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| 1 | Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17显示文摘雌激素涉及支持肺癌症房间分割和转移。云母和 MICB 为 NKG2D 作为 ligands 工作,在生来的杀手(NK ) 上表示的重要 immunoreceptor 房间。然而,雌激素是否调整 MICA/B 表示并且影响肿瘤免疫者逃跑,仍然保持未知。在这研究,我们测量了非小的房间肺癌症(NSCLC ) 房间线与雌激素对待的云母, MICB 和 ADAM17in 的 mRNA 层次。LTEP-a2 和 A549 上的 MICA/B 的表面表示用流动 cytometry 被检测。我们证明 mRNA 和在肺腺癌房间线的 MICA/B 的能分泌的蛋白质层次是由 estradiol 的 upregulated。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。MICA/B downregulated 的这分泌物 NK92 房间的表面上的 NKG2D 受体并且损害了 NK 房间的细胞毒素的活动。Estradiol 提高了 ADAM17 的表示,它与 MICA/B 的分泌物被联系。而且,在 estradiol 和云母的表示的集中之间的重要关联在 NSCLC 病人的肿瘤纸巾被发现。因此,我们断定雌激素能通过 ADAM17 调整 MICA/B 的表示和分泌物,它帮助肺癌症房间逃离调停 NKG2D 的有免疫力的监视。 | Jing Ren Yunzhong Nie Mingming Lv Sunan Shen Ruijing Tang Yujun Xu Yayi Hou Shuli Zhao Tingting Wang | 2015 | Cellular & Molecular Immunology2015，12，6： | 6 |
| 2 | Pyrrolidine dithiocarbamate protects pancreatic β-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats显示文摘Pyrrolidine dithiocarbamate (PDTC ) 罐头降低血葡萄糖水平并且在糖尿病的 rats.However 改进胰岛素敏感,在糖尿病的老鼠位于 PDTC 治疗的这效果下面的机制仍然保持不明确。在这研究,我们 PDTC 与 experimentaltype 在老鼠对胰腺的小岛房间的氧化损坏由授与保护的 evaluatedthe 机制 2 糖尿病 mellitus (DM ) 。在老鼠的 DM 被伴有单个 intraperitoneal (i.p ) 的长期的高脂肪的饮食得到 streptozotocin 的低剂量的注射。在 PDTC (50 mg/kg/day i.p ) 的一个 7 天的政府以后,血 glucoselevels 被测量,胰腺的纸巾为各种各样的生物化学、酶的 activitiesusing immunohistochemistry, immunofluorescence,和西方的污点技术的决心是镇定的。apoptotic 的百分比胰腺的小岛房间被流动 cytometry 检测。结果证明糖尿病的老鼠提高了血葡萄糖层次和 insulinresistance,随 malondialdehyde 内容, nitrotyrosine 生产,和可诱导的氮的 oxidesynthase 表示的增加伴随了。在 superoxide dismutase 和谷胱甘肽 peroxidase 活动的减少也在 DM 老鼠被观察,与提高的房间 apoptosis 达到顶点。PDTC 处理显著地减少了氧化损坏和房间 apoptosis,并且也通过下面调整的 FoxO1 acetylation 和建议的起来调整的原子 PDX-1 level.These 数据增加了胰岛素生产那 PDTC 能保护小岛房间免受氧化损坏的伤害并且在一个 DM 老鼠模型通过 regulationof PDX-1 和 FoxO1 改进胰岛素生产。 | Haiyan Ding Tienian Zhu Xiaomei Yin Jiankun Liu Lizhong Zhang Michel Bemier Ruijing Zhao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 4 |
| 3 | Environmental taxation and regional inequality in China显示文摘In order to combat environmental pollution, China enacted the Environmental Protection Tax Law in early 2018. Yet the impacts of the environmental tax on individual regions with different socioeconomic statuses, which are crucial for social justice and public acceptance, remain unclear. Based on a MultiRegional Input-Output(MRIO) table and a nationally regulated tax payment calculation method, this study analyzes the distributional impacts of an environmental tax based upon province’s consumption from both inter-provincial and rural-urban aspects. The national tax revenue based on the current levy mechanism is estimated to be only one seventh of the economic loss from premature mortality caused by ambient particulate matter(PM2.5). The taxation may slightly alleviate urban-rural inequality but may not be helpful with reducing inter-provincial inequality. We further analyze two alternative levy mechanisms. If each province imposes taxes to products it consumes(rather than produces, as in the current mechanism), with the tax rate linearly dependent on its per capita consumption expenditure, this would moderately increase the national tax revenue and significantly reduce inter-provincial inequality.To better compensate for the economic costs of air pollution and reduce regional inequality, it would be beneficial to increase the tax rate nationwide and implement a levy mechanism based on provincially differentiated levels of consumption and economic status. | Jingxu Wang Jintai Lin Kuishuang Feng Peng Liu Mingxi Du Ruijing Ni Lulu Chen Hao Kong Hongjian Weng Mengyao Liu Giovanni Baiocchi Yu Zhao Zhifu Mi Jing Cao Klaus Hubacek | 2019 | Science Bulletin2019，64，22： | 3 |
| 4 | FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR显示文摘Filamin A (FLNa ) 是无所不在地表示的细胞质的蛋白质,它 24 次象 Ig 一样重复跟随的一个 N 终端肌动朊绑定领域(ABD ) 创作。FLNa 作为连接 transmembrane 受体的细胞骨架蛋白质工作,包括 integrins,到 F 肌动朊并且用作发信号的中介。最近的研究作为与超过 90 蛋白质交往并且在细胞的发信号的 transduction 起重要作用的支架蛋白质识别了 FLNa。在人的 FLNa 基因的变化或缺点被显示了引起众多的发展缺点。而且, FLNa 的异常表示在许多癌症被观察了例如甲状旁腺的肿瘤,颈的癌症,和乳癌。然而,它在肺腺癌的角色很少被讨论了。在现在的学习,我们的在里面 vitro 并且在 vivo,研究证明在肺癌症房间线 A549 房间的那 silencing FLNa 表情由提高表皮的生长因素受体和英皇家空军之阶级最低之兵发信号小径的激活支持了 A549 房间的增长,移植,和侵略。这些结果在肺癌症和揭开的新奇机制使 FLNa 的新奇功能清楚些,这些结果为肺腺癌为预言和治疗提供了可能的目标。 | Yuna Zhang Tienian Zhu Jingpu Liu Jiankun Liu Dongmei Gao Tongyi Su Ruijing Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 5 | The effect ofcalcium on the treatment of fresh leachate in an expanded granularsludge bed bioreactor 显示文摘 | Liu Jianyong Hu Jun Zhong Jiangping Luo Jinghuan Zhao Aihua Liu Feng Hong Ruijing Qian Guangren Xu Zhiping | 2011 | Bioresource Technology2011，102，： | 1 |
| 6 | 3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α显示文摘 | Lijie Ma Yilin Zhao Beixi Li Qingwei Wang Xueying Liu Xiangjun Chen Yandong Nan Li Liang Ruijing Chang Lifeng Liang Peipei Li Faguang Jin | 2013 | Respiratory Physiology & Neurobiology2013，，3： | 1 |
| 7 | Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer显示文摘Circularly permuted TRAIL(CPT),a novel recombinant TRAIL mutant,is a potent antitumor agent.However,its efficacy in triple-negative breast cancer(TNBC)remains unclear.Treatment with CPT alone and in combination with doxorubicin(Dox)is explored for its effects on the proliferation and apoptosis of MDA-MB-231(MB231)and MDAMB-436(MB436)breast cancer cells in vitro and in vivo.Here,we show that CPT combined with Dox exhibits timeand dose-dependent synergy to inhibit cell viability and enhance apoptosis of MB231 and MB436 cells.Combined treatment substantially increases caspase-8,caspase-3,and PARP cleavage in both cell lines and significantly suppresses tumor growth in nude mice bearing MB231 xenografts.Collectively,our findings demonstrate that treatment with CPT in combination with Dox exerts synergistic antitumor effects through activation of the caspase cascade pathway,a mechanism that is partly dependent on the Dox-induced upregulation of death receptor 4 and death receptor 5.Therefore,CPT combined with Dox may be a feasible therapeutic strategy for the management of TNBC. | Jia Liu Tienian Zhu Jiankun Liu Yujie Cui Shifang Yang Ruijing Zhao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 8 | In situ kinetics and flocs conformation studies of kaolinite flocculated by Chi-g-CPAM显示文摘This study presents a comparative study of the flocculation behavior of kaolinite induced by chitosan-graft-poly(acrylamide-dimethyl diallyl ammonium chloride)(Chi-g-CPAM) and a commercial cationic polyacrylamide(CPAM).The flocculation behaviour was characterised in terms of both flocculation kinetics and the corresponding morphology changes during flocculation.Both Chi-g-CPAM and CPAM were grafted from silica wafers by means of atom transfer radical polymerization(ATRP).The quartz crystal microbalance with dissipation(QCM-D) tests were conducted.The equilibrium time flocculated by Chi-g-CPAM was found to be 0.46 times as that of CPAM,together with a larger total mass of kaolinite layer.The flocculation behaviour by Chi-g-CPAM can be well captured by a pseudo-first-order model.In contrast,the presence of CPAM leads to a more complex kinetics.A relatively larger fitting slope(0.4663) was obtained at the initial stage but the fitting slope droped to 0.2026 after 800 min,indicating a densification process caused by CPAM.The flocculation kinetics of CPAM can be captured by the Elovich model for the inital stage but the combination of pseudo-first-order and pseudo-second-order models for the latter stages,which can be attributed to the long chain of CPAM.With a dosage of 75 g/t,the settling test with Chi-g-CPAM exhibits the same turbidity in the supernatant but a smaller layer thickness of the settlement compared to CPAM.The study enables a better understanding of the flocculation behavior and contributes to the development of efficient flocculants in mineral processing and tailings treatment. | Ruijing Xu Wenjie Zou Bo Rao Wei Zhao Ting Wang Zhijun Zhang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，5： | 0 |
| 9 | Clinical case discussions-Hypopituitarism and pituitary apoplexy caused by pituitary Adenomas显示文摘A case of“Hypopituitarism and pituitary apoplex induced by pituitary Adenomas”was collected in the Third Affiliated Hospital of Inner Mongolia medical University Geriatric Department.A rare and atypical disease as it is,delayed diagnosis and treatment is easily seen among those cases.Therefore,the paper aims to investigate the difference of clinical characteristics and treatment outcome of pituitary adenomas in elder patient through the case analysis.Clinically,patients with pituitary dysfunction may have life-threatening crisis so that timely diagnosis and aggressive treatment can be effective in reducing the pituitary crisis and reducing the misdiagnosis rate. | Gaisheng Tian Qinxue Li Dan Zhao Ying Wang Ruijing Yan | 2015 | Discussion of Clinical Cases2015，2，1： | 0 |
| 10 | Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders显示文摘Mutations of the X-linked methyl-CpG-binding protein 2(MECP2)gene in humans are responsible for most cases of Rett syndrome(RTT),an X-linked progressive neurological disorder.While genome-wide screens in clinical trials have revealed several putative RTT-associ-ated mutations in MECP2,their causal relevance regarding the functional regulation of MeCP2 at the etiologic sites at the protein level requires more evidence.In this study,we demonstrated that MeCP2 was dynamically modified by O-linked-P-N-acetylglucosamine(O-GlcNAc)at threonine 203(T203),an etiologic site in RTT patients.Disruption of the O-GlcNAcylation of MeCP2 specifically at T203 impaired dendrite development and spine maturation in cultured hippocampal neurons,and disrupted neuronal migration,dendritic spine morphogenesis,and caused dysfunction of synaptic transmission in the developing and juvenile mouse cerebral cortex.Mechanistically,genetic disruption of O-GlcNAcylation at T203 on MeCP2 decreased the neuronal activity-induced induction of Bdnf transcription.Our study highlights the critical role of MeCP2 T203 O-GlcNAcylation in neural development and synaptic transmission potentially via brain-derived neurotrophic factor. | Juanxian Cheng Zhe Zhao Liping Chen Ying Li Ruijing Du Yan Wu Qian Zhu Ming Fan Xiaotao Duan Haitao Wu | 2022 | Neuroscience Bulletin2022，38，2： | 0 |
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