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| 1 | SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity outcome.Although cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral replication.We found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell apoptosis.In addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)patients.The rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung tissue.These results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host. | Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson Louis-Marie Bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda | 2022 | Journal of Molecular Cell Biology2022，14，4： | 1 |
| 2 | Enhancement of leukocyte functions in aged mice supplemented with the antioxidant thioproline显示文摘 | DE LA FUENTE M FERRANDEZ MD DEL RIO M | 1998 | Mech Ageing Dev1998，104，3： | 1 |
| 3 | Imaging elementary events of calcium release in skeletal muscle cells 显示文摘 | Tsugorka A Rios E Blatter LA | 1995 | Science1995，26，9： | 1 |
| 4 | Improvement of murine immune functions in vitro by thioproline显示文摘 | CORREA R DEL RIO M DE LA FUENTE M | 1999 | Immunopharmacology1999，44，3： | 1 |
| 5 | Genome sequence of the Thermotoga thermarum type strain (LA3T) from an African solfataric spring 显示文摘 | G?ker M Spring?S Scheuner C Anderson I Zeytun A Nolan M Lucas S Tice H Del Rio TG Cheng JF Han C Tapia R Goodwin LA Pitluck S Liolios K Mavromatis K Pagani I Ivanova N Mikhailova N Pati A Chen A Palaniappan K Land M Hauser L Chang YJ Jeffries CD Rohde M Detter JC Woyke T Bristow J Eisen JA Markowitz V Hugenholtz P Kyrpides NC Klenk HP Lapidus A | 2014 | Stand Genomic Sci2014，9，3： | 1 |
| 6 | Age at stroke: Temporal trends in stroke incidence in a large, biracial population显示文摘 | Brett M. Kissela Jane C. Khoury Kathleen Alwell Charles J. Moomaw Daniel Woo Opeolu Adeoye Matthew L. Flaherty Pooja Khatri Simona Ferioli Felipe De Los Rios La Rosa Joseph P. Broderick Dawn O. Kleindorfer | 2012 | Neurology2012，，17： | 1 |
| 7 | Glutathione S - trans- ferases:an overview in cancer research显示文摘 | Di Petro G Magno LA Rios - Santos F | 2010 | Expert Opin Drug Metab Toxieol2010，6，2： | 1 |
| 8 | Storiformtype malignant histiocytoma of the lung显示文摘 | Rios Zambudia A Roca Cavo MJ Polo Garcia LA | 2003 | Arch Bronconeumol2003，39，9： | 1 |
| 9 | Evaluating the etticiency of a combination of pygeum africanum and stinging nettle ( urtica dioica) extracts in treating benign prostatic hyperplasia (BPH) : double- blind, randomized, placebo controlled trial 显示文摘 | Melo EA Bertem EB Rios LA | 2002 | Int Braz J Urol2002，28，5： | 1 |
| 10 | Changes with aging in the mod-ulation by neurc^eptide Y (rf murine peritmeal macroi^iages functitms显示文摘 | De la Fuaite M Dd Rio M Medina S | 2001 | J Neuroimmunol2001，116，2： | 1 |
| 11 | Serotonin receptor activation leads to neurite outgrowth and neuronal survival显示文摘 | Fricker AD Rios C Devi LA | 2005 | Brain Res Mol Brain Res2005，138，2： | 1 |
| 12 | Evidence for the ascorbate-glutathione cycle in mitochondria and peroxisomes of pea leaves显示文摘 | Jiménez A Hernández JA del Rio LA Sevilla F | 1997 | Plant Physiol1997，114，12： | 1 |
| 13 | Fruit infesting tephritids (Diptera: Tephritidae) and associated parasitoids in Chiapas, Mexico显示文摘 | Aluja M Guillen J Liedo P Cabrera M Rios E de la Rosa G Celedonio H Mota D | 1990 | Entomophaga1990，35，1： | 1 |
| 14 | Influence of magnetic field on the adsorption of organic compound by clays modified with iron显示文摘 | Aline Auxiliadora Tireli Francielle Candian Firmino Marcos Laís Ferreira Oliveira Iara do Rosário Guimar?es Mário César Guerreiro Joaquim Paulo Silva | 2014 | Applied Clay Science2014，，： | 1 |
| 15 | The expression of the hormonereceptors in the endometrium and endometrial polyps In postmenopausal women and its relationship to bodymass index显示文摘 | Belisário MS Vassallo J Andrede LA | 2006 | Maturitas2006，53，1： | 1 |
| 16 | Reactive oxygen species,antioxidant systems and nitric oxide in peroxisomes显示文摘 | DEL RIO LA CORPAS FJ SANDALIO LM | 2002 | Journal of Experimental Botany2002，53，372： | 1 |
| 17 | Bombesin,gastrinreleasing peptide,and neuromedin C modulate murine lymphocyte proliferation through adherent accessory cells and activate protein kinase C显示文摘 | Del Rio M Hernanz A de la Fuente M | 1994 | Peptides1994，15，1： | 1 |
| 18 | A telerehabilitation program by virtual reality-video games improves balance and postural control in multiple sclerosis patients 显示文摘 | Guti6rrez RO Galen del Rio F Cano de la Cuerda R et al | 2013 | Neuro Rehabilitation2013，33，4： | 1 |
| 19 | Peroxisomes as a cellular source of reactive nitrogen species signal molecules显示文摘 | Del Rio LA | 2011 | Arch Biochem Biophys2011，506，1： | 1 |
| 20 | Eligibility for intravenous recombinant tissue-type plasminogen activator within a population: the effect of the European Cooperative Acute Stroke Study (ECASS) III Trial 显示文摘 | de Los RIos la Rosa F Khoury J Kissela BM | 2012 | Stroke2012，43，6： | 1 |
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