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| 1 | Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives显示文摘Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health concern.Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis.The deregulation of epigenetic mechanisms,which maintain heritable gene expression changes and chromatin organization,is implicated in the development of multiple cancers,including HCC.This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC,with an emphasis on HCC mediated by chronic hepatitis B virus infection.This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers,and highlights the future potential of similar therapies in the treatment of HCC. | Li Ma Mei-Sze Chua Ourania Andrisani Samuel So | 2014 | World Journal of Gastroenterology2014，20，2： | 12 |
| 2 | Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients显示文摘AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)patients.METHODS:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent assay.Findings were correlated with clinical data,histology,and survival.RESULTS:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 positive.The ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative ones.They had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative patients.ANEA positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ones.CONCLUSION:The presence of ANEA and anti-gp210 identifies a subgroup of PBC patients with advanced disease severity and poor prognosis. | Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos Elias Castanas Elias A Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，39： | 11 |
| 3 | Increased ΤGF-β3 in primary biliary cirrhosis: An abnormality related to pathogenesis?显示文摘AIM: To investigate the transforming growth factor-β (TGF-β) isoforms in the peripheral and hepatic venous blood of primary biliary cirrhosis (PBC) patients. METHODS: We examined TGF-β1, TGF-β2 and TGF-β3 (enzyme-linked immunosorbent assay), in 27 stage Ⅳ PBC patients (27 peripheral and 15 hepatic vein sera), 35 early (Ⅰ-Ⅱ) PBC and 60 healthy controls. As disease controls 28 hepatitis C virus (HCV) cirrhosis (28 peripheral and 17 hepatic vein serum), 44 chronic HCV hepatitis and 38 HCV-related hepatocellular carcinomas were included. We also tested liver tissue by immunohistochemistry to identify localization of TGF isoforms. RESULTS: TGF-β1 was significantly decreased in all cirrhotics (PBC Ⅲ-Ⅳ: median 13.4 ng/mL; range, 7.4-26.2, HCV cirrhosis: 11.6 ng/mL; range, 5.0-33.8), compared to controls (30.9 ng/mL; range, 20.9-37.8). TGF-β2 was increased in viral cirrhosis but not in PBC and chronic hepatitis. TGF-β3 (47.2 pg/mL; range, 27.0-79.7 in healthy controls) was increased in early and late PBC (Ⅰ-Ⅱ: 94.3 pg/mL; range, 41.5-358.6; Ⅲ-Ⅳ: 152.8 pg/mL; range, 60.4-361.2; P < 0.001) and decreased in viral cirrhosis (37.4 pg/mL; range, 13.3-84.0; P < 0.05). Hepatic vein TGF-β levels were analogous to those in peripheral blood. Immunohistochemistry identified all isoforms in portal tract lymphocytes, sinusoidal cells and cholangiocytes. TGF-β3 was additionally overexpressed in hepatocytes in PBC patients. CONCLUSION: The serum profile of TGF-β isoforms is different in cirrhotics. Increased TGF-β3 is characteristic of PBC. These findings may be related to the immunological abnormalities of PBC. | Argyro Voumvouraki Mairi Koulentaki Maria Tzardi Ourania Sfakianaki Penelope Manousou George Notas Elias Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 4 | No Effects of Gluten in Patients With Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of Fermentable, Poorly Absorbed, Short-Chain Carbohydrates显示文摘 | Jessica R. Biesiekierski Simone L. Peters Evan D. Newnham Ourania Rosella Jane G. Muir Peter R. Gibson | 2013 | Gastroenterology2013，，2： | 3 |
| 5 | Octreotide modulates the effects on fibrosis of TNF-α, TGF-β and PDGF in activated rat hepatic stellate cells显示文摘 | Stefanos Klironomos George Notas Ourania Sfakianaki Foteini Kiagiadaki Costas Xidakis Elias Kouroumalis | 2014 | Regulatory Peptides2014，，： | 2 |
| 6 | Presence of disease specific autoantibodies against liver sinusoidal cells in primary biliary cirrhosis显示文摘AIM: To investigate the presence of autoantibodies directed against liver sinusoidal cells in primary biliary cirrhosis(PBC).METHODS: Liver biopsies from 21 PBC patients were studied and compared with 12 liver biopsies from disease controls [3 patients with hepatitis B(HBV) virus,3 patients with hepatitis C virus(HCV), 3 patients with non-alcoholic steatohepatitis and 3 patients with acute alcoholic hepatitis(AAH)]. As healthy controls, we used tissue specimens adjacent to metastatic liver adenocarcinoma. Normal serum was taken from staff members of the unit. The determination of the cell type targetedby autoantibodies present in the patients sera was performed by indirect immunofluorescence(IIF) analysis using paraffin-embedded liver sections as a substrate.Sera from homologous or heterologous PBC patients or sera from the disease control group were used as primary antibodies. The presence of autoantibodies was identified using confocal microscopy.RESULTS: In total, 18/21(85.7%) PBC patients exhibited positive staining in the sinusoidal cells, 10/21(47.6%) in lymphocytes, 8/21(38%) in cholangiocytes and 7/21(33.3%) in hepatocytes, when homologous serum and fluorescein isothiocyanate-conjugated immunoglobulin type G(IgG) secondary antibody were used. PBC sections incubated with heterologous PBC serum showed reduced staining(20% for sinusoidal cells, 20% for lymphocytes, 20% for cholangiocytes and 13.3% for hepatocytes). When IgM immunoglobulin, instead of IgG, was used as secondary antibody,positive staining was observed in 75% of lymphocytes,62.5% of cholangiocytes, 37.5% of hepatocytes and50% of the sinusoidal cells with a much stronger staining intensity. No staining was observed when either normal or PBC sera were used as a primary antibody on liver sections from the disease control group. When PBC sera were incubated with healthy control sections,weak positive staining of cholangiocytes was observed in 3/21(14.3%) PBC serum samples. Steatohepatitis serum on PBC sections gave a positive staining of some hepatocytes and lymphocytes but no staining on viral hepatitis sections. Incubation with HBV sera stained some hepatocytes, cholangiocytes and intra-sinusoidal or portal lymphocytes of PBC, HBV and AAH patients but not HCV patients.CONCLUSION: In this study, for the first time in diseased liver tissue, we have demonstrated that a large proportion of PBC patients have disease specific autoantibodies against liver sinusoidal cells. | Ourania Sfakianaki Maria Tzardi Argyro Voumvouraki Aikaterini Afgoustaki Meri Koulentaki Elias Kouroumalis | 2013 | World Journal of Hepatology2013，5，10： | 2 |
| 7 | Effects of exercise training on diastolic and systolic dysfunction in patients with chronic heart failure显示文摘BACKGROUND Chronic heart failure(CHF)is a complex syndrome characterized by a progressive reduction of the left ventricular(LV)contractility,low exercise tolerance,and increased mortality and morbidity.Diastolic dysfunction(DD)of the LV,is a keystone in the pathophysiology of CHF and plays a major role in the progression of most cardiac diseases.Also,it is well estimated that exercise training induces several beneficial effects on patients with CHF.AIM To evaluate the impact of a cardiac rehabilitation program on the DD and LV ejection fraction(EF)in patients with CHF.METHODS Thirty-two stable patients with CHF(age:56±10 years,EF:32%±8%,88%men)participated in an exercise rehabilitation program.They were randomly assigned to aerobic exercise(AER)or combined aerobic and strength training(COM),based on age and peak oxygen uptake,as stratified randomization criteria.Before and after the program,they underwent a symptom-limited maximal cardiopulmonary exercise testing(CPET)and serial echocardiography evaluation to evaluate peak oxygen uptake(VO2peak),peak workload(Wpeak),DD grade,right ventricular systolic pressure(RVSP),and EF.RESULTS The whole cohort improved VO2peak,and Wpeak,as well as DD grade(P<0.05).Overall,9 patients(28.1%)improved DD grade,while 23(71.9%)remained at the same DD grade;this was a significant difference,considering DD grade at baseline(P<0.05).In addition,the whole cohort improved RVSP and EF(P<0.05).Not any between-group differences were observed in the variables assessed(P>0.05).CONCLUSION Exercise rehabilitation improves indices of diastolic and systolic dysfunction.Exercise protocol was not observed to affect outcomes.These results need to be further investigated in larger samples. | Ioannis Chaveles Ourania Papazachou Manal al Shamari Dimitrios Delis Argirios Ntalianis Niki Panagopoulou Serafim Nanas Eleftherios Karatzanos | 2021 | World Journal of Cardiology2021，13，9： | 2 |
| 8 | DNA methylation in the human placenta and fetal growth (Review)显示文摘 | Ourania Koukoura Stavros Sifakis Demetrios Spandidos | 2012 | Molecular Medicine Reports2012，，4： | 1 |
| 9 | LAe-Ra new learning analytics tool in moodle for assessing students' performance 显示文摘 | OURANIA PETROPOULOU KATERINA KASIMATIS IOAN- NIS DIMOPOULOS | 2014 | Bulletin of the IEEE Technical Committee on Learning Technoogy2014，16，1： | 1 |
| 10 | Accuracy and privacy aspects in free online reverse geocoding services显示文摘 | Ourania Kounadi Thomas J Lampoltshammer Michael Leitner | 2013 | Cartography & Geographic Information Science2013，40，2： | 1 |
| 11 | Designer Xanthone显示文摘 | Ourania G. Zoi Trias N. Thireou Vagelis E. Rinotas Petros G. Tsoungas Elias E. Eliopoulos Eleni K. Douni Nikolaos E. Labrou Yannis D. Clonis | 2013 | Journal of Biomolecular Screening2013，，： | 1 |
| 12 | Compari octreotide administration vs conservative treatment management of inoperable bowel obstruction in patien far advanced cancer: a randomized, double-blind, co clinical trial 显示文摘 | Kyriaki M Eleni T Ourania K | 2002 | Anticancer Res2002，22，： | 1 |
| 13 | Valve-Sparing Aortic Root Replacement: Early and Midterm Outcomes in 83 Patients显示文摘 | Joseph S. Coselli Michael S. Hughes Susan Y. Green Matt D. Price Samantha Zarda Kim I. de la Cruz Ourania Preventza Scott A. LeMaire | 2014 | The Annals of Thoracic Surgery2014，，4： | 1 |
| 14 | Tsihrintzis: An improved neural-network - bassi face detection and facial expression classification system显示文摘 | Ioanna - Ourania S George A | 2004 | SMC2004，，1： | 1 |
| 15 | Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFα in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy显示文摘 | Aristotelis Bamias Vasiliki Koutsoukou Evangelos Terpos Marinos L. Tsiatas Christina Liakos Ourania Tsitsilonis Alexandros Rodolakis Zannis Voulgaris G. Vlahos Theocharis Papageorgiou G. Papatheodoridis A. Archimandritis A. Antsaklis M.A. Dimopoulos | 2007 | Gynecologic Oncology2007，，2： | 1 |
| 16 | The influence of the hyper- ten-sive patient, s education in compliance with their medication显示文摘 | Maria S Ourania P Georgi F | 2001 | Public Health nursing2001，18，6： | 1 |
| 17 | First trimester 3D volumetry. Association of the gestational volumes with the birth weight显示文摘 | Aris Antsaklis Eleftherios Anastasakis Ourania Komita Marianna Theodora Petros Hiridis George Daskalakis | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，8： | 1 |
| 18 | The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients显示文摘 | Margarita Skopeliti Ioannis F. Voutsas Persefoni Klimentzou Marinos L. Tsiatas Alexander Beck Aristotelis Bamias Maria Moraki Evangelia Livaniou Monica Neagu Wolfgang Voelter Ourania E. Tsitsilonis | 2006 | Cancer Immunology Immunotherapy2006，，10： | 1 |
| 19 | Polycystic ovary syndrome: etiology and pathogenesis显示文摘 | I. Matalliotakis A. Kourtis Ourania Koukoura D. Panidis | 2006 | Archives of Gynecology and Obstetrics2006，，4： | 1 |
| 20 | Sleep problems in adolescence A study of senior high school students in Greece显示文摘 | Helen Lazaratou Dimitris G. Dikeos Dimitris C. Anagnostopoulos Ourania Sbokou Costantin R. Soldatos | 2005 | European Child & Adolescent Psychiatry2005，，4： | 1 |
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