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| 1 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 2 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 3 | Characterization and adsorption behavior of a novel triolein-embedded activated carbon composite adsorbent显示文摘A novel triolein-embedded activated carbon composite adsorbent was developed. Experiments were car-ried out in areas such as the preparation method, the char-acterization of physicochemical properties, and the adsorp-tion behavior of the composite adsorbent in removing diel-drin from aqueous solution. Results suggested that the novel composite adsorbent was composed of the supporting acti-vated carbon and the surrounding triolein-embedded cellu-lose acetate membrane. The adsorbent was stable in water, for no triolein leakage was detected after soaking the ad-sorbent for five weeks. The adsorbent had good adsorption capability to dieldrin, which was indicated by a residual di-eldrin concentration of 0.204 μg·L?1. The removal efficiency of the composite adsorbent was higher than the traditional activated carbon adsorbent. | RU Jia LIU Huijuan QU Jiuhui WANG Aimin DAI Ruihua | 2005 | Chinese Science Bulletin2005，50，23： | 6 |
| 4 | Dieldrin and endrin removal from water by trioleinembedded adsorbent显示文摘A novel triolein-embedded adsorbent for re-moval of persistent organic pollutants (POPs) from water was developed. In this paper, taking dieldrin and endrin as the target pollutants, different factors (temperature, ion strength, pH, and concentration of humic acid) that affect the adsorption rate were investigated. Adsorption isotherms of these two pollutants fitted to Freundlich model well identi-fied the partition mechanism between the adsorbent and water. However, the equilibrium constant of dieldrin was larger than that of endrin due to larger octanol-water coeffi-cient of dieldrin. Adsorption rate of dieldrin increased with the increase of temperature, the decrease of ion strength, pH and concentration of humic acid, whereas adsorption rate of endrin decreased with the increase of temperature and pH. Humic acid firstly increased, and then decreased the adsorp-tion rate of endrin. Ion strength hardly affected the adsorp-tion rate of endrin. | HUO Jinxian LIU Huijuan QU Jiuhui RU Jia LIU Haining LI Guoting | 2005 | Chinese Science Bulletin2005，50，23： | 5 |
| 5 | Phototransformation of nitrobenzene in the Songhua River:Kinetics and photoproduct analysis显示文摘Nitrobenzene (NB) pollution of the Songhua River caused by an explosion at a petrochemical plant in Jilin City,Jilin Province, China,attracted public concern over the fate of NB in the river.As one of the efforts to predict the fate of residual NB in the river,the kinetics and mechanism of phototransformation of NB in natural water from four sections of the Songhua River were investigated.It was found that photodegradation of NB in water proceeded via pseudo-first-order reaction kinetics under simulated ... | WANG, Aimin HU, Chun QU, Jiuhui YANG, Min LIU, Huijuan RU, Jia QI, Rong SUN, Jingfang | 2008 | Journal of Environmental Sciences2008，20，7： | 4 |
| 6 | Preparation and characterization of a novel adsorbent for removing lipophilic organic from water显示文摘A novel composite adsorbent containing a kind of lipid-triolein is studied. The ad-sorbent is prepared by embedding triolein into cellulose acetate (CA) sphere. The preparation method, the physical-chemical properties of the adsorbent and the removal efficiency of two or-ganochlorinated pesticides are studied. The adsorbent is stable in water and no triolein leaks into water for 465 h soaking. The adsorbent has high adsorption capacity for organochlorinated pes-ticides such as dieldrin and aldrin. The results suggest that triolein-containing adsorbent could serve as a good adsorbent for lipophilic organic pollutants. The adsorption rate for lipophilic pol-lutants is very fast and has relation with the logKow of the compounds. | LIU Huijuan1, DAI Ruihua1, QU Jiuhui1 & RU Jia1,2 1. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China 2. Graduate School of the Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Chemistry2005，48，6： | 3 |
| 7 | Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia–reperfusion injury显示文摘 | Ge Zhao Hongwei Ma Xin Shen Gao-Feng Xu Yu-Lin Zhu Baoying Chen Ru Tie Ping Qu Yi Lv Haifeng Zhang Jun Yu | 2013 | Journal of Surgical Research2013，，： | 1 |
| 8 | Fast coding in digital steganography显示文摘Dynamical running coding was previously proposed as a method for construction of steganographic schemes in digital steganography.In this article,a new approach of fast coding is proposed to improve steganographic efficiency.Original embedding method is discussed in two cases of constructing different generating matrix;however,the proposed method generalizes the problem to only one case by changing the construction method from the original method.Therefore,the complexity of the proposed method is less than the original method.Meanwhile,both theoretical analysis and experiment results show better performance in terms of distortions and alterations of the cover objects when embedding the same amount of information data bits,which proves a better resistance against steganalysis. | FU Yu | 2009 | The Journal of China Universities of Posts and Telecommunications2009，16，6： | 1 |
| 9 | A STRUCTURE-PRESERVING DISCRETIZATION OFNONLINEAR SCHRDINGER EQUATION显示文摘1.IntroductionManyimportantdifferentialequationsofevolutiontypeinphysicsandmechanicshavespecificgeometricstructure.Forinstance,theHamiltoniansystemsinclassicalmechanics,theSchrodingerequationinquantum,theKorteweg-deVriesandKleinGordonequationsofnonli... | Ming-you Huang Ru Qu Cheng-chun Gong(Institute of Mathematics, Jilin University, Changchun 130023 P.R. China) | 1999 | Journal of Computational Mathematics1999，17，5： | 1 |
| 10 | Mineralization of an azo dye Acid Red 14 by Electro-Fenton's reagent using an activated carbon fiber cathode显示文摘 | Wang A Qu J Ru J | 2005 | Dyes Pigments2005，65，： | 1 |
| 11 | Mineralization of an azo dye acid red 14 by electro- Fenton's reagent using an activated carbon fiber cathode 显示文摘 | Wang A Qu J Ru J | 2005 | Dyes Pigments2005，65，3： | 1 |
| 12 | Mineralization of an azo dye Acid Red 14 by electro-Fenton's reagent using an activated carbon fiber cathode显示文摘 | Wang A Qu J Ru J | 2005 | Dyes and Pigments2005，65，3： | 1 |
| 13 | Mineralization of an azo dye Acid Red B by electro-Fenton's reagent using an activated carbon fiber cathode 显示文摘 | Wang A Qu J Ru J | 2005 | Dyes Pigments2005，65，3： | 1 |
| 14 | 显示文摘 | Qu Xingping Ru Guoping Xu Beilei | 2000 | Chinese Journal Semiconductos2000，21，5： | 1 |
| 15 | Mineralization of an azo dye acid red 14 by electro-Fenton's reagent using an activated carbon fiber cathode显示文摘 | Wang A M Qu J H Ru J | 2005 | Dyes and Pigments2005，65，： | 1 |
| 16 | Mineralization of an azo dye acid red 14 by electro · Fenton' s reagent using an activated carbon fiber cathode 显示文摘 | Wang Aimin Qu Jiuhui Ru Jia | 2005 | Dyes and Pigments2005，65，3： | 1 |
| 17 | Mineralization of an azo dye Acid Red 14 by electro: Fenton' s reagent using an activated carbon fiber cathode 显示文摘 | Wang A Qu J Ru J | 2005 | Dyes Pigm2005，65，3： | 1 |
| 18 | Removal of persistent organic pollutants from micro-polluted drinking water by trio lein embedded absorbent显示文摘 | LIU Huijun RU Jia QU Jiuhui | 2009 | Bioresource Technology2009，100，12： | 1 |
| 19 | Relationship of energy charge and toxin content of Microcystis aeruginosa in nitrogen-limited or phosphorous-limited cultures显示文摘 | Ruihua Dai Huijuan Liu Jiuhui Qu Xu Zhao Jia Ru Yining Hou | 2007 | Toxicon2007，，4： | 1 |
| 20 | Simple optical method for determination of crystal orientation in photorefraetive crystals显示文摘 | QU Di GUO Ru LIu Simin | 2006 | Applied Optics2006，45，24： | 1 |
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