|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Heyan Kuntai capsule versus dehydroepiandrosterone in treating Chinese patients with infertility caused by diminished ovarian reserve: a multicenter, randomized controlled trial显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month period.RESULTS: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were observed.CONCLUSION: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment.HYKT might be an alternative to the treatment of infertility caused by DOR. | Gao Hui Xia Tian Ma Ruihong Zhao Zhimei Song Xueru Wang Baojuan Liu Lijing Han Kaimei Wang Guoqing Fu Yu Hao Guimin | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 14 |
| 2 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 3 | Drought tolerance evaluation of tobacco plants transformed with different set of genes under laboratory and field conditions显示文摘尽管广泛的研究证明了许多干旱应答的基因授与干旱忍耐到植物,能力在各种各样的自然条件下面由不同基因授与的干旱忍耐的比较很少有报导。我们评估了并且比较 transgenes,干旱应答的基因(AtDREB1B 和 AtCBL1 ) 和根的二个集合的效果调整建筑学的基因(iaaM 和 AtCKX ) ,在在 Nicotiana tabacum 的干旱忍耐上,植物使遭到了到不同条件。根特定的倡导者 PYK10 驾驶的 AtCKX3 的表示(此后指定了为 P10;P10 : AtCKX3 ) , 35S:AtCKX3,或 P10:iaaM 支持了根生长和开发。比作怀有 P10 的植物: 展出的 AtCKX3, 35S:AtCKX3, P10:iaaM,或空向量,那些带的 35S:AtDREB1B, 35S:AtCBL1,或 35S:iaaM 在控制实验室的条件下面增加了干旱忍耐。相反地,在地里,条件,与 35S:AtDREB1 转变的植物, 35S:AtCBL1,或 35S:iaaM 对干旱应力敏感。在地条件下面,干旱应力戏剧性地减少了生长和而它在带 P10 的植物上有小效果,怀有 35S:AtDREB1B, 35S:AtCBL1, 35S:iaaM,或空向量的植物的种子生产: AtCKX3, 35S:AtCKX3,或 P10:iaaM。这研究证明到有环境条件的干旱压力变化的植物忍耐,和我们的结果显示操作控制根建筑学的基因的表示可能为处于自然条件与改进干旱忍耐设计植物是重要的。 | Yuanhua Wang Ruihong Dang Jinxi Li Yu Han Ning Ding Xingliang Li Meiru Jia Ziqiang Li Lingzhi Wei Jinzhu Jiang Yijuan Fan Bingbing Li Wensuo Jia | 2015 | Science Bulletin2015，60，6： | 3 |
| 4 | Dilute acid pretreatment and fermentation of sugar beet pulp to ethanol显示文摘 | Yi Zheng Christopher Lee Chaowei Yu Yu-Shen Cheng Ruihong Zhang Bryan M. Jenkins Jean S. VanderGheynst | 2012 | Applied Energy2012，，： | 1 |
| 5 | Geological information prediction for shield machine using an enhanced multi-head self-attention convolution neural network with two-stage feature extraction显示文摘Due to the closed working environment of shield machines,the construction personnel cannot observe the construction geological environment,which seriously restricts the safety and efficiency of the tunneling process.In this study,we present an enhanced multi-head self-attention convolution neural network(EMSACNN)with two-stage feature extraction for geological condition prediction of shield machine.Firstly,we select 30 important parameters according to statistical analysis method and the working principle of the shield machine.Then,we delete the non-working sample data,and combine 10 consecutive data as the input of the model.Thereafter,to deeply mine and extract essential and relevant features,we build a novel model combined with the particularity of the geological type recognition task,in which an enhanced multi-head self-attention block is utilized as the first feature extractor to fully extract the correlation of geological information of adjacent working face of tunnel,and two-dimensional CNN(2dCNN)is utilized as the second feature extractor.The performance and superiority of proposed EMSACNN are verified by the actual data collected by the shield machine used in the construction of a double-track tunnel in Guangzhou,China.The results show that EMSACNN achieves at least 96%accuracy on the test sets of the two tunnels,and all the evaluation indicators of EMSACNN are much better than those of classical AI model and the model that use only the second-stage feature extractor.Therefore,the proposed EMSACNN achieves high accuracy and strong generalization for geological information prediction of shield machine,which is of great guiding significance to engineering practice. | Chengjin Qin Guoqiang Huang Honggan Yu Ruihong Wu Jianfeng Tao Chengliang Liu | 2023 | Geoscience Frontiers2023，14，2： | 1 |
| 6 | Maximum power point tracking from a wind turbine emulator using a DC - DC converter controlled 显示文摘 | Yu Ruihong Li Yanqin Cai Jianxian | 2014 | International Journal of Control and Automation2014，7，1： | 1 |
| 7 | Water-soluble brown carbon in atmospheric aerosols from the resource-dependent cities:Optical properties,chemical compositions and sources显示文摘As a vital type of light-absorbing aerosol,brown carbon(BrC)presents inherent associations with atmospheric photochemistry and climate change.However,the understanding of the chemical and optical properties of BrC is limited,especially in some resource-dependent cities with long heating periods in northwest China.This study showed that the annual average abundances of Water-soluble BrC(WS-BrC)were 9.33±7.42 and 8.69±6.29μg/m^(3)in Baotou and Wuhai and the concentrations,absorption coefficient(Abs_(365)),and mass absorption efficiency(MAE365)of WS-BrC presented significant seasonal patterns,with high values in the heating season and low values in the non-heating season;while showing opposite seasonal trends for the Absorption Angstr?m exponent(AAE_(300-400)).Comparatively,the levels of WS-BrC in developing regions(such as cities in Asia)were higher than those in developed regions(such as cities in Europe and Australia),indicating the significant differences in energy consumption in these regions.By combining fluorescence excitation-emission matrix(EEM)spectra with the parallel factor(PARAFAC)model,humic-like(C1 and C2)and proteinlike(C3)substances were identified,and accounted for 61.40%±4.66%and 38.6%±3.78%at Baotou,and 60.33%±6.29%and 39.67%±4.17%at Wuhai,respectively.The results of source apportionment suggested that the potential source regions of WS-BrC varied in heating vs.non-heating seasons and that the properties of WS-BrC significantly depended on primary emissions(e.g.,combustion emissions)and secondary formation. | Haoji Wang Yue Su Yangzheng Liu Fei Xie Xingjun Zhou Ruihong Yu Changwei Lü Jiang He | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 8 | Interobserver Agreement for Classifying Infections in Patients with Decompensated Cirrhosis Based on Centers for Disease Control and Prevention Criteria显示文摘Background:Bacterial infections are common in patients with decompensated cirrhosis,largely owing to bacterial translocation and cirrhosis-associated immune dysfunction.This study aims to determine the reliability for classifying infections in patients with decompensated cirrhosis based on the Centers for Disease Control and Prevention(CDC)criteria.Methods:The patients with decompensated cirrhosis with suspicious infection in a registered prospective cohort of cirrhosis from May 1,2014 to February 25,2015 in the ward of First Affiliated Hospital of Zhejiang University were retrospectively identified.Agreement assessment was conducted focusing on site of infection,the possibility of infection,and pathogens of infection on both system level and specific diagnosis level.A subgroup analysis was performed based on with/without acute-on-chronic liver failure(ACLF).Results:A total of 402 infectious episodes among 351 patients were enrolled for consistency analysis.The overall agreement for site of infection was 94%(378/402)(k=0.90,95%CI 0.86–0.94)on system level and 86%(346/402)(k=0.84,95%CI 0.80–0.88)on specific diagnosis level.On possibility of infection,the overall agreement was 81%(306/378)(weighted k=0.71,95%CI 0.65–0.77),with 84%(224/267)(weighted k=0.75,95%CI 0.63–0.87)in patients with ACLF and 80%(70/88)(weighted k=0.68,95%CI 0.60–0.76)in patients without ACLF,respectively.On pathogens of infection,the overall agreement was 72%(60/83)(k=0.70,95%CI 0.60–0.80)among most frequent infections.Conclusion:The agreement for classifying infections in patients with decompensated cirrhosis based on CDC criteria is acceptable overall,suggesting that it can be a useful tool for clinical management in patients with decompensated cirrhosis with suspicious infections. | Haotang Ren Junjie Yao Ruihong Zhao Kai Gong Shanshan Sun Xia Yu Wei Shen Jinnan Duan Jifang Sheng Yu Shi | 2022 | Infectious Diseases & Immunity2022，2，1： | 0 |
| 9 | Research and Analysis on Refined Precipitation Forecast Method of Highway during Flood Season in Gansu Province显示文摘In this paper,T639 global spectral model numerical forecast products issued by numerical prediction center of China Meteorological Administration and precipitation data at 676 regional stations of Gansu during flood season were used firstly for interpretation.Then,through the establishment of multiple linear stepwise regression equation,daily precipitation forecast with the time interval of 6hduring 0-72 hin May,2013 in Gansu Province was obtained.By precipitation forecast verification analysis,it was found that the precipitation forecast in Hexi region and central Gansu Province had best effect;forecast in some places of east Hedong region had relatively good effect;part of the city or state forecast effect in the plateau slope zone was relatively lower.The refined precipitation forecast had certain reference and use value in the post-production Gansu Province highway forecasting during flood season. | Liu Kang Li Zhaorong Wang Yousheng Zhang Yu Yang Ruihong He Jinmei Wang Dongmei Yin Chun | 2015 | Meteorological and Environmental Research2015，6，1： | 0 |
| 10 | Spatial changes and driving factors of lake water quality in Inner Mongolia, China显示文摘Lakes play important roles in sustaining the ecosystem and economic development in Inner Mongolia Autonomous Region of China,but the spatial patterns and driving mechanisms of water quality in lakes so far remain unclear.This study aimed to identify the spatial changes in water quality and the driving factors of seven lakes(Juyanhai Lake,Ulansuhai Lake,Hongjiannao Lake,Daihai Lake,Chagannaoer Lake,Hulun Lake,and Wulannuoer Lake)across the longitudinal axis(from the west to the east)of Inner Mongolia.Large-scale research was conducted using the comprehensive trophic level index(TLI(Σ)),multivariate statistics,and spatial analysis methods.The results showed that most lakes in Inner Mongolia were weakly alkaline.Total dissolved solids and salinity of lake water showed obvious zonation characteristics.Nitrogen and phosphorus were identified as the main pollutants in lakes,with high average concentrations of total nitrogen and total phosphorus being of 4.05 and 0.21 mg/L,respectively.The values of TLI(Σ)ranged from 49.14 to 71.77,indicating varying degrees of lake eutrophication,and phosphorus was the main driver of lake eutrophication.The lakes of Inner Mongolia could be categorized into lakes to the west of Daihai Lake and lakes to the east of Daihai Lake in terms of salinity and TLI(Σ).The salinity levels of lakes to the west of Daihai Lake exceeded those of lakes to the east of Daihai Lake,whereas the opposite trend was observed for lake trophic level.The intensity and mode of anthropogenic activities were the driving factors of the spatial patterns of lake water quality.It is recommended to control the impact of anthropogenic activities on the water quality of lakes in Inner Mongolia to improve lake ecological environment.These findings provide a more thorough understanding of the driving mechanism of the spatial patterns of water quality in lakes of Inner Mongolia,which can be used to develop strategies for lake ecosystem protection and water resources management in this region. | REN Xiaohui YU Ruihong LIU Xinyu SUN Heyang GENG Yue QI Zhen ZHANG Zhuangzhuang LI Xiangwei WANG Jun ZHU Penghang GUO Zhiwei WANG Lixin XU Jifei | 2023 | Journal of Arid Land2023，15，2： | 0 |
| 11 | Greenhouse gas emissions from Daihai Lake,China:Should eutrophication and salinity promote carbon emission dynamics?显示文摘Greenhouse gases(GHGs)emitted or absorbed by lakes are an important component of the global carbon cycle.However,few studies have focused on the GHG dynamics of eutrophic saline lakes,thus preventing a comprehensive understanding of the carbon cycle.Here,we conducted four sampling analyses using a floating chamber in Daihai Lake,a eutrophication saline lake in Inner Mongolia Autonomous Region,China,to explore its carbon dioxide(CO_(2))and methane(CH_(4))emissions.The mean CO_(2)emission flux(FCO_(2))and CH_(4)emission flux(FCH_(4))were 17.54±14.54 mmol/m^(2)/day and 0.50±0.50 mmol/m^(2)/day,respectively.The results indicated that Daihai Lake was a source of CO_(2)and CH_(4),and GHG emissions exhibited temporal variability.The mean CO_(2)partial pressure(p CO_(2))and CH_(4)partial pressure(p CH_(4))were 561.35±109.59μatm and 17.02±13.45μatm,which were supersaturated relative to the atmosphere.The regression and correlation analysis showed that the main influencing factors of p CO_(2)were wind speed,dissolved oxygen(DO),total nitrogen(TN)and Chlorophyll a(Chl.a),whereas the main influencing factors of p CH_(4)were water temperature(WT),Chl.a,nitrate nitrogen(NO_(3)^(-)-N),TN,dissolved organic carbon(DOC)and water depth.Salinity regulated carbon mineralization and organic matter decomposition,and it was an important influencing factor of p CO_(2)and p CH_(4).Additionally,the trophic level index(TLI)significantly increased p CH_(4).Our study elucidated that salinity and eutrophication play an important role in the dynamic changes of GHG emissions.However,research on eutrophic saline lakes needs to be strengthened. | Xiangwei Li Ruihong Yu Jun Wang Heyang Sun Xinyu Liu Xiaohui Ren Shuai Zhuang Zhiwei Guo Xixi Lu | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 12 | Mechanistic investigation of zwitterionic MOF-catalyzed enyne annulation using UNLPF-14-Mn^(Ⅲ) as catalyst显示文摘Hybrid quantum mechanics/molecular mechanics calculations were performed to elucidate how[Mn^(Ⅲ)porphyrin]^(+X−)-based metal-organic frameworks(MOFs)catalyze the[2+1]cycloisomerization of enynes and why zwitterionic MOFs exhibit strong activity in Lewis acid catalysis.The calculations showed that zwitterionic MOFs have a“pure cationic active center”leading to a concerted nucleophilic attack pathway with lower barriers.In contrast,metals with coordinating anions have reduced electrophilicity,resulting in a stepwise radical-type pathway with much higher barriers.Further calculations showed the nature of catalysis was strongly depended on the charge on the anion ligand.A good linear relationship between the NPA charge and barrier was found,and verified by 73 anions with small derivations,which presents a universal adaptive character for various coordinated anions. | Taotao Liu Ruihong Duan Yanyan Wang Shijun Li Lingbo Qu Jinshuai Song Qiang Liu Yu Lan | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 13 | Research on the Innovation of Personalized Education in Colleges and Universities under the Context of Big Data显示文摘The advent of the big data era has opened up unprecedented quantifiable dimensions for all walks of life,while also presented many opportunities and challenges.The widespread application of big data in the field of education will inevitably promote the innovation and transformation of the higher education in colleges and universities which introduce new opportunities and challenges to personalized education in colleges and universities.How to promote the indepth integration of big data and higher education to meet the needs of students’personalized development is one of the hot topics in the theoretical field today.In view of this,this article starts with explaining the connotation of personalized education in colleges and universities,analyzes the opportunities and challenges faced by personalized education in colleges and universities under the context of big data,and proposes the ideas of innovating personalized education in colleges and universities under the context of big data. | Ruihong Yu | 2020 | Journal of Contemporary Educational Research2020，4，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员