rim S Kye W H	2003	Phys Lett A2003，320，1：	1
4	In vivo molecular imaging of acute and subacute thrombois using a fibrin-binding magnetic resonance imaging contrast agent 显示文摘	Botnar RIM Perez AS Witte S	2004	Circulation2004，109，16：	1
5	A randomized, open-label study to evalu- ate the efficacy and safety of pitavastatin compared with simvastatin in Korean patients with hypercholesterolemia 显示文摘	Park S Kang H Rim S	2005	Clin Ther2005，27，7：	1
6	Combined treatment with silver ions and organic acid enhances growth-inhibition of Escherichia coli O157 : H7 显示文摘	Jo S C Rim A R Park H J	2007	Food Control2007，18，10：	1
7	Physicians Who Use Social Media and Other Intemet-Based Communication Technologies显示文摘	Cooper C P Gelb C A Rim S H	2012	Journal of the American Medical Informatics Association2012，19，6：	1
8	Strain rate dependence of deformation behavior of high - nitrogen austenitic steels 显示文摘	Rim Y S Nama S M Kim S J		Journal of Materials Processing Technology0，，：	1
9	Ap-plication of computational techniques for studies ofwind pressure coefficients around an odd-geometricalbuilding显示文摘	Sang Ho S Hyung Woon R Ha Rim K	1997	Journal of Wind Engineering and Indus-trial Aerodynamics1997，6768，：	1
10	Humanpapillmavirus genotyping by HPV DNA chip in cervical cancer and precancerous lesions显示文摘	Lee G Y Kim S M Rim S Y	2005	Int J Gyneml Cancer2005，15，1：	1
11	Estimation of rice field area using two-date Landsat TM images in Korea 显示文摘	Hong S Y Lee K S Rim S K et at	1999	Proceeding of IGARSS1999，6，2：	1
12	Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide显示文摘	Laia Alemany Ma?lle Saunier Isabel Alvarado‐Cabrero Beatriz Quirós Jorge Salmeron Hai‐Rim Shin Edyta C. Pirog Núria Guimerà Gustavo Hernandez‐Suarez Ana Felix Omar Clavero Belen Lloveras Elena Kasamatsu Marc T. Goodman Brenda Y. Hernandez Jan Laco Leopold	2015	Int. J. Cancer2015，，1：	1
13	CT of metal implants: reduction of artifacts using an extended CT scale technique 显示文摘	Link riM Beming W Scherf S	2000	J Comput Assist Tomogr2000，24，1：	1
14	Anti-synchronizati on of chaotic oscillators显示文摘	Kim C M Rims S Key W H	2003	Physics Letters A2003，，320：	1
15	Silver ion oscillation through calyx azacrown tube 显示文摘	Kin J S Yang S H Rim J A	2001	Tetrahedron Letters2001，42，：	1
16	The relationship between intravesical prostatic protrusion and pressure flow study findings in patients with benign prostate obstruction/lower urinary tract symptoms显示文摘	Park S C Lee J W Rim J S	2012	Actas Urol Esp2012，36，3：	1
17	Optimal Design of plane Frames 显示文摘	Arora J S Rim K Haug E J	1975	Journal of the Structural Division1975，101，10：	1
18	Sublimation Kinetics and Sublimation End-Point Times during Freeze-Drying of Pharmaceutical Active Principle with Organic Co-Solvent formulations显示文摘	Rim Daoussi Séverine Vessot Julien Andrieu		0，，87：	1
19	Control of osteo- genic differentiation and mineralization of human mesenchymal stem ceils on composite nanofibers containing poly and hydroxyapatite 显示文摘	LEE 2I H RIM N G JUNG H S	2010	Macromol Biosci2010，10，2：	1
20	Fast high-voltage pulse generation using nonlinear capacitors显示文摘	Rim G H Lee H S Pavlov E P	2000	IEEE Trans on Plasma Sci2000，28，5：	1

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