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| 1 | The optimal configuration of reciprocating engine based on maximum entransy loss显示文摘A class of two-heat-reservoir heat engine model with heat leakage,finite heat capacity high-temperature source and infinite heat capacity low-temperature heat sink,is researched with the finite-time thermodynamic theory and the entransy theory.The optimal configuration based on the minimum entropy generation and the maximum entransy loss under the given cycle is searched,which are compared with the optimal configuration based on the maximum output work,and all the heat transfer in the model is assumed to obey the Newton’s law.The results show that,for the infinite heat capacity high-temperature source,the optimal configuration does not change whether heat leakage exists or not;however,for the finite hightemperature reservoir,the optimal configuration is different among which based on the minimum entropy generation,the maximum entransy loss,and the maximum output work when the heat leakage exists. | Aibo Yang Lingen Chen Shaojun Xia Fengrui Sun | 2014 | Chinese Science Bulletin2014，59，17： | 14 |
| 2 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 3 | Design,modeling and experimental investigation of a magnetically modulated rotational energy harvester for low frequency and irregular vibration显示文摘Vibration energy harvesting is a promising approach for sustainable energy generation from ambience to meet the development of self-powered systems.Here,we propose a novel compact non-resonant magnetically modulated rotational energy harvester(MMR-EH)for low frequency and irregular vibration.Through the rational arrangement of multiple magnetic fields in space,a ring route with low potential energy is established.A movable magnet can be non-contact modulated by the magnetic force to move along the ring route under irregular vibration,which is instrumental in electromechanical energy conversion.A dynamic model of the MMR-EH is developed based on the energy method and verified experimentally.The effects of key parameters on the magnetically modulated route are analysed.The simulation and experimental results demonstrate that the MMR-EH can effectively harvest the energy from ultra-low frequency(3 Hz)and irregular vibration.At a reciprocating vibration frequency of 10 Hz and an amplitude of 20 mm,the harvester can produce an average power of 0.29 mW. | ZHAO LinChuan ZOU HongXiang GAO QiuHua YAN Ge WU ZhiYuan LIU FengRui WEI KeXiang YANG Bin ZHANG WenMing | 2020 | Science China(Technological Sciences)2020，63，10： | 5 |
| 4 | LRIF1 interacts with HPla to coordinate accurate chromosome segregation during mitosis显示文摘Heterochromatin protein 1α (HP1α)regulates chromatin specification and plasticity during cell fate decision.Different structural determinants account for HP1α Localization and function during cell division cycle.Our earlier study showed that centromeric Localization of HP1α depends on the epigenetic mark H3K9me3 in interphase,while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors.Here,we identified a PXVXL-containing protein,Ligand-dependent nuclear receptorinteracting factor 1 (LRIF1),which recruits HPla to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis.LRIF1 interacts directly with HPla chromoshadow domain via an evolutionariLy conserved PXVXL motif within its C-terminus.Importantly,the LRIF1-HPla interaction is critical for Aurora B activity in the inner centromere.Mutation of PXVXL motif of LRIF1 Leads to defects in HPla centromere targeting and aberrant chromosome segregation.These findings reveal a previously unrecognized direct Link between LRIF1 and HP1α in centromere plasticity control and illustrate the critical role of LRIF1-HP1α interaction in orchestrating accurate cell division. | Saima Akram Fengrui Yang Junying Li Gregory Adams Yingying Liu Xiaoxuan Zhuang Lingluo Chu Xu Liu Nerimah Emmett Winston Thompson McKay Mullen Saravana Muthusamy Wenwen Wang Fei Mo Xing Liu | 2018 | Journal of Molecular Cell Biology2018，10，6： | 5 |
| 5 | Mechanism of Incompatible Herb Pairs, Panax ginseng and Veratrum nigrum L,: Material Basis and Metabolic Profiles of Ginsenosides in Rat Intestinal Bacteria显示文摘在繁体中文药理论,人参属人参和 Veratrum nigrum L。是重要不兼容的植物对。在老鼠的新陈代谢上的主要部件和影响的内容变化上的研究肠的细菌是有用的理解这的不兼容的机制植物对。在这研究,人参皂甙和他们的 metaboltic 的内容变化在 P 的摘录介绍。P 的人参和相容性。有 V 的人参。nigrum L。(G-V ) 用 electrospray 电离团 spectrometry (ESIMS ) 和 UPLCMS n , 分别地。大多数人参皂甙的相对内容在 G-V 的摘录被减少。而且,人参皂甙 Rb 1, Rb 2, Rc 和 Rd 能在老鼠被使产生代射变化到 Rd, F2 和 C-K 肠的细菌。在在 10:5, 10:7 和 10:10 和人参皂甙 Rb 1, Rb 2 的新陈代谢的率的比率的 G-V 摘录的 Rb 1, Rb 2 和 Rc 和到 Rd 的 Rc 的新陈代谢的速度,到在所有相容性摘录的 F2 的 Rd 在 P 是比那低的。人参摘录。在结论,这研究说明了机制由相对内容的比较和在 P 的相容性以后的人参皂甙的新陈代谢的侧面减少效果。人参和 V。nigrum L。 | Xiudong Yang Xue Li Ying Xu Zifeng Pi Na Lin Zhiqiang Liu Fengrui Song | 2015 | Chinese Journal of Chemistry2015，33，9： | 3 |
| 6 | Influence of Cr^(3+) Concentration on SO_2 Removal over TiO_2 Based Multi-walled Carbon Nanotubes显示文摘In this study, titanium dioxide supported by multi-walled carbon nano tubes(MWCNTs/TiO_2) and Cr-doped TiO_2 supported by MWCNTs(MWNTs/Cr-TiO_2) were synthesized by the sol-gel method. The prepared samples were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, the BrunauerEmmett-Teller analysis, and the Raman spectroscopy. The oxidation and efficiency for removal of SO_2 in a simulated flue gas were investigated experimentally in a fixed-bed reactor. The 15% MWCNTs/Cr-Ti02 sample displayed excellent adsorption properties, and a SO_2 removal rate equating to 30.415 1 mg/g from the simulated flue gas containing 2 300 μg/g of SO_2, 8% of 02, and 5% of H20 was achieved under optimal conditions covering a temperature of 333.15 K, and a space velocity of 1 275 h^(-1). The adsorption process was enhanced because Cr doping modified the pore structure and inhibited the grain growth of TiO_2. In addition, the Freundlich and Langmuir models revealed that SO_2 was mainly adsorbed through chemical adsorption on the sample surfaces, and the thermodynamic model analysis indicated that the adsorption was a spontaneous, exothermic, and entropy-reducing process. The adsorption kinetics of SO_2 can be described by the pseudosecond-order kinetic and the Bangham dynamics models. The possible reaction mechanism involved in desulfurization process was also proposed. | Yang Yanchun Jia Fengrui Jian Weiwei Zhang Shaopeng Ma Danzhu Liu Guangxin | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 2 |
| 7 | Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity显示文摘Dear Editor,The promptness and continuous expansion of the coronavirus disease 2019(COVID-19)pandemic,elicited by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants,has presented an unprecedented impact on human health(WHO Coronavirus(COVID-19)Dashboard,2021).Although vaccination has attenuated the severe symptoms,there is no specific antiviral medication available for preventing the viral spread(Drayman et al.,2021). | Wenwen Wang Fengrui Yang Jie Lin Saravanakumar Muthusamy Shihao Du McKay Mullen Fatima Garba Wanjuan Wang Xu Liu Tao Li Zhihong Yang Xia Ding Felix Aikhionbare Xinjiao Gao Zhikai Wang Xing Liu Xuebiao Yao | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 8 | Uncertainty evaluation for bearing fatigue property of CFRP double-lap,single-bolt joints显示文摘The considerable uncertainty in mechanical properties of composite bolted joints not only prevents advanced composite materials from efficient applications,but also threatens the safety and reliability of the aircraft structures.In this paper,the uncertainty in bearing fatigue properties of a CFRP double-lap,single-bolt joint was evaluated by combing a Progressive Fatigue Damage Model(PFDM)with the interval analysis method.In the PFDM,a residualstrain-based gradual material degradation model and a strain-based fatigue failure criterion were combined with a micromechanics-based sudden material degradation model to predict fatigue properties of the joint.Based on the interval analysis,the key uncertain parameters,which were firstly picked out from eighteen structural parameters of the joint,were described by estimated intervals,and the envelope cases were determined to estimate the lower and upper bounds of fatigue properties of the joint.The predicted results have the same tendency with the experimental results in literatures,which indicates that the PFDM combined with the interval analysis shows potential in efficiently evaluating the fatigue reliability of the complex bolted joints with an adequate accuracy. | Meijuan SHAN Fengrui LIU Wen YANG Libin ZHAO Jianyu ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 9 | Mechanisms and regulation underlying membraneless organelle plasticity control显示文摘Evolution has enabled living cells to adopt their structural and functional complexity by organizing intricate cellular compartments,such as membrane-bound and membraneless organelles(MLOs),for spatiotemporal catalysis of physiochemical reactions essential for cell plasticity control.Emerging evidence and view support the notion that MLOs are built by multivalent interactions of biomolecules via phase separation and transition mechanisms.In healthy cells,dynamic chemical modifications regulate MLO plasticity,and reversible phase separation is essential for cell homeostasis.Emerging evidence revealed that aberrant phase separation results in numerous neurodegenerative disorders,cancer,and other diseases.In this review,we provide molecular underpinnings on(i)mechanistic understanding of phase separation,(ii)unifying structural and mechanistic principles that underlie this phenomenon,(iii)various mechanisms that are used by cells for the regulation of phase separation,and(iv)emerging therapeutic and other applications. | Hazrat Ismail Xu Liu Fengrui Yang Junying Li Ayesha Zahid Zhen Dou Xing Liu Xuebiao Yao | 2021 | Journal of Molecular Cell Biology2021，13，4： | 1 |
| 10 | Exergoeconomic performance optimization of an endoreversible inter- cooled regenerative Brayton combined heat and power plant coupled to variable-temperature heat reservoirs 显示文摘 | Yang 13o Chen Lingen Sun Fengrui | 2012 | International Journal Energy and Environment2012，3，4： | 1 |
| 11 | NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation显示文摘Oriented cell divisions are controlled by a conserved molecular cascade involving Gαi, LGN, and NuMA. Here, we show that NDP52 regulates spindle orientation via remodeling the polar cortical actin cytoskeleton. siRNA-mediated NDP52 suppression surprisingly revealed a ring-like compact subcortical F-actin architecture surrounding the spindle in prophase/prometaphase cells, which resulted in severe defects of astral microtubule growth and an aberrant spindle orientation. Remarkably, NDP52 recruited the actin assembly factor N-WASP and regulated the dynamics of the subcortical F-actin ring in mitotic cells. Mechanistically, NDP52 was found to bind to phosphatidic acid-containing vesicles, which absorbed cytoplasmic N-WASP to regulate local filamentous actin growth at the polar cortex. Our TIRFM analyses revealed that NDP52-containing vesicles anchored N-WASP and shortened the length of actin filaments in vitro. Based on these results we propose that NDP52-containing vesicles regulate cortical actin dynamics through N-WASP to accomplish a spatiotemporal regulation between astral microtubules and the actin network for proper spindle orientation and precise chromosome segregation. In this way, intracellular vesicles cooperate with microtubules and actin filaments to regulate proper mitotic progression. Since NDP52 is absent from yeast, we reason that metazoans have evolved an elaborate spindle positioning machinery to ensure accurate chromosome segregation in mitosis. | Huijuan Yu Fengrui Yang Peng Dong Shanhui Liao Wei R. Liu Gangyin Zhao Bo Qin Zhen Dou Zhe Liu Wei Liu Jianye Zang Jennifer Lippincott-Schwartz Xing Liu Xuebiao Yao | 2019 | Cell Research2019，29，8： | 1 |
| 12 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 13 | Association of Parkinson’s disease with six single nucleotide polymorphisms located in four PARK genes in the northern Han Chinese population显示文摘 | Yishu Zhou Xiaoguang Luo Fengrui Li Xiaofei Tian Lanhui Zhu Yichun Yang Yan Ren Hao Pang | 2011 | Journal of Clinical Neuroscience2011，，7： | 1 |
| 14 | An algorithm study on the identification of a pipeline's irregular inner boundary based on thermographic temperature measurement显示文摘 | Chunli Fan Fengrui Sun Li Yang | 2007 | Measurement Science and Technology2007，18，： | 1 |
| 15 | Exergoeconomic performance optimization of an endoreversible intercooled regenerative Brayton combined heat power plant coupled to variable- temperature reservoirs 显示文摘 | Yang Bo Chen Lingen Sun Fengrui | 2012 | International Journal of Energy and heat and Environment2012，3，4： | 1 |
| 16 | PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres显示文摘Dear Editor,Promyelocytic leukemia(PML)is the scaffold protein that organizes PML bod-ies,which are nuclear membraneless organelles involved in various biologi-cal processes,including tumor suppres-sion and antiviral responses(Ugge et al.,2022).Early electron microscopic analy-ses revealed contacts between the sur-face of PML bodies and chromatin struc-ture(Corpet et al.,2020).In fact,sev-eral chromatin and cell cycle regulators,such as TIP60,P300,and heterochro-matin protein 1(HP1),are localized in PML bodies in interphase cells(Corpet et al.,2020). | Junying Li Xiao Yuan Fengrui Yang Jun Cao Chunyue Wang Saima Akram Peng Zou Felix Aikhionbare Xuejun Li Yong Chen Liangyu Zhang Chuanhai Fu Zhikai Wang Xing Liu Xuebiao Yao | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
| 17 | Mechanical behavior of TiAl alloys显示文摘Intermetallic TiAl alloys attract much attention in advanced engineering fields due to their low density(3.9–4.2 g/cm3) and excellent high-temperature properties. After more than half a century of research and development, TiAl alloys have found applications in aerospace, automotive, and related industries. However, as a kind of semi-brittle materials, intermetallic TiAl alloys exhibit different mechanical behavior from metallic and ceramic materials. Thus, it is necessary to systematically understand their mechanical behavior to ensure further developments and safe engineering applications. In this paper, the principal mechanical behavior of Ti Al alloys was reviewed comprehensively, including tension, creep, fatigue, and strengthening mechanisms. The mechanical performance and the corresponding deformation mechanisms are summarized and discussed in detail. The future directions of mechanical research on TiAl alloys are also overviewed to expedite their extensive utilization in engineering fields. | XIANG HengGao CHEN Yang QI ZhiXiang ZHENG Gong CHEN FengRui CAO YueDe LIU Xu ZHOU Bing CHEN Guang | 2023 | Science China(Technological Sciences)2023，66，9： | 0 |
| 18 | Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing显示文摘Cellular senescence is a stress-induced,stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment,leading to chronic inflammation and age-associated diseases.Determining the fundamental molecular pathways driving senescence instead of apoptosis could enable the identification of senolytic agents to restore tissue homeostasis.Here,we identify thrombomodulin(THBD)signaling as a key molecular determinant of the senescent cell fate.Although normally restricted to endothelial cells,THBD is rapidly upregulated and maintained throughout all phases of the senescence program in aged mammalian tissues and in senescent cell models.Mechanistically,THBD activates a proteolytic feed-forward signaling pathway by stabilizing a multi-protein complex in early endosomes,thus forming a molecular basis for the irreversibility of the senescence program and ensuring senescent cell viability.Therapeutically,THBD signaling depletion or inhibition using vorapaxar,an FDA-approved drug,effectively ablates senescent cells and restores tissue homeostasis in liver fibrosis models.Collectively,these results uncover proteolytic THBD signaling as a conserved pro-survival pathway essential for senescent cell viability,thus providing a pharmacologically exploitable senolytic target for senescence-associated diseases. | Christopher C.Pan Raquel Maeso-Díaz Tylor R.Lewis Kun Xiang Lianmei Tan Yaosi Liang Liuyang Wang Fengrui Yang Tao Yin Calvin Wang Kuo Du De Huang Seh Hoon Oh Ergang Wang Bryan Jian Wei Lim Mengyang Chong Peter B.Alexander Xuebiao Yao Vadim Y.Arshavsky Qi-Jing Li Anna Mae Diehl Xiao-Fan Wang | 2023 | Cell Research2023，33，7： | 0 |
| 19 | Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics显示文摘Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability. | Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward Fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo Qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，6： | 0 |
| 20 | Article Navigation Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis显示文摘Dear Editor,The hallmarks of cancer comprise several distinct biological characteristics acquired during the multistep development of human tumors with the unique feature of genomic instability(Shen,2011).These cancer characteristics include sustaining proliferative signaling,evading growth suppressors,resisting cell death,enabling replicative immortality,inducing angiogenesis,and activating invasion and metastasis(Chen et al.,2011;Song et al.,2018).Triple-negative breast cancer(TNBC),an aggressive disease with increased risks for visceral metastases,has a poor prognosis due to unavailable and viable therapeutic targets(Bianchini et al.,2016).A TNBC diagnosis indicates that cancer cells test negative for three key receptors:estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2(Bianchini et al.,2016).The absence of these three receptors renders existing hormone and targeted therapies ineffective. | McKay Mullen Fengrui Yang Jun Cao Yang Cao Xu Liu Gee Young Lee Tao Li William Yao Zhihong Yang Jiahai Zhang Kela Johnson Felix Aikhionbare Yong Chen Xinjiao Gao Dongmei Wang Xia Ding Hadiyah-Nicole Green Xing Liu Xuebiao Yao | 2021 | Journal of Molecular Cell Biology2021，13，11： | 0 |
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