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| 1 | Gα_s signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling显示文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases. | Ruoshi Xu Sanjoy Kumar Khan Taifeng Zhou Bo Gao Yaxing Zhou Xuedong Zhou Yingzi Yang | 2018 | Bone Research2018，6，4： | 7 |
| 2 | Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than Doxil?显示文摘Although the appearance of Doxil alleviated the cardiotoxicity of DOX, the progression-free survival of patients was not prolonged compared with traditional medication regimens, and side effects such as hand-foot syndrome has occurred. In order to solve this dilemma, we have designed a novel co-delivery strategy to construct a co-loaded liposome of berberine(BER) and doxorubicin(DOX), which was called Lipo Be Do. The optimal synergistic ratio of the two drugs was screened by cell cytotoxicity experiments in vitro, and the optimal attenuation ratio was further determined by in vivo cardiac H&E staining pathological sections. The optimal combination treatment caused a robust increase in apoptotic cells of 4T1, as compared to drug alone treatment. The prepared co-loaded liposome, Lipo Be Do, had high encapsulation efficiency and good stability. The nanoliposome carrier controlled the biological fate of the drugs and maintained a pre-defined optimal ratio in vivo. The Lipo Be Do significantly inhibited tumor growth in 4T1 murine mammary carcinoma model compared with Doxil(P < 0.05), and completely overcame the myocardial rupture toxicity caused by Doxil in mice. Our co-loaded liposome delivery platform technology provided a new direction for the clinical treatment of triple-negative breast cancer and the safe application of DOX. | Ruoshi Zhang Yingxi Zhang Yue Zhang Xin Wang Xuanming Gao Yuyan Liu Xuanbo Zhang Zhonggui He Dun Wang Yongjun Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 4 |
| 3 | Application of nano-patterned InGaN fabricated by selfassembled Ni nano-masks in green InGaN/GaN multiple quantum wells显示文摘The nano-patterned InGaN film was used in green InGaN/GaN multiple quantum wells(MQWs)structure,to relieve the unpleasantly existing mismatch between high indium content InGaN and GaN,as well as to enhance the light output.The different self-assembled nano-masks were formed on InGaN by annealing thin Ni layers of different thicknesses.Whereafter,the InGaN films were etched into nano-patterned films.Compared with the green MQWs structure grown on untreated InGaN film,which on nano-patterned InGaN had better luminous performance.Among them the MQWs performed best when 3 nm thick Ni film was used as mask,because that optimally balanced the effects of nano-patterned InGaN on the crystal quality and the light output. | Ruoshi Peng Shengrui Xu Xiaomeng Fan Hongchang Tao Huake Su Yuan Gao Jincheng Zhang Yue Hao | 2023 | Journal of Semiconductors2023，44，4： | 0 |
| 4 | Effects of chitin nanocrystals on coverage of coating layers and water retention of coating color显示文摘This study assessed the applicability of chitin nanocrystals prepared by 2,2,6,6-Tetramethyl-1-Piperidine-1-oxyl radical(TEMPO)-mediated oxidation in traditional papermaking coating color systems.The��-chitin nanocrystals(CTNCs)with different carboxyl content,size,and morphology were prepared from crab shells by alkali pretreatment and TEMPO-mediated oxidation in the water at pH 10,and then the ratio of CTNCs to latex was applied to traditional coating color system to replace part of latex.The results showed that when the amount of NaClO added as co-oxidant in the oxidation was 15.0 mmol/g of chitin,the carboxyl content of alkali-pretreated CTNCs was up to 0.76 mmol/g.The amount of carboxyl groups presented a linear relation with the degree of individualization of nanocrystals and dispersion.When the ratio of latex to CTNCs was 90꞉10,the water retention value of the coating was 92%lower than that of the pure latex system,and the rheological property was better.The relationship between the addition amount of CTNCs and the surface strength and the coverage of coating layers were also studied,and results showed that when the ratio of latex to CTNCs was 95꞉5,the surface strength was the highest of 1.45 m/s,and the coverage of coating layers rate reached the highest of 78%. | Ruoshi Gao Yi Jing Yeyan Ni Qiwen Jiang | 2022 | Journal of Bioresources and Bioproducts2022，7，3： | 0 |
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