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| 1 | Path from schizophrenia genomics to biology:gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing显示文摘Schizophrenia(SZ) is a devastating mental disorder afflicting 1% of the population. Recent genome-wide association studies(GWASs) of SZ have identified >100 risk loci. However,the causal variants/genes and the causal mechanisms remain largely unknown,which hinders the translation of GWAS fi ndings into disease biology and drug targets. Most risk variants are noncoding,thus likely regulate gene expression. A major mechanism of transcriptional regulation is chromatin remodeling,and open chromatin is a versatile predictor of regulatory sequences. Micro RNA-mediated post-transcriptional regulation plays an important role in SZ pathogenesis. Neurons differentiated from patient-specifi c induced pluripotent stem cells(i PSCs) provide an experimental model to characterize the genetic perturbation of regulatory variants that are often specifi c to cell type and/or developmental stage. The emerging genome-editing technology enables the creation ofisogenic i PSCs and neurons to effi ciently characterize the effects of SZ-associated regulatory variants on SZ-relevant molecular and cellular phenotypes involving dopaminergic,glutamatergic,and GABAergic neurotransmissions. SZ GWAS fi ndings equipped with the emerging functional genomics approaches provide an unprecedented opportunity for understanding new disease biology and identifying novel drug targets. | Jubao Duan | 2015 | Neuroscience Bulletin2015，31，1： | 2 |
| 2 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 3 | Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor显示文摘 | Jubao Duan Mark S Wain Wright | 2003 | Human Molecular Genetics2003，12，3： | 1 |
| 4 | Finite Element Analysis of the Packer at Fracturing显示文摘 | Zhimiao Li Jubao Liu Yuqi Ding | 2013 | Applied Mechanics and Materials2013，，： | 1 |
| 5 | Corrosion and degradation performance of novel absorbent for CO2 capture in pilot-scale 显示文摘 | GAO Jubao WANG Shujuan ZHOU Shan | 2011 | Energy Procedia2011，4，： | 1 |
| 6 | The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells显示文摘 | Du Jubao Yan Hui Cheung Yiufai | 2004 | Heart Vessels2004，19，： | 1 |
| 7 | Synonymous mutations in the human dopamine receptor D2 (DRD2)affect rnRNA stability and synthesis of the receptor 显示文摘 | Jubao Duan Mark S Wain Wright | 2003 | Human Molecular Genetics2003，12，3： | 1 |
| 8 | Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury显示文摘The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after fluid percussion injury. Diazepam can inhibit the hyperexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment significantly increased the slope of input-output curves in rat neurons after fluid percussion injury. Diazepam significantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the fluid percussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area. | Lei Cao Xiaohua Bie Su Huo Jubao Du Lin Liu Weiqun Song | 2014 | Neural Regeneration Research2014，9，21： | 1 |
| 9 | Corrosion and Degradation Performance of Novel Absorbent for CO2 Cap- ture in Pilot-Plant显示文摘 | GAO Jubao WANG Shujuan ZHOU Shan | 2011 | Energy Procedia2011，4，： | 1 |
| 10 | Potential diagnostic biomarkers for schizophrenia显示文摘Schizophrenia(SCH)is a complex and severe mental disorder with high prevalence,disability,mortality and carries a heavy disease burden,the lifetime prevalence of SCH is around 0.7%–1.0%,which has a profound impact on the individual and society.In the clinical practice of SCH,key problems such as subjective diagnosis,experiential treatment,and poor overall prognosis are still challenging.In recent years,some exciting discoveries have been made in the research on objective biomarkers of SCH,mainly focusing on genetic susceptibility genes,metabolic indicators,immune indices,brain imaging,electrophysiological characteristics.This review aims to summarize the biomarkers that may be used for the prediction and diagnosis of SCH. | Weihua Yue Hailiang Huang Jubao Duan | 2022 | Medical Review2022，2，4： | 0 |
| 11 | Study on micro-water-collecting technique in dryland field of spring maize显示文摘I.IntroductionMicrowatercolectingtechniqueisakindofagriculturalmeasurethatmeanstocolectrainfalextensivlyfromalargeareabyset... | ZHONG Zhaozhan ZHAO Jubao MEI Xurong Institute of Agrometeorology, Chinese Academy of Agricultural Sciences, Beijing 100081 CHINA | 1998 | Journal of Geographical Sciences1998，8，3： | 0 |
| 12 | A STUDY ON FIELD WATER CIRCULATION PATTERN IN THE DRYLAND OF NORTHERN CHINA显示文摘Based on the observed data of soil moisture from locating experiments from 1986 to 1990, the pattern of field water circulation in dryland of northern China, where the mean annual precipitation is 300 600 mm, is studied in this paper using the method of water balance. The results show that water satisfying ratio of spring seeding crops is 83.7 90.8 percent and that of winter wheat is about 70 percent in these areas; about 80 90 percent of water consumption of spring seeding crops and about 60 70 percent of water consumption of winter wheat comes from precipitation during the growing period, the rest comes from the soil water storage before the seeding period. But the available soil water is not used thoroughly, about 30 70 percent of available soil water remains unused when the crops are harvested. At the fallow period, the amount of soil water lost by evaporation is very important, which takes up 57 68 percent of precipitation in winter wheat field and 73 244 percent in field of spring seeding crops. Thus restraining soil evaporation, raising the storage ratio of natural precipitation and the soil water utilization efficiency of crops, strengthening the circulation ability of soil water by adopting efficient measures of agricultural techniques, are the main ways for exploiting and developing the potential productivity of natural precipitation in these areas. | Zhong Zhaozhan Zhao Jubao Institute of Agrometeorology, Chinese Academy of Agricultural Sciences Beijing 100081 People’s Republic of China | 1997 | Journal of Geographical Sciences1997，7，4： | 0 |
| 13 | Human stem cell modeling of neuropsychiatric disorders:from polygenicity to convergence显示文摘Neuropsychiatric disorders(NPD)are prevalent and devastating,posing an enormous socioeconomic burden to modern society.Recent genetic studies of NPD have identified a plethora of common genetic risk variants with small effect sizes and rare risk variants of high penetrance.While exciting,there is a pressing need to translate these genetic discoveries into better understanding of disease biology and more tailored clinical interventions.Human induced pluripotent stem cell(hiPSC)-derived 2D and 3D neural cultures are becoming a promising cellular model for bridging the gap between genetic findings and disease biology for NPD.Leveraging the accessibility of patient biospecimen to convert into stem cells and the power of genome editing technology to engineer disease risk variants,hiPSC model holds the promise to disentangle the disease polygenicity,model genetic interaction with environmental factors,and uncover convergent gene pathways that may be targeted for more tailored clinical intervention. | Jubao Duan | 2023 | Medical Review2023，3，4： | 0 |
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