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| 1 | 实体瘤CART治疗面临的挑战显示文摘嵌合性抗原受体T细胞疗法在CD19表达阳性的血液系统恶性肿瘤中取得了惊人的效果。靶向CD19的CART细胞(CART CD19)可使急性淋巴细胞白血病的缓解率提高。然而,CART疗法对实体肿瘤的疗效近几年一直未有实质性的突破。实体肿瘤免疫治疗中存在诸多亟待解决的问题,如CART如何进入实体瘤微环境并在其中保持活力、怎样更加快速准确的识别肿瘤细胞、如何克服免疫抑制发挥作用等。本文主要探讨CART细胞治疗实体瘤所面临的挑战。 | 丁烁 赵磊 Rojina Shilpakar 魏云巍 | 2018 | 中国免疫学杂志2018，34，4： | 7 |
| 2 | Incidence and Management of Gastrointestinal Bleeding With Continuous Flow Assist Devices显示文摘 | Ashim Aggarwal Rojina Pant Shivani Kumar Priya Sharma Colleen Gallagher Antone J. Tatooles Pat S. Pappas Geetha Bhat | 2012 | The Annals of Thoracic Surgery2012，，： | 1 |
| 3 | Temperature monitoring from 2012 to 2019 in central part of Suntar-Khayat Ridge,Russia显示文摘In recent decades,research of the Alps,Qinghai-Tibet Plateau,and Cordillera have made great progress in understanding the phenomenon of permafrost.For the most part,this has been made possible due to temperature monitoring.However,the permafrost parameters in an area of more than 2 million square km of the mountainous regions of northeast Asia,for the most part,remain a blank spot in the scientific community.Due to the lack and insufficiency of factual materials,in 2012 the P.I.Melnikov Permafrost Institute began to take temperature measurements in the upper part of the permafrost in the central part of the VerkhoyanKolyma uplands,namely the Suntar-Khayat ridge.The article describes the temperature characteristics of air,surface and rocks of the active layer in the range of heights from 850 to 1821 m,in various landscape and topographic elements.For the observation period from 2012 to 2019,we obtained information on temperatures in the soils of the active layer at depths of 1 m,3 m,4 m,and 5 m and also air and surface temperature parameters.The availability of data on automated monitoring of rock temperatures in the active layer and the upper horizons of the layer of annual heat rotations made it possible to substantiate the most typical conditions of the temperature conditions of the permafrost zone of the characterized region.The parameters of permafrost existence and development are in favorable conditions.This is shown in the analysis of temperature data of air,surface and active layer.Soil temperatures in the active layer of annual heat rotations are most clearly represented at a depth of 1 m.Currently,on the territory of the mountain regions of Eastern Siberia,there are no more such sites for monitoring the temperature regime of soils.Information on the permafrost parameters in the region will allow us to begin the process of creating new models or checking existing forecasts and the distribution of the temperature pattern.It will also make it possible to evaluate the response of sensitive and vulnerable frozen soils of mountain regions to climate change. | Robert SYSOLYATIN Sergei SERIKOV Mikhai Yana TIKHONRAVOVA Vladimir ZHIZHIN Maria ROJINA | 2020 | Journal of Mountain Science2020，17，10： | 0 |
| 4 | 微波消融与无水乙醇消融治疗单纯性甲状腺囊肿的效果比较显示文摘目的比较两种消融方法治疗单纯性甲状腺囊肿的疗效。方法回顾性比较我院2014年8月~2017年3月超声引导下分别应用无水乙醇消融(无水乙醇组,n=30)或微波消融方法(微波消融组,n=30)治疗60例单纯性甲状腺囊肿患者的临床资料。比较两组患者术后临床疗效、治疗前后甲状腺激素水平变化及术中术后并发症。结果术中自觉颈部疼痛者21例,其中无水乙醇组16例,微波消融组5例,差异有统计学意义(χ^2=8.864,P=0.003);术中穿刺后发生较明显出血者3例,其中无水乙醇组2例,微波消融组1例,差异无统计学意义(χ^2=0.351,P=0.554);术后无水乙醇组出现声音嘶哑者2例,微波消融组0例,差异无统计学意义(χ^2=2.069,P=0.150)。术后随访3~5个月,两组远期临床效果无差异(Z=-3.611,P=0.718),两组治疗前后甲状腺激素水平均在正常范围内。结论微波消融术与无水乙醇消融术治疗单纯性甲状腺囊肿疗效相似,但前者术中疼痛发生率低;两种方法治疗单纯性甲状腺囊肿对甲状腺内分泌功能均无明显影响。 | 刘鲁嘉 张健 Shilpakar Rojina 李爱东 | 2020 | 哈尔滨医科大学学报2020，54，2： | 0 |
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