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| 1 | Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties显示文摘Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications. | Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu Ruizi Peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan | 2019 | Research2019，，1： | 2 |
| 2 | Construction of bilayer PdSe2 on epitaxial graphene显示文摘Two-dimensional (2D) materials have received significant attention due totheir unique physical properties and potential applications in electronics andoptoelectronics. Recent studies have demonstrated that exfoliated PdSe2, alayered transition metal dichalcogenide (TMD), exhibits ambipolar field-effecttransistor (FET) behavior with notable performance and good air stability, andthus serves as an emerging candidate for 2D electronics. Here, we report thegrowth of bilayer PdSe2 on a graphene-SiC(0001) substrate by molecular beamepitaxy (MBE). A bandgap of 1.15±0.07 eV was revealed by scanning tunnelingspectroscopy (STS). Moreover, a bandgap shift of 0.2 eV was observed in PdSe2layers grown on monolayer graphene as compared to those grown on bilayergraphene. The realization of nanoscale electronic junctions with atomicallysharp boundaries in 2D PdSe2 implies the possibility of tuning its electronicor optoelectronic properties. In addition, on top of the PdSe2 bilayers, PdSe2nanoribbons and stacks of nanoribbons with a fixed orientation have beenfabricated. The bottom-up fabrication of low-dimensional PdSe2 structures isexpected to enable substantial exploration of its potential applications. | En Li Dongfei Wang Peng Fan Ruizi Zhang Yu-Yang Zhang Geng Li Jinhai Mao Yeliang Wang Xiao Lin Shixuan Du Hong-Jun Gao | 2018 | Nano Research2018，11，11： | 2 |
| 3 | Functional nucleic acid-based cell imaging and manipulation显示文摘Cells are the basic structural and functional units of organisms.Dynamic analysis and manipulation of specific components in living cells would provide valuable information for the study of related biological processes.Advances in fluorescence microscopy have allowed real-time monitoring of biological events at the molecular level.Meanwhile,the development of highperformance fluorescence probes has become a critical issue.Functional nucleic acids(FNAs)are oligonucleotides with special chemical and biological functions,and aptamers with excellent molecular recognition capability are one of the most important representatives.They have attracted extensive attention in the field of live-cell study,owing to intrinsic advantages of simple synthesis,convenient modification,low immunogenicity and high programmability.This review focuses on recent research progress in fluorescence imaging and manipulation of cells using FNAs,particularly aptamers,as the molecular tools.Finally,a summary is provided and the related challenges are discussed. | Yan Zhou Yuting Zhuo Ruizi Peng Yutong Zhang Yulin Du Qiang Zhang Yue Sun Liping Qiu | 2021 | Science China Chemistry2021，64，11： | 1 |
| 4 | A Magnetocatalytic Propelled Cobalt-Platinum@Graphene Navigator for Enhanced Tumor Penetration and Theranostics显示文摘Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment.However,one of the key challenges is to prepare nanomotors with an adequately small size,good biocompatibility,and precise positioning.Herein,we demonstrate a simple,ultrasmall,versatile,and real-time motion guidance strategy for magnetocatalytic CoPt@graphene navigators(MCGNs)that can enable highly efficient propulsion in the presence of H_(2)O_(2) or magnetic actuation.MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting,and the amount of drug in the tumor was three times than without navigation.By engaging movements powered through in situ energy conversion,MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery. | Liang Zhang Qian Dong Hui Zhang Jieqiong Xu Shen Wang Lufeng Zhang Wentao Tang Zhaoqian Li Xin Xia Xinqi Cai Shengkai Li Ruizi Peng Zhengyu Deng Michael JDonovan Long Chen Zhuo Chen Weihong Tan | 2022 | CCS Chemistry2022，4，7： | 1 |
| 5 | New Insights from Chemical Biology:Molecular Basis of Transmission,Diagnosis,and Therapy of SARS-CoV-2显示文摘Coronavirus disease 2019(COVID-19)is caused by a novel strain of coronavirus,designated as severe acute respiratory syndrome coronavirus 2(SARSCoV-2).It has caused a global pandemic rapidly sweeping across all countries,bringing social and economic hardship to millions.Most countries have implemented early warning measures to detect,isolate,and treat patients infected with SARS-CoV-2.This minireview summarizes some of those steps,in particular,testing methods and drug development in the context of chemical biology,and discusses the molecular basis of COVID-19’s virulent transmissibility. | Zilong Zhao Yaling Wang Liping Qiu Ting Fu Yu Yang Ruizi Peng Mengyu Guo Lichun Mao Chunying Chen Yuliang Zhao Weihong Tan | 2021 | CCS Chemistry2021，3，1： | 0 |
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