|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials显示文摘 | G. Musso M. Cassader F. Rosina R. Gambino | 2012 | Diabetologia2012，，4： | 7 |
| 2 | Inflammatory bowel disease: Traditional knowledge holds the seeds for the future显示文摘Despite the level of sophistication they have reached nowadays, the available tools for treatment of inflammatory bowel disease(IBD) can at best chronicize the disease but not cure it. Chances to make leap forward from this hold-back may include designs to reach personalized treatment strategies taking advantage of modern genome associated studies, and shift resources towards unfolding inciting pathogenetic steps rather than continuing to develop drugs that address down-stream phenomena. We have arbitrarily chosen to scrutinize a few projects that may make their way in 2015 and mark the history of IBD research. The list includes: the role of appendix as a regulating factor in pathogenesis of ulcerative colitis/proctitis; the reappraisal of(auto)immune phenomena in the era of microbiome; projects to treat IBD by stem cell infusion; recognition of the crucial pathogenetic role of gut microbiome, and attempts to modify it to treat enteric diseases, from clostridium difficile infection to IBD. | Giovanni C Actis Rinaldo Pellicano Floriano Rosina | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，2： | 6 |
| 3 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 5 |
| 4 | Inflammatory bowel disease:An archetype disorder of outer environment sensor systems显示文摘The pathogenesis of the two inflammatory bowel disease(IBD) phenotypes ulcerative colitis(UC) and Crohn' s disease(CD) has remained elusive,thus frustrating attempts at defining a cure.IBD often presents as a complex inflammatory process wherein colon lesions(UC) or widespread ulceration and fissure(CD) might be accompanied by ancillary extra-intestinal manifestations involving the eye,skin,joints or liver,but also by full-blown 'autoimmune' disorders from psoriasis and multiple sclerosis to rheumatoid arthritis;attempts at unraveling a link or a hierarchical order in these entities have proven almost fruitless.More recently,the input of genetics has suggested that the IBDs might be multiorgan inflammatory processes,elicited by a large number of low-penetrance susceptibility genes,with environmental factors needed to induce full-blown disease.At a noteworthy exception to this rule,the description of the nucleotide-oligomerization domain(NOD) gene mutations in CD came at the beginning of the 2000s:the NOD-LRR are part of a highly conserved microbial sensor system which respond to bacterial peptidoglycans by mounting an inflammatory response.At least in Caucasian patients,the prevalently loss-of-function mutation of NOD permitted to unexpectedly define CD as an immune deficiency state,and upon its recent description in apparently unrelated disorders such as the Blau syndrome(a granulomatous pediatric syndrome),and perhaps in psoriasis and chronic obstructive pulmonary disorders,has contributed to revolutionize our view of IBD and CD in particular.The latter affection,together with psoriasis and chronic pulmonary disease can now be included into a newly identified category named 'barrier organ disease',wherein a barrier organ is defined as a large mucosal or epithelial surface with an abundant metagenomic microbial population and an underneath reactive tissue,the whole structure being in contact with the outer environment and capable to react to it.Personalized treatments and empowerment of research across different disease phenotypes should be the advantages of this novel mindset. | Giovanni C Actis Floriano Rosina | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3： | 5 |
| 5 | Lack of association between seroprevalence of Helicobacterpylori infection and primary biliary cirrhosis显示文摘AIM: To determine the association between seroprevalence of Helicobacter pylori(Hpylon) infection and primary biliary cirrhosis (PBC).METHODS: In this case-control study, 149 consecutive patients (10 males, 139 females, mean age 58.2+11 years, range 26-82 years) suffering from PBC and 619 consecutive healthy volunteer blood donors (523 males, 96 females, mean age 47±5.3 years, range 18-65 years) attending the Hospital Blood Bank and residing in the same area were recruited. A commercial enzyme linked immunosorbent assay was used to detect anti-Hpylori(IgG) antibodies in serum.RESULTS: Antibodies to Hpyloriwere present in 78 (52.3%) out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P= 0.24, OR 1.24, 95% CI 0.85-1.80). In the subjects less than 60 years old, the prevalence of Hpylori infection among PBC-patients (40/79) was slightly higher than in controls (50.6% vs46.2%) P= 0.46, OR = 1.19, 95% CI: 0.72-1.95). In those over 60 years, the prevalence of H pyloriinfection was similar between PBC-patients and controls (54.2% vs57.8%, P= 0.7, OR 0.86, 95% CI 0.36-2.07). CONCLUSION: There is no association between seroprevalence of Hpyloriinfection and primary biliary cirrhosis. | Marilena Durazzo Floriano Rosina Alberto Premoli Enrico Morello Sharmila Fagoonee Rosaria Innarella Enrico Solerio Rinaldo Pellicano Mario Rizzetto | 2004 | World Journal of Gastroenterology2004，10，21： | 4 |
| 6 | Inflammatory bowel diseases: Current problems and future tasks显示文摘Current knowledge on inflammatory bowel disease(IBD)is mainly endorsed by controlled trials and epidemiologic studies. Yet,we seldom look at the messages from real-world practice. Among a patient population followed since2008,we looked at an unselected sample of 64 IBD patients [26 Crohn's disease(CD) and 38 ulcerative colitis(UC)] who had been seen as out-patients in the last year.Inducing remission,mesalamines(86% for UC/69% for CD/33%-16% as MMX formulation) prevailed as prescrip-tions; steroids(55%/19% for UC/CD) ranked second.Prescription of third-party drugs(antibiotics,NSAIDs,biologics) and adherence,were issues in the maintenance.34% of CD,and 23% of UC patients showed accompany-ing immunologic diseases: CD-associated familiar psoriasis(4:9) ranked first. Main Message. The association between IBD(CD mainly) and psoriasis,now found in our practice,matches current basic science gathering IBD together with psoriasis(and perhaps chronic respiratory disease) under the comprehensive term 'barrier organ disease' wherein an epithelial surface with sensor system srules contacts between outer antigens and a reactive underneath tissue,with the balance between inflammation and quiescence kept at any time by mucosal permeability.IBD is thus viewed as a polyfactorial/polygenic/syndromic disorder,embedded into a galaxy of immune conditions offering multiple points of attack. This mindset of splitting the IBDs into pathogenic categories may allow overcoming the uniformly targeting of a single cytokine by biological drugs,in favor of demarcating the boundaries between different disease-subtype-specific indications,and paving the way to future personalized strategies. | Giovanni C Actis Floriano Rosina Rinaldo Pellicano | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 3 |
| 7 | MBTI人格类型量表的效度分析显示文摘 | 苗丹民 皇甫恩 Rosina C.Chia Ren Jianjun | 2000 | 心理学报2000，，03： | 3 |
| 8 | The influence of canopy-layer composition on understory plant diversity in southern temperate forests显示文摘Background: Understory plants represents the largest component of biodiversity in most forest ecosystems and plays a key role in forest functioning.Despite their importance, the influence of overstory-layer composition on understory plant diversity is relatively poorly understood within deciduous-evergreen broadleaved mixed forests.The aim of this work was to evaluate how tree overstory-layer composition influences on understory-layer diversity in three forest types(monospecific deciduous Nothofagus pumilio(Np), monospecific evergreen Nothofagus betuloides(Nb), and mixed N.pumilio-N.betuloides(M) forests), comparing also between two geographical locations(coast and mountain) to estimate differences at landscape level.Results: We recorded 46 plant species: 4 ferns, 12 monocots, and 30 dicots.Canopy-layer composition influences the herb-layer structure and diversity in two different ways: while mixed forests have greater similarity to evergreen forests in the understory structural features, deciduous and mixed were similar in terms of the specific composition of plant assemblage.Deciduous pure stands were the most diverse, meanwhile evergreen stands were least diverse.Lack of exclusive species of mixed forest could represent a transition where evergreen and deciduous communities meet and integrate.Moreover, landscape has a major influence on the structure, diversity and richness of understory vegetation of pure and mixed forests likely associated to the magnitude and frequency of natural disturbances, where mountain forest not only had highest herb-layer diversity but also more exclusive species.Conclusions: Our study suggests that mixed Nothofagus forest supports coexistence of both pure deciduous and pure evergreen understory plant species and different assemblages in coastal and mountain sites.Maintaining the mixture of canopy patch types within mixed stands will be important for conserving the natural patterns of understory plant composition in southern beech mixed forests. | Luciana Mestre Monica Toro-Manriquez Rosina Soler Alejandro Huertas-Herrera Guillermo Martinez-Pastur Maria Vanessa Lencinas | 2017 | Forest Ecosystems2017，4，2： | 3 |
| 9 | Acute hepatitis B caused by a vaccine-escape HBV strain in vaccinated subject: Sequence analysis and therapeutic strategy显示文摘 | Monica Luongo Rosina Critelli Antonella Grottola Stefano Gitto Veronica Bernabucci Mirco Bevini Chiara Vecchi Giuliano Montagnani Erica Villa | 2014 | Journal of Clinical Virology2014，，： | 2 |
| 10 | Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials显示文摘 | G. Musso M. Cassader F. Rosina R. Gambino | 2012 | Diabetologia2012，，4： | 2 |
| 11 | Immunoreactivity of hen egg allergens:Influence on in vitro gastrointestinal digestion of the presence of other egg white proteins and of egg yolk显示文摘 | Gustavo M Rosina L F Elena M | 2013 | Food Chemistry2013，136，： | 1 |
| 12 | Impact of erarent treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review amd meta-analysis of randomised trials显示文摘 | MUSSO G CASSADER M ROSINA F | 2012 | Diabetologia2012，55，4： | 1 |
| 13 | Glycosylation of individual whey proteins by Maillard reaction using dextran of different molecular mass显示文摘 | Laura Jiménez-Casta?o Mar Villamiel Rosina López- Fandi?o | 2007 | Food Hydrocolloids2007，21，3： | 1 |
| 14 | Influence of the Carbohydrate Moieties on the Immunoreactivity and Digestibility of the Egg Allergen Ovomucoid显示文摘 | Sara Be Rosina L Marta R | 2013 | PLOS ONE2013，8，11： | 1 |
| 15 | Monoclonal antibodies reveal expression of the CGRP receptor in Purkinje cells, interneurons and astrocytes of rat cerebellar cortex 显示文摘 | Morara S Wimalawansa S J Rosina A | 1998 | Neuroreport1998，9，16： | 1 |
| 16 | How to avoid the introduction of porcine reproductive and respiratory syndrome virus onto a farm显示文摘 | Rosina S Dotti S Martelli P | 2007 | Rivista di Suinicoltura2007，48，4： | 1 |
| 17 | Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non- alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials 显示文摘 | Musso G Cassader M Rosina F | 2012 | Diabetologia2012，55，4： | 1 |
| 18 | Porcine reproductive and respiratory syndrome, good control limits economic losses显示文摘 | Dotti S Rosina S Martelli P | 2007 | Rivista di Suinicoltura2007，48，5： | 1 |
| 19 | MBTI人格类型量表的效度分析显示文摘 | 苗丹民 皇甫恩 Rosina C.Chia Ren Jianjun | 2000 | 心理学报2000，，03： | 1 |
| 20 | Psoriasis and sideeffects of mesotherapy 显示文摘 | Rosina P Chieregato C Miccolis D | 2001 | Int J Dermatol2001，40，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员