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| 1 | Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report显示文摘BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare.Polycythemia is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and obesity.Here we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated polycythemia.CASE SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous uterus.She suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several months.Laboratory analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of polycythemia.Arterial blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 mmHg.Abdominal computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 cm.To reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic hysterectomy.The uterus weighed 5400 g and the histology confirmed a diagnosis of leiomyoma.We did not find increased erythropoietin levels in the supernatant of the myomatous uterine tissue.There were no complications.On postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,respectively.Arterial blood gas analysis after surgery showed a pO2 of 144.7 mmHg.These results suggested the diagnosis of myomatous erythrocytosis syndrome.The patient was discharged on the second postoperative day in very good condition with no symptoms.CONCLUSION We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and obesity.Multiple VTE risk factors warranted a laparoscopic approach. | Antonio Macciò Giacomo Chiappe Fabrizio Lavra Elisabetta Sanna Romualdo Nieddu Clelia Madeddu | 2019 | World Journal of Clinical Cases2019，7，19： | 5 |
| 2 | Characterization and modeling of weighted networks显示文摘 | Marc Barthélemy Alain Barrat Romualdo Pastor-Satorras Alessandro Vespignani | 2004 | Physica A: Statistical Mechanics and its Applications2004，，1： | 2 |
| 3 | Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features显示文摘AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed population.METHODS O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.RESULTS Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk.CONCLUSION The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings. | Diego Marques Layse Raynara Ferreira-Costa Lorenna Larissa Ferreira-Costa Romualdo da Silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito Carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 4 | Epidemic spreading in scale-free networks显示文摘 | Romualdo Pastor Satorras Alessandro Vespignani | | 0，，： | 1 |
| 5 | Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation显示文摘 | Romualdo Belardinelli Francesca Lacalaprice Ernesto Faccenda Loretta Volpe | 2008 | European Journal of Cardiovascular Prevention & Rehabilitation2008，，5： | 1 |
| 6 | Cardiomyopathy/Congestive Heart Failure/Exercise Training: Exercise Training Improves Left Ventricular Diastolic Filling in Patients With Dilated Cardiomyopathy: Clinical and Prognostic Implications显示文摘 | Romualdo Belardinelli Demetrios Georgiou Giovanni Cianci Nancy Berman Leonard Ginzton Augusto Purcaro | 1995 | Circulation1995，，11： | 1 |
| 7 | Epidemic dynamics and endemic states in complex networks显示文摘 | Romualdo Pastor-Satorras Alessandro Vespignani | | 0，，： | 1 |
| 8 | Immunization of complex networks显示文摘 | Romualdo P S Alessandro V | 2002 | Physical Review E2002，65，03： | 1 |
| 9 | Can lignin be accurately measured 显示文摘 | Ronald H Romualdo S F | 2005 | Crop Science2005，45，3： | 1 |
| 10 | Epidemic spreading in scale-free networks显示文摘 | Romualdo P S and Alessandro V | 2001 | Physical Review Letters2001，86，： | 1 |
| 11 | Diagnostic accura- cy of presepsin ( soluble CD14 subtype) for prediction of bacteremia in patients with systemic inflammatory response syndrome in the e- mergency department显示文摘 | Romualdo LG Torrella PE Gonzalez MV | 2014 | Clin Biochem2014，47，78： | 1 |
| 12 | IP over IEEE -1394: Using the Internet Protocol over a high - performance serial bus 显示文摘 | Romualdo Santamaria | 2000 | Dedicated Sys- tems Magazine2000，1，： | 1 |
| 13 | The network of networks: a growing self-organized system 显示文摘 | Romualdo P S Alessandro V | 2008 | Evolution and Structure of the Internet2008，，7： | 1 |
| 14 | Thresholds for epidemic spreading in networks显示文摘 | Claudio C Romualdo P S | 2010 | Physical Review Letters2010，105，21： | 1 |
| 15 | Electrochemical degradation of sulfamethoxazole and trimethoprim at boron-doped diamond electrode:Performance,kinetics and reaction pathway显示文摘 | De Amorim K P Romualdo L L Andrade L S | 2013 | Separation and Purification Technology2013，120，： | 1 |
| 16 | Epidemic Spreading in Scale-Free Networks显示文摘 | Pastor-Satorras Romualdo Alessandro Vespignani | 2001 | Phys Rev Lett2001，86，14： | 1 |
| 17 | The architecture of complex weighted networks显示文摘 | Barrat Alain Barthelemy Marc Satorras Romualdo Pastor | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，11： | 1 |
| 18 | A New Approach to the Kinetic Modeling of the Reaction of Gaseous HCl with Solid Lime at Low Temperatures显示文摘 | Ana M Fonseca Jos J Orfao Romualdo L Salcedo | 2003 | Chemical Engineering Science2003，58，15： | 1 |
| 19 | Can lignin be accurately measured显示文摘 | RONALD Hatfield ROMUALDO S FUKUSHMA | 2005 | Crop science2005，45，3： | 1 |
| 20 | Den- toskeletal effects of 3 maxillary expanders in patients with clefts: A cone-beam computed tomography study 显示文摘 | Figueiredo D S Bartolomeo F U Romualdo C R | 2014 | Am J Orthod Dentofacial Ortho2014，146，1： | 1 |
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