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| 1 | Clinical implication of 14-3-3 epsilon expression in gastric cancer显示文摘AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric carcinogenesis.METHODS:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process. | Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2012 | World Journal of Gastroenterology2012，18，13： | 6 |
| 2 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 3 | Adoption of Laparoscopy for Elective Colorectal Resection: A Report from the Surgical Care and Outcomes Assessment Program显示文摘 | Steve Kwon Richard Billingham Ellen Farrokhi Michael Florence Daniel Herzig Karen Horvath Terry Rogers Scott Steele Rebecca Symons Richard Thirlby Mark Whiteford David R. Flum | 2012 | Journal of the American College of Surgeons2012，，6： | 3 |
| 4 | miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation显示文摘 | Dale G. Schaar Daniel J. Medina Dirk F. Moore Roger K. Strair Yi Ting | 2009 | Experimental Hematology2009，，2： | 3 |
| 5 | Measurements of coupled fluid and sediment motion over mobile sand dunes in a laboratory flume显示文摘The relationship between turbulent fluid motions and sediment particle motions over mobile sand dunes was investigated by using a laser Doppler velocimeter and an acoustic backscatter system in laboratory experiments performed at the USDA-ARS-National Sedimentation Laboratory. Profiles of acoustic backscatter from particles and at-a-point turbulence data were collected while translating both measurement devices downstream at the speed of mobile dune bedforms. The resulting data set was used to examine the frequency (recurrence frequency) at which the fluctuating backscatter and fluid velocity signals exceeded magnitude thresholds based on the standard deviation (σ) of the local velocity and the magnitude the acoustic signal resulting from backscatter from suspended particles. The slope of the downstream and vertical velocity recurrence frequencies generally indicated a gradually increasing recurrence time with increasing elevation. The recurrence frequency for acoustic backscatter data was not strongly variable with elevation. The closest correspondence between the recurrence frequencies of sediment backscatter and vertical velocities at the 1σ magnitude threshold was in a region defined by X/L<0.4 and y<6 cm. The downstream velocity was most closely related to backscatter in a small region at 0.4 | Daniel G.WREN Roger A.KUHNLE | 2008 | International Journal of Sediment Research2008，23，4： | 3 |
| 6 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 7 | MicroRNAs and colon and rectal cancer: Differential expression by tumor location and subtype显示文摘 | Martha L.Slattery EricaWolff Michael D.Hoffman Daniel F.Pellatt BrettMilash Roger K.Wolff | 2011 | Genes Chromosom Cancer2011，，3： | 2 |
| 8 | Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism显示文摘 | K. Ganesh Kumar James L. Trevaskis Daniel D. Lam Gregory M. Sutton Robert A. Koza Vladimir N. Chouljenko Konstantin G. Kousoulas Pamela M. Rogers Robert A. Kesterson Marie Thearle Anthony W. Ferrante Randall L. Mynatt Thomas P. Burris Jesse Z. Dong Heathe | 2008 | Cell Metabolism2008，，： | 2 |
| 9 | Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes显示文摘 | Andrew Maiorana Gerard O'Driscoll Carmel Goodman Roger Taylor Daniel Green | 2002 | Diabetes Research and Clinical Practice2002，，2： | 2 |
| 10 | Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease 显示文摘 | Slow Elizabeth J Van Raamsdonk Jeremy Rogers Daniel | 2003 | Hum Mol Genet2003，12，13： | 1 |
| 11 | mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms显示文摘 | Kathleen A. Wilson-Edell Mariya A. Yevtushenko Daniel E. Rothschild Aric N. Rogers Christopher C. Benz | 2014 | Breast Cancer Research and Treatment2014，，： | 1 |
| 12 | Single amino acid substitutions in influenza hemagglutinin change receptor binding specificity显示文摘 | Rogers G N Paulson J C Daniels R S | 1983 | Nature1983，304，5921： | 1 |
| 13 | Cognitive Dysfunction and Depression in Adult Kidney Transplant Recipients: Baseline Findings from the FAVORIT Ancillary Cognitive Trial (FACT)显示文摘 | Aron M. Troen Tammy M. Scott Kristen E. D’Anci Denish Moorthy Beverly Dobson Gail Rogers Daniel E. Weiner Andrew S. Levey Gerard E. Dallal Paul F. Jacques Jacob Selhub Irwin H. Rosenberg | 2012 | Journal of Renal Nutrition2012，，2： | 1 |
| 14 | Single amino acid substitutions in influenza hemagglutinin change receptor binding specificity显示文摘 | ROGERS G N PAULSON J C DANIELS R S | 1983 | Nature1983，304，： | 1 |
| 15 | Mapping the Biological Oxidative Damage of Engineered Nanomaterials显示文摘 | Shu‐Feng Hsieh Dhimiter Bello Daniel F. Schmidt Anoop K. Pal Aaron Stella Jacqueline A. Isaacs Eugene J. Rogers | 2013 | Small (鈥?)2013，，9： | 1 |
| 16 | Analysing nitrogen response sol cereals to prioritize routes to the improvement of nitrogen use efficiency显示文摘 | Roger S B Daniel R K | 2009 | Exp Bot2009，60，7： | 1 |
| 17 | Surgical Neuropathology Update: A Review of Changes Introduced by the WHO Classification of Tumours of the Central Nervous System, 4th Edition显示文摘 | Brat Daniel J Parisi Joseph E Kleinschmidt-DeMasters Bette K Yachnis Anthony T Montine Thomas J Boyer Philip J Powell Suzanne Z Prayson Richard A McLendon Roger E | 2008 | Archives of Pathology & Laboratory Medicine2008，，6： | 1 |
| 18 | Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With Advanced Heart Failure显示文摘 | Mariell Jessup Barry Greenberg Donna Mancini Thomas Cappola Daniel F. Pauly Brian Jaski Alex Yaroshinsky Krisztina M. Zsebo Howard Dittrich Roger J. Hajjar | 2011 | Circulation2011，，3： | 1 |
| 19 | Anti-tumor therapy with macro encapsulated endostatin producer cells显示文摘 | Danielle BR Roger C Natfdia VM | 2010 | BMC Biotechnol2010，10，5： | 1 |
| 20 | Do Farm Programs Encourage Native Grassland Losses?显示文摘 | Claassen Roger Carriazo Fernando Cooper Joseph C Hellerstein Daniel | 2011 | Amber Waves2011，，3： | 1 |
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