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| 1 | RAB31 marks and controls an ESCRT-independent exosome pathway显示文摘Exosomes are generated within the multivesicular endosomes(MVEs)as intraluminal vesicles(ILVs)and secreted during the fusion of MVEs with the cell membrane.The mechanisms of exosome biogenesis remain poorly explored.Here we identify that RAB31 marks and controls an ESCRT-independent exosome pathway.Active RAB31,phosphorylated by epidermal growth factor receptor(EGFR),engages flotillin proteins in lipid raft microdomains to drive EGFR entry into MVEs to form ILVs,which is independent of the ESCRT(endosomal sorting complex required for transport)machinery.Active RAB31 interacts with the SPFH domain and drives ILV formation via the Flotillin domain of flotillin proteins.Meanwhile,RAB31 recruits GTPase-activating protein TBC1D2B to inactivate RAB7,thereby preventing the fusion of MVEs with lysosomes and enabling the secretion of ILVs as exosomes.These findings establish that RAB31 has dual functions in the biogenesis of exosomes:driving ILVs formation and suppressing MVEs degradation,providing an exquisite framework to better understand exosome biogenesis. | Denghui Wei Weixiang Zhan Ying Gao Liyan Huang Run Gong Wen Wang Ruhua Zhang Yuanzhong Wu Song Gao Tiebang Kang | 2021 | Cell Research2021，31，2： | 12 |
| 2 | Comparative study of MCe_(0.75)Zr_(0.25)O_(y)(M=Cu,Mn,Fe)catalysts for selective reduction of NO by CO:Activity and reaction pathways显示文摘Basic oxygen furnace steelmaking leads to the production of CO-rich off-gas.When CO and NO are combined in off-gas,selective catalytic reduction by CO(CO-SCR)effectively achieves the synergistic removal of both pollutants.In this paper,CuCe_(0.75)Zr_(0.25)O_(y),MnCe_(0.75)Zr_(0.25)O_(y),and FeCe_(0.75)Zr_(0.25)O_(y) catalysts are prepared and evaluated for their CO-SCR activity,and the results show that the reaction system needs to be anaerobic;thus,the CO-SCR reaction can be dominant.The T_(90) values of CuCe_(0.75)Zr_(0.25)O_(y) and FeCe_(0.75)Zr_(0.25)O_(y) are 200℃ and 223℃,respectively.The activities of these two catalysts are higher than that of MnCe_(0.75)Zr_(0.25)O_(y)(T_(90)=375℃).Linear nitrate and bridged bidentate nitrate are the main intermediate species involved in NO conversion on the catalyst surface,and bidentate CO_(3)^(2-)��coordination is the main intermediate species involved in CO conversion on the catalyst surface.CuCe_(0.75)Zr_(0.25)O_(y) has high lattice oxygen mobility and is more likely to react with NO and CO.In the presence of oxygen,most CO is oxidized by O_(2),which increases continuously to 100%,100%,and 98%for CuCe_(0.75)Zr_(0.25)O_(y),FeCe_(0.75)Zr_(0.25)O_(y),and MnCe_(0.75)Zr_(0.25)O_(y),respectively;additionally,CO is oxidized by O_(2),and the CO-SCR reaction cannot be carried out. | Junyao He Running Kang Xiaolin Wei Junqin Huang Feng Bin Kwun Nam Hui Kwan San Hui Dongyin Wu | 2021 | Carbon Resources Conversion2021，4，1： | 2 |
| 3 | A regional phenology model for detecting onset of greenness in temperate mixed forests,Korea:an application of MODIS leaf area index显示文摘 | KANG S RUNNING S W LIM J H | 2003 | Remote Sensing of Environmental Management2003，86，2： | 1 |
| 4 | Simulating effects of fire disturbance and climate change on boreal forest productivity and evapotranspiration显示文摘 | Kang S Kimball J S Running S W | 2006 | Science of the Total Environment2006，362，1： | 1 |
| 5 | A regional phenology model for detecting onset of greenness in temperate mixed forests,Korea:an application of MODIS leaf area index显示文摘 | Kang S Steven W Running Lim J H | | 0，，： | 1 |
| 6 | A regional phenology model for detecting onset of greenness in temperate mixed forests,Korea:An application of MODIS leaf area index显示文摘 | Kang SK Running SW Lim JH | | 0，，： | 1 |
| 7 | A Regional Phenology Model for Detecting Onset of Greenness in Temperate Mixed For- ests,Korea:An Application of MODIS Leaf Area Index显示文摘 | Kang S Running S Lim J | 2003 | Remote Sensing of Environment2003，86，2： | 1 |
| 8 | Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity显示文摘STING,an endoplasmic reticulum(ER)transmembrane protein,mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy.Here,we report that activated STING could be transferred between cells to promote antitumor immunity,a process triggered by RAB22A-mediated non-canonical autophagy.Mechanistically,RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex,inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome,in which STING activated by agonists or chemoradiotherapy is packaged.This RAB22A-induced autophagosome fuses with RAB22A-positive early endosome,generating a new organelle that we name Rafeesome(RAB22A-mediated non-canonical autophagosome fused with early endosome).Meanwhile,RAB22A inactivates RAB7 to suppress the fusion of Rafeesome with lysosome,thereby enabling the secretion of the inner vesicle of the autophagosome bearing activated STING as a new type of extracellular vesicle that we define as R-EV(RAB22A-induced extracellular vesicle).Activated STING-containing R-EVs induce IFNβrelease from recipient cells to the tumor microenvironment,promoting antitumor immunity.Consistently,RAB22A enhances the antitumor effect of the STING agonist diABZI in mice,and a high RAB22A level predicts good survival in nasopharyngeal cancer patients treated with chemoradiotherapy.Our findings reveal that Rafeesome regulates the intercellular transfer of activated STING to trigger and spread antitumor immunity,and that the inner vesicle of non-canonical autophagosome originated from ER is secreted as R-EV,providing a new perspective for understanding the intercellular communication of organelle membrane proteins. | Ying Gao Xueping Zheng Boyang Chang Yujie Lin Xiaodan Huang Wen Wang Shirong Ding Weixiang Zhan Shang Wang Beibei Xiao Lanqing Huo Youhui Yu Yilin Chen Run Gong Yuanzhong Wu Ruhua Zhang Li Zhong Xin Wang Qiuyan Chen Song Gao Zhengfan Jiang Denghui Wei Tiebang Kang | 2022 | Cell Research2022，32，12： | 1 |
| 9 | Growth and characterization of highly oriented CuBr thin films through room temperature electrochemical route显示文摘 | Li He Liu Run Kang Honglan | 2008 | Electrochimica Acta2008，54，2： | 1 |
| 10 | Self-sustained catalytic combustion of CO enhanced by micro fluidized bed: stability operation, fluidization state and CFD simulation显示文摘A micro fluidized bed reactor was used to study the self-sustaining catalytic combustion of carbon monoxide(CO).The Cu_(1−x)Ce_(x)O_(y) catalyst,as well as the pure CuO and CeO_(2),are used to investigate the contributing mechanism of different active sites including dispersed CuO and Cu–Ce solid solutions.The ignition temperature(Ti)of CO over these catalysts at a flow rate of 2000 mL/min followed the order:74℃(Cu_(0.5)Ce_(0.5)O_(y))<75℃(Cu_(0.25)Ce_(0.75)O_(y))<84℃(Cu_(0.75)Ce_(0.25)O_(y))<105℃(CuO)<500℃(CeO_(2)).Furthermore,the lean combustion limits(equivalence ratioϕ)over these catalysts under the flow rates of 750–3000 mL/min(through fixed,bubbling,and fluidized bed)were also measured,which are Cu_(0.5)Ce_(0.5)O_(y) | Zirui Zhang Chenhang Zhang Huan Liu Feng Bin Xiaolin Wei Running Kang Shaohua Wu Wenming Yang Hongpeng Xu | 2023 | Frontiers of Environmental Science & Engineering2023，17，9： | 1 |
| 11 | Role of oxygen species and active phase of CuCeZrO_(x) prepared with bacterial cellulose for toluene catalytic oxidation显示文摘The present study investigates the active phases and the role of oxygen species in the toluene oxidation process over CuCeZrO_(x) catalysts prepared with bacterial cellulose(BC),and compares them with nitric acid pickling CuCeZrO_(x)-BC(H)and CeZrO_(x)-BC catalysts.The investigation is carried out using in-situ DRIFT,O_(2)-TPD,H_(2)-TPR,XRD,and TEM techniques.Our findings suggest that dispersed CuO species on the catalyst surface,Cu-Ce-Zr-O,and Ce-Zr-O solid solutions are active for toluene oxidation over CuCeZrO_(x)-BC,with corresponding activities decreasing successively.The in-situ DRIFT results demonstrate that gaseous oxygen facilitates the chemisorption of toluene on active oxygen species,forming benzoyl oxide species and partially oxidizing the absorbed intermediates to benzyl alcohol at room temperature.Furthermore,lattice oxygen is experimentally found to be involved in the deep oxidation of toluene,and the lattice oxygen present in dispersed CuO species dominates the toluene oxidation process over CuCeZrO_(x)-BC. | Chenhang Zhang Chenchen Zhao Running Kang Qinglan Hao Baojuan Dou Feng Bin | 2023 | Carbon Resources Conversion2023，6，4： | 0 |
| 12 | RMI2 plays crucial roles in growth and metastasis of lung cancer显示文摘Dear Editor,Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death in the world,but its therapeutic targets are still being explored.Genome instability as a key hallmark of cancer not only contributes to cancer initiation and progression,1 but also creates vulnerabilities that are relatively specific to cancer cells,which may be potential therapeutic targets for cancer patients.During DNA Double-Strand Breaks(DSBs)repair,BTR(BLM-Topo IIIα-RMI1/RMI2)complex promotes the dissolution of double Holliday junctions to form non-crossover products and is often considered as a tumor suppressor.2 However,the function of each individual component of this BTR complex in cancer remains largely unknown. | Weixiang Zhan Yina Liu Ying Gao Run Gong Wen Wang Ruhua Zhang Yuanzhong Wu Tiebang Kang Denghui Wei | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 13 | A highly efficient transacetalization of 2-formylpyrrole acetals in alkaline media显示文摘有在在倒流温度的白酒的钠 alkoxide 的 2-formylpyrrole 缩荃的反应顺利继续了在将近量的收益产生相应 transacetalization 产品。包含高度反应的中间的 azafulvene 种的形成的嘴巧的机制被建议解释观察转变。 | Zhao Hua Yan Run Hua Kang Yong Jie Liu Sen Lin | 2012 | Chinese Chemical Letters2012，23，1： | 0 |
| 14 | Insights on copper,manganese,and Nickel/ZSM-5 catalytic mechanisms for nitric oxides selective reduction with ammonia显示文摘The elucidation of the selective catalytic reduction mechanisms over state-of-the-art metal-promoted zeolites is essential for nitric oxides removal in automobile and stationary source applications.In this work,H/ZSM-5 catalysts modified with transition metals,including copper,manganese,and nickel,were prepared by using an incipient wetness impregnation method and were evaluated for the selective reduction of nitric oxides with ammonia.Results indicate that copper/ZSM-5 exhibits the highest catalytic activity,with>90%nitric oxide conversion at a broad operation temperature window(221–445◦C).The nitric oxide conversion profiles of nickel/ZSM-5 shows two peaks that correspond to weak activity among the catalysts;the low-temperature peak(290◦C)was induced by nickel clusters dispersed on the ZSM-5 surface,while the high-temperature peak(460◦C)was assigned to the bulk nickel oxides.The size of granular nickel monoxide crystallites with an exposed(202)plane is 2–30 nm,as confirmed by Scanning electron microscopy,X-ray diffraction,and Transmission electron microscope measurements.Temperature-programmed reductions with hydrogen results testified that the copper and nickel cations,as the main species contributing to selective catalytic reduction,were reduced via Cu^(2+)/Cu^(+)→Cu^(0) and Ni^(2+)→Ni^(0) for copper/ZSM-5 and nickel/ZSM-5,respectively,while for the manganese/ZSM5,the Mn3+species in manganese clusters were reduced to Mn^(2+) by hydrogen.Particularly,temperatureprogrammed desorption coupled with mass spectrometer(TPD-MS)and in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)were comprehensively used to reveal the relationship between zeolite structure and catalysts’properties for improving selective catalytic reduction.These results confirm that the ammonia is adsorbed and activated on both Brønsted and Lewis acid sites.The nitrous oxide desorbs in two stages during nitric oxide-TPD-MS measurements,corresponding to the desorption of nitric oxide bounded to amorphous clusters and the nitric oxide strongly bounded to bulk metal oxides,respectively.The selective catalytic reduction process follows the L-H mechanism at low temperatures,in which nitric oxide and ammonia molecules were adsorbed and activated on the catalyst surface.The selective catalytic reduction rates reached the maximum value of 1.8×10^(8)(218◦C),6.4×10^(7)(227◦C),and 3.9×10^(7)s^(−1)(235◦C)for copper,manganese,and nickel/ZSM-5,respectively. | Cheng Liu Running Kang Feng Bin Xiaolin Wei Kwun Nam Hui Saravanan Kasipandi Kwan San Hui | 2022 | Carbon Resources Conversion2022，5，1： | 0 |
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