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| 1 | Identification of blood vascular endothelial stem cells by the expression of protein C receptor显示文摘脉管的生长并且改变依赖于从干细胞和 perivascular 细胞的参与的新 endothelial 细胞的产生维持容器正直和功能。存在和脉管的 endothelial 干细胞(VESC ) 的细胞的身份仍然保持不清楚。在成年纸巾的 perivascular pericytes 被认为在早开发期间从间充质的祖先的招募和区别产生。在这研究,我们识别了蛋白质 C 表示受体(Procr +) endothelial 房间作为在多重纸巾的 VESC。Procr + VESC 在文化,在移植的高容器体质效率,在系跟踪的长期的同种细胞的扩大,和 EndMT 特征展出柔韧的 clonogenicity。而且, Procr + VESC 是 bipotent,产生 endothelial 房间和 pericytes 的 de novo 形成。这在成年 angiogenesis 代表 pericytes 的新奇起源,重塑我们血容器开发和 homeostatic 过程的理解。我们的学习可以也提供一个更精确的治疗学的目标禁止病理学的 angiogenesis 和肿瘤生长。 | Qing Cissy Yu Wenqian Song Daisong Wang Yi Arial Zeng | 2016 | Cell Research2016，26，10： | 12 |
| 2 | IntegrinαEβ7^(+)T cells direct intestinal stem cell fate decisions via adhesion signaling显示文摘Intestinal stem cell(ISC)differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying(TA)cells.However,whether and how lymphocyte–stem/TA cell contact affects ISC differentiation is largely unknown.Here,we uncover a novel role of T cell–stem/TA cell contact in ISC fate decisions.We show that intestinal lymphocyte depletion results in skewed ISC differentiation in mice,which can be rescued by T cell transfer.Mechanistically,integrinαEβ7 expressed on T cells binds to E-cadherin on ISCs and TA cells,triggering E-cadherin endocytosis and the consequent Wnt and Notch signaling alterations.BlockingαEβ7−E-cadherin adhesion suppresses Wnt signaling and promotes Notch signaling in ISCs and TA cells,leading to defective ISC differentiation.Thus,αEβ7^(+)T cells regulate ISC differentiation at single-cell level through cell–cell contact-mediatedαEβ7−E-cadherin adhesion signaling,highlighting a critical role of the T cell–stem/TA cell contact in maintaining intestinal homeostasis. | Shiyang Chen Yajuan Zheng Xiaojuan Ran Hui Du Hua Feng Lei Yang Yating Wen Changdong Lin Shihui Wang Mengwen Huang Zhanjun Yan Dianqing Wu Hongyan Wang Gaoxiang Ge An Zeng Yi Arial Zeng Jianfeng Chen | 2021 | Cell Research2021，31，12： | 3 |
| 3 | Hormones induce the formation of luminal-derived basal cells in the mammary gland显示文摘In the mammary gland, it is widely believed that the luminal cells are unipotent after birth, contributing only to the luminal compartment in normal development. Here, by lineage tracing, we uncovered an unexpected potential of luminal cells that can give rise to basal cells during pregnancy. These luminal-derived basal cells (LdBCs) persisted through mammary regression and gen erated more proge ny in successive rounds of preg nan cies. LdBCs express basal markers as well as estroge n receptor a (ERa). I n ovariectomized (OVX) mice, stimulation with estrogen and progesterone promoted the formation of LdBCs. In serial transplantation assays, LdBCs were able to rec on stitute new mammary glands in a hormone-depende nt manner. Tran scriptome an alysis and genetic experiments suggest that Wnt/p-catenin signaling is essential for the formation and maintenance of LdBCs. Our data uncover an unexpected bi-potency of luminal cells in a physiological context. The discovery of ERa+ basal cells, which can respond to hormones and are endowed with stem cell-like regenerative capacity in parous mammary gland, provides new insights into the association of hormones and breast cancer. | Wenqian Song Ran Wang Weimin Jiang Qi Yin Guangdun Peng Ruikai Yang Qing Cissy Yu Jianfeng Chen Jingsong Li Tom H. Cheung Naihe Jing Yi Arial Zeng | 2019 | Cell Research2019，29，3： | 2 |
| 4 | Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers显示文摘Breast cancer is a heterogeneous disease.In particular,triple-negative breast cancer(TNBC)comprises various molecular subgroups with unclear identities and currently has few targeted treatment options.Our previous study identified protein C receptor(Procr)as a surface marker on mammary stem cells(MaSCs)located in the basal layer of the normal mammary gland.Given the possible connection of TNBC with basal layer stem cells,we conducted comparative analyses of Procr in breast cancers of mouse and human origin.In mouse mammary tumors,we showed that Procr+cells are enriched for cancer stem cells(CSCs)in Wnt1 basal-like tumors,but not in Brea basal-like tumors or PyVT luminal tumors.In human cancers,PROCR was robustly expressed in half of TNBC cases.Experiments with patient-derived xenografts(PDXs)revealed that PROCR marks CSCs in this discrete subgroup(referred to as PROCR+TNBC).Interfering with the function of PROCR using an inhibitory nanobody reduced the CSC numbers,arrested tumor growth and prevented rapid tumor recurrence.Our data suggest a key role of MaSC in breast tumorigenesis.Moreover,our work indicates that PROCR can be used as a biomarker to stratify TNBC into clinically relevant subgroups and may provide a novel targeted treatment strategy for this clinically important tumor subtype. | Daisong Wang Xin Hu Chunye Liu Yingying Jia Yiqin Bai Cheguo Cai Jingqiang Wang Lanyue Bai Ruikai Yang ChangDong Lin Yi-Rong Liu Shan Li Feng Qiao Ling Yao Li Chen Gaoxiang Ge Hai Jiang Dianfan Li Lin Li JianFeng Chen Zhi-Ming Shao Yi Arial Zeng | 2019 | Cell Research2019，29，10： | 2 |
| 5 | SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling显示文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy. | Liang Xu Peixue Li Xue Hao Yi Lu Mingxian Liu Wenqian Song Lin Shan Jiao Yu Hongyu Ding Shishuang Chen Ailing Yang Yi Arial Zeng Lei Zhang Hai Jiang | 2021 | Protein & Cell2021，12，3： | 1 |
| 6 | Tumoricidal activity of tumornecrosis factor-related apoptosis inducing ligand in vi- vo显示文摘 | Walezak H Miller RE Arial K | 1999 | Nat Med1999，5，2： | 1 |
| 7 | Adoption and Abandonment of Irrigation Technologies显示文摘 | Dinar Arial Yaron Dan | 1992 | Agricultural Economics1992，，4： | 1 |
| 8 | Examination of circuit parameters for stable high efficiency TETS for artificial hearts显示文摘 | Shinsuke Arial Hidekazu Miura Fumihiro Sato | 2005 | IEEE Transactions on Magnetics2005，41，10： | 1 |
| 9 | Tumoricidal activity of tumor necrosis factor-related apoptosis inducing ligand in vivo 显示文摘 | Walczak H Miller RE Arial K | 1999 | Nat Med1999，5，2： | 1 |
| 10 | Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture显示文摘 | Yi Arial Zeng Roel Nusse | 2010 | Cell Stem Cell2010，，6： | 1 |
| 11 | Author Correction:Hormones induce the formation of luminal-derived basal cells in the mammary gland显示文摘In the initial published version of this article,there was a mistake in one author name(Jingsong Li).The correct name should be“Jinsong Li”.This correction does not affect the description of the results or the conclusions of this work. | Wenqian Song Ran Wang Weimin Jiang Qi Yin Guangdun Peng Ruikai Yang Qing Cissy Yu Jianfeng Chen Jingsong Li Tom H.Cheung Naihe Jing Yi Arial Zeng | 2019 | Cell Research2019，29，4： | 1 |
| 12 | Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo 显示文摘 | Walczak H Miller R E Ariall K | 1999 | Nat Med1999，5，2： | 1 |
| 13 | Effort,reward and self-reported mental health:a simulation study on negative affectivity bias显示文摘 | Arial M Wild P | | 0，，： | 1 |
| 14 | Predicting factors for endometrial thickness during treatment with assisted reproductive technology 显示文摘 | Amir W Micha B Arial H | 2007 | Fertility and Sterility2007，87，4： | 1 |
| 15 | Factors associated with lower uterine segment thickness near term in women with previous caesarean section显示文摘 | Berube L Arial M Gagnon G | | 0，，06： | 1 |
| 16 | Binary mixed solvent electrolytes containing trifluoropropylene carbonate for secondary batteries显示文摘 | ARIAL J KATAYAMA I L AKABOSHI H J | | 0，，02： | 1 |
| 17 | Binary mixed solvent electrolytes containing trifluoropropylene carbonate for lithium secondary batteries显示文摘 | ARIAL J KATAYAMA H AKAHOSHI H | 2002 | Journal of the Electrochemical Society2002，149，2： | 1 |
| 18 | Factors associated with lower uterine segment thickness near term in women with previous caesarean section显示文摘 | Berube L Arial M Gagnon G | 2011 | J Obstet Gynaol Can2011，33，6： | 1 |
| 19 | 吃遍泰国需要多少钱?显示文摘春节除了待在家和家人团圆和朋友欢聚,越来越多的人选择跑得远一点,玩得野一点,吃得美一点,上班一族假期时间有限,掰指头算算,也就奔到东南亚一带晒晒太阳比较划算,泰国洪水一退,各种泰国游线路再次纷至沓来,去那个充满美食处处五彩热烈的地方走一趟真是今年春节出行的热门选择!说到泰国,就连还没去过的人大概也能顺口讲出'泰好看,泰好玩,泰好吃'。没错,这九个字丝毫也不言过其实。泰国之迷人,在于它从不吝于展现它的美丽。不论你去繁华的首都、悠闲的海滩、肃穆的宫殿,或是别致的村落,它总是以那缤纷的景致和多变的样貌来迎接你好奇的目光。你大概也觊觎这岛国已久,但懒惰却是人类最大的绊脚石,面对一个完全陌生的地方,要如何将它的方方面面全部压缩在一张薄薄的excel表格里,以日期地点和预算标记出一个立体的行程呢?术业有专攻,作为美食精英团队,我们义不容辞地担负起制作美食攻略的责任。泰国的货币泰铢目前与人民币的汇率约为4.9:1,人民币在当地还是很耐花的。好歹是付了几千块机票钱飞来了泰国,要怎样才能吃个够本?我们为你严选了泰国各个区域的代表城市,深入美食市场,亲尝每种味道,希望以我们的精挑细选和精打细算,为你造出一张立体的泰国美食攻略。但愿到时你能按图索骥,完成圆满的'泰美味'之旅。 | Arial | 2012 | 天下美食2012，，1： | 0 |
| 20 | Preface to the special topic on tissue stem cell research显示文摘Stem cells have the ability to self-renew,divide for a long period of time,and differentiate into specialized cells with distinct functions.Scientists are hopeful that,in the future,stem cells will be used to cure a wide range of diseases and traumatic injuries with some application of cell therapy.Currently,donated organs and tissues are used to replace lost or damaged tissue in many disorders. | Jinsong Li Yi Arial Zeng | 2021 | Science China(Life Sciences)2021，64，12： | 0 |
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