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| 1 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 2 | Application of autocorrelation method on ionospheric short--term forecasting in China显示文摘Adopting the autocorrelation method in the ionospheric short-term forecasting, we put for- ward a simple and practical forecasting method― the sectional autocorrelation method, that is, for pre- dictions of one hour to four hours ahead the auto- correlation coefficient of RDF with the “iteration” method is selected, for prediction of more than four hours ahead, the autocorrelation coefficient of f0F2 with the “at once” method is used. The prediction precisions have been quantitatively estimated based on the data from Chongqing and Guangzhou Ionos- onde Stations. It is shown that the method is much improved for the predictions of one hour to four hours ahead. For the predictions of more than four hours ahead the prediction error reaches a saturation value, which is still lower than that of the “median” method. This new method could also be applied to the short-term forecasting of other ionospheric parame- ters. | LIU Ruiyuan LIU Shunlin XU Zhonghua WU Jian WANG Xianyi ZHANG Beichen HU Hongqiao | 2006 | Chinese Science Bulletin2006，51，3： | 17 |
| 3 | SuperDARN CUTLASS Finland radar observations of high-latitude magnetic reconnections under northward interplanetary magnetic field (IMF) conditions显示文摘A number of backscatter power enhancement events with 'equatorward-moving radar auroral forms' in the high-latitude ionosphere were observed by SuperDARN CUTLASS Finland radar when the IMF was northward during 09:00 -10:00 UT on 26 March 2004. These events were also associated with sunward flow enhancements at each location in the Northern Hemisphere which were shown in ionospheric convections measured by the SuperDARN radars. These are typical features of high-latitude (lobe) magnetic reconnections. The durations of the velocity enhancements imply that the evolution time of the lobe reconnections is about 8-16 min from their origin at the reconnection site to their addition to the magnetotail lobe again. In additional, the Double Star TC-1 spacecraft was moving from magnetosheath into magnetosphere, and crossing the magnetopause near the subsolar region during this interval, and observed typical low-latitude magnetic reconnection signatures. This infers that the dayside high- and low-latitude reconnections may occur simultaneously. | ZHANG QingHe LIU RuiYuan YANG HuiGen HU HongQiao ZHANG BeiChen DUNLOP Malcolm LESTER Mark BOGDANOVA Yulia WALSH Andrew | 2012 | Science China(Technological Sciences)2012，55，5： | 5 |
| 4 | Perfection of Perovskite Grain Boundary Passivation by Rhodium Incorporation for Efficient and Stable Solar Cells显示文摘Organic cation and halide anion defects are omnipresent in the perovskite films,which will destroy perovskite electronic structure and downgrade the properties of devices.Defect passivation in halide perovskites is crucial to the application of solar cells.Herein,tiny amounts of trivalent rhodium ion incorporation can help the nucleation of perovskite grain and passivate the defects in the grain boundaries,which can improve efficiency and stability of perovskite solar cells.Through first-principle calculations,rhodium ion incorporation into the perovskite structure can induce ordered arrangement and tune bandgap.In experiment,rhodium ion incorporation with perovskite can contribute to preparing larger crystalline and uniform film,reducing trap-state density and enlarging charge carrier lifetime.After optimizing the content of 1% rhodium,the devices achieved an efficiency up to 20.71% without obvious hysteresis,from 19.09% of that pristine perovskite.In addition,the unencapsulated solar cells maintain 92% of its initial efficiency after 500 h in dry air.This work highlights the advantages of trivalent rhodium ion incorporation in the characteristics of perovskite solar cells,which will promote the future industrial application. | Wei Liu Nanjing Liu Shilei Ji Hongfeng Hua Yuhui Ma Ruiyuan Hu Jian Zhang Liang Chu Xing’ao Li Wei Huang | 2020 | Nano-Micro Letters2020，12，9： | 4 |
| 5 | Statistical characteristics of ionospheric backscatter observed by SuperDARN Zhongshan radar in Antarctica显示文摘Zhongshan HF radar, as one component of SuperDARN, has been established and in operation since April, 2010. Using data from the first two years of its operation, this paper investigates the radar's performance, the diurnal and seasonal variations of ionospheric echoes, and their dependence on geomagnetic activity. Statistical studies show that the occurrence of echoes in different beams varies at different frequencies, which arises from the direction of the beam and the area over which the beam can achieve the orthogonality condition between the wave vector and the Earth's magnetic field. The diurnal variation is obvious with double peak structures both in the occurrence rate and average power at 04-08 UT and 16-17 UT. The line-of-sight velocities are mainly positive on the dayside and negative on the nightside for Beam 0, which is the opposite of the trend for Beam 15. The spectral widths on the dayside are often higher than those on the nightside owing to the high energy particle precipitation in the cusp region. The seasonal variations are more obvious for those beams with larger numbers. The occurrence, the average power, the line-of-sight velocity, and the spectral widths are generally larger in the winter months than in the summer months. The influence of geomagnetic activity on radar echoes is significant. The peak echo occurrence appears on the dayside during geomagnetically quiet times, and shifts toward the nightside and exhibits an obvious decrease with increasing Kp. With increasing geomagnetic activity, the line-of-sight velocities increase, whereas the spectral widths decrease. The frequency dependence is investigated and it is found that in the operating frequency bands in 2010, 9-10 MHz is the most appropriate band for the SuperDARN Zhongshan radar. | HU Hongqiao LIU Erxiao LIU Ruiyuan YANG Huigen ZHANG Beichen | 2013 | Advances in Polar Science2013，24，1： | 4 |
| 6 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 7 | A new technique for deriving the quiet day curve from imaging riometer data at Zhongshan Station, Antarctic显示文摘A new technique for estimating quiet day curve(QDC)was suggested.To validate the new approach,QDCs were derived from data acquired by the imaging riometer installed at the Chinese Zhongshan Station in Antarctic.The evaluation was performed by comparing the difference between QDC derived by the new technique and those derived by Tanaka’s technique.The results were discussed in terms of the diurnal variation and discrepancy.Also,cosmic noise absorption(CNA)images were built using both techniques in order to evaluate the implications of the changes when obtaining them using different methods of the QDC determination.The influence of the multiplicative factor value on the QDC determination in Tanaka’s technique was evaluated. | HE Fang HU HongQiao HU ZeJun LIU RuiYuan | 2014 | Science China(Technological Sciences)2014，57，10： | 2 |
| 8 | Evaluation of the Occurrence Possibility of SNP in Brassica napus with Sliding Window Features by Using RBF Networks显示文摘We extract some physical and chemical features re-lated to the occurrence of single nucleotide polymorphism (SNP) from three groups of sliding windows around SNP site,and then make the predictions about accuracy by using radial basis function (RBF) networks. The result of the forward sliding windows sug-gests that the accuracies and Matthews correlation coefficient (MCC values) ascend with the increasing of length of sliding windows. The accuracies range from 73.27 % to 80.69 %,and MCC values range from 0.465 to 0.614. The backward sliding windows and the sliding windows with fixed length three are de-signed to find the crucial sites related to SNP. The results imply that the occurrence possibility of SNP relies heavily on the above physical and chemical features of sites which are at a distance around 20 bases from the SNP site. Compared with the support vector machine (SVM),our RBF network approach has achieved more satisfactory results. | HU Xuehai LI Ruiyuan 2ENG Jinling XIONG Huijuan XIA Jingbo LI Zhi | 2011 | Wuhan University Journal of Natural Sciences2011，16，1： | 2 |
| 9 | Work function engineering to enhance open-circuit voltage in planar perovskite solar cells by g-C_(3)N_(4) nanosheets显示文摘Enhancement of open-circuit voltage(Voc)is an effective way to improve power conversion efficiency(PCE)of the perovskite solar cells(PSCs).Theoretically,work function engineering of TiO2 electron transport layer can reduce both the loss of Voc and current hysteresis in PSCs.In this work,two-dimensional g-C_(3)N_(4) nanosheets were adopted to modify the compact TiO2 layers in planar PSCs,which can finely tune the work function(WF)and further improve the energy level alignment at the interface to enhance the Voc and diminish the hysteresis.Meanwhile,the quality of perovskite films and charge transfer of the devices were improved by g-C_(3)N_(4) nanosheets.Therefore,the PCE of the planar PSCs was champed to 19.55%without obvious hysteresis compared with the initial 15.81%,mainly owing to the remarkable improvement of VOC from 1.01 to 1.11 V.In addition,the stability of the devices was obviously improved.The results demonstrate an effective strategy of W_(F) engineering to enhance Voc and diminish hysteresis phenomenon for improving the performance of PSCs. | Jian Yang Liang Chu Ruiyuan Hu Wei Liu Nanjing Liu Yuhui Ma Waqar Ahmad Xing’ao Li | 2021 | Nano Research2021，14，7： | 1 |
| 10 | Novel photoelectric material of perovskite-like(CH_(3))_(3)SPbI_(3) nanorod arrays with high stability显示文摘Organometallic halide perovskite materials make great achievements in optoelectronic fields,especially in solar cells,in which the organic cations contain amine components.However,the amine with NàH bonds is easily hydrolyzed with moisture in the air,weakening the perovskite materials stability.It is desirable to develop other non-amine stable perovskite materials.In this work,sulfur-based perovskite-like(CH_(3))_(3)SPbI_(3) nanorod arrays were fabricated by a solution-processed method,which can be indexed hexagonal crystal structure in the space group P63 mc.The binding force is exceptionally strong between the non-amine(CH_(3))_(3) S+and[PbI_(6)]_(4)-octahedral,leading to high stability of(CH_(3))_(3)SPbI_(3).The(CH_(3))_(3)SPbI_(3) nanorod arrays can keep the morphology and crystal structure in an ambient atmosphere over 60 days.In addition,the(CH_(3))_(3)SPbI_(3) nanorod arrays can offer direct charge transfer channels,which show excellent optoelectronic properties.The(CH_(3))_(3)SPbI_(3) nanorod arrays-based solar cells with VOx hole transfer layers achieved a power conversion efficiency of 2.07%with negligible hysteresis.And the(CH_(3))_(3)SPbI_(3) nanorod arrays were also effectively applied in photodetectors with interdigitated gold electrodes.This work demonstrates that sulfur-based perovskite-like(CH_(3))_(3)SPbI_(3) is a novel promising stable compound with great potential for practical optoelectronic applications. | Ruiyuan Hu Chuangye Ge Liang Chu Yifei Feng Shanshan Xiao Yuhui Ma Wei Liu Xing'ao Li Mohammad Khaja Nazeeruddin | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 11 | Self-assembled TiO_(2)hole-blocking layers for efficient perovskite solar cells显示文摘The self-assembly process for compatible functional layers of devices is a simple,feasible,and energy-saving strategy.In mesoporous perovskite solar cells(PSCs),compact and scaffold TiO_(2) films generally function as the hole-blocking and electron-transporting layers,respectively.However,both of these layers are usually generated through a high-temperature annealing process.Here,we deposited TiO_(2) compact films through a room-temperature self-assembly process as effective hole-blocking layers for PSCs.The thickness of TiO_(2) compact films can be easily controlled by the deposition time.Through the optimization of TiO_(2) compact films(80 nm),the power conversion efficiency(PCE)of mesoporous PSCs without and with hole conductor layers increases up to 10.66%and 17.95%,respectively.Notably,an all-low-temperature planar PSC with the self-assembled TiO_(2) layer exhibits a PCE of 16.41%. | Zhongbao Que Liang Chu Shuaibo Zhai Yifei Feng Chen Chen Wei Liu Ruiyuan Hu Jing Hu Xing’ao Li | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 0 |
| 12 | Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro显示文摘The recent outbreak of novel coronavirus pneumonia(COVID-19)caused by a new coronavirus has posed a great threat to public health.Identifying safe and effective antivirals is of urgent demand to cure the huge number of patients.Virusencoded proteases are considered potential drug targets.The human immunodeficiency virus protease inhibitors(lopinavir/ritonavir)has been recommended in the global Solidarity Trial in March launched by World Health Organization.However,there is currently no experimental evidence to support or against its clinical use.We evaluated the antiviral efficacy of lopinavir/ritonavir along with other two viral protease inhibitors in vitro,and discussed the possible inhibitory mechanism in silico.The in vitro to in vivo extrapolation was carried out to assess whether lopinavir/ritonavir could be effective in clinical.Among the four tested compounds,lopinavir showed the best inhibitory effect against the novel coronavirus infection.However,further in vitro to in vivo extrapolation of pharmacokinetics suggested that lopinavir/ritonavir could not reach effective concentration under standard dosing regimen[marketed as Kaletraò,contained lopinavir/ritonavir(200 mg/50 mg)tablets,recommended dosage is 400 mg/10 mg(2 tablets)twice daily].This research concluded that lopinavir/ritonavir should be stopped for clinical use due to the huge gap between in vitro IC50 and free plasma concentration.Nevertheless,the structure–activity relationship analysis of the four inhibitors provided further information for de novel design of future viral protease inhibitors of SARS-CoV-2. | Leike Zhang Jia Liu Ruiyuan Cao Mingyue Xu Yan Wu Weijuan Shang Xi Wang Huanyu Zhang Xiaming Jiang Yuan Sun Hengrui Hu Yufeng Li Gang Zou Min Zhang Lei Zhao Wei Li Xiaojia Guo Xiaomei Zhuang Xing-Lou Yang Zheng-Li Shi Fei Deng Zhihong Hu Gengfu Xiao Manli Wang Wu Zhong | 2020 | Virologica Sinica2020，35，6： | 0 |
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