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| 1 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 2 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 3 | A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants显示文摘Objective: To evaluate the total phenolic content and total antioxidant capacity of ethyl acetate extracts of 21 endophytic fungi isolated from five Sudanese medicinal plants: Calotropis procera, Catharanthus roseus, Euphorbia prostrate, Vernonia amygdalina and Trigonella foenumgraecum. Methods: Crude extracts of endophytic fungi and their host plants were tested by classical Folin-Ciocalteu colorimetric method to determine the total phenolic content, also total antioxidant capacity was estimated using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging in vitro method. Results: Among the endophytes, endophytic fungus Aspergillus sp. from Trigonella foenum-graecum seeds demonstrated the highest both total phenolic content in term of gallic acid equivalent(GAE) [(89.9±7.1 mg GAE/g)] and antioxidant activity for 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay [IC50:(18.0±0.1 μg/m L)]. A high positive linear correlation(R2=0.999 1) was found between total antioxidant capacity and total phenolic content of endophytic fungi isolated from Vernonia amygdalina. Conclusions: The present study revealed that some endophytic fungi from the five Sudanese medicinal plants could be a potential source of novel natural antioxidant compounds. | Afra Khiralla Ietidal Mohamed Justinne Thomas Beno t Mignard Rosella Spina Sakina Yagi Dominique Laurain-Mattar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 9 |
| 4 | Gastric cancer:The times they are a-changin'显示文摘Gastric cancer is the third leading cause of cancer death worldwide.Even though during these last decades gastric cancer incidence decreased in Western countries,it remains endemic and with a high incidence in Eastern countries.The survival in advanced and metastatic stage of gastric cancer is still very poor.Recently the Cancer Genoma Atlas Research Network identified four subtypes with different molecular profiles to classify gastric cancer in order to offer the optimal targeted therapies for pre-selected patients.Indeed,the key point is still the selection of patients for the right treatment,on basis of molecular tumor characterization.Since chemotherapy reached a plateau of efficacy for gastric cancer,the combination between cytotoxic therapy and biological agents gets a better prognosis and decreases chemotherapeutic toxicity.Currently,Trastuzumab in combination with platinum and fluorouracil is the only approved targeted therapy in the first line for c-erb B2 positive patients,whereas Ramucirumab is the only approved targeted agent for patients with metastatic gastric cancer.New perspectives for an effective treatment derived from the immunotherapeutic strategies.Here,we report an overview on gastric cancer treatments,with particular attention to recent advances in targeted therapies and in immunotherapeutic approach. | Maria Antonietta Satolli Lucio Buffoni Rosella Spadi Ilaria Roato | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 6 |
| 5 | Anxiety,depression,and quality of life in Parkinson's disease:the implications of multidisciplinary treatment显示文摘Anxiety and depression in Parkinson's disease(PD)reduce well-being of the patients.Emotional alterations influence motor skills and cognitive performance;moreover,they contribute significantly and independently to worsen rehabilitative treatment response.We investigated anxiety,depression,and quality of life in PD patients subjected to multidisciplinary rehabilitative training.The self-controlled study included 100 PD patients(49 males and 51 females with the mean age of 64.66 years)admitted to 60 days hospitalization rehabilitative program,between January 2017 and December 2018.Motor,cognitive,linguistic abilities,and functional independence were evaluated at admission(T0 baseline visit)and 60 days after(T1)the multidisciplinary rehabilitation including motor exercises,speech therapies,and cognitive intervention.The multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood,motor abilities,autonomy in the activities of daily life,perception of quality of life,cognitive performance and speech skills.Non-motor symptoms may worsen severe disability and reduce quality of life.They are often poorly recognized and inadequately treated.Nonetheless,multidisciplinary rehabilitative training represents an optimal strategy to improve disease management.The study was approved by Istituito di Ricovero e Cura a Carattere Scientifico(IRCCS)Centro Neurolesi'Bonino-Pulejo'Ethical Committee(approval No.6/2016)in June 2016. | Viviana Lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo Placido Bramanti Silvia Marino Giuseppe Di Lorenzo Lilla Bonanno | 2021 | Neural Regeneration Research2021，16，3： | 5 |
| 6 | No Effects of Gluten in Patients With Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of Fermentable, Poorly Absorbed, Short-Chain Carbohydrates显示文摘 | Jessica R. Biesiekierski Simone L. Peters Evan D. Newnham Ourania Rosella Jane G. Muir Peter R. Gibson | 2013 | Gastroenterology2013，，2： | 3 |
| 7 | Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances显示文摘A simple analytical high-performance liquid chromatography(HPLC) method was applied for the enantiomeric excess determination of esomeprazole((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase(CSP)under reversed-phase conditions. The results were evaluated and compared with those obtained by the of fi cial enantioselective method of European Pharmacopoeia used as the reference for checking the enantiomeric excess of(S)-OME. It has been established that the use of the Chiralpak ID-3 CSP allows the determination of the enantiomeric purity of(S)-OME without any interference coming from its chiral and achiral related substances. The analytical procedure of the drug regulatory agencies based on the AGP CSP suffered instead from poor speci fi city due to overlap of the peaks pertinent to the achiral impurity A and the chiral impurity(R)-OME(impurity F). | Bruno Gallinella Rosella Ferretti Leo Zanitti Isabella Sestili Antonina Mosca Roberto Cirilli | 2016 | Journal of Pharmaceutical Analysis2016，6，2： | 2 |
| 8 | Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting显示文摘Pediatric neuroblastomas(NBs)are heterogeneous,aggressive,therapy-resistant embryonal tumours that originate from cells of neural crest(NC)origin and in particular neuroblasts committed to the sympathoadrenal progenitor cell lineage.Therapeutic resistance,post-therapeutic relapse and subsequent metastatic NB progression are driven primarily by cancer stem cell(CSC)-like subpopulations,which through their self-renewing capacity,intermittent and slow cell cycles,drug-resistant and reversibly adaptive plastic phenotypes,represent the most important obstacle to improving therapeutic outcomes in unfavourable NBs.In this review,dedicated to NB CSCs and the prospects for their therapeutic eradication,we initiate with brief descriptions of the unique transient vertebrate embryonic NC structure and salient molecular protagonists involved NC induction,specification,epithelial to mesenchymal transition and migratory behaviour,in order to familiarise the reader with the embryonic cellular and molecular origins and background to NB.We follow this by introducing NB and the potential NC-derived stem/progenitor cell origins of NBs,before providing a comprehensive review of the salient molecules,signalling pathways,mechanisms,tumour microenvironmental and therapeutic conditions involved in promoting,selecting and maintaining NB CSC subpopulations,and that underpin their therapy-resistant,self-renewing metastatic behaviour.Finally,we review potential therapeutic strategies and future prospects for targeting and eradication of these bastions of NB therapeutic resistance,post-therapeutic relapse and metastatic progression. | Antonietta Rosella Farina Lucia Annamaria Cappabianca Veronica Zelli Michela Sebastiano Andrew Reay Mackay | 2021 | World Journal of Stem Cells2021，13，7： | 2 |
| 9 | 协调社会与产业的目标:药品定价中的议价模型显示文摘药品费用在世界许多国家快速增长,这激起了人们对药品定价的关注,因此许多国家都试图通过定价手段来达到降低药品费用的目的。各国对药品价格都有一定形式的规制,其中一种做法就是最高限价,即通过制定药品价格的上限以达到控制成本。 | Stefano Capri Rosella Levaggi 汤涵 董朝晖 | 2009 | 中国药物经济学2009，，2： | 2 |
| 10 | The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study显示文摘 | Ombretta Salvucci Amélie Bouchard Andrea Baccarelli Jean Deschenes Guido Sauter Ronald Simon Rosella Bianchi Mark Basik | 2006 | Breast Cancer Research and Treatment2006，，3： | 2 |
| 11 | Unusual retention behavior of omeprazole and its chiral impurities B and E on the amylose tris(3-chloro-5-methylphenylcarbamate)chiral stationary phase in polar organic mode显示文摘Recent reports have demonstrated that the new commercially available immobilized-type chiral stationary phases(CSPs) containing amylose tris(3-chloro-5-methylphenylcarbamate)(ACMPC) as a selector exhibit not only an exceptionally high enantioselectivity in high-performance liquid chromatography(HPLC) but they are also applicable to a wide range of chiral analytes. Herein, we report the results obtained in the HPLC analysis of omeprazole and its impurities B and E on the ACMPC-based Chiralpak IG-3 CSP(CSP) under polar organic conditions. A systematic evaluation of the retention characteristics of the selected benzimidazole chiral probes was carried out by changing the composition of the mobile phase and the column temperature. It is worth emphasizing that the high affinity of both enantiomers of all analytes recorded in pure methanol mode dramatically decreased incorporating small volumes of either basic or acid additives in the mobile phase. Unspecified sites of the IG-3 CSP presumably involved in strong and non-stereoselective H-bonding contacts with chiral analytes are assumed responsible for the unproductive retention process. | Rosella Ferretti Leo Zanitti Adriano Casulli Roberto Cirilli | 2018 | Journal of Pharmaceutical Analysis2018，8，4： | 2 |
| 12 | Do Physiological Integration and Soil Heterogeneity Influence the Clonal Growth and Foraging of Schoenoplectus pungens?显示文摘 | Allison Poor Chad Hershock Kristin Rosella Deborah E. Goldberg | 2005 | Plant Ecology2005，，1： | 1 |
| 13 | TAPP or TEP? Population-based analysis of prospective data on 4552 patients undergoing endoscopic inguinal hernia repair显示文摘 | Gass M Banz V M Rosella L et aI | 2012 | World J Surg2012，36，12： | 1 |
| 14 | Trends in influenza vacci- nation in Canada, 1996/1997 to 2005 显示文摘 | Kwong JC Rosella LC Johansen H | 2007 | Health Rep2007，18，4： | 1 |
| 15 | TAPP or TEP? Popu- lation-based analysis of prospective data on 4,552 patients undergoing endoscopic inguinal hernia repair显示文摘 | Gass M Banz VM Rosella L | 2012 | World J Surg2012，36，12： | 1 |
| 16 | The' provision of impure public goods in a non competitive market显示文摘 | Mcmillan B Rosella | 2002 | Economic Modelling2002，，19： | 1 |
| 17 | Integrated care programmes for chronically ill patients:a rev- iew of systematic reviews显示文摘 | Marielle Ouwens Hub Wollersheim Rosella Hermens | 2005 | International Journal for Quality in Health Care2005，17，2： | 1 |
| 18 | Compensatory cortical mechanisms in Parkinson's disease evidenced with fMRI during the performance of pre-learned sequential movements 显示文摘 | MALLOL Rosella BARRoS-LOSCERTALES Alfonso LoPEZ Mario | 2007 | Brain Research2007，1147，： | 1 |
| 19 | Comparative study between the polysaccharide based Chiralcel OJ and Chiralcel OD CSPs in chromatographic enantioseparation of imidazole analogues of Fluoxetine and Miconazole显示文摘 | Roberto Cirilli Rosella Ferretti Bruno Gallinella | | 0，，07： | 1 |
| 20 | Factors affecting the genotype × environment interaction in spring triticale grown in a Mediterranean environment显示文摘 | Rosella M Francesco G Mauro D | 2001 | Euphytica2001，121，： | 1 |
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