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| 1 | Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy显示文摘Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor site.Herein, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy. | Peng Xue Ruihao Yang Lihong Sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang | 2018 | Nano-Micro Letters2018，10，4： | 3 |
| 2 | A two-step multi-frequency receiver function inversion method for shallow crustal S-wave velocity structure and its application across the basin-mountain range belts in Northeast China显示文摘A shallow crustal velocity structure(above 10 km depth) is essential for understanding the crustal structures and deformation and assessing the exploration prospect of natural resources, and also provides priori information for imaging deeper crustal and mantle structure. Passive-source seismic methods are cost-effective and advantageous for regional-scale imaging of shallow crustal structures compared to active-source methods. Among these passive methods, techniques utilizing receiver function waveforms and/or body-wave amplitude ratios have recently gained prominence due to their relatively high spatial resolution. However, in basin regions, reverberations caused by near-surface unconsolidated sedimentary layers often introduce strong non-uniqueness and uncertainty, limiting the applicability of such methods. To address these challenges, we propose a two-step inversion method that uses multi-frequency P-RF waveforms and P-RF horizontal-to-vertical amplitude ratios. Synthetic tests indicate that our two-step inversion method can mitigate the non-uniqueness of the inversion and enhance the stability of the results. Applying this method to teleseismic data from a linear seismic array across the sedimentary basins in Northeast China, we obtain a high-resolution image of the shallow crustal S-wave velocity structure along the array. Our results reveal significant differences between the basins and mountains. The identification of low-velocity anomalies(<2.8 km s^(-1)) at depths less than 1.0 km beneath the Erlian Basin and less than 2.5 km beneath the Songliao Basin suggests the existence of sedimentary layers. Moreover, the high-velocity anomalies(~3.4–3.8 km s^(-1)) occurring at depths greater than 7 km in the Songliao Basin may reflect mafic intrusions emplaced during the Early Cretaceous. Velocity anomaly distribution in our imaging result is consistent with the location of the major faults, uplifts, and sedimentary depressions, as well as active-source seismic results. This application further validates the effectiveness of our method in constraining the depth-dependent characteristics of the S-wave velocity in basins with unconsolidated sedimentary cover. | Ruihao YANG Xu WANG Ling CHEN Mingye FENG Qifu CHEN | 2024 | Science China Earth Sciences2024，67，3： | 0 |
| 3 | Ginsenoside Rg1 improves anti-tumor efficacy of adoptive cell therapy by enhancing T cell effector functions显示文摘Adoptive cell therapy(ACT)has emerged with remarkable efficacies for tumor immunotherapy.Chimeric antigen receptor(CAR)T cell therapy,as one of most promising ACTs,has achieved prominent effects in treating malignant hematological tumors.However,the insufficient killing activity and limited persistence of T cells in the immunosuppressive tumor microenvironment limit the further application of ACTs for cancer patients.Many studies have focused on improving cytotoxicity and persistence of T cells to achieve improved therapeutic effects.In this study,we explored the potential function in ACT of ginsenoside Rg1,the main pharmacologically active component of ginseng.We introduced Rg1 during the in vitro activation and expansion phase of T cells,and found that Rg1 treatment upregulated two T cell activation markers,CD69 and CD25,while promoting T cell differentiation towards a mature state.Transcriptome sequencing revealed that Rg1 influenced T cell metabolic reprogramming by strengthening mitochondrial biosynthesis.When co-cultured with tumor cells,Rg1-treated T cells showed stronger cytotoxicity than untreated cells.Moreover,adding Rg1 to the culture endowed CAR-T cells with enhanced anti-tumor efficacy.This study suggests that ginsenoside Rg1 provides a potential approach for improving the anti-tumor efficacy of ACT by enhancing T cell effector functions. | Yue Liu Lingna An Chengfei Yang Xiaoqi Wang Ruihao Huang Xi Zhang | 2023 | Blood Science2023，5，3： | 0 |
| 4 | Synthesis of Clionastatins A and B through Enhancement of Chlorination and Oxidation Levels of Testosterone显示文摘A full account of semisyntheses of polychlorinated marine steroids clionastatins A and B is described.We have developed a unique two-stage chlorination-oxidation strategy that enabled concise and divergent semisyntheses of clionastatins A and B in 16 steps from inexpensive testosterone.Key transformations in chlorination stage include(a)conformationally controlled,stereospecific dichlorination through an unusualβ-chloronium intermediate to install the diequatorial C1,C2-dichloride;(b)C4-OH directed C19–H oxygenation followed by challenging neopentyl chlorination to install the C19–Cl.The high oxidation level was constructed through(a)the desaturation at C6–C7 through one-pot photochemical dibromination–reductive debromination;(b)regioselective anti-Markovnikov oxidation of the C6–C7 double bond by photoredox-metal dual catalysis to forge the B ring enone;(c)late-stage desaturation with SeO_(2)to introduce C8–C9 double bond.Wharton transposition was used to forge the D-ring enone,and thermodynamically driven epimerization secured the cis-fused C/D ring system.Furthermore,we also provided a 14-step approach to clionastatin A by optimizing the construction of the D-ring enone with a dehydration-oxidation sequence. | Hao Cui Yang Shen Ruifeng Wang Haoxiang Wei Xin Lei Yanyu Chen Pengfei Fu Haoxiang Wang Ruihao Bi Yandong Zhang | 2022 | Chinese Journal of Chemistry2022，40，23： | 0 |
| 5 | Combined molecular docking, homology modeling and DFTmethod for the modification of bovine serum albumin (BSA) toimprove fluorescence spectroscopy for phthalate acid esterschelated with BSA显示文摘While phthalate acid esters(PAEs)cannot fluoresce alone,they can be detected by fluorescence spectroscopy after chelation with bovine serum albumin(BSA).In this study,the types of amino acid residues at the active site of PAEs chelated with BSA were determined using molecular docking technology.A modification scheme of BSA with higher detection sensitivity fluorescence spectroscopy for PAEs was proposed based on the docking results and constructed for a novel BSA structure with a higher detection sensitivity of fluorescence spectroscopy using a homologous modeling method.Density functional theory(DFT)was employed to explore the influence before and after BSA modification on PAEs’detection through fluorescence spectroscopy.The results showed that the docking scores between BSAs and dimethyl phthalate(DMP),dibutyl phthalate(DBP)and di-n-octyl phthalate(DNOP)were increased up to 26.45%,16.82%and 16.30%,respectively,indicating that the active site modification of BSA could enhance the binding affinity between BSA and PAEs.The fluorescence intensity of PAEs chelated with modified BSAs were calculated.The fluorescence intensity of fluorescence spectroscopy for DMP,DBP and DNOP chelated with BSAs after modification was increased up to 2.8-,104.51-and 62.43-fold,respectively,which achieved the purpose of theoretically modifying BSA to improve the detection sensitivity of fluorescence spectroscopy for PAEs. | MINGHAO LI YOULI QIU WENHUI ZHANG RUIHAO SUN MEIJIN DU LUZE YANG YU LI | 2020 | BIOCELL2020，44，2： | 0 |
| 6 | Temperature-field history dependence of the elastocaloric effect for a strain glass alloy显示文摘The singular change of the order parameter at the first order martensitic transformation(MT)temperature restricts the caloric response to a narrow temperature range.Here the MT is tuned into a sluggish strain glass transition by defect doping and a large elastocaloric effect appears in a wide temperature range.Moreover,an inverse elastocaloric effect is observed in the strain glass alloy with history of zerofield cooling and is attributed to the slow dynamics of the nanodomains in response to the external stress.This study offers a design recipe to expand the temperature range for good elastocaloric effect. | Deqing Xue Ruihao Yuan Yuanchao Yang Jianbo Pang Yumei Zhou Xiangdong Ding Turab Lookman Xiaobing Ren Jun Sun Dezhen Xue | 2022 | Journal of Materials Science & Technology2022，，8： | 0 |
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