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| 1 | Ordovician radiolarians from the Yinisala ophiolitic melange and their significance in western Junggar, Xinjiang, NW China显示文摘The Yinisala ophiolitic mélange is located in the southern part of the Xiemisitai Mountains in western Junggar(NW China), and is composed of mafic-ultra mafic rocks, siliceous blocks, marble(marbleized limestone) and pyroclastic rocks, which all crop out as faulted blocks. Rich radiolarian and sponge spicule fossils are found in the siliceous rock for the first time. There are six genera of radiolarians(including one gen. et sp. Indet.) belonging to two families: Inaniguttid gen. et sp. Indet., Inanigutta sp., Inanibigutta sp., Inanihella bakanasensis(Nazarov), Triplococcus acanthicus(Danelian and Popov), Antygopora sp., which are identified to be of late Early to Middle Ordovician age, representing the upper limit of the formation age of the Yinisala ophiolite mélange. The ophiolites were developed in the Early Cambrian-Middle Ordovician oceanic environment, probably an important part of the early Paleozoic Paleo-Asian Ocean, based on the composition and structure of the siliceous rock and associated deep-water fossils. The Yinisala, Taerbahatai, and Hongguleleng ophiolitic mélange belts can be correlated as a suite of unified subduction accretionary complex, which extends eastward to the eastern Junggar. We consider that there existed an ancient ocean connecting the east and west of northern Junggar in the Early Cambrian-Middle Ordovician. | ZONG RuiWen WANG ZiZhang GONG YiMing WANG GuoCan XIAO Long WANG ZhiHong FAN RuoYing | 2015 | Science China Earth Sciences2015，58，5： | 4 |
| 2 | Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders显示文摘The concept of the glial-vascular unit(GVU)was raised recently to emphasize the close associations between brain cells and cerebral vessels,and their coordinated reactions to diverse neurological insults from a“glio-centric”view.GVU is a multicellular structure composed of glial cells,perivascular cells,and perivascular space.Each component is closely linked,collectively forming the GVU.The central roles of glial and perivascular cells and their multi-level interconnections in the GVU under normal conditions and in central nervous system(CNS)disorders have not been elucidated in detail.Here,we comprehensively review the intensive interactions between glial cells and perivascular cells in the niche of perivascular space,which take part in the modulation of cerebral blood flow and angiogenesis,formation of the blood-brain barrier,and clearance of neurotoxic wastes.Next,we discuss dysfunctions of the GVU in various neurological diseases,including ischemic stroke,spinal cord injury,Alzheimer’s disease,and major depression disorder.In addition,we highlight the possible therapies targeting the GVU,which may have potential clinical applications. | Di Yao Ruoying Zhang Minjie Xie Fengfei Ding Minghuan Wang Wei Wang | 2023 | Neuroscience Bulletin2023，39，3： | 1 |
| 3 | Electrospun nanofiber/hydrogel composite materials and their tissue engineering applications显示文摘Electrospun nanofiber/hydrogel composites combine the excellent biochemical properties of hydrogel with the biomimetic nature of electrospun fibers,and have attracted widespread attention in the last few years.Besides,nanofiber/hydrogel composites with tunable mechanical properties can mimic the microstructure of extracellular matrix(ECM)of various tissues and the microenvironment of different cells.These features enable electrospun fiber/hydrogel composites have uniquely advantageous for tissue repair.However,a comprehensive review of electrospun fiber/hydrogel composites as tissue engineering scaffolds is still lacking.Thus,this article systematically reviewed the preparation of electrospun fiber/hydrogel composites and their application in tissue engineering.First,the preparation strategies of electrospun fiber/hydrogel composites are classified and discussed.Second,the application of electrospun fiber/hydrogel-based scaffolds in tissue engineering,involving skin,blood vessel,nerve,bone and other tissue engineering,are summarized.Finally,future research directions for functional electrospun fiber/hydrogel scaffold materials are proposed. | Miaomiao Zhang Shixin Xu Ruoying Wang Yongan Che Cuicui Han Wei Feng Chengwei Wang Wen Zhao | 2023 | Journal of Materials Science & Technology2023，，31： | 0 |
| 4 | Ground–Space–Sky Observing System Experiment during Tropical Cyclone Mulan in August 2022显示文摘Forecasting tropical cyclone track and intensity is a great challenge for the meteorological community,and safeguarding the life and property of people living near the coast is an important issue.One major reason for challenging forecasts is the lack of observations over the vast oceans.During tropical cyclone Mulan between 8 and 10 August 2022 over the northern part of the South China Sea,the meteorological authority and research institutes of Chinese mainland collaborated with the meteorological service in Hong Kong on conducting the first-ever ground–space–sky observing system experiment on tropical cyclone Mulan.The enhanced targeted observations collected during the experiment include Geostationary Interferometric Infrared Sounder,round-trip radiosondes,and aircraft-launched dropsondes.This paper describes the campaign,technical details of the meteorological models used,and impact of the additional targeted observation data on the tropical cyclone forecast.Ideally,similar enhanced observation campaigns could be conducted in the future,not only in the northern part of the South China Sea,but also in other ocean basins. | Pak-wai CHAN Wei HAN Betty MAK Xiaohao QIN Yongzhu LIU Ruoying YIN Jincheng WANG | 2023 | Advances in Atmospheric Sciences2023，40，2： | 0 |
| 5 | Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics显示文摘Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability. | Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward Fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo Qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，6： | 0 |
| 6 | Electroactive and antibacterial wound dressings based on Ti_(3)C_(2)T_(x)MXene/poly(ε-caprolactone)/gelatin coaxial electrospun nanofibrous membranes显示文摘Endogenous electric fields(EFs)are capable of regulating the behaviors of skin cells in wound healing.However,majority of current dressings are primarily engaged in the passive repair of defective tissue,as they lack the ability to actively respond to physiological electrical signals.In this work,a series of nanofibrous membranes(NFMs)were fabricated by coaxial electrospinning,combining the good mechanical properties of poly(ε-caprolactone)(PCL),the bioactivity of gelatin and the electroactivity of Ti_(3)C_(2)T_(x)MXene,as electroactive and antibacterial dressings for cutaneous wound healing.The obtained NFMs exhibited suitable mechanical properties and hydrophilicity,excellent electroactivity,antibacterial activity,and biocompatibility.Especially,Ti_(3)C_(2)T_(x)MXene/PCL/gelatin-6(MPG-6,6 wt.%of Ti_(3)C_(2)T_(x)MXene in sheath spinning liquids)showed the optimal conductivity and antibacterial activity.Excitingly,this scaffold significantly promoted the adhesion,proliferation,and migration of NIH 3T3 cells under the electrical stimulation(ES).The in vivo evaluation in a full-thickness wounds defect model demonstrated that the MPG-6 films significantly accelerated wound closure,increased granulation tissue formation,increased collagen deposition,and promoted wound vascularization.In summary,the versatile scaffold is expected to be an ideal candidate as wound dressings due to its ability to promote the transmission of physiological electrical signals and thus improved the therapeutic outcomes of wound regeneration. | Shixin Xu Chen Du Miaomiao Zhang Ruoying Wang Wei Feng Chengwei Wang Qinsong Liu Wen Zhao | 2023 | Nano Research2023，16，7： | 0 |
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