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| 1 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | 3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi显示文摘 | Michael Schwarz Barbel Kopcke Roland W S Weber | 2004 | Phytochemistry2004，65，： | 1 |
| 3 | Extended time-dependent mild-slope and wave-action equations for wave-bottom and wave-current interactions显示文摘 | Toledo Y Hsu T W Roland A | 2012 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Science2012，468，2137： | 1 |
| 4 | The role of routine polio immunization in the post-certification era显示文摘 | Victor M Pedro M | 2004 | Bull WHO2004，82，1： | 1 |
| 5 | Conflict or synergy : university industry research rela-tions 显示文摘 | Roland W | 2011 | Accountability in research2011，，5： | 1 |
| 6 | Bacterial translocation after intraperitoneal implantation of rubber fragments in the splenectomized rat显示文摘 | Guo WD Roland A Rogar W etal | 1994 | J Surg Res1994，57，： | 1 |
| 7 | Microbiology of normal external auditory canal显示文摘 | STROMAN D W ROLAND P S DOHAR J | 2001 | Laryngoscope2001，111，： | 1 |
| 8 | Formation characteristics of PCDD and PCDF during pyrolysis processes显示文摘 | Takeshi S | 2001 | Chemosphere2001，45，： | 1 |
| 9 | LightowlersI-dentification and characterization of myophilin,a muscle- specific antigen of Echinoeoceus granulosus 显示文摘 | Roland M Martin Malcolm K Jones Marshall W | 1995 | Molecular and Biochemical Parasitology1995，70，： | 1 |
| 10 | A histological study of interactions between avirulent races of stem rust and wheat containing resistance genes Sr5, Sr6, St8, or Sr22 显示文摘 | ROHRINGER ROLAND KIM W K | 1978 | Canada Journal of Botany1978，57，： | 1 |
| 11 | Cohesiveness and organizational eitizenship behavior: a multilevel analysis using work groups and individuals显示文摘 | ROLAND E KIDWELL JR KEVIN W MOSSHOLDER NATHAN BENNETT | 1997 | Journal of Management1997，23，6： | 1 |
| 12 | 显示文摘 | Roland W Takashi S Shunichiro U | 2002 | Chemosphere2002，49，： | 1 |
| 13 | Lesions of the petrous apex: diagnosis and management 显示文摘 | ISAACSON B KUTZ J W ROLAND P S | 2007 | Otolaryngol Clin N Am2007，40，3： | 1 |
| 14 | Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial显示文摘 | Talmadge E King Carlo Albera Williamson Z Bradford Ulrich Costabel Phil Hormel Lisa Lancaster Paul W Noble Steven A Sahn Javier Szwarcberg Michiel Thomeer Dominique Valeyre Roland M du Bois | 2009 | The Lancet . 2009 (9685)2009，，： | 1 |
| 15 | Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery显示文摘 | ROLAND B L SUTTON S W WILSON S J | 1999 | Endocrinology1999，140，12： | 1 |
| 16 | CVD preparation of catalytic membranes for reduction of nitrates in water 显示文摘 | Kristian D Volker K W Roland D | 2001 | Catalysis Today2001，67，： | 1 |
| 17 | Long-distance DD-PCR and cDNA microarrays 显示文摘 | ROLAND J JOHN W B | 2000 | Current Opinion in Microbiology2000，3，： | 1 |
| 18 | Determination of orthotropic bone elastic constants using FEA and modal analysis显示文摘 | TAYLOR W R ROLAND E PLOEG H | 2002 | J Biomech2002，5，6： | 1 |
| 19 | Anatomical Distribution of Prolactin - Releasing Peptide and its Receptor Suggests Additional Functions in the Central Nervous System and Periphery 显示文摘 | Roland B L Sutton S W Wilson S J | 1999 | Endocrinology1999，140，12： | 1 |
| 20 | Decision making under uncertainty in case of soil remediation 显示文摘 | Roland W S | 2006 | Journal of Environmental Management2006，80，2： | 1 |
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