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| 1 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria 显示文摘 | Robert AM Kramer RS Dacey LJ | 2010 | Ann Thorac Surg2010，90，： | 1 |
| 4 | Northern New England Cardiovascular Disease Study G:Cardiac surgery-associated acute kidney injury:a comparison of two consensus criteria显示文摘 | Robert AM Kramer RS Dacey LJ | 2010 | Ann Thorac Surg2010，90，6： | 1 |
| 5 | Rume acid:A proposed common name for the majorconjugated linoleic acid isomer food in nature products显示文摘 | Petee W Parodi RobeRT G Tensen | 1998 | Lipids1998，33，8： | 1 |
| 6 | Survey of furan inf oods and coffees from five European Union cotlntries显示文摘 | Crews Colin Roberts Dominic Lauryssen Sigrid and Kramer Ger- ard | 2009 | Food Add itives and Contaminants Part B2009，2，2： | 1 |
| 7 | Synthetic Vision Enhanced Surface Operations With Head-Worn Display for Commercial Aircraft显示文摘 | Jarvis J. Arthur Lawrence J. Prinzel Kevin J. Shelton Lynda J. Kramer Steven P. Williams Randall E. Bailey Robert M. Norman | 2009 | The International Journal of Aviation Psychology2009，，2： | 1 |
| 8 | Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in Coronary Artery Disease显示文摘 | L Kristin Newby Nancy M. Allen LaPointe Anita Y. Chen Judith M. Kramer Bradley G. Hammill Elizabeth R. DeLong Lawrence H. Muhlbaier Robert M. Califf | 2006 | Circulation2006，，2： | 1 |
| 9 | Strategies for the design of hydrophilic matrix tablets with controlled microenvironmental pH显示文摘 | Stefanie Siepe Barbara Lueckel Andrea Kramer Angelika Ries Robert Gurny | 2006 | International Journal of Pharmaceutics2006，，1： | 1 |
| 10 | 显示文摘 | Kramer RM Roberts EF Um SL | 1996 | J Biol Chem1996，271，27： | 1 |
| 11 | Formation of soluble organo-chromium(III)complexes after chromate reduction in the presence of cellular organics显示文摘 | PUZON G J ROBERTS A G KRAMER D M | 2005 | Environmental Science&Technology2005，39，8： | 1 |
| 12 | Cy- tosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain显示文摘 | KRAMER RM STEPHENSON DT ROBERTS EF | 1996 | J Lipid Mediat Cell Signal1996，14，1： | 1 |
| 13 | Genomic and proteomic studies on the effects of the insect growth regulator diflubenzuron in the model beetle species Tribolium castaneum显示文摘 | Hans Merzendorfer Hee Shin Kim Sujata S. Chaudhari Meera Kumari Charles A. Specht Stephen Butcher Susan J. Brown J. Robert Manak Richard W. Beeman Karl J. Kramer Subbaratnam Muthukrishnan | 2011 | Insect Biochemistry and Molecular Biology2011，，4： | 1 |
| 14 | Classification and management of early complications in open lumbar mierodisectomy显示文摘 | Robert Kramer Alexander Wild Holger HaaK | 2003 | Enr Spine J2003，12，1： | 1 |
| 15 | Cardiac surgery- associated acute kidney injury: a comparison of two consensus criteria显示文摘 | Robert AM Kramer RS Dacey LJ | 2010 | Ann Thorac Surg2010，90，6： | 1 |
| 16 | Diagnosis and Treatment of Perianal Crohn Disease: NASPGHAN Clinical Report and Consensus Statement显示文摘 | Edwin F. de Zoeten Brad A. Pasternak Peter Mattei Robert E. Kramer Howard A. Kader | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，3： | 1 |
| 17 | Cardiac surgery-associated acute kidney injury: a comparison of two consensus criteria显示文摘 | Robert AM Kramer RS Dacey U | 2010 | Ann Thorae Surg2010，90，6： | 1 |
| 18 | The MOGE(S) Classification for a Phenotype–Genotype Nomenclature of Cardiomyopathy显示文摘 | Eloisa Arbustini Navneet Narula G. William Dec K. Srinath Reddy Barry Greenberg Sudhir Kushwaha Thomas Marwick Sean Pinney Riccardo Bellazzi Valentina Favalli Christopher Kramer Robert Roberts William A. Zoghbi Robert Bonow Luigi Tavazzi Valentin Fuster J | 2013 | Journal of the American College of Cardiology2013，，22： | 1 |
| 19 | Formation of soluble organo-chromium(Ⅲ) complexes after chromate reduction in the presence of cellular organics显示文摘 | Puzon G J Roberts A G Kramer D M | 2005 | Environmental Science & Technology2005，39，8： | 1 |
| 20 | Classification and management of early complications in open lumbar microdiscectomy显示文摘 | Robert Kramer Alexander Wild Holger Haak etc | 2003 | Eur Spine J2003，12，： | 1 |
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