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| 1 | Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes显示文摘Infection is one of the major causes of failure of orthopedic implants. Our previous study demonstrated that nanotube modification of the implant surface, together with nanotubes loaded with quaternized chitosan(hydroxypropyltrimethyl ammonium chloride chitosan, HACC), could effectively inhibit bacterial adherence and biofilm formation in vitro. Therefore, the aim of this study was to further investigate the in vitro cytocompatibility with osteogenic cells and the in vivo anti-infection activity of titanium implants with HACC-loaded nanotubes(NT-H). The titanium implant(Ti), nanotubes without polymer loading(NT), and nanotubes loaded with chitosan(NT-C) were fabricated and served as controls. Firstly, we evaluated the cytocompatibility of these specimens with human bone marrow-derived mesenchymal stem cells in vitro.The observation of cell attachment, proliferation, spreading, and viability in vitro showed that NT-H has improved osteogenic activity compared with Ti and NT-C. A prophylaxis rat model with implantation in the femoral medullary cavity and inoculation with methicillin-resistant Staphylococcus aureus was established and evaluated by radiographical, microbiological, and histopathological assessments. Our in vivo study demonstrated that NT-H coatings exhibited significant anti-infection capability compared with the Ti and NT-C groups. In conclusion, HACC-loaded nanotubes fabricated on a titanium substrate show good compatibility with osteogenic cells and enhanced anti-infection ability in vivo, providing a good foundation for clinical application to combat orthopedic implant-associated infections. | Ying Yang Haiyong Ao Yugang Wang Wentao Lin Shengbing Yang Shuhong Zhang Zhifeng Yu Tingting Tang | 2016 | Bone Research2016，4，3： | 9 |
| 2 | Identification,bioinformatic analysis and expression profiling of candidate mRNA-like non-coding RNAs in Sus scrofa显示文摘Messenger RNA-like non-coding RNAs(mlncRNAs) are a newly identified group of non-coding RNAs(ncRNAs) that may be in-volved in a number of critical cellular events.In this study,93 candidate porcine mlncRNAs were obtained by computational prediction and screening,among which 72 were mapped to the porcine genome.Further analysis of 8 representative candidates revealed that these mlncRNA candidates are not highly conserved among species.Remarkably,one of the candidates,sTF35495,was found to be precursor of a putative porcine microRNA.By RACE PCR,we determined that the full length of sTF35495 was 3 kb.The protein-coding potential of this RNA was tested in silico with no significant finding.Semi-quantitative RT-PCR analysis of the subgroup of 8 candidates revealed two distinct expression profiles and two molecules were further validated by real-time PCR.The predicted pre-microRNA sequence in this study provides a potentially interesting insight into the in vivo function of porcine mlncRNAs and our findings suggest that they play key biological roles in Sus scrofa. | Bang Xiao Xingju Zhang Yong Li Zhonglin Tang Shulin Yang Yulian Mu Wentao Cui Hong Ao Kui Li | 2009 | Journal of Genetics and Genomics2009，36，12： | 7 |
| 3 | BIFURCATIONS OF TRAVELLING WAVE SOLUTIONS FOR THE GENERALIZED DODD-BULLOUGH-MIKHAILOV EQUATION显示文摘在这份报纸,概括 Dodd-Bullough-Mikhailov 方程被学习。周期的波浪和无界的波浪解决方案的存在被使用动态系统的分叉理论的方法证明。在不同参量的条件下面,保证上述答案的存在的各种各样的足够的条件被给。上述旅行答案的一些准确明确的参量的代表被获得。 | Tang Shengqiang Huang Wentao | 2007 | Applied Mathematics(A Journal of Chinese Universities)2007，22，1： | 7 |
| 4 | Investigation and Analysis of Rabies Viral Infection and Distribution in China in 2005-2012显示文摘Dear Editor, We report the results of a preliminary investigation of data collected between 2005 and 2012. A National Human Rabies Surveillance program was initiated in high rabies incidence regions in 2005, and subsequently carried out nationally to monitor rabies situation. Our work presents a summary of epidemiological and etiologic rabies surveillance data collected since the implementation of the program. | Wentao Jiao Hao Li Xiaoyan Tao Miao Song Xinxin Shen Zhenyang Guo Yunjiao Zhao Qing Tang Guodong Liang | 2013 | Virologica Sinica2013，28，3： | 6 |
| 5 | Detection of quantitative trait loci and heterotic loci for plant height using an immortalized F_2 population in maize显示文摘A set of recombinant inbred lines (RIL) derived from Yuyu22, an elite hybrid widespread in China, was used to construct an immortalized F2 (IF2) population comprising 441 different crosses. Genetic linkage maps were constructed containing 10 linkages groups with 263 simple sequence repeat (SSR) molecular markers. Twelve and ten quantitative trait loci (QTL) were detected for plant height in the IF2 and RIL populations respectively, using the composite interval mapping method, and six same QTL were identified in the two populations. In addition, ten unique heterotic loci (HL) located on seven different chromosomes were revealed for plant height using the mid-parent heterosis as the input data. These HL explained 1.26%―8.41% of the genotypic variance in plant height heterosis and most expressed overdominant effects. Only three QTL and HL were located in the same chromosomal region, it implied that plant height and its heterosis might be controlled by two types of genetic mechanisms. | TANG JiHua MA XiQing TENG WenTao YAN JianBing WU WeiRen DAI JingRui LI JianSheng | 2007 | Chinese Science Bulletin2007，52，4： | 5 |
| 6 | Precise editing of methylated cytosine in Arabidopsis thaliana using a human APOBEC3Bctd-Cas9 fusion显示文摘Dear Editor,Precise editing of specific genomic sites holds great promise in basic research and modern crop breeding,and some cytosine base editors(CBEs)have been developed for this purpose(Komor et al.,2016;Zong et al.,2018). | Zhi-Hong Liu Shanjie Tang Wentao Hu Ruo Lv Hailiang Mei Rongxin Yang Xianwei Song Xiaofeng Cao Dong Wang | 2022 | Science China(Life Sciences)2022，65，1： | 3 |
| 7 | Mechanisms of carbon storage and the coupled carbon, nitrogen and sulfur cycles in regional seas in response to global change显示文摘1.Great challenges in scientific frontiers of marine carbon storage in the scenario of global change The marine carbon cycle is influenced by anthropogenic activities,affecting global climate change and casting a significant impact on ecosystems.However,the complex spatiotemporal process of the marine carbon cycle results in the uncertainty in the estimation of marine carbon budget。 | XIE ShuCheng CHEN JianFang WANG FengPing XUN LuYing TANG Kai ZHAI WeiDong LIU JiHua MA WenTao | 2017 | Science China Earth Sciences2017，60，5： | 3 |
| 8 | Selective laser melting of dense and crack-free AlCoCrFeNi_(2.1) eutectic high entropy alloy: Synergizing strength and ductility显示文摘Additively manufactured high-entropy alloys generally suffer from low strength and/or poor ductility.In this work,by leveraging the good castability of eutectic high entropy alloys and high cooling rate of selective laser melting(SLM),we report a nearly fully dense and crack-free as-SLM AlCoCrFeNi_(2.1) eutectic high entropy alloy with an exceptional strength-ductility synergy,showing an ultrahigh yield strength of 982.1±35.2 MPa and an ultimate tensile strength of 1322.8±54.9 MPa together with an elongation to fracture of 12.3±0.5%.Such strength-ductility enhancement is owing to the heterogeneous eutectic microstructure consisting of the columnar,equiaxed,and“L-shape”cells with much refined sizes down to nanoscales.The morphology of cells in the transition zone is related to the misorientation between the growth direction of adjacent layers.This heterogeneous eutectic microstructure is the result of the graingrowth behavior dominated by the mechanisms of the epitaxial growth and growth of heterogeneous nuclei in SLM.Our current results provide a new methodology for the future design of ultrahigh-strength and ductile SLM-fabricated metallic materials including HEAs,and other printable alloys for various structural applications. | Lin He Shiwei Wu Anping Dong Haibin Tang Dafan Du Guoliang Zhu Baode Sun Wentao Yan | 2022 | Journal of Materials Science & Technology2022，，22： | 2 |
| 9 | One-step laser induced conversion of a gelatin-coated polyimide film into graphene:Tunable morphology,surface wettability and microsupercapacitor applications显示文摘Latest advances have witnessed the laser induction process on polyimide(PI)films for the formation of porous graphene.Herein,a fully converted graphene film was prepared by Nd:YAG laser scribing a gelatin coated PI film.It was found that the gelatin played the role of'shield'well in absorbing intense laser impact and benefit for the surface morphology modulation.Laser treatment lower than a critical fluence point of~4.00 J mm^(-2) contributed to a crater-like surface morphology due to the dispersed nature of Nd:YAG laser beam.By tuning laser fluence above the threshold,carbonized surface turned into continuous morphology.A fluid dynamics process accompanied by outgassing occurred during the carbonization,and the surface morphology gradually varied from stretched droplets to porous strips and finally to amorphous porous structures.The morphology evolution in combination with surface chemistry is responsible for the significant wettability transition from superhydrophobic to superhydrophilic,and a Janus superhydrophobic/superhydrophilic surface wettability was achieved under a laser fluence of~8.00 J mm^(-2).Eventually,microsupercapacitors(MSCs)were fabricated to show the great potential of our prepared graphene in flexible electronics. | WANG WenTao LU LongSheng XIE YingXi LI ZeHong WU WeiBin LIANG RongXuan TANG Yong | 2021 | Science China(Technological Sciences)2021，64，5： | 2 |
| 10 | Zeolite templated carbon nanodots for broadband ultrafast pulsed fiber laser generation显示文摘Carbon nanodots(C-dots) with a uniform size of about 2 nm are synthesized via in situ pyrolysis of n-propylamine that is confined in the nanochannels of zeolite Linde Type A(LTA). The as-synthesized C-dots@LTA composite shows nonlinear optical saturable absorption properties in a broad wavelength band and can be used as saturable absorber(SA) to generate ultrafast pulsed fiber lasers. By inserting a zeolite LTA single crystal hosting C-dots into the fiber laser cavity, mode-locked fiber lasers with long-term operation stability at 1.5 μm and 1 μm are achieved. These results show that the C-dots@LTA are a promising SA material for ultrafast pulsed fiber laser generation in a broad wavelength band. To the best of our knowledge, this is the first demonstration of a C-dots@LTA-based mode-locked fiber laser. | XINTONG XU JIAQI CHEN WENTAO SHI DALIN SUN SHAOWEN CHU LANG SUN WENFEI ZHANG YANPING CHEN JIANPANG ZHAI SHUANGCHEN RUAN ZIKANG TANG | 2019 | Photonics Research2019，7，10： | 2 |
| 11 | Controlling the laser induction and cutting process on polyimide films for kirigami-inspired supercapacitor applications显示文摘The recently emerging laser-induced graphene(LIG)technology,with one-step processing and designable features,has been widely used in the fabrication of wearable/portable electronics.Herein,by taking inspiration from kirigami,we designed a stretchable supercapacitor(SC)step by step through controlling laser induction and cutting process on the polyimide(PI)film,with the use of one single CO_(2) laser source.Firstly,the carbonized basic geometric units of lines were produced on PI films to investigate the processing-structure relationships.Then,the complex photothermal conversion and heat transfer progress involved in the carbonized process were simulated by a photothermal model.Both experimental and theoretical results suggested that the laser power,scan rate and focus condition have great influence on the size,shape and morphology of the carbonized lines.Finally,we optimized the parameters of laser induction and cutting process to fabricate the kirigami-inspired SCs with reliable electrochemical properties and editable mechanical flexibility,showing great potential in the field of flexible electronics. | WANG WenTao LU LongSheng XIE YingXi WU WeiBin LIANG RongXuan LI ZeHong TANG Yong | 2021 | Science China(Technological Sciences)2021，64，3： | 2 |
| 12 | Preparation and Characteristics of CoreeShell Structure Eu(DBM)_3Phen@SiO_2 Micro-Sphere显示文摘Sphere-shape Eu(DBM)3Phen@SiO2 nanoparticles were fabricated by employing a modified alkaline catalyzed hydrolysis and precipitation method.The silica coated on the particles surface was obtained by means of hydrolysis and condensation of tetraethyl orthosilicate(TEOS).In this study,the particles morphology was analyzed by scanning electron microscopy(SEM) and the surface composition of samples was characterized by X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR).It is confirmed that the SiO2 shell has been coated on the rare earth complexes successfully.Moreover,the near-infrared photoluminescence emission analysis on the nanoparticles showed that the SiO2 shell would increase the luminescence intensity of Eu(DBM)3Phen.This is primarily due to the reason that SiO2 shell with chemical inertness can effectively reduce the ion Eu3+ non-radiation transition probabilities,as well as the probability of rare earth luminescence quenching caused by the external medium. | Mingguang Yu Guangxue Chen Jiangwen Liu Baoling Tang Wentao Huang | 2013 | Journal of Materials Science & Technology2013，29，9： | 1 |
| 13 | Target-fieldmethod for MRI biplanar gradient coil design显示文摘 | Liu Wentao Zu Donglin Tang Xin | 2007 | Appliedphysics2007，40，15： | 1 |
| 14 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 15 | Dissection of the genetic basis of heterosis in an elite maize hybrid by QTL mapping in an immortalized F 2 population显示文摘 | Jihua Tang Jianbing Yan Xiqing Ma Wentao Teng Weiren Wu Jingrui Dai Baldev S. Dhillon Albrecht E. Melchinger Jiansheng Li | 2010 | Theoretical and Applied Genetics2010，，2： | 1 |
| 16 | Enhanced electrochemical properties of poly (ethylene oxide )-based composite polymer electrolyte with ordered mesoporous materials for lithium polymer battery 显示文摘 | Jingyu Xi Xinping Qiu Wentao Zhu Xiaozhen Tang | 2006 | Microporous and Mesoporous Materials2006，88，： | 1 |
| 17 | Cell-free DNA derived from cancer cells facilitates tumor malignancy through Toll-like receptor 9 signaling-triggered interleukin-8 secretion in colorectal cancer显示文摘 | Zhengchuan Niu Wentao Tang Tianyu Liu Pingping Xu Dexiang Zhu Meiling Ji Wenbai Huang Li Ren Ye Wei Jianmin Xu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 1 |
| 18 | Application of ionic liquid for extraction and separation of bioactive compounds from plants 显示文摘 | Baokun Tang Wentao Bi Minglei Tian | 2012 | Journal of Chromatography B2012，904，： | 1 |
| 19 | Bifurcations of travelling wave solutions for the K(n,-n ,2n) equations显示文摘 | Tang Shengqiang Huang Wentao | 2008 | Applied Math ematics and Computation2008，203，1： | 1 |
| 20 | A Magnetocatalytic Propelled Cobalt-Platinum@Graphene Navigator for Enhanced Tumor Penetration and Theranostics显示文摘Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment.However,one of the key challenges is to prepare nanomotors with an adequately small size,good biocompatibility,and precise positioning.Herein,we demonstrate a simple,ultrasmall,versatile,and real-time motion guidance strategy for magnetocatalytic CoPt@graphene navigators(MCGNs)that can enable highly efficient propulsion in the presence of H_(2)O_(2) or magnetic actuation.MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting,and the amount of drug in the tumor was three times than without navigation.By engaging movements powered through in situ energy conversion,MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery. | Liang Zhang Qian Dong Hui Zhang Jieqiong Xu Shen Wang Lufeng Zhang Wentao Tang Zhaoqian Li Xin Xia Xinqi Cai Shengkai Li Ruizi Peng Zhengyu Deng Michael JDonovan Long Chen Zhuo Chen Weihong Tan | 2022 | CCS Chemistry2022，4，7： | 1 |
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