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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Influence of lamination on the flexural strength of a dental castable glass ceramic 显示文摘 | al-Shehri SA Mohammed H Wilson CA | 1996 | J Prosthet Dent1996，76，1： | 1 |
| 3 | Influence of Lamination on Flexural strength of a dental castable glass ceramic显示文摘 | Al-Shehri SA Mohammed H Wilson CA | 1996 | Int J Prosth1996，76，： | 1 |
| 4 | Treatment with intravitreal steroid reduces blood-retinal bar-rier breakdown due to retinal photocoagulation显示文摘 | Wilson CA Berkowitz BA Sato Y Ando N Handa JT de Juan EJr | 1992 | Arch Oph-Mmol1992，110，8： | 1 |
| 5 | Low-shear modeled microgravity:a global environmental regulatory signal affecting bacterial gene expression,physiology,and pathogenesis显示文摘 | Nickerson CA Ott CM Wilson JW | | 0，，01： | 1 |
| 6 | Analysis of telomere lengths in human corneal endothelial cells from donors of different ages显示文摘 | Egan CA Savre-Train I Shay JW Wilson SE Bourne WM | 1998 | Invest Ophthalmol Vis Sci1998，39，3： | 1 |
| 7 | An in vitro study of the antibacterial and antifungal properties of an irreversible hydrocolloid impression material impregnated with disinfectant显示文摘 | Tobias RS Browne RM Wilson CA | 1989 | J Prosthet Dent1989，62，： | 1 |
| 8 | Schistosoma mansoni Annexin 2: molecular characterization and im- munolocalization 显示文摘 | Tararam CA Farias LP Wilson RA | 2010 | Exp Parasitol2010，126，2： | 1 |
| 9 | Endothelial dysfunction in patients with recent myocardial infarction and hyperhomocysteinaemia: effects of vitamin supplementation 显示文摘 | Chia S Wilson R Ludlam CA | 2005 | Clin Sci ( Lond )2005，108，1： | 1 |
| 10 | The effect of dynamic posterior stabilization on facet joint contact forces:an in vitro investigation显示文摘 | Niosi CA Wilson DC Zhu Q | 2008 | Spine2008，33，1： | 1 |
| 11 | GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides显示文摘 | Phiel CJ Wilson CA Lee VM Klein PS | 2003 | Nature2003，423，6938： | 1 |
| 12 | Trafficking of immune cells in the central nervous system显示文摘 | Wilson EH Weninger W Hunter CA | 2010 | J Clin Invest2010，120，5： | 1 |
| 13 | Assessing annotation transfer for genomics:quantifying the relations between protein sequence,structure and function through traditional and probabilistic scores显示文摘 | WILSON CA KREYCHMAN J GERSTEIN M | 2000 | J Mol Biol2000，297，1： | 1 |
| 14 | Development of a pericardial acellular matrix biomaterial:biochemical and mechanical effects of cell extraction显示文摘 | Courtman DW Pereira CA Kashef V McComb D Lee JM Wilson GJ | | 0，，06： | 1 |
| 15 | HER-2 overexpression differentially alters transforming growth factor-β responses in luminal versus mesenchymal human breast cancer cells显示文摘 | Wilson CA Cajulis EE Green JL | 2005 | Breast Cancer Res2005，7，6： | 1 |
| 16 | Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells显示文摘 | Wilson CA Wong S Muller J | 1998 | J Virol1998，72，4： | 1 |
| 17 | Sudden onset bilateral sensorineural hearing loss:a manifestation of occult breast carcinoma 显示文摘 | Uppal HS Ayshford CA Wilson F | 2001 | J Laryngol Otol2001，115，11： | 1 |
| 18 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, doubleblind, placebo-controlled study 显示文摘 | DeFronzo RA Fleck PR Wilson CA | 2008 | Diabetes Care2008，31，12： | 1 |
| 19 | GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides显示文摘 | Phiel C J Wilson CA Lee VM | 2003 | Nature2003，423，6938： | 1 |
| 20 | Interrupted aortic arch:an epidemiologic study显示文摘 | Loffredo CA Ferencz C Wilson PD | 2000 | Teratology2000，61，5： | 1 |
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