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| 1 | Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases:A cross-sectional and longitudinal analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is common in the German population,with an even higher prevalence in inflammatory bowel disease patients.AIM To investigate the risk factors for NAFLD in inflammatory bowel disease patients.METHODS This monocentric retrospective study with a cross-sectional and a longitudinal part included 694 patients.Inclusion criteria were diagnosed inflammatory bowel disease,age≥18 years,availability of at least one abdominal ultrasound.Patients with infectious or suspected alcoholic fatty liver disease were excluded.NAFLD was defined by increased echogenicity at liver ultrasound.Demographic characteristics,disease activity and medications were analyzed as potential risk factors.Parameters influencing the course of NAFLD were identified by a generalized linear mixed model.RESULTS Forty-eight percent of Crohn’s disease(CD)patients and 44%of ulcerative colitis patients suffered from NAFLD.Its occurrence was associated with greater age,hypertension and body mass index(BMI)in both groups,and with higher disease activity and dyslipidemia in CD.2467 ultrasound results were included in the longitudinal analysis.Risk factors for NAFLD were age,BMI,higher disease activity,bowel resection(s),endoscopic activity and azathioprine use in CD;and BMI and endoscopic activity in ulcerative colitis.CONCLUSION NAFLD was highly prevalent in this cohort of German inflammatory bowel disease patients.Its risk increased mainly with rising age and BMI.This analysis provides a rationale for non-invasive liver screening in inflammatory bowel disease patients. | Peter Hoffmann Victoria Jung Rouven Behnisch Annika Gauss | 2020 | World Journal of Gastroenterology2020，26，46： | 8 |
| 2 | Hydrogenative regeneration of a Pt/La-Y zeolite catalyst deactivated in the isobutane/n-butene alkylation显示文摘 | Klingmann Raoul Josl Rouven Traa Yvonne | 2005 | Applied Catalysis A:General2005，281，： | 1 |
| 3 | Influence of the process parameters on the multi-directional forging operation of a two cylinder crankshatt显示文摘 | Mueller Sven Lau Philipp Nickel Rouven | 2008 | Materials processing and properties2008，，3： | 1 |
| 4 | Passively mode-locked diode laser with optimized dispersion man- agement 显示文摘 | Jan C B Rouven O H P Benjamin D | 2015 | IEEE Journal of Selected Topics in Quan- tum Electronics2015，21，11： | 1 |
| 5 | Do Business Angel Networks Deliver Value to Business Angels显示文摘 | Knyphausen-Aufse Dodo Zu Westphal Rouven | 2008 | Venture Capital2008，，2： | 1 |
| 6 | Functional Characterization of Novel Mutations Affecting S urvivin ( BIRC 5)‐Mediated Therapy Resistance in Head and Neck Cancer Patients显示文摘 | Shirley K. Knauer Britta Unruhe Sarah Karczewski Rouven Hecht Verena Fetz Carolin Bier Sandra Friedl Barbara Wollenberg Ralph Pries Negusse Habtemichael Ulf‐Rüdiger Heinrich Roland H. Stauber | 2012 | Human Mutation2012，，： | 1 |
| 7 | Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines 显示文摘 | Rouven J Wool L Paul B | 1998 | J Virol1998，72，4： | 1 |
| 8 | The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation显示文摘Next-generation sequencing(NGS) is getting routinely used in the diagnosis of hereditary diseases, such as human cardiomyopathies. Hence, it is of utter importance to secure high quality sequencing data, enabling the identi?cation of disease-relevant mutations or the conclusion of negative test results. During the process of sample preparation, each protocol for target enrichment library preparation has its own requirements for quality control(QC); however, there is little evidence on the actual impact of these guidelines on resulting data quality. In this study, we analyzed the impact of QC during the diverse library preparation steps of Agilent Sure Select XT target enrichment and Illumina sequencing. We quanti?ed the parameters for a cohort of around 600 samples, which include starting amount of DNA, amount of sheared DNA, smallest and largest fragment size of the starting DNA; amount of DNA after the pre-PCR, and smallest and largest fragment size of the resulting DNA; as well as the amount of the ?nal library, the | Rouven Nietsch Jan Haas Alan Lai Daniel Oehler Stefan Mester Karen S. Frese Farbod Sedaghat-Hamedani Elham Kayvanpour Andreas Keller Benjamin Meder | 2016 | Genomics, Proteomics & Bioinformatics2016，14，4： | 1 |
| 9 | Improved assessment of biodegadation extent and prediction of petroleum quality显示文摘 | Rouven E Andrea V Angelo R | 2007 | Organic Geochemistry2007，38，12： | 1 |
| 10 | Do Business Angel Networks Deliver Value to Business Angels显示文摘 | Knyphausen Aufse Dodo Zu Westphal Rouven | 2008 | Venture Capital2008，，2： | 1 |
| 11 | Isotactic Polypropylene Nanocomposites Based upon Boehmite Nanofillers 显示文摘 | Rouven C Thomann R Mulhaupt R | 2008 | Macromol Mater Eng2008，293，21： | 1 |
| 12 | Position-controlled data acquisition embedded system for mag-netic NDE of bridge stay cables显示文摘 | Rocio Maldonado-Lopez Rouven Christen | 2011 | Sensors2011，，11： | 1 |
| 13 | Hydrogenative regeneration of a Pt/La-Y zeolite catalyst deactivated in the isobutane/ n -butene alkylation显示文摘 | Raoul Klingmann Rouven Josl Yvonne Traa Roger Gl?ser Jens Weitkamp | 2004 | Applied Catalysis A General2004，，1： | 1 |
| 14 | 搜寻小质量暗物质显示文摘人们传统上依赖大型设备来搜寻比质子还重的暗物质粒子,但最近正将目光转向对轻质量粒子敏感的小型实验。依据暗物质粒子与各种材料中电子或原子核之间的非弹性碰撞,新的探测方案拟搜寻所谓的亚GeV暗物质,其质量可低于质子质量的百万分之一。 | 徐仁新(编译) Rouven Essig | 2021 | 物理2021，50，3： | 0 |
| 15 | Insights into CODE-DE–Germany’s Copernicus data and exploitation platform显示文摘This article presents and analyses the modular architecture and capabilities of CODE-DE(Copernicus Data and Exploitation Platform–Deutschland,www.code-de.org),the integrated German operational environment for accessing and processing Copernicus data and products,as well as the methodology to establish and operate the system.Since March 2017,CODE-DE has been online with access to Sentinel-1 and Sentinel-2 data,to Sentinel-3 data shortly after this time,and since March 2019 with access to Sentinel-5P data.These products are available and accessed by 1,682 registered users as of March 2019.During this period 654,895 products were downloaded and a global catalogue was continuously updated,featuring a data volume of 814 TByte based on a rolling archive concept supported by a reload mechanism from a long-term archive.Since November 2017,the element for big data processing has been operational,where registered users can process and analyse data themselves specifically assisted by methods for value-added product generation.Utilizing 195,467 core and 696,406 memory hours,982,948 products of different applications were fully automatically generated in the cloud environment and made available as of March 2019.Special features include an improved visualization of available Sentinel-2 products,which are presented within the catalogue client at full 10 m resolution. | Tobias Storch Christoph Reck Stefanie Holzwarth Bert Wiegers Nico Mandery Ulrich Raapea Christian Strobl Rouven Volkmann Martin Böttcher Andreas Hirner Johanna Senft Nicolae Plesia Thomas Kukuk Stephan Meissl Jens-Rainer Felske Thomas Heege Vanessa Keuck Michael Schmidt Helmut Staudenrausch | 2019 | Big Earth Data2019，3，4： | 0 |
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