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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Treatment of peri-anal fistula in Crohn's disease显示文摘Anal fistulas are a common manifestation of Crohn's disease(CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently em-ployed. However, at the moment, none of these tech-niques appear superior to the others in terms of healing rate. Surgery is always indicated to treat symptomatic, simple, low intersphincteric fistulas refractory to medi-cal therapy and those causing disabling symptoms. Ut-most attention should be paid to correcting the balance between eradication of the fistula and the preservationof fecal continence. | Giuseppe S Sica Sara Di Carlo Giorgia Tema Fabrizio Montagnese Giovanna Del Vecchio Blanco Valeria Fiaschetti Giulia Maggi Livia Biancone | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 3 | Determination of drug,excipients and coating distribution in pharmaceutical tablets using NIR-CI显示文摘The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition).In this work,the concentration and distribution of the major and minor components of pharmaceutical tablets are determined and the spatial distribution from the internal and external sides has been obtained.In addition,the same NIR-CI allowed the coating thickness and its surface distribution to be quantified.Images were processed to extract the target data and calibration models constructed using the Partial Least Squares (PLS) algorithms.The concentrations of Active Pharmaceutical Ingredient (API) and excipients obtained for uncoated cores were essentially identical to the nominal values of the pharmaceutical formulation.But the predictive ability of the calibration models applied to the coated tablets decreased as the coating thickness increased. | Anna Palou Jordi Cruz Marcelo Blanco Jaume Tomàs Joaquín de los Ríos Manel Alcalà | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 4 |
| 4 | Nitrate regulates rhizobial and mycorrhizal symbiosis in common bean(Phaseolus vulgaris L.)显示文摘Nitrogen‐limited conditions are considered to be a prerequisite for legume‐rhizobial symbiosis, but the effects of nitrate‐rich conditions on symbiotic status remain poorly understood. We addressed this issue by examining rhizobial(Rhizobim tropici) and arbusclarmycorrhizal(Glomus intraradices) symbiosis in Phaseolus vulgaris L. cv. Negro Jamapa under nitrate pre‐incubation and continuous nitrate conditions. Our results indicate that nitrate pre‐incubation, independent of the concentration, did not affect nodule development. However, the continuous supply of nitrate at high concentrations impaired nodule maturation and nodule numbers. Low nitrate conditions, in addition to positively regulating nodule number, biomass, and nitrogenase activity, also extended the span of nitrogen‐fixing activity. By contrast, for arbuscular mycorrhizae, continuous 10 and 50mmol/L nitrate increased the percent root lengthcolonization, concomitantly reduced arbuscule size, and enhanced ammonia transport without affecting phosphate transport. Therefore, in this manuscript, we have proposed the importance of nitrate as a positive regulator in promoting both rhizobial and mycorrhizal symbiosis in the common bean. | Kalpana Nanjareddy Lourdes Blanco Manoj‐Kumar Arthikala Xochitl Alvarado Affantrange Federico Sánchez Miguel Lara | 2014 | Journal of Integrative Plant Biology2014，56，3： | 3 |
| 5 | Concentration versus non-concentrating reactors for solar photocatalytic degradation of p - nitrotoluene - o - sulfonic 显示文摘 | Para S malato S Blanco J | 2001 | Wat Sci Technol2001，44，5： | 2 |
| 6 | Adalimumab induction and maintenance therapy for patients with ulcerative colitis previously treated with infliximab显示文摘 | C.Taxonera J.Estellés I.Fernández‐Blanco O.Merino I.Marín‐Jiménez M.Barreiro‐de Acosta C.Saro V.García‐Sánchez E.Gento G.Bastida J. P.Gisbert I.Vera P.Martinez‐Montiel S.Garcia‐Morán M. C.Sánchez J. L.Mendoza | 2011 | Alimentary Pharmacology & Therapeutics2011，，3： | 2 |
| 7 | Assessment of a new test to detect Legionella urinary antigen for the diagnosis of Legionnaires' disease显示文摘 | Dominguez J Gali N Blanco S | 2001 | Diagn Microbiol Infect Dis2001，41，4： | 1 |
| 8 | Sarcoplasmic calcium-binding protein is an EF-hand–type protein identified as a new shrimp allergen显示文摘 | Rosalía Ayuso Galina Grishina María Dolores Ibá?ez Carlos Blanco Teresa Carrillo Ramon Bencharitiwong Silvia Sánchez Anna Nowak-Wegrzyn Hugh A. Sampson | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 9 | Simulated geochemical weathering of a mineral ash-rich biochar in a modified Soxhlet reactor显示文摘 | YAO F X ARBESTAIN M C VIRGEL S BLANCO F | 2010 | Chemosphere2010，80，7： | 1 |
| 10 | Functions in Sampling Spaces显示文摘 | Blanco C Cabrelli C Heineken S | 2006 | Sampling Theory in Signal and Image Processing2006，5，3： | 1 |
| 11 | Compound parabolic concentrator technology de- velopment to commercial solar detoxification applications 显示文摘 | Blanco J Malato S | 1999 | Solar Energy1999，67，426： | 1 |
| 12 | Speciation of mercuty by capillary electrophoresis -inductively coupled plasa mass spectrometry显示文摘 | DA-ROCHA S M SOLDADO A B BLANCO -GONZALEZ E | 2000 | Biomed Chromatogr2000，14，： | 1 |
| 13 | The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer显示文摘 | Medina P P Castillo S D Blanco S | 2009 | Hum Mol Genet2009，18，7： | 1 |
| 14 | New large solar photocatalytic plant:set-up and preliminary results显示文摘 | Malato S Blanco J Vidal A | 2002 | Chemosphere2002，47，： | 1 |
| 15 | Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer 显示文摘 | Kalimutho M Di Cecilia S Del Vecchio Blanco G | 2011 | Br J Cancer2011，104，： | 1 |
| 16 | The stabilisation of carbon fibres studied by micro-thermal analysis显示文摘 | Blanco C Lu S Appleyard S P | 2003 | Carbon2003，41，1： | 1 |
| 17 | Pivotalrole of TLR4 receptors in alcohol-induced neuroinflammation andbrain damage显示文摘 | Alfonso-Loeches S Pascual-Lucas M Blanco AM | 2010 | J Neurosci2010，30，24： | 1 |
| 18 | A review of recent, unconventional applications of ion mobility spectrome- try(IMS)显示文摘 | Armenta S Alcala M Blanco M | 2011 | Analytica Chimica Acta2011，703，11： | 1 |
| 19 | Hepatic subcapsular biloma secondary to laparoscopic cholecystectomy 显示文摘 | Mocanu S N Rodrlguez Blanco M Palmer Sancho J | 2012 | Cir Esp2012，90，10： | 1 |
| 20 | Wavelet entropy: a new tool for analysis of short duration brain electrical signals 显示文摘 | Rosso OA Blanco S Yordanova J | 2001 | Journal of Neuroscience Methods2001，105，1： | 1 |
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