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| 1 | Intrahepatic cholestasis of pregnancy:When should you look further?显示文摘Pruritis with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy(ICP),a condition associated with significant fetal complications.Although the etiology of ICP is unclear in many cases,certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease.We report a kindred of Anglo-Celtic descent,among whom many members present with ICP,gallstones or cholestasis related to use of oral contraception.Genetic studies revealed a novel mutation in the ABCB4 gene,which codes for a phospholipid transport protein.The clinical significance of this mutation and the importance of identifying such patients are discussed. | Winita Hardikar Shivani Kansal Ronald P J Oude Elferink Peter Angus | 2009 | World Journal of Gastroenterology2009，15，9： | 22 |
| 2 | Sensitivity of Labile Soil Organic Carbon Pools to Long-Term Fertilizer, Straw and Manure Management in Rice-Wheat System显示文摘Labile soil organic carbon(SOC) pools, estimated through chemical fractionation techniques, are considered sensitive indicators of management-induced changes in quality and composition of soil organic matter. Although the impacts of organic manure and crop residue applications on C sequestration in rice-wheat system are fairly well documented, their influence on labile SOC pools is relatively less known. Impacts of organic manure, rice straw, and inorganic fertilizer nitrogen(N) applications on soil total organic carbon(TOC)and SOC pools including water-extractable organic C(WEOC), hot water-soluble organic C(HWOC), potassium permanganateoxidizable organic C(KMnO 4-C), microbial biomass C(MBC), mineralizable organic C(Cmin), and the oxidizable fractions of decreasing oxidizability(easily-oxidizable, oxidizable, and weakly-oxidizable) were investigated in an 11-year field experiment under rice-wheat system. The field experiment included treatments of different combinations of farmyard manure, rice straw, and fertilizer N application rates, with C inputs estimated to be in the range from 23 to 127 Mg ha-1. After 11 years of experiment, WEOC,HWOC, and KMnO 4-C were 0.32%–0.50%, 2.2%–3.3%, and 15.0%–20.6% of TOC, respectively. The easily-oxidizable, oxidizable,and weakly-oxidizable fractions were 43%–57%, 22%–27%, and 10%–19% of TOC, respectively. The applications of farmyard manure and rice straw improved WEOC, HWOC, KMnO 4-C, easily-oxidizable fraction, Cmin, and MBC, though the rates of change varied considerably from-14% to 145% and-11% to 83% of TOC, respectively. At the C input levels between 29 and 78 Mg C ha-1during the 11-year period, the greatest increase was observed in WEOC and the minimum in KMnO 4-C. Water-extractable organic C exhibited a relatively greater sensitivity to management than TOC, suggesting that it may be used as a sensitive indicator of management-induced changes in soil organic matter under rice-wheat system. All the other labile SOC pools exhibited almost the same sensitivity to management as TOC. Most of the SOC pools investigated were positively correlated to each other though their amounts differed considerably. Long-term applications of farmyard manure and rice straw resulted in build-up of not only the labile but also the recalcitrant pool of SOC, emphasizing the need for continued application of organic amendments for permanence of the accrued C under the experimental conditions. | Dinesh K.BENBI Kiranvir BRAR Amardeep S.TOOR Shivani SHARMA | 2015 | Pedosphere2015，25，4： | 16 |
| 3 | 首乌熟地饮对MPTP致帕金森病小鼠模型多巴胺能神经元的影响显示文摘为了研究首乌熟地饮对1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methy-4-phenyl-1,2,3,6-te-trahydropyridine,MPTP)诱致帕金森病模型小鼠多巴胺能神经元的影响及其可能机制。该实验将小鼠分为4组:正常组、首乌熟地饮组(对照组)、MPTP组(模型组)、MPTP+首乌熟地饮组(干预组),分别给予首乌熟地饮(对照组和干预组)和去离子水(正常组和模型组)灌胃30d;随后模型组和干预组腹腔注射MPTP,正常组和对照组腹腔注射等量生理盐水,7 d后应用免疫组化检测各组黑质区酪氨酸羟化酶(TH)阳性神经元细胞数目,聚合酶链式反应(PCR)检测各组TH m RNA及谷胱甘肽过氧化物酶(GPX)m RNA的表达量。结果显示,腹腔注射MPTP的模型组和干预组的TH阳性神经元数和TH m RNA表达量均明显少于正常组和对照组(P<0.05);但模型组与干预组之间黑质的TH阳性神经元数和TH m RNA表达量无明显差异。与模型组相比,首乌熟地饮使干预组黑质区4种亚型谷胱甘肽过氧化物酶(GPX)的m RNA表达量均有不同程度增加,但差异并无统计学意义。这表明了首乌熟地饮对MPTP诱致帕金森病模型小鼠多巴胺能神经元凋亡不具有预防保护作用,但其或许通过增加GPX表达从而增强小鼠的抗氧化能力。 | Tunje Reginachizi 叶阳烈 Sonauddin Ahmed Hansraj Bhugun Ngawang Sangye Shivani Sharma 张雄 祝建洪 刘荣培 | 2016 | 中国中药杂志2016，41，18： | 8 |
| 4 | Retinal structural-vascular-functional relationship using optical coherence tomography and optical coherence tomography -angiography in myopia显示文摘Background:To examine the retinal structure–vascular-function relationship using optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)in myopia.Methods:This was a prospective cross-sectional study comprising 86 eyes of 45 individuals with varying axial lengths and spherical equivalents and no posterior segment abnormalities.All eyes underwent optical coherence tomography with the Spectralis SD-OCT and OCTA with RTVue-XR Avanti;Optovue.Individual macular retinal layer thicknesses and flow areas and vessel densities were measured on OCT and OCTA,respectively.Linear correlations were made between the macular layer thicknesses,flow areas and vessel densities with axial length,spherical equivalent and visual acuity.Results:The participants’mean ages were 33.34±14.45 years,mean spherical equivalent refractions were−7.17±5.71 D and axial lengths were 25.95±2.41 mm.There were significant positive correlations of foveal angle(r=0.757,p=0.001),inner retinal(r=0.764,p=0.001)and outer plexiform layer(r=0.771,p=0.001)thickness on OCT and vessel densities in deep capillary plexus(r=0.313,p=0.003)on OCTA with axial length and negative correlations with spherical equivalents and visual acuity.Significant negative correlations of outer nuclear layer(r=−0.560,p=0.03)and photoreceptor outer segment layer thickness(r=−0.856,p<0.001)were noted on OCT with axial length and positive correlations with spherical equivalents and visual acuity.Conclusion:The lateral retinal stretching in myopia could possibly explain the correlation between retinal layer thickness,vascular density and visual acuity in these eyes.Further research is required to investigate this. | Ramesh Venkatesh Shivani Sinha Deepika Gangadharaiah Santosh G.K.Gadde Ashwin Mohan Rohit Shetty Naresh Kumar Yadav | 2019 | Eye and Vision2019，6，1： | 7 |
| 5 | Novel targeting approaches and signaling pathways of colorectal cancer: An insight显示文摘Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC. | Ankita Tiwari Shivani Saraf Amit Verma Pritish Kumar Panda Sanjay K Jain | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 6 | 一种直观的一般秩相关系数(英文)显示文摘相关分析是研究数据模式和预测的有效机制。在看似无关的数据中建立相关性可得到许多有趣发现。提出一种算法,用于量化相关性理论并得出一个直观且更精确的相关系数。为计算配对值之间相关性,提出一项预测指标,称为一般秩相关系数。其满足预测指标的5个基本标准:样本规模的独立性、数值介于-1与1之间、测量单调性程度、对异常值不敏感性、直观演示。此外,使用实时数据集和随机数模拟实验对该指标进行验证。同时,展示了所提方程的数学推导过程,并与斯皮尔曼等级相关系数比较。结果表明,该指标在所有预测度量标准上均优于现存指标。 | Divya PANDOVE Shivani GOEL Rinkle RANI | 2018 | Frontiers of Information Technology & Electronic Engineering2018，19，6： | 2 |
| 7 | Top 100 cited articles in ophthalmic epidemiology between 2006 and 2016显示文摘AIM: To identify the most-cited articles in ophthalmic epidemiology over the last decade.METHODS: We performed a cited reference search on articles that were included in the ISI Web of Science database using the terms 'Epidemi*' AND 'ophthalm*' AND 'population*' during year 2006 to 2016. TOP 100 most cited articles(T100) in ophthalmic epidemiology were short listed and analysed using bibliometrics.RESULTS: These top 100 articles in ophthalmic epidemiology were cited between 61 to 333 times. Of these T100 articles, 36% originated from United States, and 34% were published in the Ophthalmology journal. The three major topics identified were age-related macular degeneration(AMD, n=23), glaucoma(n=16) and visual impairment(n=12). The top-cited article was a study on outdoor activities and its association with the prevalence of myopia in school-aged children, published in 2008. CONCLUSION: This bibliometric analysis provides useful insights into the current development in ophthalmicepidemiology in the past decade and can help recognizing the quality of the researches, discoveries, and trends steering ophthalmic epidemiology. | Lei Liu Yan Li Gui-Sen Zhang Jing-Yang Wu Shivani Majithia Yih-Chung Tham Han Zhang Lei Chen | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 2 |
| 8 | Molecular characterization of antimicrobial multi-drug resistance in non-typhoidal Salmonellae from chicken and clam in Mangalore, India显示文摘Salmonella enterica has been documented as one of the leading causes of salmonellosis throughout the world and is most commonly associated with the consumption of contaminated food products. Thus, this research was aimed at studying the antimicrobial susceptibility pattern and detection of quinolone resistance in Salmonella spp isolated from food of animal origin. Thirty-six Salmonella isolates comprising 8 from poultry and 28 from seafood(clams) were identified, serotyped and characterized for their antimicrobial susceptibility against 10 different antibiotics. Plasmid DNA was isolated from all the isolates by alkaline lysis, quinolone resistant non-typhoidal S. Weltevreden were examined for mutation in the DNA gyrase coding gene. Among the 36 Salmonella isolates, 20 were S. weltevreden(8 from poultry and 12 from seafood) and 16 were S. Typhimurium(from seafood). All the isolates showed multiple resistance to nalidixic acid, tetracycline, co-trimoxazole and nitrofurantoin, but, interestingly, the isolates were 100% susceptible to ampicillin, chloramphenicol and gentamicin. Resistant isolates from the study carried the genes responsible for resistance to respective antibiotics. The strain S130 isolated in the study showed single point mutation,Asp87Gly, at position 87 in quinolone resistance determining region. It revealed mutation in quinolone resistance determining region as a cause for quinolone resistance in non-typhoidal Salmonellae. The occurrence of genes accountable for plasmid mediated resistance to quinolones(viz., qnrA, qnrB and qnrS) in plasmid of non-typhoidal Salmonellae isolates provides evidence for plasmid mediated quinolone resistance. | Yemisi Olukemi Adesiji Santhosh Kogaluru Shivakumaraswamy Vijaya Kumar Deekshit Girisha Shivani Kallappa Indrani Karunasagar | 2018 | The Journal of Biomedical Research2018，32，3： | 2 |
| 9 | A potato late blight resistance gene protects against multiple Phytophthora species by recognizing a broadly conserved RXLR-WY effector显示文摘Species of the genus Phytophthora,the plant killer,cause disease and reduce yields in many crop plants.Although many Resistance to Phytophthora infestans(Rpi)genes effective against potato late blight have been cloned,few have been cloned against other Phytophthora species.Most Rpi genes encode nucleotide-binding domain,leucine-rich repeat-containing(NLR)immune receptor proteins that recognize RXLR(Arg-X-Leu-Arg)effectors.However,whether NLR proteins can recognize RXLR effectors from multiple Phytophthora species has rarely been investigated.Here,we identified a new RXLR-WY effector AVRamr3 from P.infestans that is recognized by Rpi-amr3 from a wild Solanaceae species Solanum americanum.Rpi-amr3 associates with AVRamr3 in planta.AVRamr3 is broadly conserved in many different Phytophthora species,and the recognition of AVRamr3 homologs by Rpi-amr3 activates resistance against multiple Phytophthora pathogens,including the tobacco black shank disease and cacao black pod disease pathogens P.parasitica and P.palmivora.Rpi-amr3 is thus the first characterized resistance gene that acts against P.parasitica or P.palmivora.These findings suggest a novel path to redeploy known R genes against different important plant pathogens. | Xiao Lin Andrea Olave-Achury Robert Heal Marina Pais Kamil Witek Hee-Kyung Ahn He Zhao Shivani Bhanvadia Hari S.Karki Tianqiao Song Chih-hang Wu Hiroaki Adachi Sophien Kamoun Vivianne G.A.A.Vleeshouwers Jonathan D.G.Jones | 2022 | Molecular Plant2022，15，9： | 2 |
| 10 | Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis显示文摘OBJECTIVE: The fatality of cancer is mostly dependent on the possibility of occurrence of metastasis. Thus, if the development of metastasis can be prevented through novel therapeutic strategies targeted against this process, then the success of cancer treatment will drastically increase. In this study, therefore, we evaluated the antimetastatic potentials of an extract of Khaya senegalensis and curcumin on the metastatic liver cell line HepG2, and also assessed the anticancer property of the extract.METHODS: Cells were cultured and treated with graded concentrations of test substances for 24, 48, or 72 h with provisions made for negative controls. Treated cells were assessed as follows: nanotechnologically—atomic force microscopy(AFM) was used to determine cell stiffness; biochemically—cell cytotoxicity, glutathione level and adenosine triphosphate status, caspase activation and mitochondrial toxicity were considered; and microbiologically—a carrot disk assay was used to assess the anticancer property of the extract of K. senegalensis.RESULTS: Curcumin and K. senegalensis increased the cell stiffness by 2.6-and 4.0-fold respectively, indicating their antimetastatic effects. Corresponding changes in redox(glutathione level) and energy(adenosine triphosphate) status of the cells were also demonstrated. Further mechanistic studies indicated that curcumin was not mitotoxic in HepG2 cells unlike the K. senegalensis extract. In addition, the extract potently inhibited the Agrobacterium tumefaciens-induced genetic transformation based on carrot disk assay.CONCLUSION: Cell elasticity measurement data, using AFM, strongly suggested, for the first time, that both curcumin and the extract of K. senegalensis exhibited antimetastatic properties on HepG2 cells. | Jeremiah Olorunjuwon Olugbami Robert Damoiseaux Bryan France Michael A. Gbadegesin Adam Z. Stieg Shivani Sharma Oyeronke A. Odunola James K. Gimzewski | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 11 | Quantum chemical analysis for the formation of glycine in the interstellar medium显示文摘Glycine (C2H5NO2) was the first amino acid to be detected in space by the stardust space probe in Comet Wild2, and is used by living organisms to make proteins. We discuss three different reaction paths for the formation of glycine in interstellar space from some simpler molecules detected in the interstellar medium. The possibility of the formation of glycine in interstellar space is considered by radical-radical and radical-molecule interaction schemes using quantum chemical calculations with density functional theory at the B3LYP/6-31G (d,p) level. In the chemical pathways we discuss, a few reactions are found to be totally exothermic and barrierless while others are endothermic with a very small reaction barrier, thus giving rise to a high probability of forming glycine in interstellar space. | Amresh Singh Shivani Alka Misra Poonam Tandon | 2013 | Research in Astronomy and Astrophysics2013，13，8： | 1 |
| 12 | U- tilization of molasses sugar for lactic acid production by Lactoba- cillus delbrueckii subsp, delbrueckii mutant Ue-3 in batch fer- mentation显示文摘 | Arti Dumbrepatil Mukund Adsul Shivani Chaudhari | 2008 | Applied and Environmental Microbiology2008，74，1： | 1 |
| 13 | Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy显示文摘Occurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immunocompromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Although, a large number of antifungal agents are available for treatment of skin fungal infections, but, their toxic profile and physicochemical characteristics reduce therapeutic outcome. When these antifungal agents are delivered topically using conventional formulations like creams and gels, they may cause various side effects like redness, burning, and swelling at the site of application. Therefore, various vesicular formulations(phospholipid based or non phospholipid based) have been explored by pharmaceutical scientists to treat skin fungal infections topically. Vesicular formulation explored for the purpose are liposomes, ethosomes, transfersomes, transethosomes, niosomes, spanlastics, oleic acid vesicles, and nanoparticles.These formulations show various advantages like bioavailability enhancement of bioactives,high skin permeation power, no side effects at application site, dosing frequency reduction,and sustained drug release. Therefore, in the present article, we have discussed about the utility of various vesicular nanocarrier systems to treat skin fungal infections. | Shivani Verma Puneet Utreja | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 1 |
| 14 | Eradication of superficial fungal infections by conventional and novel approaches: a comprehensive review显示文摘 | Lalit Kumar Shivani Verma Ankur Bhardwaj Shubha Vaidya Bhuvaneshwar Vaidya | 2014 | Artificial Cells, Nanomedicine, and Biotechnology2014，，： | 1 |
| 15 | Myocardial ischemic memory imaging with molecular echocardiography 显示文摘 | Flordeliza SV Erxiong L Shivani B | 2007 | Circulation2007，115，： | 1 |
| 16 | Rationally designed oxaliplatin - nanopartiele for enhanced antitumor efficacy 显示文摘 | Abhimanyu Paraskar Shivani Soni Bhaskar Roy | 2012 | Nanoteehnology2012，23，7： | 1 |
| 17 | An overview of history,pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults显示文摘 | Prabhu V Shivani A | 2014 | Ann Med Health Sci Res2014，4，1： | 1 |
| 18 | Zinc ( II ) perchlorate hexahydrate catalyzed opening of epoxide ring by amines : Applications to synthesis of (R/S) / ( R ) - propranolols and (R/S) / ( R ) / (S) - naftopidils 显示文摘 | SHIVANI S PUJALA B CHAKRABORTI A K | 2007 | J Org Chem2007，72，10： | 1 |
| 19 | Cell Dismpfion Optimization and Covalent Immobilization of β-D-Galactosidase from Kluyveromyces marxianus YW-1 for Lactose Hydrolysis in Milk显示文摘 | MUNISH PURl SHIVANI GUPTA PARVEEN PAHUJA | 2010 | Applied Biochemistry and Biotechnology2010，160，01： | 1 |
| 20 | Highly ef- ficient plant regeneration through somatic embryogenesis in Sapin- dus mukorossi 显示文摘 | Upma Dobhal Snehlata Bhandari Shivani Bisht | 2009 | Plant Archives2009，2，6： | 1 |
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