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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Batch proxy quantum blind signature scheme显示文摘Motivated by proxy signature and blind signature for the secure communications,the batch signature is proposed to create a novel quantum cryptosystem.It is based on three-dimensional two-particle-entangled quantum system which is used to distribute the quantum keys and create strings of quantum-trits(qutrits) for messages.All of the messages,which are expected to be signed,are encrypted by the private key of the message owner during communications.Different from the classical blind signature,an authenticity verification of signatures and an arbitrator's efficient batch proxy signature are simultaneously applied in the present scheme.Analysis of security and efficiency shows that it enables us to achieve a large number of quantum blind signatures for quantities of messages with a high efficiency with the arbitrator's secure batch proxy blind signature. | SHI JinJing SHI RongHua GUO Ying PENG XiaoQi TANG Ying | 2013 | Science China(Information Sciences)2013，56，5： | 7 |
| 3 | An Optimization Approach for Stiffener Layout of Composite Stiffened Panels Based on Moving Morphable Components(MMCs)显示文摘An explicit topology optimization method for the stiffener layout of composite stiffened panels is proposed based on moving morphable components(MMCs).The skin and stiffeners are considered as panels with different bending stiffnesses,with the use of equivalent stiffness method.Then the location and geometric properties of composite stiffeners are determined by several MMCs to perform topology optimization,which can greatly simplify the finite element model.With the objective of maximizing structural stiffness,several typical cases with various loading and boundary conditions are selected as numerical examples to demonstrate the proposed method.The numerical examples illustrate that the proposed method can provide clear stiffener layout and explicit geometry information,which is not limited within the framework of parameter and size optimization.The mechanical properties of composite stiffened panels can be fully enhanced. | Zhi Sun Ronghua Cui Tianchen Cui Chang Liu Shanshan Shi Xu Guo | 2020 | Acta Mechanica Solida Sinica2020，33，5： | 2 |
| 4 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 5 | Quantum codes based on fast pauli block transforms in the finite field显示文摘 | Shi Ronghua Guo Ying Lee M H | 2010 | Quan- tum Information Processing2010，9，5： | 1 |
| 6 | A User-Centered Multi-space Collaborative Visual Analysis for Cyber Security显示文摘Based on a university's practice in upgrading its network management platform, presents a visual analytic system which integrates network topological space,IP space and network geographical space into a collaborative solution to help network administrators address difficulties in locating end user and troubleshooting. Throughout the development cycle, we worked alongside with users to clarify their actual demands and habitual operations through scenario application, interviews and a variety of evaluation. This user-centered approach guides us step by step to apply cyber security visualization and visual analytic technology to actual use. | ZHONG Zengsheng ZHAO Ying SHI Ronghua SHENG Yingshuai LIU Junrong MENG Hua LIN Dan | 2018 | Chinese Journal of Electronics2018，27，5： | 1 |
| 7 | An Adaptive Transmission Scheme in Cooperative Relay Networks with Energy Accumulation显示文摘We investigate a wireless-powered cooperative relay network, where an energy constrained relay node accumulates the energy harvested from radio frequency signals, and then assists source signal transmission. An adaptive cooperative transmission scheme for cooperative relay network is developed. The relay helps to transmit the source signal only if it has harvested enough energy and the channels between source and relay do not suffer from an outage. Before each transmission block, one out of two transmission modes, i.e., Half-duplex(HD) or Full-duplex(FD), is dynamically adopted based on the maximal instantaneous capacity of the system. A closed-form expression for the exact outage probability of the system with the proposed scheme is derived. Monte Carlo simulations are run to validate the accuracy of the mathematical analysis, and numerical results show that the proposed protocol outperforms the existing fixed cooperative transmission modes. | TANG Kun SHI Ronghua GUO Yabo SHI Heyuan DONG Jian | 2019 | Chinese Journal of Electronics2019，28，1： | 1 |
| 8 | A well-defined diblock eopolymer of poly(ethylene oxide)-block-poly(4-vinylpyridine) for separation of basic proteins by capillary zone electrophoresis 显示文摘 | Liu Hang Shi Ronghua Wan Wenming | 2008 | Electrophoresis2008，29，13： | 1 |
| 9 | Partial delamination of the organo-montmorillonite with surfactant containing hydroxyl groups in maleated poly(propylene carbonate)显示文摘 | Zhihao Zhang Qiang Shi Juan Peng Jianbin Song Qingyong Chen Junliang Yang Yumei Gong Ronghua Ji Xiaofeng He Joong-Hee Lee | 2006 | Polymer2006，，26： | 1 |
| 10 | The dining cryptographer problem-based anonymous quantum communication via non-maximally entanglement state analysis显示文摘 | SHI Ronghua SU Qian GUO Ying | 2013 | International JOurnal of Theoretical Physics2013，52，2： | 1 |
| 11 | The placement of antenna elements in aperture synthesis microwave radiometers for optimum radiometric sen- sitivity 显示文摘 | DONG Jian LI Qingxia SHI Ronghua | 2011 | IEEE Transactions on Antennas and Propagation2011，59，11： | 1 |
| 12 | 显示文摘 | ZHOU Dan WANG Yanmei YANG Runmiao ZHANG Wenlong SHI Ronghua | 2007 | Electrophoresis2007，28，18： | 1 |
| 13 | The binding number of a graph and its triangle显示文摘 | Shi Ronghua | 1985 | Acta Mathematicae Applicatae Sinica1985，2，1： | 1 |
| 14 | A Fast Iterative Algorithm for Solving the Towers of Hanoi Problem显示文摘 | Shi Ronghua | 1995 | Journal of Changsha Railway University1995，13，3： | 1 |
| 15 | Minimum Redundancy MIMO Array Synthesis by means of Cyclic Difference Sets显示文摘 | Jian Dong Ronghua Shi Wentai Lei Ying Guo Wenhua Chen | 2013 | International Journal of Antennas and Propagation2013，，： | 1 |
| 16 | Processcontext Aware Matchmaking for Web Service Com- position显示文摘 | Han Weili Shi Xingdong Chen Ronghua | 2008 | Journal of Network and Computer Applications2008，31，4： | 1 |
| 17 | Dynamic metabolite alterations of Portunus trituberculatus during larval development显示文摘A mass mortality often occurs from molting to the megalopa stage during the larval development of the swimming crab Portunus trituberculatus. Larvae with insuffcient nutrient accumulation during the zoeal stages are probably unable to develop into juvenile swimming crabs. However, the nutritional information such as the primary metabolites is scarce for P. trituberculatus larvae. The aim of this work is to obtain an insight into the metabolite traits of P. trituberculatus at early developmental stages. 1 H nuclear magnetic resonance spectroscopy coupled with multivariate data analysis was used to determine how the metabolite pro?les shift during larval development in P. trituberculatus. Our results show that the trend of total metabolites exhibited a rise from zoea 1 to zoea 3, followed by a drop from zoea 4 to megalopa and recovery during the ?rst juvenile stage. A large-scale depletion of total metabolites in the zoea 4 and megalopa stages suggests a deep depression of metabolic activity, which may be linked to the mass mortality from molting to the megalopa stage. These ?ndings provided essential metabolic information about the larval development of P. trituberculatus and important clues for understanding the nutritional requirements of P. trituberculatus in early developmental stages. | SHI Ce ZENG Tinglan LI Ronghua WANG Chunlin YE Yangfang MU Changkao | 2019 | Journal of Oceanology and Limnology2019，37，1： | 1 |
| 18 | Preparation and characterization of polar polymeric adsorbents with high surface area for the removal of phenol from water显示文摘 | Xiaowei Zeng Tingjun Yu Peng Wang Ronghua Yuan Qing Wen Yunge Fan Chunhong Wang Rongfu Shi | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 19 | Superconductivity in Ba_(1-x)Sm_xFFeAs and Eu_(1-x)Sm_xFFeAs systems显示文摘We synthesized the samples Ba1-xSmxFFeAs and Eu1-xSmxFFeAs with ZrCuSiAs-type structure. These samples were characterized by resistivity and susceptibility. It is found that the substitution of rare earth metal for alkaline earth metal in the two systems suppresses the anomaly in resistivity and in-duces superconductivity. Superconductivity at 54 K in nominal composition Ba0.5Sm0.5FFeAs and at 51 K for Eu0.5Sm0.5FFeAs is realized, indicating that the superconducting transition temperatures in the iron arsenide fluorides is the same as that in oxypnictides with the same structure. | WU Gang XIE YaLi CHEN Hong ZHONG Min LIU RongHua SHI BingCai LI QiuJu WANG XiangFeng WU Tao YAN YaJun YING JianJun CHEN XianHui | 2009 | Chinese Science Bulletin2009，54，11： | 1 |
| 20 | A LOCALIZATION CONDITION FORBIPANCYCLIC BIPARTITE GRAPHS显示文摘In this paper we prove the following: Let G be connected balanced bipartite graph of order 2n> 4. If G satisfies the localization condition |NZ(u)\N(v)| + 2 < d(u), for any u,v∈ V(G) and d(u, v) = 3 where N(u) = {w|w∈V(G) and d(u, w)= 2}, then G is either bipancyclic or isomorphic to C6. Furthermore, a conjecture is proposed. | SHI Ronghua (Department of Applied Mathematics, Naming University of Science and Technology,Nanjing 210094, China)LOU Dingjun (Department of Computer Science, Zhongshan University, Guangzhou 510275, China) | 1997 | Systems Science and Mathematical Sciences1997，10，1： | 0 |
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