|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of early gastrointestinal neuroendocrine neoplasms显示文摘Neuroendocrine neoplasms (NENs) of the stomach, duo- denum, appendix or rectum that are small (≤ 1 cm) and well differentiated can be considered 'early' tumors, since they generally have a (very) good prognosis. In the new WHO classification of 2010, these neoplasms are called neuroendocrine tumors/ carcinoids (NETs), grade (G) 1 or 2, and distinguished from poorly differentiated neuroendocrine carcinomas (NECs), G3. NETs are increasing, with a rise in the age-adjusted incidence in the U.S.A. by about 700 % in the last 35 years. Improved early detection seems to be the main reason for these epidemiological changes. Both the better generalavailability of endoscopy, and imaging techniques, have led to a shift in the discovery of smaller-sized (≤ 10-20 mm) intestinal NETs/carcinoids and earlier tumor stages at diagnosis. Endoscopic screening is therefore effective in the early diagnosis, not only of colorectal adenocarcinomas, but also of NETs/carcinoids. Endoscopic removal, followed up with endoscopic surveillance is the treatment of choice in NETs/carcinoids of the stomach, duodenum and rectum that are ≤ 10 mm in size, have a low proliferative activity (G1), do not infiltrate the muscular layer and show no angioinvasion. In all the other intestinal NENs, optimal treatment generally needs surgery and/or medical therapy depending on type, biology and stage of the tumor, as well as the individual situation of the patient. | Hans Scherübl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Günter Klppel | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 13 |
| 2 | Neuroendocrine tumors of the small bowels are on the rise:Early aspects and management显示文摘Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today,most neuroendocrine tumors (NETs) of the duodenum are detected 'incidentally' and therefore recognized at an early stage. Duodenal NETs which are well differentiated,not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for well-differentiated duodenal NET tumors greater than 20 mm,for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with longacting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management,tumor biology,type,localization and stage of the neoplasm,as well as the patient's individual circumstances have to be taken into account. | Hans Scherbl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Gnter Klppel | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，10： | 10 |
| 3 | Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy(from the Multicenter Automatic Defibrillator Implantation Trial-Ⅱ)显示文摘 | William N Robert T John KL | | 0，，05： | 1 |
| 4 | Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1显示文摘 | Ivins S van Beuren KL Roberts C | 2005 | Dev Biol2005，285，2： | 1 |
| 5 | Single pass albumin dialysis (SPAD) in fulminant Wilsonian liver failure: a case report 显示文摘 | Collins KL Roberts EA Adeli K | 2008 | Pediatr Nephrol2008，23，6： | 1 |
| 6 | Molecular Mechanism of Lipopolysaccharide - Induced SOCS - 3 Gene Expression in Macrophages and Microglia显示文摘 | Qin HW Roberts KL Niyongere SA | 2007 | J Immunol2007，179，9： | 1 |
| 7 | IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3 显示文摘 | Qin H Wilson CA Roberts KL | 2006 | J Immunol2006，177，11： | 1 |
| 8 | IL-10 inhibits lipopolysac- charide-induced CIMO gene expression through induction of suppressor of cytokine signaling-3 显示文摘 | Qin H Wilson CA Roberts KL | 2006 | J Immunol2006，177，9： | 1 |
| 9 | Low-moisture-content limits to relations between seed longevity and moisture显示文摘 | Ellis RH Hong TD Roberts EH Tao KL | 1990 | Ann Bot1990，65，： | 1 |
| 10 | Molecular mechanism oflipopolysaccharide-induced SOCS-3 gene expression in macrophagesand microglia显示文摘 | Qin H Roberts KL Niyongere SA | 2007 | J Immunol2007，179，9： | 1 |
| 11 | An ultrastructural analysis of tissue surrounding a microdialysis probe显示文摘 | Clapp-Lilly KL Roberts RC Duffy LK | 1999 | J Neurosci Methods1999，90，2： | 1 |
| 12 | Pathogenesis of Henoch-Sch?nlein purpura nephritis显示文摘 | Keith KL Hitoshi S Robert J | 2010 | Pediatric Nephrology2010，25，1： | 1 |
| 13 | Postoperative seroma deep to mesh after laparoscopic ventral hernia repair: computed tomography appearance and implications for treatment 显示文摘 | Scott PD Harold KL Craft RO Roberts CC | 2015 | Radiol Case Rep2015，3，1： | 1 |
| 14 | Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbxl 显示文摘 | Ivins S van Beuren KL Roberts C | 2005 | Dev Biol2005，285，2： | 1 |
| 15 | Theprognosis of allocentric and egocentric neglect : evidence fromclinical scans 显示文摘 | CHECHLACZ M ROTSHTEIN P ROBERTS KL | 2012 | PLoS One2012，7，47： | 1 |
| 16 | Dynamic characteristics of the tissues of the head 显示文摘 | McElhaney JH Stalnaker KL Roberts VJ | 1995 | J Neurotrauma1995，12，2： | 1 |
| 17 | Tracking the optic nerve head in OCT video using dual eigenspaees and an adaptive vascular distribution model 显示文摘 | Koozekanani D Boyer KL Roberts C | 2003 | IEEE Transaction on Medical Imaging2003，22，12： | 1 |
| 18 | Characterization of natural-显示文摘 | Dall KL Scarpini CG Roberts I | 2008 | Cancer Res2008，68，20： | 1 |
| 19 | Molecular probes for diagnosis of fungal infections显示文摘 | 4,Sandhu GB,Stockman KL and Robert G | 1995 | J Clin1995，33，： | 1 |
| 20 | Serum erythropoietin levels during infancy:associations with erythropoiesis显示文摘 | Kl ing PJ Schmidt RL Roberts RA | 1996 | J-Pediatr1996，128，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员