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| 1 | Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components--Guidance of the inflammatory response as basis for osteochondral regeneration显示文摘The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the(molecular)weight loss and the morphological and mechanical variations after immersion in SBF.The in vivo study focused on analysis of the tissue reactions and differences in the implant bed vascularization using an established subcutaneous implantation model in CD-1 mice and established histological and histomorphometrical methods.Both scaffold parts kept their structural integrity,while changes in morphology were observed,especially for the PLA/G5 scaffold.Mechanical properties decreased with progressive degradation,while the PLA/G5 scaffolds presented higher compressive modulus than PLA scaffolds.The tissue reaction to PLA included low numbers of BMGCs and minimal vascularization of its implant beds,while the addition of G5 lead to higher numbers of BMGCs and a higher implant bed vascularization.Analysis revealed that the use of a bi-layered scaffold shows the ability to observe distinct in vivo response despite the physical proximity of PLA and PLA/G5 layers.Altogether,the results showed that the addition of G5 enables to reduce scaffold weight loss and to increase mechanical strength.Furthermore,the addition of G5 lead to a higher vascularization of the implant bed required as basis for bone tissue regeneration mediated by higher numbers of BMGCs,while within the PLA parts a significantly lower vascularization was found optimally for chondral regeneration.Thus,this data show that the analyzed bi-layered scaffold may serve as an ideal basis for the regeneration of osteochondral tissue defects.Additionally,the results show that it might be able to reduce the number of experimental animals required as it may be possible to analyze the tissue response to more than one implant in one experimental animal. | Mike Barbeck Tiziano Serra Patrick Booms Sanja Stojanovic Stevo Najman Elisabeth Engel Robert Sader Charles James Kirkpatrick Melba Navarro Shahram Ghanaati | 2017 | Bioactive Materials2017，2，4： | 3 |
| 2 | Breast cancer subtypes based on ER/PR and Her2 Ex pression : comparison of clinicopathologic features and sur-vival显示文摘 | Adedayo A Onitilo Jessica M Engel Robert T Greenlee | 2009 | Clin Med Res2009，7，： | 1 |
| 3 | Fi- nancial Accounting Information,Organizational Complexity and Corporate Governance Systems E显示文摘 | Robert Bushman Qi Chen Ellen Engel Abbie Smith | 2004 | Journal of Accounting and Eco- nomics2004，，37： | 1 |
| 4 | Financial Accounting Information, Organizational Complexity and Corporate Governance Systems显示文摘 | Bushman Robert Qi Chen Ellen Engel and Abbie Smith | 2004 | Journal of Accounting and Economics2004，，37： | 1 |
| 5 | Drugs for the control of parasitic diseases: current status and development in schistosomiasis显示文摘 | Alan Fenwick Lorenzo Savioli Dirk Engels N. Robert Bergquist Matthew H. Todd | 2003 | Trends in Parasitology2003，，11： | 1 |
| 6 | Financial accounting information,or- ganizational complexity and corporate governance systems显示文摘 | Bushman Robert Qi Chen EUen Engel and Ab- bie Smith | 2004 | Journal of Accounting and Economics2004，37，2： | 1 |
| 7 | A continuous-time observer which converges in finite time 显示文摘 | Robert Engel Gerhard Kreisselmeier | 2002 | IEEE Transactuios on Automatic Control2002，47，7： | 1 |
| 8 | Cancer Risk After ABO-Incompatible Living-Donor Kidney Transplantation显示文摘 | Erin C. Hall Eric A. Engels Robert A. Montgomery Dorry L. Segev | 2013 | Transplantation Journal2013，，5： | 1 |
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| 10 | Autoregressive Conditional Heteroskedasticity with Estimates of the Variance of UK inflation显示文摘 | Engel Robert F | 1982 | Econometrica1982，50，： | 1 |
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| 12 | Breast cancer subtypes based on ER/PR and HER-2 expression:Comparison of clinicopathologic features and survival显示文摘 | Adedayo A Onitilo Jessica M Engel Robert T | 2009 | Clin Med & Res2009，7，12： | 1 |
| 13 | High-level secretion of biologically active aprotinin from the yeastPichia pastoris显示文摘 | Thomas Vedvick Richard G. Buckholz Michael Engel Mary Urcan Jennifer Kinney Sally Provow Robert S. Siegel Gregory P. Thill | 1991 | Journal of Industrial Microbiology1991，，3： | 1 |
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| 15 | Cardiac myocyte apoptosis pro- vokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression 显示文摘 | Engel D Peshock R Robert C | 2004 | AJP - Heart2004，287，： | 1 |
| 16 | Electrocerebral activity and epileptic attacks at various blood sugar levels显示文摘 | Rudolf Engel M. D. Franz Halberg Fae Y. Tichy Robert Dow | 1954 | Acta Neurovegetativa (-)1954，，1： | 1 |
| 17 | , An improved oxidation of alkyl halides to aldehydes显示文摘 | Paritosh Dave Hoe - Sup Byun Robert Engel | 1986 | Synthetic Commun1986，16，11： | 1 |
| 18 | Autoregressive Conditional Heteroskedastieity with Estimates of the Varianee of UK inflation 显示文摘 | Engel Robert F | 1982 | Eeonometriea1982，50，： | 1 |
| 19 | Trends in cancer risk among people with AIDS in the United States 1980–2002显示文摘 | Eric A Engels Ruth M Pfeiffer James J Goedert Phillip Virgo Timothy S McNeel Steven M Scoppa Robert J Biggar | 2006 | AIDS2006，，12： | 1 |
| 20 | Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging显示文摘 | Georgios I. Papaioannou Christos Kasapis Richard L. Seip Neil J. Grey Deborah Katten Frans J. Th. Wackers Silvio E. Inzucchi Samuel Engel Amy Taylor Lawrence H. Young Deborah A. Chyun Janice A. Davey Ami E. Iskandrian Robert E. Ratner Evelyn C. Robinson S | 2006 | Journal of Nuclear Cardiology2006，，3： | 1 |
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