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| 1 | 全新世长江泥沙堆积的时空分布及通量估算显示文摘利用长江中下游、河口及口外、浙-闽沿岸陆架6个主要沉积盆地的40个晚第四纪钻孔及其年代学数据和长江口外、陆架的浅地层剖面,计算了全新世不同阶段各沉积盆地的沉积速率,并进行了近7 000年来泥沙堆积通量的估算.研究发现全新世早期距今10 000年至8 000年间长江口下切古河谷是长江泥沙的主要堆积中心,沉积速率可高达15 m/ka.随着海平面上升,全新世中期长江中下游也成为长江泥沙的重要沉积盆地,其中江汉盆地的沉积速率可达10 m/ka.近2 000年来,口外、陆架的堆积呈明显增加趋势,反映长江中下游盆地和河口可容空间日益减小.根据沉积速率估算,距今7 000年来长江中下游堆积泥沙约13 074×10^8t,同期水下三角洲和陆架的泥沙堆积量约为9 470×10^8 t.研究还发现全新世以来有两个异常低沉积速率时期:距今8 000-7 000年期间上述各沉积盆地沉积速率均显著低,未见长江泥沙的沉积中心;距今4 000-2 000年期间长江口呈现低沉积速率.这两次异常的原因推测与海平面、气候波动事件密切相关. | 王张华 Jingpu Paul Liu 赵宝成 | 2007 | 古地理学报2007，9，4： | 9 |
| 2 | Cloned goats (Gapra hircus) from foetal fibroblast cell lines显示文摘Mammalian cloning has been one of the most active research topics in the world. Cioning with in vitro culured foetal fibroblast cells, in comparison with embryonic cells, can be used not only to theoretically study the embryonic or cellular development and differentiation in mammals, but also to utilize the unlimited fibroblast cells to produce large numbers of clonings. The preliminary results are as follows: (i) The division and development of the cloned embryos with embryonic donor cells and goat foetal fibroblast donor cells were 55%, 77% and 35%, 31%, respectively. There is no significant statistical difference between them. (? These studies result in the birth of two cloned goats derived from two 30-day foetal fibroblast celi lines, which are the first cloned mammals from somatic cells in China. This project has established a technological data base for the furture research on adult mammalian somatic cloning and nucleocytoplasmic interactions in animal development, and a novel technique for the | WANG Yuge ZOU Xiangang LIU Jie ZHANG Jingpu ZHANG Xuechen LAO Weide DU Miao CHENG Guoxing CHENG Yong CHEN Jianquan ZHANG Suolin XU Shaofu | 2000 | Chinese Science Bulletin2000，45，1： | 4 |
| 3 | Application of a new wind driving force model in soil wind erosion area of northern China显示文摘The shear stress generated by the wind on the land surface is the driving force that results in the wind erosion of the soil.It is an independent factor influencing soil wind erosion.The factors related to wind erosivity,known as submodels,mainly include the weather factor(WF)in revised wind erosion equation(RWEQ),the erosion submodel(ES)in wind erosion prediction system(WEPS),as well as the drift potential(DP)in wind energy environmental assessment.However,the essential factors of WF and ES contain wind,soil characteristics and surface coverings,which therefore results in the interdependence between WF or ES and other factors(e.g.,soil erodible factor)in soil erosion models.Considering that DP is a relative indicator of the wind energy environment and does not have the value of expressing wind to induce shear stress on the surface.Therefore,a new factor is needed to express accurately wind erosivity.Based on the theoretical basis that the soil loss by wind erosion(Q)is proportional to the shear stress of the wind on the soil surface,a new model of wind driving force(WDF)was established,which expresses the potential capacity of wind to drive soil mass in per unit area and a period of time.Through the calculations in the typical area,the WDF,WF and DP are compared and analyzed from the theoretical basis,construction goal,problem-solving ability and typical area application;the spatial distribution of soil wind erosion intensity was concurrently compared with the spatial distributions of the WDF,WF and DP values in the typical area.The results indicate that the WDF is better to reflect the potential capacity of wind erosivity than WF and DP,and that the WDF model is a good model with universal applicability and can be logically incorporated into the soil wind erosion models. | ZOU Xueyong LI Huiru LIU Wei WANG Jingpu CHENG Hong WU Xiaoxu ZHANG Chunlai KANG Liqiang | 2020 | Journal of Arid Land2020，12，3： | 2 |
| 4 | Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer显示文摘How to trigger strong anti-tumor immune responses has become a focus for tumor therapy.Here,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced immunotherapy.Ce6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes.The iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in tumor.Upon PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were activated.Meanwhile,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor.Human iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect. | Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 5 | FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR显示文摘Filamin A (FLNa ) 是无所不在地表示的细胞质的蛋白质,它 24 次象 Ig 一样重复跟随的一个 N 终端肌动朊绑定领域(ABD ) 创作。FLNa 作为连接 transmembrane 受体的细胞骨架蛋白质工作,包括 integrins,到 F 肌动朊并且用作发信号的中介。最近的研究作为与超过 90 蛋白质交往并且在细胞的发信号的 transduction 起重要作用的支架蛋白质识别了 FLNa。在人的 FLNa 基因的变化或缺点被显示了引起众多的发展缺点。而且, FLNa 的异常表示在许多癌症被观察了例如甲状旁腺的肿瘤,颈的癌症,和乳癌。然而,它在肺腺癌的角色很少被讨论了。在现在的学习,我们的在里面 vitro 并且在 vivo,研究证明在肺癌症房间线 A549 房间的那 silencing FLNa 表情由提高表皮的生长因素受体和英皇家空军之阶级最低之兵发信号小径的激活支持了 A549 房间的增长,移植,和侵略。这些结果在肺癌症和揭开的新奇机制使 FLNa 的新奇功能清楚些,这些结果为肺腺癌为预言和治疗提供了可能的目标。 | Yuna Zhang Tienian Zhu Jingpu Liu Jiankun Liu Dongmei Gao Tongyi Su Ruijing Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 6 | Holocene devel opment of the Yellow River's subaqueous delta, North Yellow Sea 显示文摘 | LIU Jingpu Milliman J D GAO Shu | 2004 | Marine Geology2004，209，14： | 1 |
| 7 | Holocene develop- ment of the Yellow River's subaqueous delta, North Yellow Sea显示文摘 | LIU Jingpu Milliman GAO Shu el al | 2004 | Marine Geology2004，209，： | 1 |
| 8 | Desertification and Blown Sand Disaster in China显示文摘 | Yanli Lyu Yanyan Yang Lanlan Guo Lianyou Liu Peijun Shi Guoming Zhang Zhiqiang Qu Xia Hu Jingpu Wang Yiying Xiong Haiming Wen Jie Lei Bo Liang Jiadong Dai | 2016 | Journal of Agricultural Science and Technology(A)2016，6，6： | 1 |
| 9 | Clinical Implications of BMI-1 in Cancer Stem Cells of Laryngeal Carcinoma显示文摘 | Dan Yu Yan Liu Jingpu Yang Chunshun Jin Xue Zhao Jinzhang Cheng Xueshibojie Liu Xinmeng Qi | 2015 | Cell Biochemistry and Biophysics2015，，1： | 1 |
| 10 | Sedimentary features of the Yangtze River-derived along-shelf elinoform deposit in the East China Sea显示文摘 | Liu Jingpu Li Anchun Xu Kehui | 2006 | Continental Shelf Research2006，26，： | 1 |
| 11 | Holocene develop-ment of the Yellow River’s subaqueous delta,North YellowSea显示文摘 | LIU Jingpu Milliman GAO Shu | 2004 | Marine Geology2004，209，： | 1 |
| 12 | A unique Yellow River-de-rived distal subaqueous delta in the Yellow Sea显示文摘 | YANG Zuosheng LIU Jingpu | 2007 | MarineGeology2007，240，： | 1 |
| 13 | A unique Yellow River-derived distal subaqueous delta in the Yellow Sea显示文摘 | Yang Zuosheng Liu Jingpu | 2007 | Marine Geology2007，240，14： | 1 |
| 14 | Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs显示文摘A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria.Compound 33a(IMBZ18G)is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant(MDR)Gram-negative strains,with a highly druglike nature.The checkerboard assay reveals its significant synergistic effect withβ-lactamase inhibitor avibactam,and the MIC values against MDR enterobacteria were reduced up to 4—512folds.X-ray co-crystal and chemoproteomic assays indicate that the anti-MDR bacteria effect of 33a results from the dual inhibition of the common PBP3 and some class A and Cβ-lactamases.Accordingly,preclinical studies of 33a alone and 33a-avibactam combination as potential innovative candidates are actively going on,in the treatment ofβ-lactamase-producing MDR Gram-negative bacterial infections. | Zhiwen Li Zhihao Guo Xi Lu Xican Ma Xiukun Wang Rui Zhang Xinxin Hu Yanxiang Wang Jing Pang Tianyun Fan Yonghua Liu Sheng Tang Haigen Fu Jingpu Zhang Yinghong Li Xuefu You Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
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