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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Pre-reforming of natural gas on a Ni catalyst criteria for carbon free operation 显示文摘 | Thomas S Chen D Rune L | 2005 | Appl Catal A: General2005，282，12： | 1 |
| 4 | Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients显示文摘 | Johan Westin Hans Nordlinder Martin Lagging Gunnar Norkrans Rune Wejst?l | 2002 | Journal of Hepatology2002，，6： | 1 |
| 5 | Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients显示文摘 | Johan Westin Hans Nordlinder Martin Lagging Gunnar Norkrans Rune Wejst?l | 2002 | Journal of Hepatology2002，，6： | 1 |
| 6 | Nitrogen deficiency enhances expression of specific MYB and bHLH transcription factors and accumulation of end products in the flavonoid pathway显示文摘 | Unni S. Lea Rune Slimestad P?l Smedvig Cathrine Lillo | 2007 | Planta2007，，5： | 1 |
| 7 | Temperature and nitrogen effects on regulators and products of the flavonoid pathway:experimental and kinetic model studies显示文摘 | Kristine M O Rune S Unni S L | 2009 | Plant Cell and Environment2009，32，： | 1 |
| 8 | Deactivation during carbon dioxide reforming of methane over Ni catalyst: microkinetic analysis显示文摘 | De Chen Rune L?deng Ame Anundskas | 2001 | Chem Engi Sci2001，56，4： | 1 |
| 9 | Heterogeneity among cells that express osteoclast-associated genes in developing bone显示文摘 | Rune J Kaechoong L Gino VS | | 0，，： | 1 |
| 10 | Tracheobronchopathia osteochondroplastica:a clinical bronchoscopic and spirometric study显示文摘 | Rune L Nils LS | | 0，，06： | 1 |
| 11 | Treatment of hepatitis C virus infection in adults and children: Updated Swedish consensus recommendations显示文摘 | Martin Lagging Ann-Sofi Duberg Rune Wejst?l Ola Weiland Magnus Lindh Soo Aleman Filip Josephson | 2012 | Scandinavian Journal of Infectious Diseases2012，，7： | 1 |
| 12 | A Vegetation Classification Logic : Based on Remote Sensing for Use in Global Biogeochemical Models显示文摘 | Runing S W Loveland T R Pierce L L | 1994 | Ambio1994，23，1： | 1 |
| 13 | siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis Lactor-alpha-induced insulin resistance in human skeletal muscle显示文摘 | AUSTIN R L RUNE A BOUZAKR K a al | 2008 | Diabetes2008，57，8： | 1 |
| 14 | Is serum gamma glutamyltransferase a marker of oxidative stress? 显示文摘 | DUK H L RUNE B DAVID R | 2004 | FreeRadicRes2004，38，： | 1 |
| 15 | Differential expression of four Arabidopsis PAL genes:PAL1 and PAL2 have functional specialization in abiotic environmental-triggered flavonoid synthesis显示文摘 | Kristine M O Unni S L Rune S | | 0，，： | 1 |
| 16 | Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds显示文摘 | Liv S?fteland Jennifer A. Kirwan Tiago S.F. Hori Trond R. St?rseth Ulf Sommer Marc H.G. Berntssen Mark R. Viant Matthew L. Rise Rune Waagb? Bente E. Torstensen Marije Booman P?l A. Olsvik | 2014 | Food and Chemical Toxicology2014，，： | 1 |
| 17 | 深圳能源大厦显示文摘深圳能源公司办公楼项目总建筑面积为96000m^2,旨在让人在深圳的文化、政治和商业中心感到亲切的同时,在城市主轴线上建造一座可持续的新公共地标。本项目的体量和高度由中心区城市总体规划决定。主体建筑由两座塔楼组成,北楼高220m,南楼高120m,两座塔楼与邻近建筑的塔楼一起在深圳的中心形成一个连续的弧形天际线。 | Bjarke Ingels Andreas Klok Pedersen Martin Voelkle He Song Andre Schmidt Alessio Zenaro Alina Tamosiunaite Alysen Hiller Ana Merino Andreas Geisler Johansen Annette Jensen Armor Rivas Balaj IIulian Brian Yang Baptiste Blot Buster Christiansen Cecilia Ho Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Dave Brown Dennis Rasmussen Doug Stechschulte Eskild Nordbud Felicia Guldberg Fred Zhou Gaetan Brunet Gül Ertekin Henrik Kania Iris Van der Heide James Schrader Jan Magasanik Jan Borgstr?m Jeppe Ecklon Jelena Vucic Jo?o Albuquerque Jonas M?nster Karsten Hansen Malte Kloe Mikkel Marcker Stubgaard Michael Andersen Michal Kristof Min Ter Lim Oana Simionescu Nicklas A. Rasch Philip Sima Rasmus Pedersen Rune Hansen Rui Huang Sofia Gaspar Stanley Lung Sun Ming Lee Takuya Hosokai Todd Bennett Xi Chen Xing Xiong Xiao Lu Xu Li Yijie Dan Zoltan Kalaszi | 2019 | 建筑实践2019，2，6： | 0 |
| 18 | 老海勒鲁普高中体育馆显示文摘位于哥本哈根北部的老海勒鲁普高中,内部拥有1100m^2的多功能大厅和最新的两层建筑,为现有学生提供了广阔的社交和创意展示空间,同时提升学校的容量,以应对持续增长的人口需求。原本校园旁边的一栋建筑里,体育设施匮乏而无法满足需求;老海勒鲁普高中也缺少大型多功能空间,用以举办体育活动、毕业典礼和社交聚会。 | Ana Merino Anders Hjortn■s Christian Alvarez Dennis Rasmussen Gül Ertekin Henrick Poulsen Hjalti Gestsson Jan Magasanik Jakob Lange Jacob Thomsen Jeppe Ecklon Ji-young Yoon Michael Sch■nemann Narisara Schr■der Riccardo Mariano Rune Hansen Snorre Nash Thomas Juul-Jensen Vincent He Xu Li Agnete Jukneviciute Ambra Chiesa Brigitta Gulyás Dennis Rasmussen Enea Michelesio Greta Krenciute H■gni Laksáfoss Isabella Eriksson Jan Magasanik Mikkel Marcker Stubgaard Jeppe Ecklon Kamilla Heskje Michael Sch■nemann Narisara Schr■der Thomas Juul-Jensen Brigitta Gulyás Enea Michelesio Jakob Lange Mikkel Marcker Stubgaard Narisara Schr■der Tobias Hjortdal Iwan Baan Peter Moldow Rasmus Hjortshoj Jens Lindhe 朱翰林 | 2019 | 城市环境设计2019，0，2： | 0 |
| 19 | 丹麦国家海事博物馆显示文摘丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身. | John Pries Jensen Henrik Kania Ariel Joy Norback Wallner Rasmus Pedersen Annette Jensen Dennis Rasmussen Jan Magasanik Jeppe Ecklon Karsten Hammer Hansen Rasmus Rodam Rune Hansen Alina Tamosiunaite Alysen Hiller Ana Merino Armen Menendian Andy Yu Andreas Johansen Baptiste Blot Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild Nordbud Felicia Guldberg Finn N■rkj■r Gül Ertekin Jan Borgstr■m James Schrader Johan Cool Jonas M■nster Kirstine Ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter Rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H■jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan Rasmus Hjortshoj Luca Santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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