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| 1 | Wnt signaling in disease and in development显示文摘The highly conserved Wnt secreted proteins are critical mediators of cell-to-cell signaling during development of animals. Recent biochemical and genetic analyses have led to significant insight into understanding how Wnt signals work. The catalogue of Wnt signaling components has exploded. We now realize that multiple extracellular, cytoplasmic, and nuclear components modulate Wnt signaling. Moreover, receptor-ligand specificity and multiple feedback loops determine Wnt signaling outputs. It is also clear that Wnt signals are required for adult tissue maintenance. Perturbations in Wnt signaling cause human degenerative diseases as well as cancer. | Roel NUSSE | 2005 | Cell Research2005，15，1： | 83 |
| 2 | Wnt signaling and stem cell control显示文摘发信号的 Wnt 在对干细胞的各种各样的类型的控制被含有并且可以充当一个壁龛因素处于一个自我更新的状态维持干细胞。当当前理解, Wnt 蛋白质在房间表面上绑在 Frizzled 和 LRP 家庭的受体。通过几个细胞质的继电器部件,信号是到 ss-catenin 的 transduced,它然后进入原子核并且与 TCF 形成建筑群激活 Wnt 目标基因的抄写。Wnts 能也通过酷氨酸 kinase 受体,特别地 ROR 和 RYK 受体发信号,导致 Wnt 发信号的其他的模式。在纸巾的生长期间,这些 ligands 和受体动态地被表示,经常, Wnt 控制的抄写联盟者表明自己,保证在增长和区别之间的正确平衡。孤立的 Wnt 蛋白质在许多干细胞上是活跃的,包括神经、乳房、胚胎的干细胞。一般来说, Wnt 蛋白质行动维持干细胞的无差别的状态,当另外的生长因素指示房间增殖时。这些另外的因素包括 FGF 和 EGF,通过酷氨酸 kinase 小径发信号。 | Roel Nusse | 2008 | Cell Research2008，18，5： | 29 |
| 3 | THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE显示文摘 | Catriona Y. Logan Roel Nusse | 2004 | Annual Review of Cell and Developmental Biology2004，，： | 6 |
| 4 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，，6： | 4 |
| 5 | β-catenin: a key mediator of Wnt signaling显示文摘 | Karl Willert Roel Nusse | 1998 | Current Opinion in Genetics & Development1998，，1： | 2 |
| 6 | Wnt/13-catenin signaling and disease 显示文摘 | Clevers Hans Nusse Roel | 2012 | Cell2012，149，6： | 1 |
| 7 | THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE显示文摘 | Catriona Y. Logan Roel Nusse | 2004 | Annual Review of Cell and Developmental Biology2004，，： | 1 |
| 8 | Wnt/β-catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，149，： | 1 |
| 9 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，，6： | 1 |
| 10 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，，6： | 1 |
| 11 | β-catenin: a key mediator of Wnt signaling显示文摘 | Karl Willert Roel Nusse | 1998 | Current Opinion in Genetics & Development1998，，1： | 1 |
| 12 | Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture显示文摘 | Yi Arial Zeng Roel Nusse | 2010 | Cell Stem Cell2010，，6： | 1 |
| 13 | Towards an inte- grated view of Wnt signaling in development 显示文摘 | Renee van Amerongen Roel Nusse | 2009 | De- velopment2009，136，： | 1 |
| 14 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，149，6： | 1 |
| 15 | Wnt/β-Catenin Signaling and Dis ease显示文摘 | Clevers H Nusse Roel | 2012 | Cell2012，149，6： | 1 |
| 16 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，，6： | 1 |
| 17 | Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor content显示文摘 | Amanda J Mikels Roel Nusse | 2006 | Plos Biol2006，4，4： | 1 |
| 18 | Wnt Proteins显示文摘 | Karl Willert Roel Nusse | 2012 | Cold Spring Harbor Perspectives in Biology2012，，9： | 1 |
| 19 | MECHANISMS OF WNT SIGNALING IN DEVELOPMENT显示文摘 | Andreas Wodarz Roel Nusse | 1998 | Annual Review of Cell and Developmental Biology1998，，： | 1 |
| 20 | Towards an integrated view of Wnt signal in development 显示文摘 | Renee Van Aerongen Roel Nusse | 2009 | Development2009，136，19： | 1 |
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