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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Hemostatic alterations in pigs fed sublethal doses of Sarcocystis miescheriana 显示文摘 | Daugschies A A Itfeld E Rommel M | 1989 | Vet Parasitol1989，34，12： | 1 |
| 3 | Carebral and basilar artery thrombosis,following cervical spinal injury显示文摘 | Niedeggen A Rommel O Theile A | 1998 | Eentralbl Neurochir1998，60，1： | 1 |
| 4 | The heat shock protein 83 ( HSP83 ) is required for Raf-mediated signalling in Drosophila显示文摘 | van der Straten A Rommel C Dickson B et ai | 1997 | EMBO J1997，16，8： | 1 |
| 5 | TGFBR1 and TG- FBR2 mutations in patients with features of Marfan syn- drome and LoeysDietz syndrome 显示文摘 | Singh KK Rommel K Mishra A | 2006 | Hum Mutat2006，27，8： | 1 |
| 6 | The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila 显示文摘 | van der Straten A Rommel C Dickson B | 1997 | EMBOJ1997，16，8： | 1 |
| 7 | Cevebral and banilar artery thrembosis following cerrical spinal injury显示文摘 | Niedeggen A Rommel O Theile A | 1999 | J Neurochir1999，60，1： | 1 |
| 8 | Mediation of IGF - 1 -induced skeletal myotube hypertrophy by PI (3)K/Akt/mTOR and PI ( 3 ) K/Akt/GSK3 pathways 显示文摘 | ROMMEL C BODINE S C CLARKE B A | 2001 | Nat Cell Biol2001，3，11： | 1 |
| 9 | Ellagic acid content of red raspber- ry juice as influenced by cuhivar, processing, and environ- mental factors显示文摘 | Rommel A Wrolstad RE | 1993 | J agric food Chem1993，41，11： | 1 |
| 10 | Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways显示文摘 | Rommel C Bodine S C Clarke B A | 2001 | Nat Cell Biol2001，3，11： | 1 |
| 11 | Mediation of IGF-l-induced skeletal myotube hypertrophy by PI (3) K/ Akt/mTOR and PI (3)K/Akt/GSK3 pathways 显示文摘 | ROMMEL C BODINE S C CLARKE B A | 2001 | Nat Cell Biol2001，，11： | 1 |
| 12 | Accuracy of wafer level alignment with substrate conformal imprint lithography 显示文摘 | Fader R Rommel M Bauer A | 2013 | Journal of Vacuum Science & Technology B2013，31，6： | 1 |
| 13 | The directional feature of current transients,application in high-speed transmission-line protection显示文摘 | ROMMEL A FABIAN P EDUARDO O | 2013 | IEEE Transactions on Power Delivery2013，28，2： | 1 |
| 14 | Ellagic acid content of red raspberry juice as influenced by cultivar, pro- cessing ,and environmental factors显示文摘 | ROMMEL A WROLSTAD R E | 1993 | J Agric Food Chem1993，41，11： | 1 |
| 15 | Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme显示文摘 | Soda Y Myskiw C Rommel A | 2013 | J Mol Med (Berl)2013，91，4： | 1 |
| 16 | Improved strategies for Radial Basis Function methods for global optimization显示文摘 | ROMMEL G Regis CHRISTINE A Shoemaker | 2007 | Journal of Global Optimization2007，37，： | 1 |
| 17 | The ant Lasius flavus alters the viable seed bank in pastures显示文摘 | Dauber J Rommeler A Wolters V | 2006 | European Journal of Soil Biology2006，42，： | 1 |
| 18 | Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials 显示文摘 | DAUGSCHIES A GASSLEIN U ROMMEL M | 1998 | Vet Parasitol1998，76，3： | 1 |
| 19 | PI3K and cancer:lessons,challenges and opportunities显示文摘 | FRUMAN D A ROMMEL C | 2014 | Nat Rev Drug Discov2014，13，2： | 1 |
| 20 | Differentiation stage specific inhibition of the Raf-MEK-ERK pathway by Akt 显示文摘 | Rommel C Clarke B A Zimmermann S | 1999 | Science1999，286，： | 1 |
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