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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Advances in the Treatment and Outcome of Brainstem Cavernous Malformation Surgery: A Single-Center Case Series of 300 Surgically Treated Patients显示文摘 | Adib A Abla Gregory P Lekovic Jay D Turner Jean G de Oliveira Randall Porter Robert F Spetzler | 2011 | Neurosurgery2011，，2： | 2 |
| 5 | The assimilation of software process innovations:An organizational learning perspective显示文摘 | Robert G Fichman Chris F Kememrer | 1997 | Management Science1997，43，10： | 1 |
| 6 | Volatile constituenis of Asina Pear (Pyrus serotin)显示文摘 | Takeoka G R Butteyry Robert A F | 1992 | J Agric Food Chem1992，，40： | 1 |
| 7 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 8 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 9 | Diurnal and seasonal variability in the radial distribution of sap flow:Predicting total stem flow in Pinus taeda trees显示文摘 | Chelcy R F Carol E G Robert J M | 2004 | Tree Physiology2004，24，： | 1 |
| 10 | An unusually large multifunctional polypeptide in the erythromycin- producing polyketide synthase of Saecharopolyspora erythraea显示文摘 | Cortes J Haydock S F Roberts G A | 1990 | Nature1990，348，： | 1 |
| 11 | Apathy in patients with Parkinson disease without dementia or depression a PET study 显示文摘 | Robert G Le Jeune F Lozachmeur C | 2012 | Neurology2012，79，11： | 1 |
| 12 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 13 | Apathy and impaired emotional facial recognition networks overlap in Parkinson's disease: a PET study with conjunction analyses 显示文摘 | Robert G Le Jeune F Dondaine T | 2014 | J Neurol Neurosurg Psychiatry2014，85，10： | 1 |
| 14 | Innovation, Market Orientation, and Organizational Learning: An Integration and Empirical Exami- nation 显示文摘 | Hurley Robert F Halt G | 1998 | Journal of Marketing1998，，： | 1 |
| 15 | Bayesian computation via related Markov chain Monte Carlo methods 显示文摘 | Smith A F M Roberts G O | 1993 | J R Statist Soc B1993，55，1： | 1 |
| 16 | Acetylation: a novel link be- tween double-strand break repair and autophagy 显示文摘 | Shubassi G Robert T Vanoli F | 2012 | Cancer Res2012，72，6： | 1 |
| 17 | Training neural networks using central force optimization and particle swarm optimization: insights and comparisons 显示文摘 | ROBERT C G WANG L F ALAM M | 2012 | Expert Systems with Applications2012，39，1： | 1 |
| 18 | An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea 显示文摘 | Cortes J Haydock S F Roberts G A | 1990 | Nature1990，348，6297： | 1 |
| 19 | Sampling errors in the estimation of empirical orthogonal functions显示文摘 | North G R Thomas L B Robert F C | 1982 | Monthly Weather Review1982，110，： | 1 |
| 20 | ZapA,a virulence factor in a rat model of Proteus mirabilis induced acute and chronic prostatitis显示文摘 | Van P Robert B Brendan F G | 2008 | Infect Immun2008，11，： | 1 |
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