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| 1 | Radial Grip Rigidity of the Matching of Lengthened Shrink-fit Holder and Cutter in High-speed Milling显示文摘Though the lengthened shrink-fit holder (LSFH) is widely applied in high speed milling of the parts characterized by deep cavities at present,its design and selection mainly depends on the experience and lacks a correct theoretical guidance.In this paper,attention is focus on the radial grip rigidity of the matching of LSFH and cutter in high speed milling.Based on the experiment modal analysis (EMA) technique,an accurate finite element model of the matching of LSFH and cutter is established firstly.Subsequently,the influence of different interference,grip length and spindle speed on the grip rigidity of LSFH are analyzed.The analysis results show that there is a reasonable interference and grip length between the LSFH and cutter so that to have a steepless grip and have a good radial grip rigidity and at the same time to avoid the strength of LSFH to exceed it’s yield limit which will reduce the precision and service life of LSFH,besides when spindle speed reach a extension the weakening influence of the centrifugal force on the radial grip rigidity of the matching of LSFH and cutter should been taken into account.Finally,the finite element analysis results are verified based on the construction of measurement method of the grip rigidity and the results fit very well.The studies provide a theoretical basis for the design,selection and the serialization and standardization of the matching of LSFH and cutter. | ZHOU Houming WANG Chengyong DENG Jianxin PENG Ruitao | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 5 |
| 2 | Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy显示文摘Here,we describe a combination strategy of black phosphorus(BP)-based photothermal therapy together with anti-CD47 antibody(aCD47)-based immunotherapy to synergistically enhance cancer treatment.Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance,along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment,remains a significant challenge for cancer immunotherapy.aCD47,an agent for CD47/SIRPαaxis blockade,induces modest phagocytic activity and a low response rate for monotherapy,resulting in failures in clinical trials.We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation,improving the inherently poor immunogenicity of tumours,which is particularly useful for enhancing cancer immunotherapy.BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses,thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers.Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy. | Zhongjian Xie Minhua Peng Ruitao Lu Xiangying Meng Weiyuan Liang Zhongjun Li Meng Qiu Bin Zhang Guohui Nie Ni Xie Han Zhang Paras N.Prasad | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 3 | Notch Effect of Materials: Strengthening or Weakening?显示文摘Notch is a very important geometry with widespread applications in engineering structural components. Finding a universal equation to predict the effect of notch on strength of materials is of much significance for structural design and materials selection. In the present work, we tried to find this universal equation from experimental results of metallic glasses(MGs) and other materials as well as theoretical derivations based on a universal fracture criterion(Qu and Zhang, Sci. Rep. 3(2013) 1117). Experimental results showed that the notch effect of the studied MG was affected by the notch geometry characterized by the stress concentration factor Kt.As Ktbecomes smaller, the notch strength ratio(NSR, which is the ratio of nominal ultimate tensile strength(UTS) of the notched sample to UTS of the unnotched sample) increases. By comparing MGs with other materials like brittle ceramics and ductile crystalline metals, we find that when Ktis same, the NSR is larger for ductile metals but smaller for brittle ceramics. Theoretically, we derived a universal equation for notch effect on strength of materials: NSR ? M/Kt, where M is a constant related to materials. This universal equation was found to be consistent with the experimental results. | Ruitao Qu Peng Zhang Zhefeng Zhang | 2014 | Journal of Materials Science & Technology2014，30，6： | 3 |
| 4 | Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons显示文摘在前脑的视下丘表明小径的 Leptin 受体(LepRb ) 响应一个改变的精力状态控制食物吸入和精力开销。在表明小径的 LepRb 的缺点能导致 leptin 抵抗和肥胖。象 1 一样的白氨酸拉链抄写因素(Lztfl1 )/BBS17 是 Bardet-Biedl 症候群(BBS ) 的一个成员基因家庭。人的 BBS 病人包括肥胖有大量病理。位于调整 Lztfl1 的肥胖下面的细胞、分子的机制是未知的。这里,我们产生了 Lztfl1 Lztfl1 能全球性并且以织物特定的方式在被删除的 f/f 老鼠模型。全球 Lztfl1 缺乏包括肥胖导致了多种的显型。Lztfl1 / 老鼠是 hyperphagic 并且作为 WT 同窝出生的人显示出类似的精力开销。Lztfl1 / 老鼠的肥胖的显型被 Lztfl1 的损失在大脑然而并非在 adipocytes 引起。Lztfl1 / 老鼠是 leptin 抵抗的。Lztfl1 的 Inactivation 在在 leptin 刺激之上在视下丘表明小径的 LepRb 废除了 Stat3 的 phosphorylation。Lztfl1 的删除没在 LepRb 膜本地化上有效果。而且,我们观察了胚胎的成纤维细胞(MEF ) 有的那只 Lztfl1 / 老鼠显著地更长的睫比 WT MEF。我们识别了潜在地与 Lztfl1 交往的几蛋白质。当这些蛋白质被知道涉及肌动朊 / 细胞骨架动力学的规定,我们建议 Lztfl1 可以调整 leptin 经由这些蛋白质发信号和睫的结构。我们的学习在在控制精力动态平衡的视下丘表明小径的 LepRb 作为一个新奇播放器识别了 Lztfl1。 | Qun Wei Yi-Feng Gu Qing-Jun Zhang Helena Yu Yan Peng Kevin W. Williams Ruitao Wang Kajiang Yu Tiemin Liu Zhi-Ping Liu | 2018 | Journal of Molecular Cell Biology2018，10，5： | 1 |
| 5 | An internal cooling grinding wheel:From design to application显示文摘The cooling and lubrication conditions during the grinding process significantly impact the nickel-based superalloy’s final service performance.The existing jet cooling and heat pipe technology can solve the heat conduction problem in the grinding process of superalloy.Still,managing cooling,lubrication,and chip removal are difficult.This paper describes the design and fabrication of a novel central fluid-through internal cooling slotted grinding wheel with an ordered grain pattern to improve the grinding machinability of a nickel-based superalloy.The pressurized grinding fluid was ejected into the grinding zone via the pipe and tool holder from the lower-end face of the inner cooling wheel.The structure of the grinding wheel was optimized using computational fluid dynamics(CFD).The flow field in the grinding area achieved the highest overall flow rate,distribution homogeneity,and effective exit flow when the internal flow channel had four throughholes.The exit for the inner runner is located at the abrasive edge and diamond staggered pattern.Single-layer brazing was used to create cubic boron nitride(CBN)abrasive rings with various abrasive patterns.The internal cooling wheel matrix and various components were prepared according to the optimized grinding wheel geometry model.A grinding test bench was built to conduct an experimental study of grinding the nickel-based alloy GH4169.The results show that,under the same conditions,a diamond-shaped staggered pattern obtains lower grinding temperature,lower surface roughness,better surface morphology,and more significant residual compressive stress distribution than an abrasive cluster diagonal circular staggered pattern or disordered pattern.The average effective flow rate calculated by CFD is increased by 42.3%when compared to the disordered pattern.In the experiment,compared to the disordered arrangement,with the increase of grinding wheel’s rotating speed and coolant pressure,the average grinding temperature of abrasive grain with diamond-interleaved arrangement decreases by 58.2%and 51.7%respectively,and its surface hardening degree decreases by 11.1%and 11.7%respectively. | Xiangwu XIAO Yufeng JIN Meiliang CHEN Ruitao PENG Heng TANG Jiangxiong GAO | 2023 | Chinese Journal of Aeronautics2023，36，11： | 1 |
| 6 | Fabrication and boiling heat transfer characterization of multiscale microgroove surfaces显示文摘Microstructural functional surfaces play an important role in energy conversion applications including power generation,air conditioning,and thermal management of electronics through the boiling process.In this study,multi-scale microgroove surfaces were fabricated by the combination of wire electrical discharge machining(WEDM)and electrical discharge shaped machining(EDSM)to achieve a better boiling performance.The WEDM,with the advantage of high efficiency,was used to fabricate the first microgroove array,and rougher surfaces were formed by intense discharge.A wavy electrode was used in EDSM to fabricate the second microgroove array.Reentrant cavities at the intersections of microgrooves and rougher micro fins with spacing distribution were formed after EDSM.The boiling performance of the multi-scale microgroove surface was studied with water as the working medium under atmospheric pressure.The results indicated that the boiling performance of the microgroove surface is significantly enhanced.The critical heat flux and maximum heat transfer coefficient of microgroove surface were higher than the surfaces fabricated only by WEDM or EDSM,which were 2.34 and 3.29 times that of smooth copper plate,respectively.This study demonstrated that the combination of WEDM and EDSM is a convenient and effective method to fabricate high-performance microgroove boiling surfaces. | TANG Heng GUO Bin TANG Yong WU XiaoYu PENG RuiTao SUN YaLong | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 7 | QTL detection and candidate gene analysis of grape white rot resistance by interspecific grape (Vitis vinifera L. × Vitis davidii Foex.) crossing显示文摘Grape white rot,a devastating disease of grapevines caused by Coniella diplodiella(Speg.)Sacc.,leads to significant yield losses in grape.Breeding grape cultivars resistant to white rot is essential to reduce the regular use of chemical treatments.In recent years,Chinese grape species have gained more attention for grape breeding due to their high tolerance to various biotic and abiotic factors along with changing climatic conditions.In this study,we employed whole-genome resequencing(WGR)to genotype the parents of‘Manicure Finger’(Vitis vinifera,female)and‘0940’(Vitis davidii,male),along with 101 F1 mapping population individuals,thereby constructing a linkage genetic map.The linkage map contained 9337 single-nucleotide polymorphism(SNP)markers with an average marker distance of 0.3 cM.After 3 years of phenotypic evaluation of the progeny for white rot resistance,we confirmed one stable quantitative trait locus(QTL)for white rot resistance on chromosome 3,explaining up to 17.9%of the phenotypic variation.For this locus,we used RNA-seq to detect candidate gene expression and identified PR1 as a candidate gene involved in white rot resistance.Finally,we demonstrated that recombinant PR1 protein could inhibit the growth of C.diplodiella and that overexpression of PR1 in susceptible V.vinifera increased grape resistance to the pathogen. | Peng Li Xibei Tan Ruitao Liu Faiz Ur Rahman Jianfu Jiang Lei Sun Xiucai Fan Jihong Liu Chonghuai Liu Ying Zhang | 2023 | Horticulture Research2023，10，5： | 0 |
| 8 | Identification of the Discrete Element Model Parameters for Rock-Like Brittle Materials显示文摘An inverse method for parameters identification of discrete element model combined with experiment is proposed.The inverse problem of parameter identification is transmitted to solve an optimization problem by minimizing the distance between the numerical calculations and experiment responses.In this method,the discrete element method is employed as numerical calculator for the forward problem.Then,the orthogonal experiment design with range analysis was used to carry out parameters sensitivity analysis.In addition,to improve the computational efficiency,the approximate model technique is used to replace the actual computational model.The intergeneration projection genetic algorithm(IP-GA)is employed as the optimization algorithm.Consequently,the parameters of the discrete element model are determined.To verify the effectiveness and accuracy of the inverse results,the comparisons of shape deviation experiments with discrete element simulations are provided.It indicates that the effective and reliable discrete element model parameters can be quickly obtained through several sets of experimental data.Hence,this inverse method can be applied more widely to determine the parameters of discrete element model for other materials. | Rui Chen Yong Wang Ruitao Peng Shengqiang Jiang Congfang Hu Ziheng Zhao | 2020 | Computer Modeling in Engineering & Sciences2020，，5： | 0 |
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