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| 1 | Role of ion channels in gastrointestinal cancer显示文摘In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell.The functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of cancer.In this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and migration.Various members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon cancer.Voltage-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle cells.The VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC samples.Studies have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer progression.Zn2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal tract.Several distinct types of K+channels are found dysregulated in the GI tract.Notable are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CRC,where KCNQ1 expression is associated with enhanced disease-free survival in stage II,III,and IV disease.Cl-channels are critical for a range of cellular and tissue processes in the GI tract,especially fluid balance in the colon.Most notable is CFTR,whose deficiency leads to mucus blockage,microbial dysbiosis and inflammation in the intestinal tract.CFTR is a tumor suppressor in several GI cancers.Cystic fibrosis patients are at a significant risk for CRC and low levels of CFTR expression are associated with poor overall disease-free survival in sporadic CRC.Two other classes of chloride channels that are dysregulated in GI cancers are the chloride intracellular channels(CLIC1,3&4)and the chloride channel accessory proteins(CLCA1,2,4).CLIC1&4 are upregulated in PC,GC,gallbladder cancer,and CRC,while the CLCA proteins have been reported to be down-regulated in CRC.In summary,it is clear,from the diverse influences of ion channels,that their aberrant expression and/or activity can contribute to malignant transformation and tumor progression.Further,because ion channels are often localized to the plasma membrane and subject to multiple layers of regulation,they represent promising clinical targets for therapeutic intervention including the repurposing of current drugs. | Kyle J Anderson Robert T Cormier Patricia M Scott | 2019 | World Journal of Gastroenterology2019，25，38： | 19 |
| 2 | 中国进行低成本CO2埋存示范项目的机遇显示文摘为了证明CO2捕集和埋存是缓解气候变化的一个主要措施,要在全世界各种不同的地质储层中开展CO2埋存示范项目。在中国,通过煤气化生产NH,的工厂有一些低成本的CO2气源。在这些工厂,因产生的CO2超过其他生产目的(例如合成尿素)的所需量,多余的CO2就作为一种相对纯净的气体排出。如果附近有适当的埋存地点,这些CO2气体可作为埋存示范项目的具有经济吸引力的潜在埋存对象。本研究调查和评估了中国现在燃煤合成氨厂CO2的可用程度。结果表明,单个工厂每年可提供相对纯净的CO2量为0.6-1.1Mt。分析了在CO2气源附近进行地质埋存的可行性。把CO2气源的地理位置标示在可能存在适合CO2埋存油气藏的中国产油沉积盆地中,发现了四对有前景的CO2气源和埋存地点。深部盐水层埋存的工程费用预计为$15-21/tCO2。此外,还评估了气源附近提高石油采收率和煤层气采收率的潜力。 | Kyle C. Meng Robert H. Williams Michael A. Celia | 2009 | 石油科技动态2009，，11： | 4 |
| 3 | Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013显示文摘 | Joseph R. Mikhael David Dingli Vivek Roy Craig B. Reeder Francis K. Buadi Suzanne R. Hayman Angela Dispenzieri Rafael Fonseca Taimur Sher Robert A. Kyle Yi Lin Stephen J. Russell Shaji Kumar P. Leif Bergsagel Steven R. Zeldenrust Nelson Leung Matthew T. D | 2013 | Mayo Clinic Proceedings2013，，4： | 2 |
| 4 | Mechanistic study of substrate-based galvanic replacement reactions显示文摘 | Kyle D. Gilroy Aarthi Sundar Pouyan Farzinpour Robert A. Hughes Svetlana Neretina | 2014 | Nano Research2014，7，3： | 2 |
| 5 | Review of 1027 Patients With Newly Diagnosed Multiple Myeloma显示文摘 | Robert A. Kyle Morie A. Gertz Thomas E. Witzig John A. Lust Martha Q. Lacy Angela Dispenzieri Rafael Fonseca S. Vincent Rajkumar Janice R. Offord Dirk R. Larson Matthew E. Plevak Terry M. Therneau Philip R. Greipp | 2003 | Mayo Clinic Proceedings2003，，1： | 2 |
| 6 | Substrate-based galvanic replacement reactions carried out on heteroepitaxially formed silver templates显示文摘流电的代替反应广泛地被用来转变驱散的银模板组织进复杂 nanoshell 几何学的答案。这里,我们在这些一样的反应的使用上报导从与内在的单个水晶底层有一种 heteroepitaxial 关系的银模板形成空支持底层的 Au-Ag nanoshells。获得的结构展出 nanohut 几何学,显示出高度悦耳的 plasmonic 性质并且用一种没有平版印刷术的技术作为周期的数组被形成。当从底层搬迁了时转换 nanohuts 在边界与一张槽口作为 nanobowls 出现。学习为利用在地点特定的地点定位的 nanoshells 的基于晶片的设备放地基。 | Kyle D. Gilroy Pouyan Farzinpour Aarthi Sundar Teng Tan Robert A. Hughes Svetlana Neretina | 2013 | Nano Research2013，6，6： | 2 |
| 7 | An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma显示文摘 | George P. Kim Michelle R. Mahoney Daniel Szydlo Tony S. K. Mok Robert Marshke Kyle Holen Joel Picus Michael Boyer Henry C. Pitot Joseph Rubin Philip A. Philip Anna Nowak John J. Wright Charles Erlichman | 2012 | Investigational New Drugs2012，，1： | 2 |
| 8 | Soil nutrients influence spatial distributions of tropical tree species显示文摘 | Robert J James W D Kyle E H | 2007 | PNAS2007，104，3： | 1 |
| 9 | Sequence of testing for monoclonal gammo-pothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，2： | 1 |
| 10 | Sequence of testing for monoclonal gammopothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，2： | 1 |
| 11 | Do medical students respond empathetically to a virtual patient?显示文摘 | Adeline M. Deladisma Marc Cohen Amy Stevens Peggy Wagner Benjamin Lok Thomas Bernard Christopher Oxendine Lori Schumacher Kyle Johnsen Robert Dickerson Andrew Raij Rebecca Wells Margaret Duerson J. Garrett Harper D. Scott Lind | 2007 | The American Journal of Surgery2007，，6： | 1 |
| 12 | Span: An Energy-Efficient Coordination Algorithm for Topology Maintenance in Ad Hoc Wireless Networks显示文摘 | Benjie Chen Kyle Jamieson Hari Balakrishnan Robert Morris | 2002 | Wireless Networks2002，，5： | 1 |
| 13 | Behavior of gold nanoparticles in an experimental algal–zooplankton food chain显示文摘 | Kyle D. Gilroy Svetlana Neretina Robert W. Sanders | 2014 | Journal of Nanoparticle Research2014，，5： | 1 |
| 14 | Analytical techniques for characterizing enzymathniic biofuel cells显示文摘 | MICHAEL J M ROBERT L A KYLE H S SHELLEY D M | 2009 | Anal Chem2009，81，23： | 1 |
| 15 | Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing显示文摘 | Robert D. Guzy Beatrice Hoyos Emmanuel Robin Hong Chen Liping Liu Kyle D. Mansfield M. Celeste Simon Ulrich Hammerling Paul T. Schumacker | 2005 | Cell Metabolism2005，，6： | 1 |
| 16 | Transferring Lead-free Piezoelectric Ceramics into Application 显示文摘 | JUrgen RSdel Kyle G W Robert Dittmer | 2015 | Journal of the European Ceramic Society2015，35，6： | 1 |
| 17 | Span: An Energy-Efficient Coordination Algorithm for Topology Maintenance in Ad Hoc Wireless Networks显示文摘 | Benjie Chen Kyle Jamieson Hari Balakrishnan Robert Morris | 2002 | Wireless Networks2002，，5： | 1 |
| 18 | Predictors of Behavioral Loyalty Among Hikers Along the Appalachian Trail显示文摘 | Gerard Kyle Alan Graefe Robert Manning James Bacon | 2004 | Leisure Sciences2004，，1： | 1 |
| 19 | Strategic Trade, Competitive Industries and Agricultural Trade Disputes 显示文摘 | Bagwell Kyle and Staiger Robert W | 2001 | Economics and Politics2001，13，2： | 1 |
| 20 | Mutilateral Tariff Cooperation during the Formation of Free Trade Areas显示文摘 | Bagwell Kyle Staiger Robert W | | 0，，02： | 1 |
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